Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
Author: Lucas G. Chase,Mohan C Vemuri
Publsiher: Springer Science & Business Media
Total Pages: 456
Release: 2012-12-12
ISBN 10: 1627032002
ISBN 13: 9781627032001
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cell Therapy Book Review:

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Orthopedic Stem Cell Surgery

Orthopedic Stem Cell Surgery
Author: Jeffrey N. Weiss
Publsiher: Springer Nature
Total Pages: 281
Release: 2021
ISBN 10: 3030732991
ISBN 13: 9783030732998
Language: EN, FR, DE, ES & NL

Orthopedic Stem Cell Surgery Book Review:

This book is a concise guide that provides an easy to follow template for other physicians to develop similar stem cell based treatments within their specialty. It identifies and summarizes the current world-wide orthopedic stem cell trials. Organized into three sections, Orthopedic Stem Cell Surgery presents clinical studies that examine the procedures for setting up and implementing stem cell surgery within the specialty of orthopedics. Chapters maintain an accessible narrative while also addressing complex studies related to orthopedic stem cell surgery. A sister text to the recently published, Retinal and Optic Nerve Stem Cell Surgery, and Neurologic Stem Cell Surgery this expertly written book examines critical Institutional Review Board (IRB) approved studies.

Orthobiologics

Orthobiologics
Author: Giuseppe Filardo,Bert R. Mandelbaum,George F. Muschler,Scott A. Rodeo,Norimasa Nakamura
Publsiher: Springer Nature
Total Pages: 402
Release: 2021-12-02
ISBN 10: 3030847446
ISBN 13: 9783030847449
Language: EN, FR, DE, ES & NL

Orthobiologics Book Review:

This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.

Bone and Cartilage Regeneration

Bone and Cartilage Regeneration
Author: Phuc Van Pham
Publsiher: Springer
Total Pages: 315
Release: 2017-01-24
ISBN 10: 3319401440
ISBN 13: 9783319401447
Language: EN, FR, DE, ES & NL

Bone and Cartilage Regeneration Book Review:

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Interface Oral Health Science 2016

Interface Oral Health Science 2016
Author: Keiichi Sasaki,Osamu Suzuki,Nobuhiro Takahashi
Publsiher: Unknown
Total Pages: 272
Release: 2020-10-08
ISBN 10: 9781013267857
ISBN 13: 1013267850
Language: EN, FR, DE, ES & NL

Interface Oral Health Science 2016 Book Review:

This volume broadens understanding of dentistry and promotes interdisciplinary research across a wide range of related fields, based on the symposium entitled "Innovative Research for Biosis-Abiosis Intelligent Interface 2016". It aims to create highly functional and autonomic intelligent interface by combining highly functional interface science with the technology of an evaluation and a control at the interface, with the various topics of biomaterials, innovation for oral science and application, regenerative oral science, and medical engineering. Since 2002, the Tohoku University Graduate School of Dentistry has hosted "Interface Oral Health Science" several times as the main theme of dental research in the twenty-first century, and this is the sixth proceedings of the symposiums following the ones in 2005, 2007, 2009, 2011, and 2014.This book benefits not only dental scientists but also other health scientists including medical physicians and pharmacologists, material scientists, engineers, and any scientist who is involved in variety of disciplines. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Stem Cell Therapy as an Alternative for Osteoarthritis of the Knee

Stem Cell Therapy as an Alternative for Osteoarthritis of the Knee
Author: Jessica Wornham
Publsiher: Unknown
Total Pages: 72
Release: 2020
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1287090976
Language: EN, FR, DE, ES & NL

Stem Cell Therapy as an Alternative for Osteoarthritis of the Knee Book Review:

Cardiac Regeneration

Cardiac Regeneration
Author: Masaki Ieda,Wolfram-Hubertus Zimmermann
Publsiher: Springer
Total Pages: 274
Release: 2017-10-27
ISBN 10: 3319561065
ISBN 13: 9783319561066
Language: EN, FR, DE, ES & NL

Cardiac Regeneration Book Review:

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Update on Mesenchymal and Induced Pluripotent Stem Cells

Update on Mesenchymal and Induced Pluripotent Stem Cells
Author: Khalid Ahmed Al-Anazi
Publsiher: BoD – Books on Demand
Total Pages: 150
Release: 2020-04-22
ISBN 10: 1789238072
ISBN 13: 9781789238075
Language: EN, FR, DE, ES & NL

Update on Mesenchymal and Induced Pluripotent Stem Cells Book Review:

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.

Stem Cells for Osteoarthritis Volume 2

Stem Cells for Osteoarthritis Volume 2
Author: Nathan Wei
Publsiher: Unknown
Total Pages: 96
Release: 2014-10-28
ISBN 10: 9781503017481
ISBN 13: 1503017486
Language: EN, FR, DE, ES & NL

Stem Cells for Osteoarthritis Volume 2 Book Review:

Osteoarthritis is the most common form of arthritis... but like Rodney Dangerfield, it doesn't get much respect. The reason is that it is so hard to treat.The types of management techniques used haven't changed in almost forty years. Very few pharmaceutical and biotech companies are willing to tackle osteoarthritis because it is such a difficult task. The number of clinical trials involving new therapies for osteoarthritis is riddled with the bodies of the fallen.For those of us in clinical practice, it has been a frustrating experience... until now...The initial volume The Book On Stem Cells For Osteoarthritis was a compilation of articles I had written on the subject of mesenchymal stem cells in the earlier days of our experience with this technology. The impetus for the first volume was to provide readers instant access to all the articles I had written on the topic rather than having to click their way through the internet. While the first book- really a booklet- was received with a lot of enthusiasm, it was clear there was also a lot of repetitive information. Unfortunately, that is the nature of a compilation of articles... there is much repetitive information.I believe the key thing is that the information is good. It is understandable. And repetition is not necessarily a bad thing when it comes to understanding knee osteoarthritis and the options available for treatment. There have been new developments in our understanding of this condition, particularly when it comes to the knee. And that's exciting for those of us who are in the Boomer demographic.In this volume I also discuss other forms of knee pain that will shed light on how difficult the diagnosis can be in certain instances.I have also updated information on stem cell biology.As the reader might imagine, the science is constantly evolving. The same is true for the procedures themselves.If the goal is to delay or even eliminate the need for joint replacement, the optimal procedure for the application of stem cell therapy is going to go through a series of improvements with the passage of time.

Mesenchymal Stem Cells in Human Health and Diseases

Mesenchymal Stem Cells in Human Health and Diseases
Author: Ahmed El-Hashash
Publsiher: Academic Press
Total Pages: 228
Release: 2020-01-06
ISBN 10: 0128197137
ISBN 13: 9780128197134
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cells in Human Health and Diseases Book Review:

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world

Early Osteoarthritis

Early Osteoarthritis
Author: Christian Lattermann,Henning Madry,Norimasa Nakamura,Elizaveta Kon
Publsiher: Springer Nature
Total Pages: 343
Release: 2021-10-09
ISBN 10: 3030794857
ISBN 13: 9783030794859
Language: EN, FR, DE, ES & NL

Early Osteoarthritis Book Review:

Early osteoarthritis is novel topic for orthopedic surgeons and its process begins immediately after joint injury. The mechanical restoration of the joint surface or ligamentous stability is not sufficient to restore the homeostatic environment in the joint, and this leads to osteoarthritis, despite mechanical stability and alignment. This book sheds light on the various mechanisms and systems involved in the gradual decline of the injured joint toward manifest osteoarthritis. Published in collaboration with ISAKOS, this volume appeals to all stakeholders in surgical orthopaedics and sports medicine.

Peripheral Nerve Stimulation

Peripheral Nerve Stimulation
Author: K.V. Slavin
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 234
Release: 2011-03-24
ISBN 10: 3805594895
ISBN 13: 9783805594899
Language: EN, FR, DE, ES & NL

Peripheral Nerve Stimulation Book Review:

In a rapidly growing field of neuromodulation against pain, this excellent publication presents a unique compilation of the latest theoretical and practical information for electrical stimulation of the peripheral nerves. Chapters cover the use of peripheral nerve stimulation in particular indications such as migraine, cluster headache, pain in Chiari malformation and fibromyalgia, as well as in specific body parts such as head and neck, trunk, and extremities. Furthermore, chapters on history, technical aspects, mechanism of action, terminology, complications and other important aspects of this pain-relieving modality give you a full overview of the field. Written by leading experts, this publication provides a comprehensive and updated summary of the currently available scientific information on peripheral nerve stimulation. All chapters contain original information making this book an invaluable reference for all who deal with the management of severe and chronic pain - including neurosurgeons and neurosurgical trainees, pain specialists and practitioners, anesthesiologists and neurologists.

Regenerative Medicine Using Pregnancy Specific Biological Substances

Regenerative Medicine Using Pregnancy Specific Biological Substances
Author: Niranjan Bhattacharya,Phillip Stubblefield
Publsiher: Springer Science & Business Media
Total Pages: 460
Release: 2010-12-25
ISBN 10: 1848827180
ISBN 13: 9781848827189
Language: EN, FR, DE, ES & NL

Regenerative Medicine Using Pregnancy Specific Biological Substances Book Review:

The proposed book is a holistic review of the clinical use of placental substances, amniotic fluid, the umbilical cord and its contents. It is intended to be a unique presentation of the current advances as well as also discussing the future applications of these substances. Attention is yet to be focused on the widespread clinical use of pregnancy-related biological substances. The aim for this book is to inform clinicians of the use of such materials and increase awareness of their therapeutic benefits. As such, this reference resource will be of great value to hematologists, rheumatologists, cardiologists, transplant technologists and all involved in regenerative medicine.

Application of Stem Cells in Canine Osteoarthritis

Application of Stem Cells in Canine Osteoarthritis
Author: Shyamal Kanti Guha,Tarani Naskar
Publsiher: LAP Lambert Academic Publishing
Total Pages: 76
Release: 2015-04-14
ISBN 10: 9783659695612
ISBN 13: 3659695610
Language: EN, FR, DE, ES & NL

Application of Stem Cells in Canine Osteoarthritis Book Review:

Stem cell therapy has emerged as a new direction in the field of regenerative medicine. Hundreds of workers throughout the world continue to refine and explore the role of bone marrow and cord blood stem cells for their regular use to solve hematological and immune mediated disorders since many years. Many of them are working to explore the uses of the different types of adult mesenchymal stem cells found in bone marrow and cord blood that could be corrected by replacing cells in the damaged tissues in their own lineages. In recent years stem cell research is being pursued in the hope of achieving major medical breakthroughs. Scientists are striving to create therapies that rebuild or replace damaged cells with tissues grown from stem cells and offer hope to people suffering from cancer, diabetes, cardiovascular disease, spinal-cord injuries, and many other neurodegenerative disorders. Both adult and embryonic stem cells may also provide a route for scientists to develop valuable new methods of drug discovery and testing.

Stem Cell Therapy for Osteoarthritis

Stem Cell Therapy for Osteoarthritis
Author: Yin Xiao
Publsiher: Academic Press
Total Pages: 300
Release: 2021-08-15
ISBN 10: 9780128219973
ISBN 13: 0128219971
Language: EN, FR, DE, ES & NL

Stem Cell Therapy for Osteoarthritis Book Review:

Stem Cell Therapy for Osteoarthritis delivers state-of-the-art knowledge of current stem cell therapies for osteoarthritis. Current literature is dated or spread across many research articles. This volume will include different sources of adult stem cells, cell derived biological agents, stem cell derived exomes, secretion factors and more. In addition to covering current therapies and technologies, the authors summarize methodologies, applications and the inclusion/exclusion criteria. The authors are world-renown experts in the field and this book fills a gap in the market. Introduces the latest updates and technologies in stem cell therapy for osteoarthritis Covers mechanisms, stem cell-based products, clinical trials, current challenges and much more Written for academic researchers, to PhD students, medical doctors, including rheumatologists and orthopaedic surgeons, other physicians and nurses

Human Mesenchymal Stem Cells

Human Mesenchymal Stem Cells
Author: Mitchell Khan
Publsiher: Nova Science Publishers
Total Pages: 134
Release: 2021
ISBN 10: 9781536192247
ISBN 13: 1536192244
Language: EN, FR, DE, ES & NL

Human Mesenchymal Stem Cells Book Review:

"In Chapter 1, the COVID-19 pandemic and the damage mechanisms on the cellular level which can be ameliorated with the cellular therapies is thoroughly evaluated. Previous and ongoing stem cell clinical trial data from diseases with similar symptoms is gathered. All this accumulated data and current clinical trial results indicate that the cellular therapies could be the most effective treatment option for COVID-19 patients to ameliorate the damaged tissues and save lives. In Chapter 2, the authors examine activated mesenchymal stem cells for stroke repair. Stem Cell treatment has shown recovery in animal models of stroke, indicating an improved regenerative and repair potential. Though stem cells are still being used in clinical trials, there is no evidence that they enhance recovery in ischemic stroke patients. Nevertheless, the multipotent mesenchymal stem has widely been explored for stroke recovery. An'Activated MSC' as a therapeutic alternative to tackling ischemic stroke is proposed, thereby the activation of MSCs by cytokines, growth factors, hypoxia, pharmacological drugs, etc., could be a novel approach to improving stroke patients' responses to receiving MSCs. In Chapter 3, the potential benefits of in vitro culture of therapeutic stem cells in the presence of HB along with the ketogenic diet, whereby higher physiological concentrations of ketone bodies can be achieved in vivo, as an adjuvant to stem cell transplantation is assessed"--

Perinatal Stem Cells

Perinatal Stem Cells
Author: Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Curtis L Cetrulo,Sean Murphy
Publsiher: Academic Press
Total Pages: 418
Release: 2018-06-14
ISBN 10: 0128120630
ISBN 13: 9780128120637
Language: EN, FR, DE, ES & NL

Perinatal Stem Cells Book Review:

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Mesenchymal Stem Cell Derived Exosomes

Mesenchymal Stem Cell Derived Exosomes
Author: Yaoliang Tang,Buddhadeb Dawn
Publsiher: Academic Press
Total Pages: 288
Release: 2015-09-02
ISBN 10: 0128004975
ISBN 13: 9780128004975
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cell Derived Exosomes Book Review:

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

Stem Cells

Stem Cells
Author: Mariusz Z. Ratajczak
Publsiher: Springer Nature
Total Pages: 406
Release: 2020-01-02
ISBN 10: 3030312062
ISBN 13: 9783030312060
Language: EN, FR, DE, ES & NL

Stem Cells Book Review:

Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.

Articular Cartilage Tissue Engineering

Articular Cartilage Tissue Engineering
Author: Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu
Publsiher: Morgan & Claypool Publishers
Total Pages: 168
Release: 2009
ISBN 10: 1598298755
ISBN 13: 9781598298758
Language: EN, FR, DE, ES & NL

Articular Cartilage Tissue Engineering Book Review:

Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions