Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
Author: Lucas G. Chase,Mohan C Vemuri
Publsiher: Springer Science & Business Media
Total Pages: 456
Release: 2012-12-12
ISBN 10: 1627032002
ISBN 13: 9781627032001
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cell Therapy Book Review:

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Regenerative Medicine for Spine and Joint Pain

Regenerative Medicine for Spine and Joint Pain
Author: Grant Cooper,Joseph Herrera,Jason Kirkbride,Zachary Perlman
Publsiher: Springer Nature
Total Pages: 268
Release: 2020-04-30
ISBN 10: 3030427714
ISBN 13: 9783030427719
Language: EN, FR, DE, ES & NL

Regenerative Medicine for Spine and Joint Pain Book Review:

Regenerative medicine (RM) is a rapidly expanding topic within orthopedic and spine surgery, sports medicine and rehabilitation medicine. In the last ten years, regenerative medicine has emerged from the fringes as a complement and challenge to evidence-based medicine. Both clinicians and patients alike are eager to be able to offer and receive treatments that don't just surgically replace or clean old joints or inject away inflammation or work as a stop-gap measure. Regenerative medicine encompasses everything from the use of stem cells and platelet-rich plasma (PRP) to prolotherapy, viscosupplementation and beyond. This book will provide healthcare practitioners dealing with spine and joint pain with the most current, up-to-date evidence-based information about which treatments work, which treatments don't, and which are on the horizon as potential game changers. Chapters are arranged in a consistent format and cover the spine, shoulder, elbow, hand and wrist, hip, knee, and foot and ankle, providing a thorough, top-to-bottom approach. A concluding chapter discusses current and future directions and applications of RM over the next decade or two. Timely and forward-thinking, Regenerative Medicine for Spine and Joint Pain will be a concise and practical resource for orthopedists, spine surgeons, sports medicine specialists, physical therapists and rehabilitation specialists, and primary care providers looking to expand their practice.

Orthobiologics

Orthobiologics
Author: Giuseppe Filardo,Bert R. Mandelbaum,George F. Muschler,Scott A. Rodeo,Norimasa Nakamura
Publsiher: Springer Nature
Total Pages: 402
Release: 2021-12-02
ISBN 10: 3030847446
ISBN 13: 9783030847449
Language: EN, FR, DE, ES & NL

Orthobiologics Book Review:

This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.

Bone and Cartilage Regeneration

Bone and Cartilage Regeneration
Author: Phuc Van Pham
Publsiher: Springer
Total Pages: 315
Release: 2017-01-24
ISBN 10: 3319401440
ISBN 13: 9783319401447
Language: EN, FR, DE, ES & NL

Bone and Cartilage Regeneration Book Review:

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Mesenchymal Stem Cells

Mesenchymal Stem Cells
Author: Phuc Van Pham
Publsiher: BoD – Books on Demand
Total Pages: 300
Release: 2017-11-29
ISBN 10: 9535136151
ISBN 13: 9789535136156
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cells Book Review:

Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: "Isolation and Characterization" and "Clinical Perspectives and Applications." In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed. This book provides a succinct yet comprehensive overview of mesenchymal stem cells for advanced students, graduate students, and researchers.

Stem Cells

Stem Cells
Author: Mariusz Z. Ratajczak
Publsiher: Springer Nature
Total Pages: 406
Release: 2020-01-02
ISBN 10: 3030312062
ISBN 13: 9783030312060
Language: EN, FR, DE, ES & NL

Stem Cells Book Review:

Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.

Cartilage Repair and Regeneration

Cartilage Repair and Regeneration
Author: Alessandro Rozim Zorzi,João Batista de Miranda
Publsiher: BoD – Books on Demand
Total Pages: 228
Release: 2018-02-14
ISBN 10: 9535137883
ISBN 13: 9789535137887
Language: EN, FR, DE, ES & NL

Cartilage Repair and Regeneration Book Review:

This work is the result of a partnership that began in 2011, when I received for the first time the invitation to be the scientific editor of a book on bone grafting, by the still little publisher known as InTech. Now six years later, InTech has grown and thrived. My respect and warm approval for the quality of the publisher's work only increased. The hyaline cartilage is a tissue that challenges tissue engineering and regenerative medicine because of its avascular nature. In the 11 chapters of this book, the reader will find texts written by researchers working on advanced topics related to basic laboratory research, as well as excellent reviews on the clinical use of currently available therapies.

Interface Oral Health Science 2016

Interface Oral Health Science 2016
Author: Keiichi Sasaki,Osamu Suzuki,Nobuhiro Takahashi
Publsiher: Springer
Total Pages: 277
Release: 2016-12-08
ISBN 10: 9811015600
ISBN 13: 9789811015601
Language: EN, FR, DE, ES & NL

Interface Oral Health Science 2016 Book Review:

This book is open access under a CC BY 4.0 license. This volume broadens understanding of dentistry and promotes interdisciplinary research across a wide range of related fields, based on the symposium entitled "Innovative Research for Biosis–Abiosis Intelligent Interface 2016". It aims to create highly functional and autonomic intelligent interface by combining highly functional interface science with the technology of an evaluation and a control at the interface, with the various topics of biomaterials, innovation for oral science and application, regenerative oral science, and medical engineering. Since 2002, the Tohoku University Graduate School of Dentistry has hosted “Interface Oral Health Science” several times as the main theme of dental research in the twenty-first century, and this is the sixth proceedings of the symposiums following the ones in 2005, 2007, 2009, 2011, and 2014. This book benefits not only dental scientists but also other health scientists including medical physicians and pharmacologists, material scientists, engineers, and any scientist who is involved in variety of disciplines.

Orthopedic Stem Cell Surgery

Orthopedic Stem Cell Surgery
Author: Jeffrey Weiss, Cmt
Publsiher: Unknown
Total Pages: 135
Release: 2022
ISBN 10: 9783030733018
ISBN 13: 3030733017
Language: EN, FR, DE, ES & NL

Orthopedic Stem Cell Surgery Book Review:

Cardiac Regeneration

Cardiac Regeneration
Author: Masaki Ieda,Wolfram-Hubertus Zimmermann
Publsiher: Springer
Total Pages: 274
Release: 2017-10-27
ISBN 10: 3319561065
ISBN 13: 9783319561066
Language: EN, FR, DE, ES & NL

Cardiac Regeneration Book Review:

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Stem Cell Transplantation for Autoimmune Diseases and Inflammation

Stem Cell Transplantation for Autoimmune Diseases and Inflammation
Author: Phuc Van Pham
Publsiher: Springer
Total Pages: 163
Release: 2019-08-13
ISBN 10: 3030234215
ISBN 13: 9783030234218
Language: EN, FR, DE, ES & NL

Stem Cell Transplantation for Autoimmune Diseases and Inflammation Book Review:

This book introduces many new technologies and clinical applications of hematopoietic stem cells and mesenchymal stem cell transplantation for the treatment of autoimmune diseases and inflammatory diseases. Presented in two parts, Part 1 focuses on stem cell therapies for autoimmune disease treatment; Part 2 focuses on stem cell therapies and their application in the treatment of common inflammatory diseases, including chronic knee osteoarthritis, chronic obstructive pulmonary disease, liver cirrhosis, Crohn's Disease, Multiple Sclerosis, and more. This book is an essential source for all advanced students and researchers involved with these diseases, stem cells, or both. Stem Cell Transplantation for Autoimmune Diseases and Inflammation and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine, or tissue engineering as well as cancer or genetics research.

Mesenchymal Stem Cells in Human Health and Diseases

Mesenchymal Stem Cells in Human Health and Diseases
Author: Ahmed H.K. El-Hashash
Publsiher: Academic Press
Total Pages: 228
Release: 2020-01-07
ISBN 10: 0128205334
ISBN 13: 9780128205334
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cells in Human Health and Diseases Book Review:

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world

Update on Mesenchymal and Induced Pluripotent Stem Cells

Update on Mesenchymal and Induced Pluripotent Stem Cells
Author: Khalid Ahmed Al-Anazi
Publsiher: BoD – Books on Demand
Total Pages: 148
Release: 2020-04-22
ISBN 10: 1789238072
ISBN 13: 9781789238075
Language: EN, FR, DE, ES & NL

Update on Mesenchymal and Induced Pluripotent Stem Cells Book Review:

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.

Peripheral Nerve Stimulation

Peripheral Nerve Stimulation
Author: K.V. Slavin
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 234
Release: 2011-03-24
ISBN 10: 3805594895
ISBN 13: 9783805594899
Language: EN, FR, DE, ES & NL

Peripheral Nerve Stimulation Book Review:

In a rapidly growing field of neuromodulation against pain, this excellent publication presents a unique compilation of the latest theoretical and practical information for electrical stimulation of the peripheral nerves. Chapters cover the use of peripheral nerve stimulation in particular indications such as migraine, cluster headache, pain in Chiari malformation and fibromyalgia, as well as in specific body parts such as head and neck, trunk, and extremities. Furthermore, chapters on history, technical aspects, mechanism of action, terminology, complications and other important aspects of this pain-relieving modality give you a full overview of the field. Written by leading experts, this publication provides a comprehensive and updated summary of the currently available scientific information on peripheral nerve stimulation. All chapters contain original information making this book an invaluable reference for all who deal with the management of severe and chronic pain - including neurosurgeons and neurosurgical trainees, pain specialists and practitioners, anesthesiologists and neurologists.

Early Osteoarthritis

Early Osteoarthritis
Author: Christian Lattermann,Henning Madry,Norimasa Nakamura,Elizaveta Kon
Publsiher: Springer Nature
Total Pages: 343
Release: 2021-10-09
ISBN 10: 3030794857
ISBN 13: 9783030794859
Language: EN, FR, DE, ES & NL

Early Osteoarthritis Book Review:

Early osteoarthritis is novel topic for orthopedic surgeons and its process begins immediately after joint injury. The mechanical restoration of the joint surface or ligamentous stability is not sufficient to restore the homeostatic environment in the joint, and this leads to osteoarthritis, despite mechanical stability and alignment. This book sheds light on the various mechanisms and systems involved in the gradual decline of the injured joint toward manifest osteoarthritis. Published in collaboration with ISAKOS, this volume appeals to all stakeholders in surgical orthopaedics and sports medicine.

Articular Cartilage Tissue Engineering

Articular Cartilage Tissue Engineering
Author: Kyriacos A. Athanasiou,Eric M. Darling,Jerry C. Hu
Publsiher: Morgan & Claypool Publishers
Total Pages: 168
Release: 2009
ISBN 10: 1598298755
ISBN 13: 9781598298758
Language: EN, FR, DE, ES & NL

Articular Cartilage Tissue Engineering Book Review:

Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions

Cartilage and Osteoarthritis

Cartilage and Osteoarthritis
Author: Massimo Sabatini,Philippe Pastoureau,Frédéric De Ceuninck
Publsiher: Springer Science & Business Media
Total Pages: 376
Release: 2004
ISBN 10: 1592598102
ISBN 13: 9781592598106
Language: EN, FR, DE, ES & NL

Cartilage and Osteoarthritis Book Review:

Osteoarthritis, the most common form of arthritis, imposes a significant burden of suffering on a growing population of the elderly. Even today, its poorly understood pathophysiology limits the discovery of molecular targets for pharmacological intervention and there are few effective medical treatments beyond pain control and surgery. In Cartilage and Osteoarthritis a distinguished panel of researchers, physicians, and opinion leaders in this challenging field describe their updated classical, but still evolving, techniques, as well as many emerging methods that promise to add significantly to our understanding of cartilage metabolism in health and disease. Volume 1: Cellular and Molecular Tools describes proven molecular and cellular techniques for the in vitro study of normal and osteoarthritic cartilage through biochemical, biomolecular, immunological, and physical approaches, with emphasis on the genetic manipulation of cells. The protocols follow the successful Methods in Molecular Medicine"!series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. A companion volume, Volume 2: Structure and In Vivo Analysis, offers cutting-edge procedures for studies-at the tissue level-of turnover, structure, and functioning in normal and diseased cartilage by invasive and noninvasive means. Comprehensive and up-to-date, the two volumes of Cartilage and Osteoarthritis provide researchers and bench scientists alike with an indispensable collection of readily reproducible protocols for new experiments-from the cellular to the animal level-designed to more clearly describe the pathophysiology of cartilage, as well as to discover novel molecular targets for pharmacological intervention

Stem Cell Therapy as an Alternative for Osteoarthritis of the Knee

Stem Cell Therapy as an Alternative for Osteoarthritis of the Knee
Author: Jessica Wornham
Publsiher: Unknown
Total Pages: 72
Release: 2020
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1287090976
Language: EN, FR, DE, ES & NL

Stem Cell Therapy as an Alternative for Osteoarthritis of the Knee Book Review:

Human Mesenchymal Stem Cells

Human Mesenchymal Stem Cells
Author: Mitchell Khan
Publsiher: Nova Science Publishers
Total Pages: 134
Release: 2021
ISBN 10: 9781536192247
ISBN 13: 1536192244
Language: EN, FR, DE, ES & NL

Human Mesenchymal Stem Cells Book Review:

"In Chapter 1, the COVID-19 pandemic and the damage mechanisms on the cellular level which can be ameliorated with the cellular therapies is thoroughly evaluated. Previous and ongoing stem cell clinical trial data from diseases with similar symptoms is gathered. All this accumulated data and current clinical trial results indicate that the cellular therapies could be the most effective treatment option for COVID-19 patients to ameliorate the damaged tissues and save lives. In Chapter 2, the authors examine activated mesenchymal stem cells for stroke repair. Stem Cell treatment has shown recovery in animal models of stroke, indicating an improved regenerative and repair potential. Though stem cells are still being used in clinical trials, there is no evidence that they enhance recovery in ischemic stroke patients. Nevertheless, the multipotent mesenchymal stem has widely been explored for stroke recovery. An'Activated MSC' as a therapeutic alternative to tackling ischemic stroke is proposed, thereby the activation of MSCs by cytokines, growth factors, hypoxia, pharmacological drugs, etc., could be a novel approach to improving stroke patients' responses to receiving MSCs. In Chapter 3, the potential benefits of in vitro culture of therapeutic stem cells in the presence of HB along with the ketogenic diet, whereby higher physiological concentrations of ketone bodies can be achieved in vivo, as an adjuvant to stem cell transplantation is assessed"--

Perinatal Stem Cells

Perinatal Stem Cells
Author: Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Curtis L Cetrulo,Sean Murphy
Publsiher: Academic Press
Total Pages: 418
Release: 2018-06-14
ISBN 10: 0128120630
ISBN 13: 9780128120637
Language: EN, FR, DE, ES & NL

Perinatal Stem Cells Book Review:

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells