Site Specific and Global Epigenomic Editing

Site Specific and Global Epigenomic Editing
Author: Feng C Zhou
Publsiher: Academic Press
Total Pages: 704
Release: 2022-06-15
ISBN 10: 9780128193983
ISBN 13: 0128193980
Language: EN, FR, DE, ES & NL

Site Specific and Global Epigenomic Editing Book Review:

In recent years, alongside the largely popularized advances in human genome editing and CRISPR-cas9-driven therapeutics, epigenomic editing has made strong strides, though a clear understanding is still forming in the field of the exact role that epigenetics play in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. Key questions for researchers embarking in this field include: Which of the hundreds of epigenomic marks and features are relevant, and which of those are likely to serve a role in regulating gene expression, cell behavior, and phenotypic outcomes? This volume is the first to provide a thorough, conceptual introduction to the field of epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation. Protocols, and applied case studies examine early disease targets and likely pathways of therapeutic significance, while also outlining common challenges in the field, and the addressing the range of bioethical questions that come with altering phenotypes. This book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research. Offers a full, conceptual and applied framework for implementing epigenomic editing in biological research and drug discovery Discusses fundamental theory, experimental design, and applied approaches alongside common research challenges and bioethical concerns Examines epigenomic editing's potential role in modulation of developmental, neuropsychiatric, and immunological disorders, as well as viral infections and cancer

Targeted Genome Editing Using Site Specific Nucleases

Targeted Genome Editing Using Site Specific Nucleases
Author: Takashi Yamamoto
Publsiher: Springer
Total Pages: 205
Release: 2015-01-05
ISBN 10: 4431552278
ISBN 13: 9784431552277
Language: EN, FR, DE, ES & NL

Targeted Genome Editing Using Site Specific Nucleases Book Review:

This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.

Epigenetics Methods

Epigenetics Methods
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 736
Release: 2020-07-08
ISBN 10: 0128194154
ISBN 13: 9780128194157
Language: EN, FR, DE, ES & NL

Epigenetics Methods Book Review:

In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Quantitative Genetics Genomics and Plant Breeding 2nd Edition

Quantitative Genetics  Genomics and Plant Breeding  2nd Edition
Author: Manjit S. Kang
Publsiher: CABI
Total Pages: 431
Release: 2020-04-01
ISBN 10: 1789240212
ISBN 13: 9781789240214
Language: EN, FR, DE, ES & NL

Quantitative Genetics Genomics and Plant Breeding 2nd Edition Book Review:

This book presents state-of-the-art, authoritative chapters on contemporary issues in the broad areas of quantitative genetics, genomics and plant breeding. Section 1 (Chapters 2 to 12) emphasizes the application of genomics, and genome and epigenome editing techniques, in plant breeding; bioinformatics; quantitative trait loci mapping; and the latest approaches of examining and exploiting genotype-environment interactions. Section 2 (Chapters 13 to 20) represents the intersection of breeding, genetics and genomics. This section describes the use of cutting-edge molecular breeding and quantitative genetics techniques in wheat, rice, maize, root and tuber crops and pearl millet. Overall, the book focuses on using genomic information to help evaluate traits that can combat biotic/abiotic stresses, genome-wide association mapping, high-throughput genotyping/phenotyping, biofortification, use of big data, orphan crops, and gene editing techniques. The examples featured are taken from across crop science research and cover a wide geographical base.

Chromatin and Epigenetics

Chromatin and Epigenetics
Author: Colin Logieand
Publsiher: Unknown
Total Pages: 135
Release: 2020
ISBN 10: 9781789849820
ISBN 13: 1789849829
Language: EN, FR, DE, ES & NL

Chromatin and Epigenetics Book Review:

DNA Methyltransferases Role and Function

DNA Methyltransferases   Role and Function
Author: Albert Jeltsch,Renata Z. Jurkowska
Publsiher: Springer
Total Pages: 535
Release: 2016-11-08
ISBN 10: 3319436244
ISBN 13: 9783319436241
Language: EN, FR, DE, ES & NL

DNA Methyltransferases Role and Function Book Review:

DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.

Reprogramming the Genome CRISPR Cas based Human Disease Therapy

Reprogramming the Genome  CRISPR Cas based Human Disease Therapy
Author: Anonim
Publsiher: Academic Press
Total Pages: 390
Release: 2021-06-12
ISBN 10: 0323853242
ISBN 13: 9780323853248
Language: EN, FR, DE, ES & NL

Reprogramming the Genome CRISPR Cas based Human Disease Therapy Book Review:

Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy, presents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 is a key technology for targeted genome editing and regulation in a number of organisms including mammalian cells. It is a rapid, simple, and cost-effective solution. CRISPR-Cas system has recently gained much scientific and public attention. This volume covers CRISPR-Cas9 based mammalian genome editing, creating disease models, cancer therapy, neurological, heredity, blood disorders, defective gene correction, stem cells therapy, epigenetic modifications, patents, ethics, biosafety and regulatory issues challenges and opportunities. This book is a key source of information on mammalian genome editing available in a single volume. This book will be useful for beginners in mammalian genome editing and also students, researchers, scientists, policymakers, clinicians and stakeholders interested in genome editing in several areas. Offers basic understanding and a clear picture of mammalian genome editing through CRISPR-Cas systems Discusses how to create mammalian disease models, stem cell modification, epigenetic modifications, correction of defective gene in blood disorders, heredity, neurological disorders and many more Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, molecular biology, translational sciences, neurobiology, neurology, cancer, stem cells, and many more

Chromatin and Epigenetics

Chromatin and Epigenetics
Author: Colin Logie,Tobias Aurelius Knoch
Publsiher: BoD – Books on Demand
Total Pages: 294
Release: 2020-01-29
ISBN 10: 1789844924
ISBN 13: 9781789844924
Language: EN, FR, DE, ES & NL

Chromatin and Epigenetics Book Review:

Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields of epigenetics and chromatin ranging from more theoretical overviews in the first four chapters to much more detailed methodologies and insights into diagnostics and treatments in the following chapters. The chapters illustrate in their depth and breadth that genetic information is stored on all structural and dynamical levels within the nucleus with corresponding modifications of functional relevance. Thus, only an integrative systems approach allows to understand, treat, and manipulate the holistic interplay of genotype and phenotype creating functional genomes. The book chapters therefore contribute to this general perspective, not only opening opportunities for a true universal view on genetic information but also being key for a general understanding of genomes, their function, as well as life and evolution in general.

Neuroepigenomics in Aging and Disease

Neuroepigenomics in Aging and Disease
Author: Raul Delgado-Morales
Publsiher: Springer
Total Pages: 525
Release: 2017-05-18
ISBN 10: 3319538896
ISBN 13: 9783319538891
Language: EN, FR, DE, ES & NL

Neuroepigenomics in Aging and Disease Book Review:

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

Mutation Specific Gene Editing for Blood Disorders

Mutation Specific Gene Editing for Blood Disorders
Author: Carsten Werner Lederer,Pietro Genovese,Annarita Miccio,Sjaak Philipsen
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-11-25
ISBN 10: 2889716880
ISBN 13: 9782889716883
Language: EN, FR, DE, ES & NL

Mutation Specific Gene Editing for Blood Disorders Book Review:

Dr. Miccio holds patents related to viral gene delivery vectors. The Topic Editors acknowledge the use of image material from kindpng.com and from Crystal and Annie Spratt on unsplash.com.

Handbook of Epigenetics

Handbook of Epigenetics
Author: Trygve O. Tollefsbol
Publsiher: Academic Press
Total Pages: 920
Release: 2022-09-23
ISBN 10: 0323919502
ISBN 13: 9780323919500
Language: EN, FR, DE, ES & NL

Handbook of Epigenetics Book Review:

Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources. Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation

Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1

Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1
Author: Anirudh Kumar,Rakesh Kumar,Pawan Shukla,Manish K. Pandey
Publsiher: Springer Nature
Total Pages: 297
Release: 2021-05-13
ISBN 10: 9811608318
ISBN 13: 9789811608315
Language: EN, FR, DE, ES & NL

Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1 Book Review:

Increasing world population, unpredictable climate and various kind of biotic and abiotic stresses necessitate the sustainable increase in crop production through developing improved cultivars possessing enhanced genetic resilience against all odds. An exploration of these challenges and near possible solution to improve yield is addressed in this book. It comprehensively and coherently reviews the application of various aspect of rapidly growing omics technology including genomics, proteomics, transcriptomics and metabolomics for crop development. It provides detailed examination of how omics can help crop science and introduces the benefits of using these technologies to enhance crop production, resistance and other values. It also provides platform to ponder upon the integrative approach of omics to deal with complex biological problems. The book highlights crop improvement such as yield enhancement, biotic and abiotic resistance, genetic modification, bioremediation, food security etc. It explores how the different omics technology independently and collectively would be used to improve the quantitative and qualitative traits of crop plants. The book is useful for graduate and post-graduate students of life science including researchers who are keen to know about the application of omics technologies in the different area of plant science. This book is also an asset to the modern plant breeders, and agriculture biotechnologist.

Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development Progression and Treatment

Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development  Progression  and Treatment
Author: Katherine Chiappinelli,Alejandro Villagra,Lidia Karabon
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-11-30
ISBN 10: 2889717305
ISBN 13: 9782889717309
Language: EN, FR, DE, ES & NL

Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development Progression and Treatment Book Review:

Gene Expression and Regulation in Mammalian Cells

Gene Expression and Regulation in Mammalian Cells
Author: Fumiaki Uchiumi
Publsiher: BoD – Books on Demand
Total Pages: 372
Release: 2018-02-28
ISBN 10: 9535138677
ISBN 13: 9789535138679
Language: EN, FR, DE, ES & NL

Gene Expression and Regulation in Mammalian Cells Book Review:

Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.

Past Present and Future Trends in Cotton Breeding

Past  Present and Future Trends in Cotton Breeding
Author: Mehboob-Ur- Rahman,Yusuf Zafar
Publsiher: BoD – Books on Demand
Total Pages: 184
Release: 2018-05-02
ISBN 10: 1789230764
ISBN 13: 9781789230765
Language: EN, FR, DE, ES & NL

Past Present and Future Trends in Cotton Breeding Book Review:

Cotton, a source of natural fiber for textile industry, has a long breeding history aiming at increasing cotton fiber yield and its quality. Newly developed cotton varieties poorly respond in low-input environments. Secondly, the impact of changing climate may threaten the cotton production in the future. To address these challenges, efforts toward the development of resilient cotton varieties have been initiated using genetic and modern genomic approaches. In this book, research updates on cotton fiber types and properties, DNA markers for selecting desirable cotton plants, and cotton fiber genomics were compiled. Also, the modern breeding trends including development of transgenic cotton and the biosafety studies and possibilities of improving cotton genome using modern genome editing tools were also compressively discussed.

Plant Genome Editing Policies and Governance

Plant Genome Editing     Policies and Governance
Author: Thorben Sprink,Ralf Alexander Wilhelm,Armin Spök,Jürgen Robienski,Stephan Schleissing,Joachim Hermann Schiemann
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-04-22
ISBN 10: 2889636704
ISBN 13: 9782889636709
Language: EN, FR, DE, ES & NL

Plant Genome Editing Policies and Governance Book Review:

Human Neural Stem Cells

Human Neural Stem Cells
Author: Leonora Buzanska
Publsiher: Springer
Total Pages: 329
Release: 2018-09-12
ISBN 10: 3319934856
ISBN 13: 9783319934853
Language: EN, FR, DE, ES & NL

Human Neural Stem Cells Book Review:

This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.

Genetics of Male Infertility

Genetics of Male Infertility
Author: Mohamed Arafa,Haitham Elbardisi,Ahmad Majzoub,Ashok Agarwal
Publsiher: Springer Nature
Total Pages: 375
Release: 2020-03-14
ISBN 10: 3030379728
ISBN 13: 9783030379728
Language: EN, FR, DE, ES & NL

Genetics of Male Infertility Book Review:

This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic. The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing. Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.

Hormonal Control of Important Agronomic Traits

Hormonal Control of Important Agronomic Traits
Author: Chi-Kuang Wen,Yunde Zhao,Yong-Ling Ruan
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2018-12-21
ISBN 10: 2889456862
ISBN 13: 9782889456864
Language: EN, FR, DE, ES & NL

Hormonal Control of Important Agronomic Traits Book Review:

One of the goals of plant science is to improve agricultural sustainability, increasing yield, food diversity, and nutrition, while minimizing the negative impact on our environment. In response to internal and external cues, plant hormones control various aspects of plant growth and development. The wealth of our knowledge on plant hormones shall greatly advance sustainable agriculture.

Untitled

Untitled
Author: Anonim
Publsiher: Springer Nature
Total Pages: 442
Release: 2022
ISBN 10: 9811921199
ISBN 13: 9789811921193
Language: EN, FR, DE, ES & NL

Untitled Book Review: