Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
Author: Klara Valko
Publsiher: Elsevier
Total Pages: 612
Release: 2000-10-13
ISBN 10: 9780080541099
ISBN 13: 0080541097
Language: EN, FR, DE, ES & NL

Separation Methods in Drug Synthesis and Purification Book Review:

Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
Author: Klara Valko
Publsiher: Elsevier
Total Pages: 788
Release: 2020-06-19
ISBN 10: 0444640711
ISBN 13: 9780444640710
Language: EN, FR, DE, ES & NL

Separation Methods in Drug Synthesis and Purification Book Review:

Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography and capillary electrophoresis used as surrogates for biological processes, and new developments in the established techniques of chromatography and preparative methods. Features descriptions and applications of all separation methods used in the pharmaceutical industry Written by the leading scientists in their respective fields, providing solutions for a wide range of industrial separation problems encountered within the pharmaceutical industry Thoroughly updated with brand new separation science techniques and the latest developments in the established techniques of chromatography

Handbook of Analytical Separations Separation methods in drug synthesis and purification

Handbook of Analytical Separations  Separation methods in drug synthesis and purification
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2000
ISBN 10: 9780444500076
ISBN 13: 0444500073
Language: EN, FR, DE, ES & NL

Handbook of Analytical Separations Separation methods in drug synthesis and purification Book Review:

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products
Author: Satinder Ahuja
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2011-03-31
ISBN 10: 9781118097755
ISBN 13: 1118097750
Language: EN, FR, DE, ES & NL

Chiral Separation Methods for Pharmaceutical and Biotechnological Products Book Review:

Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.

Recent Advances in QSAR Studies

Recent Advances in QSAR Studies
Author: Tomasz Puzyn,Jerzy Leszczynski,Mark T. Cronin
Publsiher: Springer Science & Business Media
Total Pages: 414
Release: 2010-01-19
ISBN 10: 9781402097836
ISBN 13: 1402097832
Language: EN, FR, DE, ES & NL

Recent Advances in QSAR Studies Book Review:

This book presents an interdisciplinary overview on the most recent advances in QSAR studies. The first part consists of a comprehensive review of QSAR methodology. The second part highlights the interdisciplinary aspects and new areas of QSAR modelling.

Separation Techniques in Clinical Chemistry

Separation Techniques in Clinical Chemistry
Author: Hassan Y. Aboul-Enein
Publsiher: CRC Press
Total Pages: 552
Release: 2003-05-28
ISBN 10: 1135532788
ISBN 13: 9781135532789
Language: EN, FR, DE, ES & NL

Separation Techniques in Clinical Chemistry Book Review:

This reference examines innovations in separation science for improved sensitivity and cost-efficiency, increased speed, higher sample throughput and lower solvent consumption in the assessment, evaluation, and validation of emerging drug compounds. It investigates breakthroughs in sample pretreatment, HPLC, mass spectrometry, capillary electrophor

Bioanalytical Separations

Bioanalytical Separations
Author: Anonim
Publsiher: Elsevier
Total Pages: 442
Release: 2003-09-03
ISBN 10: 9780080527864
ISBN 13: 0080527868
Language: EN, FR, DE, ES & NL

Bioanalytical Separations Book Review:

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids. - Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids - Provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use - Future trends are identified, in terms of the potential impact of new technologies

Physico Chemical Methods in Drug Discovery and Development

Physico Chemical Methods in Drug Discovery and Development
Author: Zoran Mandic
Publsiher: IAPC Publishing
Total Pages: 482
Release: 2012
ISBN 10: 9535694200
ISBN 13: 9789535694205
Language: EN, FR, DE, ES & NL

Physico Chemical Methods in Drug Discovery and Development Book Review:

Chiral Separation Techniques

Chiral Separation Techniques
Author: Ganapathy Subramanian
Publsiher: John Wiley & Sons
Total Pages: 641
Release: 2008-01-08
ISBN 10: 352761172X
ISBN 13: 9783527611720
Language: EN, FR, DE, ES & NL

Chiral Separation Techniques Book Review:

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

Physicochemical and Biomimetic Properties in Drug Discovery

Physicochemical and Biomimetic Properties in Drug Discovery
Author: Klara Valko
Publsiher: John Wiley & Sons
Total Pages: 450
Release: 2013-11-25
ISBN 10: 1118770323
ISBN 13: 9781118770320
Language: EN, FR, DE, ES & NL

Physicochemical and Biomimetic Properties in Drug Discovery Book Review:

Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measurement data for optimal drug discovery.

Sampling and Sample Preparation in Field and Laboratory

Sampling and Sample Preparation in Field and Laboratory
Author: Janusz Pawliszyn
Publsiher: Elsevier
Total Pages: 1131
Release: 2002-09-23
ISBN 10: 9780444505118
ISBN 13: 0444505113
Language: EN, FR, DE, ES & NL

Sampling and Sample Preparation in Field and Laboratory Book Review:

This title is the first comprehensive book on sampling and modern sample preparation techniques and has several main objectives: to facilitate recognition of sample preparation as both an integral part of the analytical process; to present a fundamental basis and unified theoretical approach for the professional development of sample preparation; to emphasize new developments in sample preparation technology; and to highlight the future impact of sample preparation on new directions in analytical science, particularly automation, miniaturization and field implementation. Until recently, there has been relatively little scientific interest in sampling and sample preparation, however this situation is presently changing as sampling and sample preparation become integral parts of the analytical process with their own unique challenges and research opportunities. Sampling and Sample Preparation for Field and Laboratory is an essential resource for all analytical chemists, and in particular those involved in method development. Not only does it cover the fundamental aspects of extraction, it also covers applications in various matrices and includes sampling strategies and equipment and how these can be integrated into the analytical process for maximum efficiency.

Separations Chemistry

Separations Chemistry
Author: Fedor Macášek,James D. Navratil
Publsiher: Xlibris Corporation
Total Pages: 566
Release: 2016-06-06
ISBN 10: 1514417308
ISBN 13: 9781514417300
Language: EN, FR, DE, ES & NL

Separations Chemistry Book Review:

Separation of chemical species is a gate to final success of synthesis and preparation of compounds in pure and defined state. Variability of natural and artificial mixtures to be treated is enormous. Task of chemistry is to separate components of homogeneous mixtures (the gaseous and liquid solutions). The book concentrates on understanding the basic philosophies of both equilibrium and nonequilibrium chemical thermodynamics and engineering performance that lay in principle of separation technique such as distillation, crystallization, centrifugation, sorption, membrane separations, chromatography, and liquid-liquid extraction. Specific phenomena connected with photochemical separation, isotope composition, and radioactivity are discussed as well. The book is written for advanced students of chemistry having the knowledge of physical chemistry. Calculation examples are based on the international system of units. Unique list of over 1,300 full references covers scientific literature of the eighteenth to the twenty-first centuries.

Drug Bioavailability

Drug Bioavailability
Author: Han van de Waterbeemd,Hans Lennernäs,Per Artursson
Publsiher: John Wiley & Sons
Total Pages: 602
Release: 2006-03-06
ISBN 10: 3527605150
ISBN 13: 9783527605156
Language: EN, FR, DE, ES & NL

Drug Bioavailability Book Review:

The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.

Integrated Strategies for Drug Discovery Using Mass Spectrometry

Integrated Strategies for Drug Discovery Using Mass Spectrometry
Author: Mike S. Lee
Publsiher: John Wiley & Sons
Total Pages: 576
Release: 2005-09-02
ISBN 10: 0471721026
ISBN 13: 9780471721024
Language: EN, FR, DE, ES & NL

Integrated Strategies for Drug Discovery Using Mass Spectrometry Book Review:

New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

Chiral Separations By Liquid Chromatography And Related Technologies

Chiral Separations By Liquid Chromatography And Related Technologies
Author: Hassan Y. Aboul-Enein,Imran Ali
Publsiher: CRC Press
Total Pages: 400
Release: 2003-06-03
ISBN 10: 1135530750
ISBN 13: 9781135530754
Language: EN, FR, DE, ES & NL

Chiral Separations By Liquid Chromatography And Related Technologies Book Review:

Unique in its systematic and detailed description of the various types, structures, and properties of chiral stationary phases (CSPs) and their preparation, application, and future scope, this volume highlights an assortment of liquid chromatographic approaches, including sub- and super-critical fluid chromatography, capillary electrochromatography

Pharmaceutical Profiling in Drug Discovery for Lead Selection

Pharmaceutical Profiling in Drug Discovery for Lead Selection
Author: Ronald Borchardt,Edward Kerns,Christopher Lipinski,Dhrien Thakker,Binghe Wang
Publsiher: Springer Science & Business Media
Total Pages: 482
Release: 2005-12-05
ISBN 10: 9780971176799
ISBN 13: 0971176795
Language: EN, FR, DE, ES & NL

Pharmaceutical Profiling in Drug Discovery for Lead Selection Book Review:

This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select and improve potential drug candidates.

Principles and Practice of Modern Chromatographic Methods

Principles and Practice of Modern Chromatographic Methods
Author: Kevin Robards,Danielle Ryan
Publsiher: Academic Press
Total Pages: 530
Release: 2021-05-01
ISBN 10: 012822097X
ISBN 13: 9780128220979
Language: EN, FR, DE, ES & NL

Principles and Practice of Modern Chromatographic Methods Book Review:

Principles and Practice of Modern Chromatographic Methods, Second Edition takes a comprehensive, unified approach in its presentation of chromatographic techniques. Like the first edition, the book provides a scientifically rigid, but easy-to-follow presentation of chromatography concepts that begins with the purpose and intent of chromatographic theory - the “what and why that are left out of other books attempting to cover these principles. This fully revised second edition brings the content up-to-date, covering recent developments in several new sections and an additional chapter on composite methods. New topics include sample profiling, sample preparation, sustainable green chemistry, 2D chromatography, miniaturization/nano-LC, HILIC, and more. Contains thorough chapters that begin with an updated schematic overview and a visual representation of the content Avoids the obfuscation of different terminologies and classification systems that are prevalent in the area, such as the relationship between liquid chromatography and column chromatography Provides integrated and comprehensive topic coverage based on chromatographic bibliometrics and survey reports on the relative usage of chromatographic techniques

Chemometric Methods in Capillary Electrophoresis

Chemometric Methods in Capillary Electrophoresis
Author: Grady Hanrahan,Frank A. Gomez
Publsiher: John Wiley & Sons
Total Pages: 336
Release: 2009-10-22
ISBN 10: 9780470530184
ISBN 13: 0470530189
Language: EN, FR, DE, ES & NL

Chemometric Methods in Capillary Electrophoresis Book Review:

Use chemometric techniques to develop optimum separation conditions for capillary electrophoreses For all its advantages, capillary electrophoresis (CE) also carries significant disadvantages for the researcher. Offering a unique blend of information from authors active in a variety of developments of chemometrics in CE, Chemometric Methods in Capillary Electrophoresis presents modern chemometric methods as an alternative to help alleviate the problems commonly encountered during routine analysis and method development. Focusing on current chemometric methods utilized in CE endeavours by research-active experts in the field, the book begins with a thorough introduction to CE and chemometric-related concepts and the need for modern chemometric methods in CE. Part 1 discusses differing types of screening designs and response surface methodology¿in an¿application based format Part 2 includes vital discussion on various exploratory data analysis, prediction, and classification techniques utilized in CE-related studies Part 3 provides practical information on modelling quantitative structure relationships Part 4 explores transformation techniques, in particular fundamental studies and applications of cross-correlation and Hadamard Transform Electrophoresis Showing how chemometric methods are applied in a wide array of applications including biological, medical, pharmaceutical, food, forensic, and environmental science, Chemometric Methods in Capillary Electrophoresis is not only highly significant to capillary electrophoresis-based endeavours, but instructive for investigators active in other areas of separation science who could benefit from its informative content.

Absorption and Drug Development

Absorption and Drug Development
Author: Alex Avdeef
Publsiher: John Wiley & Sons
Total Pages: 744
Release: 2012-04-11
ISBN 10: 1118286030
ISBN 13: 9781118286036
Language: EN, FR, DE, ES & NL

Absorption and Drug Development Book Review:

Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates. This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including: Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier Expanded information and methods to support pKa determination New examples explaining the treatment of practically insoluble test compounds Additional case studies demonstrating the use of the latest physicochemical techniques New, revised, and expanded database tables throughout the book Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book. This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.

Comprehensive Chemometrics

Comprehensive Chemometrics
Author: Steven Brown
Publsiher: Elsevier
Total Pages: 2896
Release: 2009-03-09
ISBN 10: 044452701X
ISBN 13: 9780444527011
Language: EN, FR, DE, ES & NL

Comprehensive Chemometrics Book Review:

Designed to serve as the first point of reference on the subject, Comprehensive Chemometrics presents an integrated summary of the present state of chemical and biochemical data analysis and manipulation. The work covers all major areas ranging from statistics to data acquisition, analysis, and applications. This major reference work provides broad-ranging, validated summaries of the major topics in chemometrics—with chapter introductions and advanced reviews for each area. The level of material is appropriate for graduate students as well as active researchers seeking a ready reference on obtaining and analyzing scientific data. Features the contributions of leading experts from 21 countries, under the guidance of the Editors-in-Chief and a team of specialist Section Editors: L. Buydens; D. Coomans; P. Van Espen; A. De Juan; J.H. Kalivas; B.K. Lavine; R. Leardi; R. Phan-Tan-Luu; L.A. Sarabia; and J. Trygg Examines the merits and limitations of each technique through practical examples and extensive visuals: 368 tables and more than 1,300 illustrations (750 in full color) Integrates coverage of chemical and biological methods, allowing readers to consider and test a range of techniques Consists of 2,200 pages and more than 90 review articles, making it the most comprehensive work of its kind Offers print and online purchase options, the latter of which delivers flexibility, accessibility, and usability through the search tools and other productivity-enhancing features of ScienceDirect