Reactive Oxygen Species ROS Nanoparticles and Endoplasmic Reticulum ER Stress Induced Cell Death Mechanisms

Reactive Oxygen Species  ROS   Nanoparticles  and Endoplasmic Reticulum  ER  Stress Induced Cell Death Mechanisms
Author: Loutfy H. Madkour
Publsiher: Academic Press
Total Pages: 780
Release: 2020-06-27
ISBN 10: 0128224967
ISBN 13: 9780128224960
Language: EN, FR, DE, ES & NL

Reactive Oxygen Species ROS Nanoparticles and Endoplasmic Reticulum ER Stress Induced Cell Death Mechanisms Book Review:

Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment

Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses

Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses
Author: Loutfy H. Madkour
Publsiher: Unknown
Total Pages: 742
Release: 2020
ISBN 10: 9783030372996
ISBN 13: 3030372995
Language: EN, FR, DE, ES & NL

Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses Book Review:

This book provides insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. It presents the recent advances in new nanomedication technologies of the effects of nanoparticles NPs on oxidative stress, RONS and ER stress. The book comprises 13 chapters covering ecotoxicology, cytotoxicity, nanotoxicity and genotoxicity mechanisms causing by the role and interactions of nanoparticles and free radicals with (RONS) and (ER) stress. Endoplasmic Reticulum (ER) Stress as a mechanism for NPs induced toxicity has been discussed. The advances of nanotechnology and the effects of nanoparticles on oxidative stress, ROS and ER stress parameters are discussed. Antioxidants, therapeutic options and regulation of the immune responses are explained throughout the book.

Nanoparticle Based Drug Delivery in Cancer Treatment

Nanoparticle Based Drug Delivery in Cancer Treatment
Author: Loutfy H. Madkour
Publsiher: CRC Press
Total Pages: 558
Release: 2022-03-03
ISBN 10: 100053216X
ISBN 13: 9781000532166
Language: EN, FR, DE, ES & NL

Nanoparticle Based Drug Delivery in Cancer Treatment Book Review:

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

RNA Delivery Function for Anticancer Therapeutics

RNA Delivery Function for Anticancer Therapeutics
Author: Loutfy H. Madkour
Publsiher: CRC Press
Total Pages: 424
Release: 2022-01-26
ISBN 10: 1000532240
ISBN 13: 9781000532241
Language: EN, FR, DE, ES & NL

RNA Delivery Function for Anticancer Therapeutics Book Review:

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.

Emerging Nanomaterials for Advanced Technologies

Emerging Nanomaterials for Advanced Technologies
Author: Anand Krishnan
Publsiher: Springer Nature
Total Pages: 135
Release: 2022
ISBN 10: 3030803716
ISBN 13: 9783030803711
Language: EN, FR, DE, ES & NL

Emerging Nanomaterials for Advanced Technologies Book Review:

Over the past decade the world has seen the rise of the fascinating and diverse field currently recognized as nanotechnology. This book covers a broad spectrum of topics within nanotechnology, including synthesis techniques, various innovative characterization techniques, growth mechanisms of nanomaterials, the physics and chemistry of nanomaterials, diverse functionalization methods, and the various applications of nanomaterials in biology, therapeutics, energy, food science, and environmental science. It also discusses applications of nanostructured materials, integrative applications such as nano- and micro-electronic sensor devices, as well as agricultural and environmental remediation applications. The book also includes a discussion of advances in functionalized nanomaterials (0D, 1D, 2D and 3D) and covers the early stages of the development of functionalized nanostructures, considering the future for 2D nanomaterials and 3D objects. Additionally, it includes a chapter on nanomaterial research development that highlights work on the life-cycle analysis of nanostructured materials and toxicity aspects. This book proves useful for researchers and professionals working in the field of nanomaterials and green technology, as well as in the field of nanotechnology. It should be useful to students and specialized researchers in a number of disciplines ranging from biology, chemistry, and materials science to engineering and manufacturing in both academia and industry.

Oxidative Stress in Heart Diseases

Oxidative Stress in Heart Diseases
Author: Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit
Publsiher: Springer Nature
Total Pages: 596
Release: 2019-11-06
ISBN 10: 9811382735
ISBN 13: 9789811382734
Language: EN, FR, DE, ES & NL

Oxidative Stress in Heart Diseases Book Review:

This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

The JNK Signaling Pathway

The JNK Signaling Pathway
Author: Anning Lin
Publsiher: CRC Press
Total Pages: 97
Release: 2006-02-15
ISBN 10: 1498713343
ISBN 13: 9781498713344
Language: EN, FR, DE, ES & NL

The JNK Signaling Pathway Book Review:

Signal transduction is one of the most exciting research areas in modern biology as it deals with how information flows from the extracellular environment into a living cell to change its metabolism, genotype and phenotype. With the completion of the genomes of human and several other species, it becomes even more important to elucidate the molecul

Carotenoids in Health and Disease

Carotenoids in Health and Disease
Author: Norman I. Krinsky,Susan T. Mayne,Helmut Sies
Publsiher: CRC Press
Total Pages: 576
Release: 2004-08-30
ISBN 10: 0203026640
ISBN 13: 9780203026649
Language: EN, FR, DE, ES & NL

Carotenoids in Health and Disease Book Review:

The first source to collect the latest evidence linking carotenoids to human health and disease, this stimulating reference studies the role of carotenoids in the prevention of chronic disease and reviews breakthrough studies from more than 40 field authorities on the latest research. The book reveals the most recent findings regarding the use of c

Nanotoxicology and Nanosafety 2 0

Nanotoxicology and Nanosafety 2 0
Author: Ying-Jan Wang
Publsiher: MDPI
Total Pages: 320
Release: 2020-12-29
ISBN 10: 303936748X
ISBN 13: 9783039367481
Language: EN, FR, DE, ES & NL

Nanotoxicology and Nanosafety 2 0 Book Review:

With the rapid development of nanotechnology, nanomaterials have been widely applied in many industrial sectors, including medicine, consumer products, and electronics. While such technology has brought benefits and convenience to our daily lives, it may also potentially threaten human health. In some cases, nanomaterials present unexpected risks to both humans and the environment. Assessments of the potential hazards associated with nanotechnology have been emerging, but substantial challenges remain, because the large number of different nanomaterials cannot be effectively evaluated in a timely manner. The development of a good strategy for a nanomaterials hazard assessment not only promotes the more widespread adoption of non-rodent or 3Rs principles, but also makes nanotoxicology testing more ethical, relevant, and cost- and time-efficient. A thorough understanding of the mechanisms by which nanomaterials perturb biological systems is critical for a more comprehensive elucidation of their nanotoxicity, and this will also facilitate the development of prevention and intervention policies against adverse outcomes induced by them. We hope that the articles included in this eBook can provide updated knowledge on nanotoxicology and nanosafety, from the point of view of both toxicology and ecotoxicology.

Metallo Drugs Development and Action of Anticancer Agents

Metallo Drugs  Development and Action of Anticancer Agents
Author: Astrid Sigel,Helmut Sigel,Eva Freisinger,Roland K.O. Sigel
Publsiher: Walter de Gruyter GmbH & Co KG
Total Pages: 588
Release: 2018-02-05
ISBN 10: 311047073X
ISBN 13: 9783110470734
Language: EN, FR, DE, ES & NL

Metallo Drugs Development and Action of Anticancer Agents Book Review:

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Toxicity Mechanisms Exposure Toxicokinetic and Risk Assessment Aspects of Metals Toxic for Animals and Humans

Toxicity Mechanisms  Exposure  Toxicokinetic and Risk Assessment Aspects of Metals  Toxic for Animals and Humans
Author: Yanzhu Zhu,Fatma Mohamady El-Demerdash,Xinwei Li,Michel Mansur Machado,Alex Boye
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-03-10
ISBN 10: 2889746402
ISBN 13: 9782889746408
Language: EN, FR, DE, ES & NL

Toxicity Mechanisms Exposure Toxicokinetic and Risk Assessment Aspects of Metals Toxic for Animals and Humans Book Review:

Interaction of Nanomaterials with the Immune System

Interaction of Nanomaterials with the Immune System
Author: James C. Bonner,Jared M. Brown
Publsiher: Springer Nature
Total Pages: 223
Release: 2020-01-30
ISBN 10: 3030339629
ISBN 13: 9783030339623
Language: EN, FR, DE, ES & NL

Interaction of Nanomaterials with the Immune System Book Review:

This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.

Colorectal Cancer

Colorectal Cancer
Author: Luis Rodrigo
Publsiher: BoD – Books on Demand
Total Pages: 440
Release: 2016-09-07
ISBN 10: 9535125443
ISBN 13: 9789535125440
Language: EN, FR, DE, ES & NL

Colorectal Cancer Book Review:

Colorectal cancer (CRC) is a major health problem because it represents around 10% of all cancers and achieves a worldwide estimate of 1.4 million newly diagnosed cases annually, resulting in approximately 700,000 deaths. Approximately 19-31% of patients present liver metastases. At diagnosis, a further 23-38% will develop extra-hepatic disease. Over the past decade, the widespread use of modern chemotherapeutic and biological agents, combined with laparoscopic surgical techniques, has improved the prognosis of metastatic CRC. A better understanding of the biology of the tumor, along with high efficiency of diagnostic and therapeutic methods, as well as the spread of screening programs, will improve the survival of the CRC patients in the near future.

Mitochondria and Cell Death

Mitochondria and Cell Death
Author: Guy C. Brown,Chris E. Cooper,David G. Nicholls
Publsiher: Unknown
Total Pages: 248
Release: 1999
ISBN 10: 1928374650XXX
ISBN 13: UOM:49015002549583
Language: EN, FR, DE, ES & NL

Mitochondria and Cell Death Book Review:

Nanomaterials for Environmental Protection

Nanomaterials for Environmental Protection
Author: Boris I. Kharisov,Oxana Vasilievna Kharissova,H. V. Rasika Dias
Publsiher: John Wiley & Sons
Total Pages: 592
Release: 2014-08-27
ISBN 10: 1118845544
ISBN 13: 9781118845547
Language: EN, FR, DE, ES & NL

Nanomaterials for Environmental Protection Book Review:

This book is divided into four main sections thoroughly analyzing the use of nanomaterials for water, air and soil solutions, and emphasizing environmental risks. Providing background on nanomaterials' two-decade study, it discusses the characterization and application of unconventional disinfectants, called antimicrobial nanomaterials, which fall into three categories and, while seemingly harmless, have potential hazards if applied improperly. Special attention is given to the process of remediation, synthetics techniques, and properties of nanomaterials, with examples to which new and trained readers in the field can relate and understand. an interdisciplinary approach, aimed at scientists in physical chemistry, nanotechnology, and environmental sciences includes applications of non-conventional techniques in environmental protection furthers the development of applied nanoscience and nanotechnology suggests new industrial projects and university courses addressing nanotechnology in and for the environment includes applications for water, air and soil protection

Handbook of Nanomaterials for Cancer Theranostics

Handbook of Nanomaterials for Cancer Theranostics
Author: Joao Conde
Publsiher: Elsevier
Total Pages: 606
Release: 2018-06-27
ISBN 10: 0128133406
ISBN 13: 9780128133408
Language: EN, FR, DE, ES & NL

Handbook of Nanomaterials for Cancer Theranostics Book Review:

Handbook of Nanomaterials for Cancer Theranostics focuses on recent developments in advanced theranostic nanomedicines from a chemical and biological perspective where the advantages of theranostics are achieved by combining multiple components. The authors explore the pros and cons of theranostic nanomaterials developed in cancer research in the last 15 years, with the different strategies compared and scrutinized. In addition, the book explores how nanomaterials may overcome the regulatory hurdles facing theranostic nanomedicines. This is an important research reference for postgraduates and researchers in nanomedicine and cancer research who want to learn more on how nanomaterials can help create more effective cancer treatments. Highlights the development of smart theranostic nanomaterials to tackle biomedical problems in cancer therapy and diagnostics Explores the regulatory hurdles facing theranostic nanomedicine Discusses how the use of nanomaterials can help create more effective cancer treatments

Plant Programmed Cell Death

Plant Programmed Cell Death
Author: Arunika N. Gunawardena,Paul F. McCabe
Publsiher: Springer
Total Pages: 306
Release: 2015-10-08
ISBN 10: 3319210335
ISBN 13: 9783319210339
Language: EN, FR, DE, ES & NL

Plant Programmed Cell Death Book Review:

Programmed cell death (PCD) is a genetically encoded, active process which results in the death of individual cells, tissues, or whole organs. PCD plays an essential role in plant development and defense, and occurs throughout a plant’s lifecycle from the death of the embryonic suspensor to leaf and floral organ senescence. In plant biology, PCD is a relatively new research area, however, as its fundamental importance is further recognized, publications in the area are beginning to increase significantly. The field currently has few foundational reference books and there is a critical need for books that summarizes recent findings in this important area. This book contains chapters written by several of the world’s leading researchers in PCD. This book will be invaluable for PhD or graduate students, or for scientists and researchers entering the field. Established researchers will also find this timely work useful as an up-to-date overview of this fascinating research area.

Principles of Free Radical Biomedicine

Principles of Free Radical Biomedicine
Author: Kostas Pantopoulos,Hyman M. Schipper
Publsiher: Nova Biomedical
Total Pages: 642
Release: 2012
ISBN 10: 9781612097749
ISBN 13: 161209774X
Language: EN, FR, DE, ES & NL

Principles of Free Radical Biomedicine Book Review:

Recent years have witnessed an avalanche of new knowledge implicating free radicals in virtually every aspect of biology and medicine. It is now axiomatic that the regulated accumulation of reactive oxygen species (ROS) contributes to organismal health and well-being and that ROS serve as signaling molecules involved in cell growth, differentiation, gene regulation, replicative senescence and apoptosis. This book is an interdisciplinary text broken up into three consecutive volumes on the biochemistry and cellular/molecular biology of free radicals, transition metals, oxidants and antioxidants, and the role of oxidative stress in human health and disease.

Mechanisms of Cell Death

Mechanisms of Cell Death
Author: Cell Death Society
Publsiher: Unknown
Total Pages: 213
Release: 1999
ISBN 10: 9781573312400
ISBN 13: 1573312401
Language: EN, FR, DE, ES & NL

Mechanisms of Cell Death Book Review:

As the body of research on apoptosis grows, it paradoxically becomes simpler as the principles that define the field become more flexible and inclusive. Discussions of the role of cell death in AIDS, inflammatory disease, lung and cardiac disease, and lupus each emphasize the importance of understanding and regulating inflammation and the production of apoptotic bodies. Included in these proceedings is an in-depth review of the role of death cell genes, including intriguing studies of the existence of inhibitors of apoptosis in embryos. Many of these researchers now feel it is a combination, rather than any single gene, that activates apoptosis.

Biomedical Applications of Nanoparticles

Biomedical Applications of Nanoparticles
Author: Nadine Millot
Publsiher: MDPI
Total Pages: 366
Release: 2020-05-29
ISBN 10: 3039285424
ISBN 13: 9783039285426
Language: EN, FR, DE, ES & NL

Biomedical Applications of Nanoparticles Book Review:

This book provides an overview of the design and physico-chemical properties of nanoparticles developed for biomedical applications such as targeting and detection of pathologies, nanovectorization of drugs, radiosensitization, metal detection, and nanocomposite implants. The considerations necessary when developing a new nanomedicine are also developed, including toxicological investigation, biodistribution, and efficacy. This book provides an accurate and current representation of the field by addressing the promises and hurdles of nanomedicine via 20 different pertinent studies. Covering a wide range of areas, this book is an excellent partner for physico-chemists, doctors, pharmacologists, and biochemists working on nanosciences dedicated to medicine, both in industry and in academia.