Protein Homeostasis Diseases

Protein Homeostasis Diseases
Author: Angel L. Pey
Publsiher: Academic Press
Total Pages: 450
Release: 2020-02-13
ISBN 10: 0128191333
ISBN 13: 9780128191330
Language: EN, FR, DE, ES & NL

Protein Homeostasis Diseases Book Review:

Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

Protein Homeostasis

Protein Homeostasis
Author: Richard I. Morimoto,Dennis J. Selkoe,Jeffery W. Kelly
Publsiher: Unknown
Total Pages: 349
Release: 2012
ISBN 10: 9781936113064
ISBN 13: 1936113066
Language: EN, FR, DE, ES & NL

Protein Homeostasis Book Review:

Proper expression, folding, transport, and clearance of proteins is critical for cell function. Chaperones and enzymes that posttranslationally assist newly synthesized proteins help ensure that they fold correctly or are degraded. Translocation machineries, proteasomes, and autophagic activities help to localize and degrade proteins as necessary. Stress and aging can cause such mechanisms to become dysfunctional or overloaded, resulting in the accumulation and aggregation of misfolded proteins a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers the entire spectrum of protein homeostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry. The contributors examine the physical biochemistry of protein folding and the roles of the various cellular compartments in protein quality control, as well as approaches for ameliorating protein misfolding and aggregation diseases. Including discussions of specific disorders such as Alzheimer's disease, Huntington's disease, and prion diseases, this book is an essential reference for not only molecular and cellular biologists but also medical scientists wishing to understand the pathological consequences of and potential therapies for protein homeostasis deficiencies in common human diseases.

Protein Homeostasis Second Edition

Protein Homeostasis  Second Edition
Author: Richard I. Morimoto,Jeffery W. Kelly,F. Ulrich Hartl
Publsiher: Perspectives Cshl
Total Pages: 562
Release: 2019
ISBN 10: 9781621822967
ISBN 13: 1621822966
Language: EN, FR, DE, ES & NL

Protein Homeostasis Second Edition Book Review:

The entire life cycle of a protein-from synthesis and folding to transport and degradation-is carefully controlled by the proteostasis network. This network, consisting of many interconnected pathways and processes, manages protein homeostasis by dynamically responding to the needs of the cell. Stress and aging can challenge the proteostasis network, resulting in the aggregation of misfolded proteins-a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on how the proteostasis network functions in healthy cells and the diseases that result when protein quality control goes awry. The contributors examine the relevant biochemical attributes of proteins (e.g., solubility), the functions of normal protein aggregates (e.g., biofilm formation in bacteria), and the various heat shock proteins, chaperones, translocation machineries, proteasomes, signaling factors, and transcriptional programs involved in proteostasis. The roles of specific subcellular structures-the endoplasmic reticulum, mitochondria, ribosomes, lysosomes, and cytoplasm-in protein quality control are covered, as is the regulation of proteostasis at the organismal level (e.g., via neuronal activity). Discussions of the responses by cells when errors in protein quality control occur, the medical disorders that can result (e.g., Alzheimer disease), and pharmacologic approaches to ameliorate protein conformational disorders are also included. This book is therefore an essential reference for biochemists, cell biologists, and all biomedical scientists wishing to understand the pathological consequences of and potential therapies for proteostasis deficiencies in common human diseases.

Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases
Author: Diana Fernandes Lázaro,Tiago F. Outeiro,Arianna Bellucci,Patrik Brundin
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-02-20
ISBN 10: 2889635074
ISBN 13: 9782889635078
Language: EN, FR, DE, ES & NL

Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases Book Review:

Proteostasis and Proteolysis

Proteostasis and Proteolysis
Author: Niki Chondrogianni,Elah Pick,Anna Gioran
Publsiher: CRC Press
Total Pages: 267
Release: 2022-12-23
ISBN 10: 1000474585
ISBN 13: 9781000474589
Language: EN, FR, DE, ES & NL

Proteostasis and Proteolysis Book Review:

Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.

Protein Metabolism and Homeostasis in Aging

Protein Metabolism and Homeostasis in Aging
Author: Nektarios Tavernarakis
Publsiher: Springer Science & Business Media
Total Pages: 249
Release: 2011-01-11
ISBN 10: 1441970029
ISBN 13: 9781441970022
Language: EN, FR, DE, ES & NL

Protein Metabolism and Homeostasis in Aging Book Review:

Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with protein metabolism are critical in the aging process. The focus of this book is on the role of protein metabolism and homeostasis in aging. An overview is provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data. Protein turnover, the balance between protein synthesis and protein degradation are carefully maintained in healthy cells. Chapters 1 and 2 illustrate that aging cells are characterised by alterations in the rate, level and accuracy of protein synthesis compared to young ones, and that mRNA translation, essential for cell growth and survival, is controlled at multiple levels. The theory that growth and somatic maintenance are believed to be antagonistic processes is described in Chapter 3: inhibition of protein synthesis results in decreased rates of growth and development, but also confers an extension of lifespan, as shown for example by the effects of dietary restriction in various models organisms.

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases
Author: Michael S. Wolfe
Publsiher: Academic Press
Total Pages: 560
Release: 2018-03-29
ISBN 10: 0128113057
ISBN 13: 9780128113059
Language: EN, FR, DE, ES & NL

The Molecular and Cellular Basis of Neurodegenerative Diseases Book Review:

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Nature s Robots

Nature s Robots
Author: Charles Tanford,Jacqueline Reynolds
Publsiher: OUP Oxford
Total Pages: 312
Release: 2003-11-27
ISBN 10: 0191578517
ISBN 13: 9780191578519
Language: EN, FR, DE, ES & NL

Nature s Robots Book Review:

Proteins are amazingly versatile molecules. They make the chemical reactions happen that form the basis for life, they transmit signals in the body, they identify and kill foreign invaders, they form the engines that make us move, and they record visual images. All of this is now common knowledge, but it was not so a hundred years ago. Nature's Robots is an authoritative history of protein science, from the origins of protein research in the nineteenth century, when the chemical constitution of 'protein' was first studied and heatedly debated and when there was as yet no glimmer of the functional potential of substances in the 'protein' category, to the determination of the first structures of individual proteins at atomic resolution - when positions of individual atoms were first specified exactly and bonding between neighbouring atoms precisely defined. Tanford and Reynolds, who themselves made major contributions to the golden age of protein science, have written a remarkably vivid account of this history. It is a fascinating story, involving heroes from the past, working mostly alone or in small groups, usually with little support from formal research groups. It is also a story that embraces a number of historically important scientific controversies. Written in clear and accessible prose, Nature's Robots will appeal to general readers with an interest in popular science, in addition to professional scientists and historians of science.

Textbook of Autoinflammation

Textbook of Autoinflammation
Author: Philip J. Hashkes,Ronald M. Laxer,Anna Simon
Publsiher: Springer
Total Pages: 820
Release: 2019-02-13
ISBN 10: 3319986058
ISBN 13: 9783319986050
Language: EN, FR, DE, ES & NL

Textbook of Autoinflammation Book Review:

This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.

Impairment of Protein Homeostasis in Parkinson s Disease

Impairment of Protein Homeostasis in Parkinson s Disease
Author: Maike Lichtenberg
Publsiher: Unknown
Total Pages: 135
Release: 2011
ISBN 10: 1928374650XXX
ISBN 13: OCLC:890150680
Language: EN, FR, DE, ES & NL

Impairment of Protein Homeostasis in Parkinson s Disease Book Review:

Proteostasis and Disease

Proteostasis and Disease
Author: Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez
Publsiher: Springer Nature
Total Pages: 348
Release: 2020-04-09
ISBN 10: 3030382664
ISBN 13: 9783030382667
Language: EN, FR, DE, ES & NL

Proteostasis and Disease Book Review:

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Principles of Bone Biology

Principles of Bone Biology
Author: John P. Bilezikian,Lawrence G. Raisz,T. John Martin
Publsiher: Academic Press
Total Pages: 1900
Release: 2008-09-29
ISBN 10: 9780080568751
ISBN 13: 0080568750
Language: EN, FR, DE, ES & NL

Principles of Bone Biology Book Review:

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

Introductory Review on Sirtuins in Biology Aging and Disease

Introductory Review on Sirtuins in Biology  Aging  and Disease
Author: Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
Publsiher: Academic Press
Total Pages: 220
Release: 2018-04-20
ISBN 10: 012813500X
ISBN 13: 9780128135006
Language: EN, FR, DE, ES & NL

Introductory Review on Sirtuins in Biology Aging and Disease Book Review:

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Protein Modificomics

Protein Modificomics
Author: Tanveer Ali Dar,Laishram Rajendrakumar Singh
Publsiher: Academic Press
Total Pages: 352
Release: 2019-04-15
ISBN 10: 9780128119136
ISBN 13: 0128119136
Language: EN, FR, DE, ES & NL

Protein Modificomics Book Review:

Protein Modificomics: From Modifications to Clinical Perspectives comprehensively deals with all of the most recent aspects of post-translational modification (PTM) of proteins, including discussions on diseases involving PTMs, such as Alzheimer's, Huntington's, X-linked spinal muscular atrophy-2, aneurysmal bone cyst, angelman syndrome and OFC10. The book also discusses the role PTMs play in plant physiology and the production of medicinally important primary and secondary metabolites. The understanding of PTMs in plants helps us enhance the production of these metabolites without greatly altering the genome, providing robust eukaryotic systems for the production and isolation of desired products without considerable downstream and isolation processes. Provides thorough insights into the post translational modifications (PTMs) of proteins in both the plant and animal kingdom Presents diagrammatic representations of various protein modification and estimation mechanisms in four-color Includes coverage of diseases involving post translational modifications

Anatomy and Physiology

Anatomy and Physiology
Author: J. Gordon Betts,Peter DeSaix,Jody E. Johnson,Oksana Korol,Dean H. Kruse,Brandon Poe,James A. Wise,Mark Womble,Kelly A. Young
Publsiher: Unknown
Total Pages: 135
Release: 2013-04-25
ISBN 10: 9781947172807
ISBN 13: 1947172808
Language: EN, FR, DE, ES & NL

Anatomy and Physiology Book Review:

The Parathyroids

The Parathyroids
Author: John P. Bilezikian,Robert Marcus,Michael A. Levine
Publsiher: Elsevier
Total Pages: 881
Release: 2001-07-21
ISBN 10: 9780080525778
ISBN 13: 0080525776
Language: EN, FR, DE, ES & NL

The Parathyroids Book Review:

Written by world experts, this books follows upon the monumental success of the first edition of The Parathyroids, which was universally acclaimed as the best text on the subject. An authoritative reference that spans the basic science of parathyroid hormone treatment to major clinical disorders in a superb, single compendium, The Parathyroids offers an objective and authoritative view on controversial clinical issues in this rapidly changing field. Every medical school library and virtually every major hospital library will need this book as a reference for students and clinicians. Key Features * Offers objective and authoritative reviews on controversial clinical issues * Written by world experts on parathyroid hormone and its disorders * Superb, state-of-the-art compendium in one convenient volume * Bridges basic science of parathyroid hormone to major clinical disorders * Practical information on clinical management of parathyroid hormone disorders

Chaperones Protein Homeostasis and Protein Aggregation Diseases

Chaperones  Protein Homeostasis and Protein Aggregation Diseases
Author: Harm Harmannus Kampinga
Publsiher: Unknown
Total Pages: 135
Release: 2014
ISBN 10: 9789036771900
ISBN 13: 9036771900
Language: EN, FR, DE, ES & NL

Chaperones Protein Homeostasis and Protein Aggregation Diseases Book Review:

Biology of C Reactive Protein in Health and Disease

Biology of C Reactive Protein in Health and Disease
Author: Waliza Ansar,Shyamasree Ghosh
Publsiher: Springer
Total Pages: 301
Release: 2016-03-23
ISBN 10: 8132226801
ISBN 13: 9788132226802
Language: EN, FR, DE, ES & NL

Biology of C Reactive Protein in Health and Disease Book Review:

This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.

Copper in Drinking Water

Copper in Drinking Water
Author: National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Copper in Drinking Water
Publsiher: National Academies Press
Total Pages: 162
Release: 2000-04-12
ISBN 10: 9780309172202
ISBN 13: 0309172209
Language: EN, FR, DE, ES & NL

Copper in Drinking Water Book Review:

The safety of the nation's drinking water must be maintained to ensure the health of the public. The U.S. Environmental Protection Agency (EPA) is responsible for regulating the levels of substances in the drinking water supply. Copper can leach into drinking water from the pipes in the distribution system, and the allowable levels are regulated by the EPA. The regulation of copper, however, is complicated by the fact that it is both necessary to the normal functioning of the body and toxic to the body at too high a level. The National Research Council was requested to form a committee to review the scientific validity of the EPA's maximum contaminant level goal for copper in drinking water. Copper in Drinking Water outlines the findings of the committee's review. The book provides a review of the toxicity of copper as well as a discussion of the essential nature of this metal. The risks posed by both short-term and long-term exposure to copper are characterized, and the implications for public health are discussed. This book is a valuable reference for individuals involved in the regulation of water supplies and individuals interested in issues surrounding this metal.

Molecular Chaperones in Health and Disease

Molecular Chaperones in Health and Disease
Author: Matthias Gaestel
Publsiher: Springer Science & Business Media
Total Pages: 442
Release: 2006-01-18
ISBN 10: 3540297170
ISBN 13: 9783540297178
Language: EN, FR, DE, ES & NL

Molecular Chaperones in Health and Disease Book Review:

Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.