Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence
Author: Michael Mahler
Publsiher: Elsevier
Total Pages: 300
Release: 2021-04-15
ISBN 10: 0128202394
ISBN 13: 9780128202395
Language: EN, FR, DE, ES & NL

Precision Medicine and Artificial Intelligence Book Review:

Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on AI, its link to PM, and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as artificial intelligence (AI) has gained significant attention in the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems has enabled the generation of large amounts of data, making autoimmunity an ideal target for AI in the field of Precision Medicine (PM). More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large data sets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to get a good overview of the field of Precision Medicine for autoimmune diseases and Artificial Intelligence Provides background, milestone and examples of precision medicine for autoimmune disease and artificial intelligence Proves the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using artificial intelligence

Precision Medicine for Autoimmune Diseases

Precision Medicine for Autoimmune Diseases
Author: Georg Lautscham
Publsiher: Academic Press
Total Pages: 366
Release: 2020-09
ISBN 10: 9780128195222
ISBN 13: 0128195223
Language: EN, FR, DE, ES & NL

Precision Medicine for Autoimmune Diseases Book Review:

Autoimmune diseases have significant economic and social impacts and represent the second-most important market for pharmaceutical companies, which is unsurprising when you consider that, while 1 in 33 American will suffer from cancer, 1 in 22 Americans will suffer from an autoimmune disease, costing the US over $ 100 billion a year. However, the uptake of precision medicine in this area has been slow at best, even though it can be extremely difficult to accurately diagnose and treat patients effectively using the tools that are currently available. If the adoption of precision medicine is to truly gather pace among diseases outside of cancer, there are still several regulatory, technological, and funding-related hurdles to be overcome. Taking lessons learned from within the field of oncology and systematically applying them to areas such as autoimmune disease will enable the development of more effective drugs across a wider range of illnesses. Most importantly, this will lead to a better outcome for patients. Precision Medicine for Autoimmune Diseases summarizes the status, the ongoing activities and provides an outlook to the future.

Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence
Author: Michael Mahler
Publsiher: Academic Press
Total Pages: 300
Release: 2021-03-12
ISBN 10: 032385432X
ISBN 13: 9780323854320
Language: EN, FR, DE, ES & NL

Precision Medicine and Artificial Intelligence Book Review:

Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions Provides background, milestone and examples of precision medicine Outlines the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using AI Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine
Author: Claudio Carini,Mark Fidock,Alain van Gool
Publsiher: CRC Press
Total Pages: 631
Release: 2019-04-16
ISBN 10: 0429576730
ISBN 13: 9780429576737
Language: EN, FR, DE, ES & NL

Handbook of Biomarkers and Precision Medicine Book Review:

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Innate Immunity in Health and Disease

Innate Immunity in Health and Disease
Author: Shailendra K. Saxena,Hridayesh Prakash
Publsiher: BoD – Books on Demand
Total Pages: 414
Release: 2021-08-25
ISBN 10: 1838807659
ISBN 13: 9781838807658
Language: EN, FR, DE, ES & NL

Innate Immunity in Health and Disease Book Review:

The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.

The Autoimmune Diseases

The Autoimmune Diseases
Author: Noel R. Rose,Ian R. Mackay
Publsiher: Academic Press
Total Pages: 1532
Release: 2019-10-15
ISBN 10: 0128122420
ISBN 13: 9780128122426
Language: EN, FR, DE, ES & NL

The Autoimmune Diseases Book Review:

The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Clinical Precision Medicine

Clinical Precision Medicine
Author: Judy S. Crabtree
Publsiher: Academic Press
Total Pages: 112
Release: 2019-11-15
ISBN 10: 0128204028
ISBN 13: 9780128204023
Language: EN, FR, DE, ES & NL

Clinical Precision Medicine Book Review:

Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

Precision Medicine in Chronic Inflammation

Precision Medicine in Chronic Inflammation
Author: Anonim
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-11-09
ISBN 10: 2889716155
ISBN 13: 9782889716159
Language: EN, FR, DE, ES & NL

Precision Medicine in Chronic Inflammation Book Review:

Immune Rebalancing

Immune Rebalancing
Author: Diana Boraschi,Giselle Penton-Rol
Publsiher: Academic Press
Total Pages: 298
Release: 2016-01-25
ISBN 10: 0128033363
ISBN 13: 9780128033364
Language: EN, FR, DE, ES & NL

Immune Rebalancing Book Review:

Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches Provides information on the new strategies for drug development in this field Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader’s strategy for addressing therapeutic immune modulations

Epigenetic Biomarker and Personalized Precision Medicine

Epigenetic Biomarker and Personalized Precision Medicine
Author: Jiucun Wang,Dongyi He,Momiao Xiong,Yun Liu
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-12-21
ISBN 10: 2889661849
ISBN 13: 9782889661848
Language: EN, FR, DE, ES & NL

Epigenetic Biomarker and Personalized Precision Medicine Book Review:

IL 1 Inhibition

IL 1 Inhibition
Author: Francesca Oliviero,Paolo Sfriso,Leonardo Punzi,Jean-Michel Dayer
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2019-06-14
ISBN 10: 2889458571
ISBN 13: 9782889458578
Language: EN, FR, DE, ES & NL

IL 1 Inhibition Book Review:

This special article collection of Frontiers in Pharmacology includes reviews and original articles on different aspects of IL-1 inhibition. Since the time IL-1 and its natural antagonist IL-1Ra have been discovered, specific IL-1 targeted therapies have been developed to cure an increasing number of diseases. The purpose of this Research Topic is to provide an overview of the different clinical uses of IL-1 blockade and new insights in basic research issues.

Genomic and Precision Medicine

Genomic and Precision Medicine
Author: Geoffrey S. Ginsburg,Huntington F Willard,Christopher W. Woods,Ephraim L. Tsalik
Publsiher: Academic Press
Total Pages: 480
Release: 2019-08-15
ISBN 10: 0128015586
ISBN 13: 9780128015582
Language: EN, FR, DE, ES & NL

Genomic and Precision Medicine Book Review:

Genomic and Precision Medicine: Infectious and Inflammatory Disease, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Offers comprehensive coverage of infectious and inflammatory disease genomics Provides succinct commentary and key learning points to assist providers with the implementation of genomic and personalized medicine Presents an up-to-date overview on major opportunities for genomic and personalized medicine Includes case studies that highlight the practical use of genomics in the management of patients

Precision Medicine for Investigators Practitioners and Providers

Precision Medicine for Investigators  Practitioners and Providers
Author: Joel Faintuch,Salomao Faintuch
Publsiher: Academic Press
Total Pages: 640
Release: 2019-11-16
ISBN 10: 0128191791
ISBN 13: 9780128191798
Language: EN, FR, DE, ES & NL

Precision Medicine for Investigators Practitioners and Providers Book Review:

Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity
Author: Christopher Chang,Qianjin Lu
Publsiher: Springer Nature
Total Pages: 403
Release: 2020-05-22
ISBN 10: 9811534497
ISBN 13: 9789811534492
Language: EN, FR, DE, ES & NL

Epigenetics in Allergy and Autoimmunity Book Review:

This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Immunogenetics A Molecular and Clinical Overview

Immunogenetics  A Molecular and Clinical Overview
Author: Muneeb U. Rehman,Azher Arafah,Md. Niamat Ali,Shafat Ali
Publsiher: Academic Press
Total Pages: 410
Release: 2021-11-30
ISBN 10: 0323903355
ISBN 13: 9780323903356
Language: EN, FR, DE, ES & NL

Immunogenetics A Molecular and Clinical Overview Book Review:

A Molecular Approach to Immunogenetics, Immunogenetics: A Molecular and Clinical Overview, Volume One provides readers with an exclusive, updated overview on the scientific knowledge, achievements and findings in the field of immunogenetics. The book presents readily available, updated information on the molecular and clinical aspects of immunogenetics, from origin and development to clinical applications and future prospects. The breadth of information goes from basics to developments, clinical applications and future prospects. The book's most attractive attribute is its academic and clinical amalgamation that covers both the theoretical and practical aspects of immunogenetics. An additional feature of the book is a special chapter on viral genetics that covers COVID-19. Above all, the book contains chapters that discuss immunogenetics in relation to pharmaco-genomics and immune-toxicology. Contains exclusive information about research on immunogenetics from around the globe Includes minute and recent details that will be the prerequisite requirement for any researcher who wants to work on immunogenetics and its applications Comes fully-equipped with pictures, illustrations and tables that deliver information in a meticulous manner

Epigenetics in Precision Medicine

Epigenetics in Precision Medicine
Author: Jose Luis Garcia-Gimenez
Publsiher: Elsevier
Total Pages: 614
Release: 2021-11-22
ISBN 10: 0323858058
ISBN 13: 9780323858052
Language: EN, FR, DE, ES & NL

Epigenetics in Precision Medicine Book Review:

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice Features chapter contributions from international leaders in the field

Precision Medicine in Cancers and Non Communicable Diseases

Precision Medicine in Cancers and Non Communicable Diseases
Author: Debmalya Barh
Publsiher: CRC Press
Total Pages: 326
Release: 2018-09-03
ISBN 10: 1351650785
ISBN 13: 9781351650786
Language: EN, FR, DE, ES & NL

Precision Medicine in Cancers and Non Communicable Diseases Book Review:

The availability of human genome, large amount of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the era of clinical practice of "Precision Medicine". This book aims to provide a readily available resource on all the important developments achieved so far in the field of oncology. All recent developments have been explained along with epidemiology, technologies and approaches to manage the included diseases. Therefore, readers will get the up to date information on the next-generation approach in tackling all kinds of cancer. Key Features • Presents the latest trend of cancer management based on precision/predictive medicine approach • Reviews the latest and up to date literature in the field of Precision Medicine • Highlights the next generation approach in tackling malignant diseases • Discusses how a life-threatening disease like cancer can be managed with the help of Precision Medicine • Encapsulates a global prospective

The Mosaic of Autoimmunity

The Mosaic of Autoimmunity
Author: Yehuda Shoenfeld,David Isenberg
Publsiher: Elsevier Science Limited
Total Pages: 523
Release: 1989
ISBN 10: 9780444811844
ISBN 13: 0444811842
Language: EN, FR, DE, ES & NL

The Mosaic of Autoimmunity Book Review:

This book comprehensively sets out the common aetiopathogenetic mechanisms shared by many, apparently diverse, diseases of the immune system. Unlike most other texts it does not emphasise the differences between autoimmune diseases, but establishes their many common links including hormonal effects, dietary and immunogenetic influences, complement deficiencies and environmental factors. Special attention is given to the effects of ageing and the relationship with malignancies. The scope of the book is very broad so as to cover the integration of the many diverse components which interact to cause autoimmunity, and it contains many 1988 and 1989 references and over 100 figures and tables, offering an attractive, up-to-date guide to modern concepts. It will greatly assist immunologists wishing to enter the field of autoimmunity, and will serve as an invaluable reference work for those already working in it.

Pharmacogenomics in Precision Medicine

Pharmacogenomics in Precision Medicine
Author: Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang
Publsiher: Springer Nature
Total Pages: 289
Release: 2020-06-12
ISBN 10: 9811538956
ISBN 13: 9789811538957
Language: EN, FR, DE, ES & NL

Pharmacogenomics in Precision Medicine Book Review:

This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Early Rheumatoid Arthritis

Early Rheumatoid Arthritis
Author: Paul Emery
Publsiher: W B Saunders Company
Total Pages: 14
Release: 2005
ISBN 10: 9781416027676
ISBN 13: 141602767X
Language: EN, FR, DE, ES & NL

Early Rheumatoid Arthritis Book Review:

This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.