Nutritional Epigenomics

Nutritional Epigenomics
Author: Anonim
Publsiher: Academic Press
Total Pages: 478
Release: 2019-07-20
ISBN 10: 0128173106
ISBN 13: 9780128173107
Language: EN, FR, DE, ES & NL

Nutritional Epigenomics Book Review:

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. Empowers the reader to employ nutritional epigenomics approaches in their own research Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies

Nutrition and Epigenetics

Nutrition and Epigenetics
Author: Emily Ho,Frederick Domann
Publsiher: CRC Press
Total Pages: 422
Release: 2014-10-16
ISBN 10: 1482203820
ISBN 13: 9781482203820
Language: EN, FR, DE, ES & NL

Nutrition and Epigenetics Book Review:

Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process. This pivotal text: Documents the epigenetic effect of antioxidants and their health benefits Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging Illustrates that the epigenetic origins of disease occur in early (fetal) development Synthesizes the data regarding nutrient and epigenomic interactions Nutrition and Epigenetics highlights the interactions among nutrients, epigenetics, and health, providing an essential resource for scientists and clinical researchers interested in nutrition, aging, and metabolic diseases.

Nutrition in Epigenetics

Nutrition in Epigenetics
Author: Mihai D. Niculescu,Paul Haggarty
Publsiher: John Wiley & Sons
Total Pages: 370
Release: 2011-06-28
ISBN 10: 081381605X
ISBN 13: 9780813816050
Language: EN, FR, DE, ES & NL

Nutrition in Epigenetics Book Review:

The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.

Handbook of Nutrition Diet and Epigenetics

Handbook of Nutrition  Diet  and Epigenetics
Author: Vinood Patel,Victor Preedy
Publsiher: Springer
Total Pages: 2290
Release: 2018-12-24
ISBN 10: 9783319555294
ISBN 13: 3319555294
Language: EN, FR, DE, ES & NL

Handbook of Nutrition Diet and Epigenetics Book Review:

This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity
Author: Alexey Moskalev,Alexander M. Vaiserman
Publsiher: Academic Press
Total Pages: 544
Release: 2017-11-17
ISBN 10: 012811083X
ISBN 13: 9780128110836
Language: EN, FR, DE, ES & NL

Epigenetics of Aging and Longevity Book Review:

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Functional Food and Human Health

Functional Food and Human Health
Author: Vibha Rani,Umesh C. S. Yadav
Publsiher: Springer
Total Pages: 694
Release: 2018-10-12
ISBN 10: 9811311234
ISBN 13: 9789811311239
Language: EN, FR, DE, ES & NL

Functional Food and Human Health Book Review:

Global health and the increasing incidence of various diseases are a cause for concern, and doctors and scientists reason that the diet, food habits and lifestyle are contributing factors. Processed food has reduced the nutritional value of our diet, and although supplementing foods with various additives is considered an alternative, the long-term impact of this is not known. Many laboratories around the world are working to identify various nutritional components in our daily food and their effect on human health. These have been classified as Nutraceuticals or functional food, and they may have preventive and therapeutic effects in a number of pathologies associated with modern dietary habits and lifestyles. This book addresses various aspects of this issue, revitalizing the discussion and consolidating the latest research on nutritional and functional food and their effects in in-vitro, in-vivo and human clinical studies.

Epigenetics and Metabolomics

Epigenetics and Metabolomics
Author: Paban K. Agrawala,Poonam Rana
Publsiher: Elsevier
Total Pages: 476
Release: 2021-08-25
ISBN 10: 0323856535
ISBN 13: 9780323856539
Language: EN, FR, DE, ES & NL

Epigenetics and Metabolomics Book Review:

Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare. Offers a synthesized discussion of epigenetic regulation of metabolic activity and systems-based approaches to power new research Discusses epigenetic control of metabolic pathways and possible therapeutic targets for cancer, neurodegenerative, and neuroendocrine diseases, among others Provides guidance in epigenomics and metabolomic research methodology

Epigenetics and Human Health

Epigenetics and Human Health
Author: Alexander Haslberger,Sabine Greßler
Publsiher: John Wiley & Sons
Total Pages: 316
Release: 2011-08-24
ISBN 10: 352764475X
ISBN 13: 9783527644759
Language: EN, FR, DE, ES & NL

Epigenetics and Human Health Book Review:

After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Human Epigenomics

Human Epigenomics
Author: Carsten Carlberg,Ferdinand Molnár
Publsiher: Springer
Total Pages: 223
Release: 2018-02-01
ISBN 10: 9811076146
ISBN 13: 9789811076145
Language: EN, FR, DE, ES & NL

Human Epigenomics Book Review:

The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of the book is based on the lecture course “Molecular Medicine and Genetics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks “Mechanisms of Gene Regulation” (ISBN 978-94-017-7741-4) and “Nutrigenomics” (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a useful reference for individuals working in biomedicine.

Nutrigenomics and the Future of Nutrition

Nutrigenomics and the Future of Nutrition
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Food and Nutrition Board,Food Forum
Publsiher: National Academies Press
Total Pages: 154
Release: 2018-08-27
ISBN 10: 0309477646
ISBN 13: 9780309477642
Language: EN, FR, DE, ES & NL

Nutrigenomics and the Future of Nutrition Book Review:

On December 5, 2017, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop titled Nutrigenomics and the Future of Nutrition in Washington, DC, to review current knowledge in the field of nutrigenomics as it relates to nutrition. Workshop participants explored the influence of genetic and epigenetic expression on nutritional status and the potential impact of personalized nutrition on health maintenance and chronic disease prevention. This publication summarizes the presentations and discussions from the workshop.

Nutrition in Epigenetics

Nutrition in Epigenetics
Author: Mihai D. Niculescu,Paul Haggarty
Publsiher: John Wiley & Sons
Total Pages: 332
Release: 2011-03-25
ISBN 10: 9780470959800
ISBN 13: 0470959800
Language: EN, FR, DE, ES & NL

Nutrition in Epigenetics Book Review:

The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.

Epigenetics and Reproductive Health

Epigenetics and Reproductive Health
Author: Anonim
Publsiher: Academic Press
Total Pages: 444
Release: 2020-09-12
ISBN 10: 0128197544
ISBN 13: 9780128197547
Language: EN, FR, DE, ES & NL

Epigenetics and Reproductive Health Book Review:

Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms. Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics. Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers Features chapter contributions from international researchers in the field

Nutrition Epigenetics and Health

Nutrition  Epigenetics and Health
Author: Burdge Graham,Lillycrop Karen
Publsiher: World Scientific
Total Pages: 236
Release: 2016-10-07
ISBN 10: 9813143320
ISBN 13: 9789813143326
Language: EN, FR, DE, ES & NL

Nutrition Epigenetics and Health Book Review:

Epigenetics is emerging as an important factor in risk of diseases of global importance including obesity, cardiovascular disease and cancer. Unlike gene polymorphisms which have been the focus of understanding the role of inherited disease susceptibility for some time, epigenetic can be modified by environmental factors, in particular nutrition. Thus research into the role of epigenetics in disease has substantial potential for explaining the impact of the environmental factors such as diet on disease risk. Since epigenetic processes can be modified by nutrition, it may be possible to modify inappropriate epigenetic marks by nutritional interventions to reduce disease risk. This book will explore current understanding of the interaction between nutrition, epigenetics and disease risk, will place this knowledge in the context of global health and discuss the ethical implications of this research.

Environmental Epigenetics in Toxicology and Public Health

Environmental Epigenetics in Toxicology and Public Health
Author: Rebecca Fry
Publsiher: Academic Press
Total Pages: 364
Release: 2020-10-18
ISBN 10: 0128199695
ISBN 13: 9780128199695
Language: EN, FR, DE, ES & NL

Environmental Epigenetics in Toxicology and Public Health Book Review:

Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with an emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects. This volume in the Translational Epigenetics series aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures. Offers a thorough discussion of the environmental factors influencing epigenetic mechanisms in early and late life, and in transgenerational inheritance Examines both animal model and human population-based research in environmental epigenetics, highlighting developmental windows of vulnerability to epigenetic modification Features contributions from international experts in the field

Handbook of Life Course Health Development

Handbook of Life Course Health Development
Author: Neal Halfon,Christopher B. Forrest,Richard M. Lerner,Elaine M. Faustman
Publsiher: Springer
Total Pages: 664
Release: 2017-11-20
ISBN 10: 3319471430
ISBN 13: 9783319471433
Language: EN, FR, DE, ES & NL

Handbook of Life Course Health Development Book Review:

This book is open access under a CC BY 4.0 license. ​This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.

Environmental Epigenetics

Environmental Epigenetics
Author: L. Joseph Su,Tung-chin Chiang
Publsiher: Springer
Total Pages: 321
Release: 2015-05-18
ISBN 10: 1447166787
ISBN 13: 9781447166788
Language: EN, FR, DE, ES & NL

Environmental Epigenetics Book Review:

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Cellular and Molecular Approaches in Fish Biology

Cellular and Molecular Approaches in Fish Biology
Author: Ignacio Fernandez,Jorge Fernandes
Publsiher: Academic Press
Total Pages: 438
Release: 2021-12-01
ISBN 10: 0128222743
ISBN 13: 9780128222744
Language: EN, FR, DE, ES & NL

Cellular and Molecular Approaches in Fish Biology Book Review:

Cellular and Molecular Approaches in Fish Biology is a highly interdisciplinary resource that will bring industry professionals up-to-date on the latest developments and information on fish biology research. The book combines an historical overview of the different research areas in fish biology with detailed descriptions of cellular and molecular approaches and recommendations for research. It provides different points-of-view on how researchers have addressed timely issues, while also describing and dissecting some of the new experimental/analytical approaches used to answer key questions at cellular and molecular levels. Provides detailed descriptions of each research approach, highlighting the tricks of the trade for its effective and successful application Includes the latest developments in fish reproduction, fish nutrition, fish wellbeing, ecology and toxicology Presents hot topic areas of research, including genetic editing, epigenetics and eDNA

Present Knowledge in Nutrition

Present Knowledge in Nutrition
Author: John W. Erdman, Jr.,Ian A. MacDonald,Steven H. Zeisel
Publsiher: John Wiley & Sons
Total Pages: 2810
Release: 2012-05-30
ISBN 10: 0470963107
ISBN 13: 9780470963104
Language: EN, FR, DE, ES & NL

Present Knowledge in Nutrition Book Review:

Present Knowledge in Nutrition, 10th Edition provides comprehensive coverage of all aspects of human nutrition, including micronutrients, systems biology, immunity, public health, international nutrition, and diet and disease prevention. This definitive reference captures the current state of this vital and dynamic science from an international perspective, featuring nearly 140 expert authors from 14 countries around the world. Now condensed to a single volume, this 10th edition contains new chapters on topics such as epigenetics, metabolomics, and sports nutrition.The remaining chapters have been thoroughly updated to reflect recent developments. Suggested reading lists are now provided for readers wishing to delve further into specific subject areas. An accompanying website provides book owners with access to an image bank of tables and figures as well as any updates the authors may post to their chapters between editions. Now available in both print and electronic formats, the 10th edition will serve as a valuable reference for researchers, health professionals, and policy experts as well as educators and advanced nutrition students.

Human Epigenetics How Science Works

Human Epigenetics  How Science Works
Author: Carsten Carlberg,Ferdinand Molnár
Publsiher: Springer Nature
Total Pages: 153
Release: 2019-09-24
ISBN 10: 3030229076
ISBN 13: 9783030229078
Language: EN, FR, DE, ES & NL

Human Epigenetics How Science Works Book Review:

The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer. This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

Early Life Origins of Health and Disease

Early Life Origins of Health and Disease
Author: E. Marelyn Wintour-Coghlan,Julie Owens
Publsiher: Springer Science & Business Media
Total Pages: 228
Release: 2007-02-26
ISBN 10: 0387326324
ISBN 13: 9780387326320
Language: EN, FR, DE, ES & NL

Early Life Origins of Health and Disease Book Review:

Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a ‘must’ for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the ‘optimal’ way in which to investigate these phenomena.