Novel Sensitizing Agents for Therapeutic Anti EGFR Antibodies

Novel Sensitizing Agents for Therapeutic Anti EGFR Antibodies
Author: Shi Hu
Publsiher: Academic Press
Total Pages: 300
Release: 2021-03-15
ISBN 10: 9780128215845
ISBN 13: 0128215844
Language: EN, FR, DE, ES & NL

Novel Sensitizing Agents for Therapeutic Anti EGFR Antibodies Book Review:

Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies presents an in-depth description of sensitizers to overcome resistance to anti-EGFR targeted antibody therapies in cancer, including novel engineered antibody drugs or other sensitizers. It gives an insight into the landscape of anti-EGFR based cancer treatment, the challenges of targeted therapy, and a glimpse into the future of antibody therapy. The book offers pertinent basic science information on strategies used for the rational design and discovery of novel sensitizing agents, and, in addition, translational studies involving pre-clinical and clinical design and execution with these novel agents. It covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on EGFR blockage resistance, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new anticancer sensitizers for anti-EGFR drug resistance. This book is an indispensable resource for cancer researchers, medicinal chemists, and other biomedical scientists involved in the development of new therapeutic agents to overcome resistance to anti-EGFR treatments. Presents detailed description of history, chemistry, mechanism of action, structure-function relationships, pharmacology, side effects, dosing, and formulation of new sensitizers to anti-EGFR antibodies Provides molecular structures for all novel anticancer drugs and strategies to overcome resistance of anti-EGFR antibodies Encompasses up-to-date information on the cancer drug discovery process, including new research tools, tumor-targeting strategies, and fundamental concepts in the emerging areas of precision medicine

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy
Author: Dong-hua Yang
Publsiher: Cancer Sensitizing Agents for
Total Pages: 300
Release: 2018-11-15
ISBN 10: 9780128164358
ISBN 13: 0128164352
Language: EN, FR, DE, ES & NL

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy Book Review:

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, Volume Four in the Cancer Sensitizing Agents for Chemotherapy Series focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials. Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment

Resistance to Immunotherapeutic Antibodies in Cancer

Resistance to Immunotherapeutic Antibodies in Cancer
Author: Benjamin Bonavida
Publsiher: Springer Science & Business Media
Total Pages: 202
Release: 2013-08-04
ISBN 10: 1461476542
ISBN 13: 9781461476542
Language: EN, FR, DE, ES & NL

Resistance to Immunotherapeutic Antibodies in Cancer Book Review:

​​​​The traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective, and can also reverse drug/radiation resistance. Monoclonal antibodies or mAbs can be used to destroy malignant tumor cells and prevent tumor growth by blocking specific cell receptors. mAbs can bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell. The book covers the common and unique features of mAbs agains various cancer, gives the latest developments on the molecular, biochemical and genetic mechanisms of resistance by various mAbs, as well as discuss novel mAbs to overcome resistance.

Novel Therapies in Head and Neck Cancer Beyond the Horizon

Novel Therapies in Head and Neck Cancer  Beyond the Horizon
Author: Maie A. St. John,No hee Park
Publsiher: Academic Press
Total Pages: 266
Release: 2020-06-29
ISBN 10: 0128209291
ISBN 13: 9780128209295
Language: EN, FR, DE, ES & NL

Novel Therapies in Head and Neck Cancer Beyond the Horizon Book Review:

Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region

Novel Anticancer Agents

Novel Anticancer Agents
Author: Alex A. Adjei,John K. Buolamwini
Publsiher: Academic Press
Total Pages: 464
Release: 2011-04-28
ISBN 10: 0080537758
ISBN 13: 9780080537757
Language: EN, FR, DE, ES & NL

Novel Anticancer Agents Book Review:

This book offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. * Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field * Presents drug discovery strategies * Discusses regulatory issues surrounding drug development *

Sensitization of Cancer Cells for Chemo Immuno Radio therapy

Sensitization of Cancer Cells for Chemo Immuno Radio therapy
Author: Benjamin Bonavida
Publsiher: Springer Science & Business Media
Total Pages: 420
Release: 2008-07-31
ISBN 10: 9781597454742
ISBN 13: 1597454745
Language: EN, FR, DE, ES & NL

Sensitization of Cancer Cells for Chemo Immuno Radio therapy Book Review:

This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.

Clinical Radiation Oncology E Book

Clinical Radiation Oncology E Book
Author: Leonard L. Gunderson,Joel E. Tepper
Publsiher: Elsevier Health Sciences
Total Pages: 1638
Release: 2015-06-16
ISBN 10: 0323370187
ISBN 13: 9780323370189
Language: EN, FR, DE, ES & NL

Clinical Radiation Oncology E Book Book Review:

Perfect for radiation oncology physicians and residents needing a multidisciplinary, treatment-focused resource, this updated edition continues to provide the latest knowledge in this consistently growing field. Not only will you broaden your understanding of the basic biology of disease processes, you'll also access updated treatment algorithms, information on techniques, and state-of-the-art modalities. The consistent and concise format provides just the right amount of information, making Clinical Radiation Oncology a welcome resource for use by the entire radiation oncology team. Content is templated and divided into three sections -- Scientific Foundations of Radiation Oncology, Techniques and Modalities, and Disease Sites – for quick access to information. Disease Sites chapters summarize the most important issues on the opening page and include a full-color format, liberal use of tables and figures, a closing section with a discussion of controversies and problems, and a treatment algorithm that reflects the treatment approach of the authors. Chapters have been edited for scientific accuracy, organization, format, and adequacy of outcome data (such as disease control, survival, and treatment tolerance). Allows you to examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches. Features an emphasis on providing workup and treatment algorithms for each major disease process, as well as the coverage of molecular biology and its relevance to individual diseases. Two new chapters provide an increased emphasis on stereotactic radiosurgery (SRS) and stereotactic body irradiation (SBRT). New Associate Editor, Dr. Andrea Ng, offers her unique perspectives to the Lymphoma and Hematologic Malignancies section. Key Points are summarized at the beginning of each disease-site chapter, mirroring the template headings and highlighting essential information and outcomes. Treatment algorithms and techniques, together with discussions of controversies and problems, reflect the treatment approaches employed by the authors. Disease Site Overviews allow each section editor to give a unique perspective on important issues, while online updates to Disease Site chapters ensure your knowledge is current. Disease Site chapters feature updated information on disease management and outcomes. Thirty all-new anatomy drawings increase your visual understanding. Medicine eBook is accessible on a variety of devices.

Abeloff s Clinical Oncology E Book

Abeloff s Clinical Oncology E Book
Author: Martin D. Abeloff,James O. Armitage,John E. Niederhuber,Michael B. Kastan,W. Gillies McKenna
Publsiher: Elsevier Health Sciences
Total Pages: 2592
Release: 2008-06-30
ISBN 10: 1437720560
ISBN 13: 9781437720563
Language: EN, FR, DE, ES & NL

Abeloff s Clinical Oncology E Book Book Review:

Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.

Radiation Oncology E Book

Radiation Oncology E Book
Author: James D. Cox,Kie Kian Ang
Publsiher: Elsevier Health Sciences
Total Pages: 1088
Release: 2009-10-29
ISBN 10: 0323076602
ISBN 13: 9780323076609
Language: EN, FR, DE, ES & NL

Radiation Oncology E Book Book Review:

Radiation Oncology: Rationale, Technique, Results, by James D. Cox, MD and K. Kian Ang, MD, PhD, provides you with authoritative guidance on the latest methods for using radiotherapy to treat patients with cancer. Progressing from fundamental principles through specific treatment strategies for the cancers of each organ system, it also addresses the effects of radiation on normal structures and the avoidance of complications. This 9th edition covers the most recent indications and techniques in the field, including new developments in proton therapy and intensity-modulated radiotherapy (IMRT). It also features, for the first time, full-color images throughout the text to match those that you see in practice, and uses new color-coded treatment plans to make targets, structures, and doses easier to read at a glance. Evidence from randomized clinical trials is included whenever possible to validate clinical recommendations. The state-of-the-art coverage inside this trusted resource equips you to target cancer as effectively as possible while minimizing harm to healthy tissue. Stands apart as the only book in the field to cover the conceptual framework for the use of radiotherapy by describing the most effective techniques for treatment planning and delivery and presenting the results of each type of therapy. Emphasizes clinical uses of radiation therapy, providing pertinent, easy-to-understand information on state-of-the-art treatments. Includes information useful for non-radiotherapists, making it "recommended reading" for other oncology specialists. Offers a practical, uniform chapter structure to expedite reference. Guides you through the use of the newest radiation oncology techniques, including principles of proton therapy and new developments in intensity-modulated radiotherapy (IMRT). Incorporates evidence from randomized clinical trials whenever possible to validate clinical recommendations. Presents full-color images throughout to match the images that you see in practice. Extensive use of "combination" imaging presents a complete picture of how to more precisely locate and target the radiotherapy field.

Abeloff s Clinical Oncology E Book

Abeloff s Clinical Oncology E Book
Author: John E. Niederhuber,James O. Armitage,James H Doroshow,Michael B. Kastan,Joel E. Tepper
Publsiher: Elsevier Health Sciences
Total Pages: 2208
Release: 2019-01-08
ISBN 10: 0323568157
ISBN 13: 9780323568159
Language: EN, FR, DE, ES & NL

Abeloff s Clinical Oncology E Book Book Review:

Easily accessible and clinically focused, Abeloff's Clinical Oncology, 6th Edition, covers recent advances in our understanding of the pathophysiology of cancer, cellular and molecular causes of cancer initiation and progression, new and emerging therapies, current trials, and much more. Masterfully authored by an international team of leading cancer experts, it offers clear, practical coverage of everything from basic science to multidisciplinary collaboration on diagnosis, staging, treatment and follow up. Includes new chapters on Cancer Metabolism and Clinical Trial Designs in Oncology and a standalone chapter on lifestyles and cancer prevention. Features extensive updates including the latest clinical practice guidelines, decision-making algorithms, and clinical trial implications, as well as new content on precision medicine, genetics, and PET/CT imaging. Includes revised diagnostic and treatment protocols for medical management, surgical considerations, and radiation oncology therapies, stressing a multispecialty, integrated approach to care. Helps you find information quickly with updated indexing related to management recommendations, focused fact summaries, updated key points at the beginning of each chapter ideal for quick reference and board review, and algorithms for patient evaluation, diagnosis, and treatment options. Offers more patient care coverage in disease chapters, plus new information on cancer as a chronic illness and cancer survivorship. Discusses today’s key topics such as immuno-oncology, functional imaging, precision medicine, the application of genetics in pathologic diagnosis and sub-categorization of tumors as well as the association of chronic infectious diseases such as HIV and cancer.

Molecular Pathomechanisms and New Trends in Drug Research

Molecular Pathomechanisms and New Trends in Drug Research
Author: Gyorgy Keri,Istvan Toth
Publsiher: CRC Press
Total Pages: 664
Release: 2002-11-14
ISBN 10: 1134473370
ISBN 13: 9781134473373
Language: EN, FR, DE, ES & NL

Molecular Pathomechanisms and New Trends in Drug Research Book Review:

Knowledge of the basic mechanisms of human disease is essential for any student or professional engaged in drug research and development. Functional gene analysis (genomics), protein analysis (proteomics), and other molecular biological techniques have made it possible to understand these cellular processes, opening up exciting opportunities for no

Brain Tumors E Book

Brain Tumors E Book
Author: Andrew H. Kaye,Edward R. Laws Jr
Publsiher: Elsevier Health Sciences
Total Pages: 1088
Release: 2011-12-06
ISBN 10: 0702048186
ISBN 13: 9780702048180
Language: EN, FR, DE, ES & NL

Brain Tumors E Book Book Review:

Meet the increasing need for effective brain tumor management with the highly anticipated revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. Benefit from the knowledge and experience of Drs. Andrew H. Kaye and Edward R. Laws, globally recognized experts in the field of neurosurgery, as well as many other world authorities.

Oncology of Infancy and Childhood E Book

Oncology of Infancy and Childhood E Book
Author: Stuart H. Orkin,David E. Fisher,A. Thomas Look,Samuel Lux,David Ginsburg,David G. Nathan
Publsiher: Elsevier Health Sciences
Total Pages: 1392
Release: 2009-06-09
ISBN 10: 1437721389
ISBN 13: 9781437721386
Language: EN, FR, DE, ES & NL

Oncology of Infancy and Childhood E Book Book Review:

To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.

IASLC Thoracic Oncology E Book

IASLC Thoracic Oncology E Book
Author: Harvey Pass,David Ball,Giorgio Scagliotti
Publsiher: Elsevier Health Sciences
Total Pages: 960
Release: 2017-04-21
ISBN 10: 0323527841
ISBN 13: 9780323527842
Language: EN, FR, DE, ES & NL

IASLC Thoracic Oncology E Book Book Review:

Global experts, in conjunction with the International Association for the Study of Lung Cancer, bring you up to date with today’s best approaches to lung cancer diagnosis, treatment, and follow-up. IASLC Thoracic Oncology, 2nd Edition, keeps you abreast of the entire scope of this fast-changing field, from epidemiology to diagnosis to treatment to advocacy. Written in a straightforward, practical style for the busy clinician, this comprehensive, multidisciplinary title is a must-have for anyone involved in the care of patients with lung cancer and other thoracic malignancies. Offers practical, relevant coverage of basic science, epidemiology, pulmonology, medical and radiation oncology, surgery, pathology, palliative care, nursing, and advocacy. Provides authoritative guidance from the IASLC – the only global organization dedicated to the study of lung cancer. Includes new content on molecular testing, immunotherapy, early detection, staging and the IASLC staging system, surgical resection for stage I and stage II lung cancer, and stem cells in lung cancer. Features a new full-color design throughout, as well as updated diagnostic algorithms.

Surgical Decision Making E Book

Surgical Decision Making E Book
Author: Robert C. McIntyre,Richard D. Schulick
Publsiher: Elsevier Health Sciences
Total Pages: 512
Release: 2019-01-08
ISBN 10: 0323567916
ISBN 13: 9780323567916
Language: EN, FR, DE, ES & NL

Surgical Decision Making E Book Book Review:

Using a proven, practical, algorithmic approach, Surgical Decision Making summarizes evidence-based guidelines and practice protocols in an easy-to-follow format. Designed to sharpen the decision-making skills of both trainees and practicing surgeons, the 6th Edition directs your focus to the critical decision points in a wide range of clinical scenarios, helping you determine optimal evaluation and management to secure the best possible patient outcomes. Algorithms are accompanied by annotations that explain all critical factors affecting decisions in a concise, readable manner. Reflects the scope of practice of today’s general surgeon, with fresh, expert perspectives from new editor Dr. Richard Schulick and numerous new contributors. Contains 58 new chapters and thoroughly revised content throughout. Includes new coverage of Preoperative Evaluation of the Geriatric Patient, Pancreatic Cystic Neoplasm, Familial Breast Cancer, Resuscitative Endovascular Balloon Occlusion of the Aorta, Blunt Cerebrovascular Injury, and much more. Uses an easy-to-follow, consistent format, with an algorithm on one page and short descriptions explaining the various steps in the decision-making process on the opposite page. Includes explanatory notes that summarize presenting signs and symptoms, laboratory investigation, diagnostic modalities, surgical therapies, and adjuvant therapies for each condition. Encompasses both general surgery and surgical subspecialties―helping you directly manage a broad range of problems. Emphasizes information that frequently appears on board exams.

Cancer Drug Resistance

Cancer Drug Resistance
Author: Beverly A. Teicher
Publsiher: Springer Science & Business Media
Total Pages: 617
Release: 2007-11-09
ISBN 10: 1597450359
ISBN 13: 9781597450355
Language: EN, FR, DE, ES & NL

Cancer Drug Resistance Book Review:

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Handbook of Cancer Treatment Related Symptoms and Toxicities E Book

Handbook of Cancer Treatment Related Symptoms and Toxicities E Book
Author: Vamsidhar Velcheti,Salman R Punekar
Publsiher: Elsevier Health Sciences
Total Pages: 352
Release: 2021-01-28
ISBN 10: 032367299X
ISBN 13: 9780323672993
Language: EN, FR, DE, ES & NL

Handbook of Cancer Treatment Related Symptoms and Toxicities E Book Book Review:

Early recognition and management of adverse effects of cancer treatments are essential for optimal care of patients with cancer, and drastically different approaches are required for different physiologic reactions. Handbook of Cancer Treatment-Related Symptoms and Toxicities is a focused, one-stop resource that enables clinicians to quickly find up-to-date, reliable information needed at the point of care. The high-yield approach prioritizes the most common toxicities associated with cancer treatment, and concise, templated chapters offer fast access to information needed in day-to-day practice. Presents a user-friendly overview of cancer treatment-related symptoms and toxicities management in a practical, easy-to-use format, allowing you to quickly find information in one convenient, concise resource. Covers systemic and radiation therapies, including chemotherapy, immunotherapy, targeted therapies, and radiation therapy, detailing symptoms of each toxicity to confirm your diagnosis. Overviews pharmacologic and non-pharmacologic approaches to symptom management. Offers recommendations for mitigating toxicities in high-risk patients. Discusses key topics such as management of infusion reactions, when the need for biopsy is warranted, and the unique challenges posed by novel immunotherapies.

Autophagy and Senescence in Cancer Therapy

Autophagy and Senescence in Cancer Therapy
Author: Anonim
Publsiher: Academic Press
Total Pages: 382
Release: 2021-04-13
ISBN 10: 0128241594
ISBN 13: 9780128241592
Language: EN, FR, DE, ES & NL

Autophagy and Senescence in Cancer Therapy Book Review:

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more. Addresses the relationship between autophagy and senescence in cancer therapy Covers autophagy and senescence in tumor dormancy Explores autophagy and senescence in disease recurrence

Radiosensitizers and Radiochemotherapy in the Treatment of Cancer

Radiosensitizers and Radiochemotherapy in the Treatment of Cancer
Author: Shirley Lehnert
Publsiher: CRC Press
Total Pages: 548
Release: 2014-12-08
ISBN 10: 1439829039
ISBN 13: 9781439829035
Language: EN, FR, DE, ES & NL

Radiosensitizers and Radiochemotherapy in the Treatment of Cancer Book Review:

Radiosensitizers and Radiochemotherapy in the Treatment of Cancer catalogs and describes the mechanism of action for entities characterized as radiosensitizers. Developments in the biological and physical sciences have introduced new radiosensitizers and defined novel targets for radiosensitization. As a result, a book about radiosensitization must now address a huge range of topics, covering everything from molecular oxygen and high Z elements to monoclonal antibodies and complex phytochemicals. At the molecular level, the understanding of the molecular consequences of DNA damage and the DNA damage response have informed the development of targeted radiosensitizers and shed light on the mode of action of radiochemotherapy protocols of known clinical efficacy. In this book the mechanisms of action at the molecular and cellular level are described for documented radiosensitizers including, where applicable, a brief history of their clinical use and most recent clinical results. In addition, the clinical context is addressed including the importance of factors such as dose and dose rate, normal tissue toxicity, and drug delivery. Intuitively organized by topic and application, the book includes extensive illustrations, end-of-chapter summaries, and a wealth of references.

Is the Recent Burst of Therapeutic Anti Tumor Antibodies the Tip of an Iceberg

Is the Recent Burst of Therapeutic Anti Tumor Antibodies the Tip of an Iceberg
Author: Leonor Kremer,Jose A. Garcia-Sanz
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2018-03-27
ISBN 10: 2889454622
ISBN 13: 9782889454624
Language: EN, FR, DE, ES & NL

Is the Recent Burst of Therapeutic Anti Tumor Antibodies the Tip of an Iceberg Book Review:

The high effectiveness of antibodies as anti-tumor therapeutic agents has led to a burst of research aiming to increase their therapeutic applications by the use of antibodies against new targets, new antibody formats or new combinations. In this e-book we present relevant research depicting the current efforts in the field.