New Combination Approaches to Enhance Rituximab Based Lymphoma Therapies

New Combination Approaches to Enhance Rituximab Based Lymphoma Therapies
Author: Anonim
Publsiher: Academic Press
Total Pages: 250
Release: 2020-11-01
ISBN 10: 0128167378
ISBN 13: 9780128167373
Language: EN, FR, DE, ES & NL

New Combination Approaches to Enhance Rituximab Based Lymphoma Therapies Book Review:

New Combination Approaches to Enhance Rituximab-Based Lymphoma Therapies provides general updated information on the resistance of various human lymphoma/leukemia subtypes to anti-CD20 therapeutic antibodies. It discusses also the description of various targeted sensitizing agents that can reverse innate or acquired resistance when used in combination with various FDA-approved anti-CD20 antibodies. There have been a lot of reports in which the treatment with anti-CD20 antibodies for various lymphomas/leukemias has resulted in significant clinical responses; however, there have been also subsets of cancer patients who did not respond initially and several of the responding patients developed resistance to subsequent treatments with the same or different regimens. Therefore, the use of various immunosensitizing agents targeting resistant factors to reverse resistance has been considered and this book discusses each of them in depth, such as Bortexomib, Immunomodulation Agents, Obinutuzumab, Tumor Suppressors, and HDAC Inhibitors. This book is a valuable source for cancer researchers, oncologists, pharmacologists and different members of biomedical field interested in fighting cancer resistance to anti-CD20 antibodies. Provides a general overview of various sensitizing agents that can work effectively when used in combination with anti-CD20 antibodies to reverse resistance Offers potential underlying mechanisms by which the cancer cells are either inherently resistant or become unresponsive to further antibody treatments Discusses how to develop new targeted agents to underlie resistance in order to expand research on this field

Resistance to Targeted Therapies in Lymphomas

Resistance to Targeted Therapies in Lymphomas
Author: Ana C. Xavier,Mitchell S. Cairo
Publsiher: Springer Nature
Total Pages: 210
Release: 2019-09-13
ISBN 10: 3030244245
ISBN 13: 9783030244248
Language: EN, FR, DE, ES & NL

Resistance to Targeted Therapies in Lymphomas Book Review:

Over the past few decades, lymphoma patient outcomes have improved as a result of multidrug chemotherapy and radiation therapy, intensification of treatment, improvement in supportive care, and better imaging and staging systems. Even more recently, there has been tremendous progress in the understanding of cancer cell biology and its microenvironment which has resulted in the development of biologic agents, also called "target" therapies. These therapies are more specific in targeting cancer cells either directly or via enhancement of the immune system. Many clinical studies have focused on biological agents in combination with traditional chemotherapy with the goal of improved outcomes, or reduced acute long term complications that are associated with lymphoma therapy. This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but will also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.

Immunotherapy and The Regulatory Immune System in Blood Cancers From Mechanisms to Clinical Applications

Immunotherapy and The Regulatory Immune System in Blood Cancers  From Mechanisms to Clinical Applications
Author: Ken H. Young,Andrés José María Ferreri,Alexandar Tzankov,Naval Daver
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2019-08-16
ISBN 10: 2889459810
ISBN 13: 9782889459810
Language: EN, FR, DE, ES & NL

Immunotherapy and The Regulatory Immune System in Blood Cancers From Mechanisms to Clinical Applications Book Review:

The Lymphoid Neoplasms 3ed

The Lymphoid Neoplasms 3ed
Author: Ian Magrath
Publsiher: CRC Press
Total Pages: 1689
Release: 2010-07-30
ISBN 10: 1444113224
ISBN 13: 9781444113228
Language: EN, FR, DE, ES & NL

The Lymphoid Neoplasms 3ed Book Review:

This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengthened for this third edition, to the environmental factors that may be relevant to disease development, and, finally, to the pragmatic aspects of disease management. The authors synthesise for the reader apsects of current knowledge and likely future developments, and direct them to the appropriate resources should they wish to pursue particular avenues of scientific or literature research.

Goldman s Cecil Medicine Expert Consult Premium Edition Enhanced Online Features and Print Single Volume 24

Goldman s Cecil Medicine Expert Consult Premium Edition    Enhanced Online Features and Print  Single Volume 24
Author: Russell La Fayette Cecil,Lee Goldman,Andrew I. Schafer
Publsiher: Elsevier Health Sciences
Total Pages: 2655
Release: 2012-01-01
ISBN 10: 1437716040
ISBN 13: 9781437716047
Language: EN, FR, DE, ES & NL

Goldman s Cecil Medicine Expert Consult Premium Edition Enhanced Online Features and Print Single Volume 24 Book Review:

Since 1927, Goldman-Cecil Medicine has been the world's most influential internal medicine resource. In the ground-breaking 25th edition, your original purchase ensures you will be up-to-date without the need for a subscription. Through the new, more powerful Expert Consult eBook platform, this "living text" provides continuous updates that will integrate the latest research, guidelines, and treatments into each chapter, ensuring that the content is as current as the day this edition was first published. Goldman-Cecil Medicine offers definitive, unbiased guidance on the evaluation and management of every medical condition, presented by a veritable "Who's Who" of modern medicine. A practical, straightforward style; templated organization; evidence-based references; and robust interactive content combine to make this dynamic resource quite simply the fastest and best place to find all of the authoritative, state-of-the-art clinical answers you need. "The content is superb, authoritative and not surprisingly very up to date." Reviewed by: Dr Harry Brown, on behalf of Glycosmedia Date: July 2015 Expert Consult eBook version included with print purchase: Access continuous updates from Editor Lee Goldman, MD, who thoroughly reviews internal medicine and specialty journals, updating online content to reflect the latest guidelines and translating that evidence into treatment. Interactive Q&A section features over 1,500 board-style questions and answers to aid in preparing for certification or recertification exams. Outstanding supplementary tools include figures, tables, videos, heart and lung sounds, treatment and management algorithms, fully integrated references, and thousands of illustrations and full-color photos. Search all of the text, figures, supplementary material, and references from the book on a variety of devices and at no additional cost - Expert Consult access is included with this title! Practical, bulleted, highly templated text with easy-to-use features including flow charts and treatment boxes. New chapters on global health, cancer biology and genetics, and the human microbiome in health and disease keep you on the cutting edge of medicine. Today's most current evidence-based medicine guidelines help you form a definitive diagnosis and create the best treatment plans possible. Focused coverage of the latest developments in biology includes the specifics of current diagnosis, therapy, and medication doses. The reference of choice for every stage of your career! Goldman-Cecil Medicine is an ideal learning tool for residents, physicians, and students as well as a valuable go-to resource for experienced healthcare professionals. Cecil - the best internal medicine resource available since 1927 - far exceeds the competition in versatility, ease-of-use and up-to-datedness.

Combinatorial Approaches to Enhance Anti Tumor Immunity Focus on Immune Checkpoint Blockade Therapy

Combinatorial Approaches to Enhance Anti Tumor Immunity  Focus on Immune Checkpoint Blockade Therapy
Author: Patrik Andersson,Christian Ostheimer
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2019-12-27
ISBN 10: 2889631613
ISBN 13: 9782889631612
Language: EN, FR, DE, ES & NL

Combinatorial Approaches to Enhance Anti Tumor Immunity Focus on Immune Checkpoint Blockade Therapy Book Review:

The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.

Non Hodgkin Lymphoma

Non Hodgkin Lymphoma
Author: Andrew M. Evens,Kristie A. Blum
Publsiher: Springer
Total Pages: 344
Release: 2015-02-06
ISBN 10: 3319131508
ISBN 13: 9783319131504
Language: EN, FR, DE, ES & NL

Non Hodgkin Lymphoma Book Review:

This book provides clinical practitioners and the research community with detailed information on the diagnosis, prognosis, and treatment of non-Hodgkin lymphoma, taking into account the significant growth in knowledge including multiple therapeutic advances that have been achieved over the past 5-10 years. The work is subdivided into epidemiology, pathogenesis, pathology, imaging, and therapy of the non-Hodgkin lymphomas. The full range of therapeutic options are examined according to the major subtypes of non-Hodgkin lymphoma and the most up-to-date information is provided on current standard treatment options, including stem cell transplantation as well as new cutting-edge therapeutics.

Neoplastic Diseases of the Blood

Neoplastic Diseases of the Blood
Author: Peter H. Wiernik,John M. Goldman,Janice P. Dutcher,Robert A. Kyle
Publsiher: Springer Science & Business Media
Total Pages: 1431
Release: 2012-09-22
ISBN 10: 1461437644
ISBN 13: 9781461437642
Language: EN, FR, DE, ES & NL

Neoplastic Diseases of the Blood Book Review:

Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. The book is divided into five major sections, with the first four covering the spectrum of hematologic neoplasia— Chronic Leukemias and Related Disorders , Acute Leukemias, Myeloma and Related Disorders, and Lymphomas. The fifth section covers a variety of topics in supportive care. Now in its fifth edition, this classic and invaluable text brings together a team of internationally renowned experts and offers in-depth coverage of the complex interface between diagnosis and therapy. Chapters feature an accessible and easy-to-read layout and provide updates on the tremendous progress made in the last decade in the understanding of the nature of hematologic malignancies and their treatment. An authoritative and indispensable resource for students, trainees, and clinicians, this fifth edition is sure to distinguish itself as the definitive reference on this topic.

Drug Benefits and Risks

Drug Benefits and Risks
Author: C.J. van Boxtel,B. Santoso,I.R. Edwards
Publsiher: IOS Press
Total Pages: 848
Release: 2008-08-06
ISBN 10: 160750345X
ISBN 13: 9781607503453
Language: EN, FR, DE, ES & NL

Drug Benefits and Risks Book Review:

This updated and revised 2nd edition of Drug Benefits and Risks is an inclusive reference exploring the scientific basis and practice of drug therapy. The key concept is to look at the balance between the benefits and risks of drugs, but in this context also highlighting the social impact which drugs have in modern societies. Taking an evidence-based approach to the problem, the practice of clinical pharmacology and pharmacotherapy in the developing as well as the developed world is examined. For this purpose the book covers general clinical pharmacology, pharmacology of various drug groups and the treatments specific to various diseases; the book gives guidance on how doctors should act so that drugs can be used effectively and safely; and it encourages the rational use of drugs in society. This publication brings together a large amount of excellent content that will be invaluable for anyone working within, or associated with, the field of clinical pharmacology and pharmacotherapy - undergraduates, postgraduates, regulatory authorities and the pharmaceutical industry.

Postgraduate Review MCQs in Hematology

Postgraduate Review  MCQs in Hematology
Author: Sanjeev Kumar Sharma,Pawan Kumar Singh
Publsiher: Jaypee Brothers Medical Publishers
Total Pages: 464
Release: 2021-11-30
ISBN 10: 9354650651
ISBN 13: 9789354650659
Language: EN, FR, DE, ES & NL

Postgraduate Review MCQs in Hematology Book Review:

Methods of Cancer Diagnosis Therapy and Prognosis

Methods of Cancer Diagnosis  Therapy  and Prognosis
Author: M. A. Hayat
Publsiher: Springer Science & Business Media
Total Pages: 476
Release: 2010-04-07
ISBN 10: 9789048131860
ISBN 13: 9048131863
Language: EN, FR, DE, ES & NL

Methods of Cancer Diagnosis Therapy and Prognosis Book Review:

There are more than 100 types of cancers In Part II, head and neck cancer is d- affecting all parts of the human body. cussed. The global number of annual new More than 11 million people are diagnosed cases of this malignancy is ~500,000. These with cancer every year, and it is estimated malignancies include oral squamous cell that there will be 16 million new cases by carcinoma, salivary gland tumors, tons- the year 2020. In 2005, 7. 6 million peo- lar cancer, tongue cancer, nasopharyngeal ple died of cancer, that is, 13% of the 58 carcinoma, and retinoblastoma, which are million deaths worldwide. It is estimated detailed. In Part III, diagnosis, therapy, and that 9 million people will die from can- prognosis of thyroid carcinoma are d- cer worldwide in 2015 and 11. 4 million cussed. The global number of new cases of will die in 2030. More than 70% of all thyroid cancer is ~141,000, and the number cancer deaths occur in low and middle of worldwide thyroid mortalities is ~35,375. income countries. These statistics underlie The number of new cases of this cancer in the fact that cancer is the deadliest of all the United States is ~33,550. Molecular human diseases. The enormity of the glo- genetics of thyroid cancer, gene expr- bal healthcare costs as a result of cancer sion markers for diagnosis, papillary t- cannot be overemphasized.

Perry s The Chemotherapy Source Book

Perry s The Chemotherapy Source Book
Author: Michael C. Perry,Donald C. Doll,Carl E. Freter
Publsiher: Lippincott Williams & Wilkins
Total Pages: 848
Release: 2012-07-30
ISBN 10: 1469803437
ISBN 13: 9781469803432
Language: EN, FR, DE, ES & NL

Perry s The Chemotherapy Source Book Book Review:

Perry’s The Chemotherapy Source Book, now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs. Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a “one-stop shop” for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification.

Management of Lymphomas A Case Based Approach

Management of Lymphomas  A Case Based Approach
Author: Jasmine Zain,Larry W. Kwak
Publsiher: Springer
Total Pages: 204
Release: 2017-04-28
ISBN 10: 3319268279
ISBN 13: 9783319268279
Language: EN, FR, DE, ES & NL

Management of Lymphomas A Case Based Approach Book Review:

This book will provide an overview of how to manage patients with lymphoma in the format of a series of engaging case studies. Lymphomas are cancers that originate in the lymphatic system. There are two main types of lymphoma: Hodgkin lymphoma and non-Hodgkin lymphoma. These lymphomas comprise various subtypes with prognosis and treatment depending on the stage and type of the cancer. Lymphoma is a major global health problem; non-Hodgkin lymphoma in particular is the tenth most common type of cancer worldwide. In response to this there have been a number of significant advances in the available treatment options for lymphoma with new breakthrough drugs being approved or registered for approval. In light of this, this case study book will be an extremely timely guide for all hematologists, oncologists, and healthcare professionals wishing to keep up-to-date with these recent developments. The format of this book is also particularly appealing as it offer readers a practical approach to the clinical management of patients with these conditions as suggested by leading physicians from the City of Hope National Medical Center in California, USA in an era of vast therapeutic development.

UICC Manual of Clinical Oncology

UICC Manual of Clinical Oncology
Author: James D. Brierley,Anil D'Cruz,Martin Fey,Raphael E. Pollock,Jan Vermorken,Shao Hui Huang
Publsiher: John Wiley & Sons
Total Pages: 856
Release: 2015-07-28
ISBN 10: 1119013127
ISBN 13: 9781119013129
Language: EN, FR, DE, ES & NL

UICC Manual of Clinical Oncology Book Review:

The Manual of Clinical Oncology, Ninth Edition, published with the International Union Against Cancer (UICC), provides a concise, accessible and feasible reference covering state of art multidisciplinary clinical oncology in order to meet the needs of clinicians caring for cancer patients throughout the world. Edited by world-renowned practising oncologists and written by key opinion leaders, this book contains authoritative and up-to-date information on cancer detection, diagnosis and treatment alongside topics such as survivorship, special populations and palliative care. Remodelled and revised for the ninth edition to provide practical information to oncology workers, the UICC Manual of Clinical Oncology is structured in two parts. Part 1 covers general principles of cancer diagnosis and management with additional attention to special settings in oncology, including supportive care and survivorship, and Part 2 covers site-specific multidisciplinary cancer management. The edition includes up-to-date summaries of all treatment modalities (medical, surgical and radiation) for all tumour sites. It also contains the latest TNM classifications outlined in the TNM Classification of Malignant Tumours. The ninth edition includes: Practical presentation with bullet points, tables, and flow charts intended to facilitate quick reference for day-to-day clinical practice in busy oncology environments, Representation of multidisciplinary care for site specific management, Evidence-based approaches to management, including specific treatment recommendations and investigations guided by clinical practice guidelines, State of art evidence-based recommendations that take into consideration the lack of availability of certain medications or resources, as well as practice variations, in different and remote regions of the world, and Contemporary topics on cancer treatment, such as cancer informatics, evidence levels, principles of prognostication, survivorship and cancer in pregnancy. Oncologists, oncologists-in-training, nurses working with cancer patients and other health professionals responsible for treating and caring for those with cancers will find the UICC Manual of Clinical Oncology an indispensable and comprehensive resource.

Antibody Fc

Antibody Fc
Author: George J. Weiner
Publsiher: Elsevier Inc. Chapters
Total Pages: 358
Release: 2013-08-06
ISBN 10: 0128060352
ISBN 13: 9780128060353
Language: EN, FR, DE, ES & NL

Antibody Fc Book Review:

Monoclonal antibodies (mAbs), including rituximab, are now a mainstay in the therapy of cancer. Despite their undeniable therapeutic value, there is much we do not fully understand about the mechanisms of action responsible for their anti-tumor effects. These mechanisms are often studied in isolation. In this chapter, we will review the mechanisms of action of anti-cancer mAbs and discuss how they interact. The focus of this discussion will be on rituximab, but similar conclusions can be reached with other mAbs.

Cancer Immunology

Cancer Immunology
Author: Nima Rezaei
Publsiher: Springer
Total Pages: 485
Release: 2014-12-29
ISBN 10: 3662449463
ISBN 13: 9783662449462
Language: EN, FR, DE, ES & NL

Cancer Immunology Book Review:

This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.

Targeted Therapies in Cancer

Targeted Therapies in Cancer
Author: Manfred Dietel
Publsiher: Springer Science & Business Media
Total Pages: 262
Release: 2007-06-10
ISBN 10: 3540460918
ISBN 13: 9783540460916
Language: EN, FR, DE, ES & NL

Targeted Therapies in Cancer Book Review:

From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.


Author: Anas Younes,Bertrand Coiffier
Publsiher: Springer Science & Business Media
Total Pages: 411
Release: 2013-05-17
ISBN 10: 1627034080
ISBN 13: 9781627034081
Language: EN, FR, DE, ES & NL

Lymphoma Book Review:

Recently, understanding the molecular pathogenesis of malignant lymphomas has led to improvement in the diagnostic precision and to the identification of a variety of molecular therapeutic targets. In addition, new drugs have been approved in the US and Europe, resulting in changes in the standard of care of several types of lymphoid malignancies. Comprehensive in scope and developed by a team of internationally renowned authors, Lymphoma: Diagnosis and Treatment provides a timely update on the most important advances in the biology, diagnosis, and therapy of lymphomas. As part of the Current Clinical Oncology series, Lymphoma: Diagnosis and Treatment will be of value to medical oncologists, hematologists, radiation oncologists, and all physicians involved in the care of patients with lymphoid malignancies.

New Drugs for Malignancy An Issue of Hematology Oncology Clinics of North America E Book

New Drugs for Malignancy  An Issue of Hematology Oncology Clinics of North America   E Book
Author: Franco Muggia
Publsiher: Elsevier Health Sciences
Total Pages: 1440
Release: 2012-05-08
ISBN 10: 1455744085
ISBN 13: 9781455744084
Language: EN, FR, DE, ES & NL

New Drugs for Malignancy An Issue of Hematology Oncology Clinics of North America E Book Book Review:

Topics include: Targeting IGF-1R, Tyrosine Kinase Inhibitors in Lung Cancer, Targeting mTOR, Targeting Hedgehog, Mitotic Inhibitors, Topoisomerase I Inhibitors , and New Strategies and Drugs Inhibiting Folate Pathways.

Conn s Current Therapy 2019

Conn s Current Therapy 2019
Author: Rick D. Kellerman,David Rakel
Publsiher: Elsevier Health Sciences
Total Pages: 1344
Release: 2018-12-06
ISBN 10: 0323596509
ISBN 13: 9780323596503
Language: EN, FR, DE, ES & NL

Conn s Current Therapy 2019 Book Review:

Follows a consistent, easy-to-use format throughout, with diagnosis, therapy, drug protocols, and treatment pearls presented in quick-reference boxes and tables for point-of-care answers to common clinical questions. Features significantly revised chapters on sepsis • bacterial pneumonia • ADHD • endometriosis • atrial fibrillation • congestive heart failure • pericarditis • diabetes mellitus • measles • myasthenia gravis • irritable bowel syndrome • Parkinson’s disease • seizures and epilepsy in adolescents and adults • acute bronchitis and other viral respiratory illnesses • urinary incontinence • neutropenia • venous thromboembolism • fungal diseases of the skin • diseases of the nails • and more. Includes all-new chapters on fatty liver, pancreatic cancer, and more. Includes nearly 300 images, including algorithms, anatomical illustrations, and photographs, that provide useful information for diagnosis. Provides current drug information thoroughly reviewed by PharmDs. Shares the knowledge and expertise of 40 new authors who provide a fresh perspective in their specialties.