Neurotherapeutics in the Era of Translational Medicine

Neurotherapeutics in the Era of Translational Medicine
Author: Richard A. Smith,Brian K. Kaspar,Clive N. Svendsen
Publsiher: Academic Press
Total Pages: 518
Release: 2020-11-28
ISBN 10: 0128172746
ISBN 13: 9780128172742
Language: EN, FR, DE, ES & NL

Neurotherapeutics in the Era of Translational Medicine Book Review:

For the first time in history, there is now hope for treating neurological disorders that had previously been considered untreatable. The remarkable confluence of events that has heralded this is the focus of Neurotherapeutics in the Era of Translational Medicine. This anthology, written by many of the prominent scientists and researchers in the field of biotechnology, recounts the breathtaking advances that are revolutionizing treatment for disorders such as amyotrophic lateral sclerosis‎, spinal muscular atrophy, multiple sclerosis, Parkinson’s disease, myasthenia gravis, migraine, and glioblastoma. The "story behind the story" of these translational efforts is told, with authors depicting the ups and downs encountered on the path of their drug discovery and development effort. In parallel with this path, advances in identifying novel biomarkers and disease models are summarized, as are contemporary issues focusing on clinical trial design, bioethics, innovative funding strategies, and collaborations between government and academia in an effort to facilitate breakthrough treatments. The book is written by members of the biotech and pharmaceutical ecosystem for those who belong to it and aspire to become part of it. Comprehensive review on the progress of translational research in neurotherapeutics for neurologic disorders Discusses important issues in clinical trials such as design and ethical issues Written for neuroscientists, neurologists and pharmacologists

NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE

NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE
Author: RICHARD A. SMITH
Publsiher: Elsevier
Total Pages: 135
Release: 2021
ISBN 10: 0323907261
ISBN 13: 9780323907262
Language: EN, FR, DE, ES & NL

NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE Book Review:

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2007

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for 2007
Author: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publsiher: Unknown
Total Pages: 135
Release: 2006
ISBN 10: 1928374650XXX
ISBN 13: MINN:31951D025981127
Language: EN, FR, DE, ES & NL

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2007 Book Review:

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2007 Testimony of members of Congress and other interested individuals and organizations

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for 2007  Testimony of members of Congress and other interested individuals and organizations
Author: United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publsiher: Unknown
Total Pages: 135
Release: 2006
ISBN 10: 1928374650XXX
ISBN 13: UCBK:C086420147
Language: EN, FR, DE, ES & NL

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2007 Testimony of members of Congress and other interested individuals and organizations Book Review:

Mind Fixers Psychiatry s Troubled Search for the Biology of Mental Illness

Mind Fixers  Psychiatry s Troubled Search for the Biology of Mental Illness
Author: Anne Harrington
Publsiher: W. W. Norton & Company
Total Pages: 384
Release: 2019-04-16
ISBN 10: 1324001976
ISBN 13: 9781324001973
Language: EN, FR, DE, ES & NL

Mind Fixers Psychiatry s Troubled Search for the Biology of Mental Illness Book Review:

Mind Fixers tells the history of psychiatry’s quest to understand the biological basis of mental illness and asks where we need to go from here. In Mind Fixers, Anne Harrington, author of The Cure Within, explores psychiatry’s repeatedly frustrated struggle to understand mental disorder in biomedical terms. She shows how the stalling of early twentieth century efforts in this direction allowed Freudians and social scientists to insist, with some justification, that they had better ways of analyzing and fixing minds. But when the Freudians overreached, they drove psychiatry into a state of crisis that a new “biological revolution” was meant to alleviate. Harrington shows how little that biological revolution had to do with breakthroughs in science, and why the field has fallen into a state of crisis in our own time. Mind Fixers makes clear that psychiatry’s waxing and waning biological enthusiasms have been shaped not just by developments in the clinic and lab, but also by a surprising range of social factors, including immigration, warfare, grassroots activism, and assumptions about race and gender. Government programs designed to empty the state mental hospitals, acrid rivalries between different factions in the field, industry profit mongering, consumerism, and an uncritical media have all contributed to the story as well. In focusing particularly on the search for the biological roots of schizophrenia, depression, and bipolar disorder, Harrington underscores the high human stakes for the millions of people who have sought medical answers for their mental suffering. This is not just a story about doctors and scientists, but about countless ordinary people and their loved ones. A clear-eyed, evenhanded, and yet passionate tour de force, Mind Fixers recounts the past and present struggle to make mental illness a biological problem in order to lay the groundwork for creating a better future, both for those who suffer and for those whose job it is to care for them.

Encyclopedia of Tissue Engineering and Regenerative Medicine

Encyclopedia of Tissue Engineering and Regenerative Medicine
Author: Anonim
Publsiher: Academic Press
Total Pages: 1418
Release: 2019-06-03
ISBN 10: 0128137002
ISBN 13: 9780128137000
Language: EN, FR, DE, ES & NL

Encyclopedia of Tissue Engineering and Regenerative Medicine Book Review:

Encyclopedia of Tissue Engineering and Regenerative Medicine provides a comprehensive collection of personal overviews on the latest developments and likely future directions in the field. By providing concise expositions on a broad range of topics, this encyclopedia is an excellent resource. Tissue engineering and regenerative medicine are relatively new fields still in their early stages of development, yet they already show great promise. This encyclopedia brings together foundational content and hot topics in both disciplines into a comprehensive resource, allowing deeper interdisciplinary research and conclusions to be drawn from two increasingly connected areas of biomedicine. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the fields of tissue engineering and regenerative medicine Contains multimedia features, including hyperlinked references and further readings, cross-references and diagrams/images Represents the most comprehensive and exhaustive product on the market on the topic

Monoclonal Antibodies in Headache

Monoclonal Antibodies in Headache
Author: Antoinette Maassen van den Brink,Paolo Martelletti
Publsiher: Springer Nature
Total Pages: 172
Release: 2021-04-28
ISBN 10: 3030690326
ISBN 13: 9783030690328
Language: EN, FR, DE, ES & NL

Monoclonal Antibodies in Headache Book Review:

Intended to promote a more appropriate and modern therapeutic approach to migraine management, this book is the first to deal with monoclonal antibodies in this context. Authored by the most respected migraine experts from around the globe and drawing on the lessons learned in both clinical trials and clinical practice, it reviews the current state of knowledge on this important therapeutic innovation, which has produced impressive data in randomized controlled trials, and the efficacy and safety of which have been confirmed in day-to-day real-world use. Given its scope, the book will appeal to a broad range of specialists, including pharmacologists, clinical pharmacologists, neurologists and internists, but also to residents and medical students.

Brain Mapping

Brain Mapping
Author: Anonim
Publsiher: Academic Press
Total Pages: 2658
Release: 2015-02-14
ISBN 10: 0123973163
ISBN 13: 9780123973160
Language: EN, FR, DE, ES & NL

Brain Mapping Book Review:

Brain Mapping: A Comprehensive Reference offers foundational information for students and researchers across neuroscience. With over 300 articles and a media rich environment, this resource provides exhaustive coverage of the methods and systems involved in brain mapping, fully links the data to disease (presenting side by side maps of healthy and diseased brains for direct comparisons), and offers data sets and fully annotated color images. Each entry is built on a layered approach of the content – basic information for those new to the area and more detailed material for experienced readers. Edited and authored by the leading experts in the field, this work offers the most reputable, easily searchable content with cross referencing across articles, a one-stop reference for students, researchers and teaching faculty. Broad overview of neuroimaging concepts with applications across the neurosciences and biomedical research Fully annotated color images and videos for best comprehension of concepts Layered content for readers of different levels of expertise Easily searchable entries for quick access of reputable information Live reference links to ScienceDirect, Scopus and PubMed

APA Handbook of Psychopharmacology

APA Handbook of Psychopharmacology
Author: Suzette M. Evans,Kenneth M. Carpenter
Publsiher: APA Handbooks in Psychology(r)
Total Pages: 776
Release: 2019
ISBN 10: 9781433830754
ISBN 13: 1433830752
Language: EN, FR, DE, ES & NL

APA Handbook of Psychopharmacology Book Review:

The APA Handbook of Psychopharmacology provides working knowledge of basic pharmacology and psychopharmacology, examines psychopharmacology for treatment of various emotional and behavioral conditions, and discusses related professional and social issues.

Regenerative Pharmacology

Regenerative Pharmacology
Author: George J. Christ,Karl-Erik Andersson
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2013-04-15
ISBN 10: 1107354730
ISBN 13: 9781107354739
Language: EN, FR, DE, ES & NL

Regenerative Pharmacology Book Review:

Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research.

Drug Discovery and Development Third Edition

Drug Discovery and Development  Third Edition
Author: James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell
Publsiher: CRC Press
Total Pages: 668
Release: 2019-12-13
ISBN 10: 1351625136
ISBN 13: 9781351625135
Language: EN, FR, DE, ES & NL

Drug Discovery and Development Third Edition Book Review:

Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

Mapping Psychopathology with fMRI and Effective Connectivity Analysis

Mapping Psychopathology with fMRI and Effective Connectivity Analysis
Author: Baojuan Li,Adeel Razi,Karl J. Friston
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2017-06-22
ISBN 10: 2889452077
ISBN 13: 9782889452071
Language: EN, FR, DE, ES & NL

Mapping Psychopathology with fMRI and Effective Connectivity Analysis Book Review:

There is a growing appreciation that many psychiatric (and neurological) conditions can be understood as functional disconnection syndromes – as reflected in aberrant functional integration and synaptic connectivity. This Research Topic considers recent advances in understanding psychopathology in terms of aberrant effective connectivity – as measured noninvasively using functional magnetic resonance imaging (fMRI). Recently, there has been increasing interest in inferring directed connectivity (effective connectivity) from fMRI data. Effective connectivity refers to the influence that one neural system exerts over another and quantifies the directed coupling among brain regions – and how they change with pathophysiology. Compared to functional connectivity, effective connectivity allows one to understand how brain regions interact with each other in terms of context sensitive changes and directed coupling – and therefore may provide mechanistic insights into the neural basis of psychopathology. Established models of effective connectivity include psychophysiological interaction (PPI), structural equation modeling (SEM) and dynamic causal modelling (DCM). DCM is unique because it explicitly models the interaction among brain regions in terms of latent neuronal activity. Moreover, recent advances in DCM such as stochastic and spectral DCM, make it possible to characterize the interaction between different brain regions both at rest and during a cognitive task.

Neuroprotective Therapy for Stroke and Ischemic Disease

Neuroprotective Therapy for Stroke and Ischemic Disease
Author: Paul A. Lapchak,John H. Zhang
Publsiher: Springer
Total Pages: 795
Release: 2017-01-12
ISBN 10: 3319453459
ISBN 13: 9783319453453
Language: EN, FR, DE, ES & NL

Neuroprotective Therapy for Stroke and Ischemic Disease Book Review:

A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.

Autoimmune Neurology

Autoimmune Neurology
Author: Anonim
Publsiher: Elsevier
Total Pages: 568
Release: 2016-03-11
ISBN 10: 0444634460
ISBN 13: 9780444634467
Language: EN, FR, DE, ES & NL

Autoimmune Neurology Book Review:

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Pain Management and the Opioid Epidemic

Pain Management and the Opioid Epidemic
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse
Publsiher: National Academies Press
Total Pages: 482
Release: 2017-09-28
ISBN 10: 0309459575
ISBN 13: 9780309459570
Language: EN, FR, DE, ES & NL

Pain Management and the Opioid Epidemic Book Review:

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Spectrums of Amyotrophic Lateral Sclerosis

Spectrums of Amyotrophic Lateral Sclerosis
Author: Christopher A. Shaw,Jessia R. Morrice
Publsiher: John Wiley & Sons
Total Pages: 240
Release: 2021-05-04
ISBN 10: 1119745519
ISBN 13: 9781119745518
Language: EN, FR, DE, ES & NL

Spectrums of Amyotrophic Lateral Sclerosis Book Review:

SPECTRUMS OF AMYOTROPHIC LATERAL SCLEROSIS Discover state-of-the-art research findings on ALS from leading authors and editors in the field In Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions, distinguished researchers and editors Dr. Christopher A. Shaw and Jessica R. Morrice deliver a practical and powerful perspective on Amyotrophic Lateral Sclerosis (ALS) as a heterogeneous spectrum of disorders. This increasingly accepted point-of-view allows researchers and medical professionals to develop better targeted interventions and more precise therapies. In the book, readers will find chapters on a wide variety of critical issues facing ALS researchers and healthcare practitioners treating ALS sufferers, including animal models of ALS, neuronal support cells known to have a pivotal role in ALS, and current challenges in ALS clinical trials, among others. The authors describe pathologic features common to all cases of ALS and why animal models, though crucial, should be interpreted with caution. Finally, multiple genetic and environmental etiologies of the disease are discussed. Readers will also benefit from the inclusion of: A thorough introduction to ALS as a spectrum disease and the implications for models, therapeutic development and clinical trial design Explorations of the genetic basis of ALS, prospective sALS etiologies, and the involvement of microbiome in ALS Discussions of ALS-PDC and environmental risk factors, protein aggregation in ALS, defects in RNA metabolism in ALS, and the non-cell autonomous nature of ALS and the involvement of glial cells Examinations of animal models of ALS and perspectives on previously failed ALS therapeutics and current therapeutic strategies Perfect for clinical neurologists, healthcare providers and caretakers, clinicians, and researchers studying motor neuron disease, Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions is also an indispensable resource for the neurodegenerative research community, neurology residents, and graduate-level neuroscience students.

Paralysis Resource Guide

Paralysis Resource Guide
Author: Sam Maddox
Publsiher: Unknown
Total Pages: 456
Release: 2015
ISBN 10: 9780996095105
ISBN 13: 0996095101
Language: EN, FR, DE, ES & NL

Paralysis Resource Guide Book Review:

The Paralysis Resource Guide, produced by the Christopher & Dana Reeve Foundation, is a reference and lifestyle tool for people affected by paralysis. The book includes details on medical and clinical subjects related to all causes of paralysis, as well as health maintenance information. The fully-illustrated book provides a detailed overview of biomedical research, assistive technology, sports and recreation activities, legal and civil rights, social security and benefits, and numerous lifestyle options.

Neuroinflammation

Neuroinflammation
Author: Alireza Minagar
Publsiher: Elsevier
Total Pages: 540
Release: 2010-12-17
ISBN 10: 9780123849144
ISBN 13: 0123849144
Language: EN, FR, DE, ES & NL

Neuroinflammation Book Review:

Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities

Brain Neurotrauma

Brain Neurotrauma
Author: Firas H. Kobeissy
Publsiher: CRC Press
Total Pages: 725
Release: 2015-02-25
ISBN 10: 1466565993
ISBN 13: 9781466565999
Language: EN, FR, DE, ES & NL

Brain Neurotrauma Book Review:

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Emerging Cognitive Neuroscience and Related Technologies

Emerging Cognitive Neuroscience and Related Technologies
Author: National Research Council,Division on Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Division on Engineering and Physical Sciences,Standing Committee for Technology Insight--Gauge, Evaluate, and Review,Committee on Military and Intelligence Methodology for Emergent Neurophysiological and Cognitive/Neural Science Research in the Next Two Decades
Publsiher: National Academies Press
Total Pages: 214
Release: 2008-12-06
ISBN 10: 0309118948
ISBN 13: 9780309118941
Language: EN, FR, DE, ES & NL

Emerging Cognitive Neuroscience and Related Technologies Book Review:

Emerging Cognitive Neuroscience and Related Technologies, from the National Research Council, identifies and explores several specific research areas that have implications for U.S. national security, and should therefore be monitored consistently by the intelligence community. These areas include: neurophysiological advances in detecting and measuring indicators of psychological states and intentions of individuals the development of drugs or technologies that can alter human physical or cognitive abilities advances in real-time brain imaging breakthroughs in high-performance computing and neuronal modeling that could allow researchers to develop systems which mimic functions of the human brain, particularly the ability to organize disparate forms of data. As these fields continue to grow, it will be imperative that the intelligence community be able to identify scientific advances relevant to national security when they occur. To do so will require adequate funding, intelligence analysts with advanced training in science and technology, and increased collaboration with the scientific community, particularly academia. A key tool for the intelligence community, this book will also be a useful resource for the health industry, the military, and others with a vested interest in technologies such as brain imaging and cognitive or physical enhancers.