Neuronal Chloride Transporters in Health and Disease

Neuronal Chloride Transporters in Health and Disease
Author: Xin Tang
Publsiher: Academic Press
Total Pages: 766
Release: 2020-06-19
ISBN 10: 0128153199
ISBN 13: 9780128153192
Language: EN, FR, DE, ES & NL

Neuronal Chloride Transporters in Health and Disease Book Review:

In the past several years, there has been an exciting body of new research that links impairments in the expression or function of neuronal chloride transporters to a growing number of diseases spanning from autism to brain aging. This book introduces the core concepts and highlights the recent advances in understanding the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters. Neuronal chloride transporter biology is reviewed, including roles in setting the transmembrane chloride gradient and the chloride transport-independent functions, such as regulating excitatory neurotransmission. Chapters are also dedicated to addressing the structure, post-translational modification, membrane trafficking, and protein interaction partners of neuronal chloride transporters, as well as the genetic and environmental factors that regulate their expression in neurons and the novel therapeutic approaches that target neuronal chloride transporters to treat neurological diseases. This new volume will provide readers with an up-to-date summary of the recent advances in neuronal chloride transporter research, with particular emphasis on some of the key emerging topics in the field. Summarizes roles of KCCs and NKCCs in regulating inhibitory and excitatory neurotransmission Reviews the molecular and cellular biology of neuronal chloride transporters Links neuronal chloride transporter deficiencies to autism, epilepsy, depression, and more Identifies role of transporter deficiencies in pain as well as brain and spinal cord injury Discusses drug research targeting neuronal chloride transporters for nervous system diseases

Epithelial Anion Transport in Health and Disease

Epithelial Anion Transport in Health and Disease
Author: Derek J. Chadwick,Jamie A. Goode
Publsiher: John Wiley & Sons
Total Pages: 284
Release: 2006-07-11
ISBN 10: 0470029560
ISBN 13: 9780470029565
Language: EN, FR, DE, ES & NL

Epithelial Anion Transport in Health and Disease Book Review:

Cl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of the SLC26 transporters family. It is now clear that the SLC26 transporters have broad physiological functions since mutations in several members are linked to a variety of diseases. This book describes the properties of this family in detail, with contributions from the leading global researchers in the field. Complementary views from experts on other ion channels are offered in the discussions, which make fascinating reading. This family consists of at least 10 genes, each of which has several splice variants. Most members of the family are expressed in the luminal membrane of epithelial cells. Characterization of anion transport by three members has revealed that all function as Cl-/HCO3- exchangers, suggesting that SLC26 transporters are responsible for the luminal Cl-/HCO3- exchange activity. The SLC26 transporters are activated by the CF transmembrane conductance regulator and activate it in turn, leading to a model in which these molecules act together to mediate epithelial Cl- absorption and HCO3- secretion. The book includes chapters on the transport of other molecules by the SLC26 family, including oxalate in the kidney and sugars in cochlear hair cells amongst others. It also describes recent discoveries that most SLC26 transporters bind to scaffold proteins and that they all contain a conserved domain predicted to participate in protein-protein interactions. These suggest the SLC26 transporters exist in complexes with other Cl- and HCO3- transporters, and possibly other regulatory proteins. This book explores the functional role of these interactions, leading to better understanding of transepithelial fluid and electrolyte secretion and the diseases associated with it.

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
Author: F. Javier Alvarez-Leefmans,Eric Delpire
Publsiher: Academic Press
Total Pages: 630
Release: 2009-08-22
ISBN 10: 9780080922034
ISBN 13: 0080922031
Language: EN, FR, DE, ES & NL

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Book Review:

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field

Cell Cell Interactions Controlling Neuronal Functionality in Health and Disease

Cell Cell Interactions Controlling Neuronal Functionality in Health and Disease
Author: Stefano Angiari,Rosa Chiara Paolicelli,Luca A. Ramenghi,Eleonora Vannini,Giuseppina D’Alessandro,Ilaria Prada
Publsiher: Frontiers Media SA
Total Pages: 141
Release: 2022-07-27
ISBN 10: 288976625X
ISBN 13: 9782889766253
Language: EN, FR, DE, ES & NL

Cell Cell Interactions Controlling Neuronal Functionality in Health and Disease Book Review:

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research
Author: Anonim
Publsiher: Unknown
Total Pages: 864
Release: 1990
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015072175162
Language: EN, FR, DE, ES & NL

Biomedical Index to PHS supported Research Book Review:

The Blood Brain Barrier in Health and Disease Volume One

The Blood Brain Barrier in Health and Disease  Volume One
Author: Katerina Dorovini-Zis
Publsiher: CRC Press
Total Pages: 426
Release: 2015-06-23
ISBN 10: 1498727069
ISBN 13: 9781498727068
Language: EN, FR, DE, ES & NL

The Blood Brain Barrier in Health and Disease Volume One Book Review:

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Over the last 25 years, we have witnessed remarkable expansion of our knowledge of the structure, biology, and function of the cerebral endothelium. In The Blood-Brain Barrier in Health and Disease, Volume 1, international experts discuss basic and new concepts and most recent advances pertaining to the development of the cerebral microvascular system. Subjects include the structure, function, permeability properties, transport mechanisms, and the inherent heterogeneity of the cerebral endothelium; the anatomy and physiological properties of the neurovascular unit; functional aspects of the choroid plexus; and important concepts and advances made over the last two decades that have shaped our understanding of the immunological function of the blood-brain barrier. This book is intended to serve as a valuable source of basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Biomedical Index to PHS supported Research pt A Subject access A H

Biomedical Index to PHS supported Research  pt  A  Subject access A H
Author: Anonim
Publsiher: Unknown
Total Pages: 1398
Release: 1994
ISBN 10: 1928374650XXX
ISBN 13: MINN:31951P003778514
Language: EN, FR, DE, ES & NL

Biomedical Index to PHS supported Research pt A Subject access A H Book Review:

GABA And Glutamate

GABA And Glutamate
Author: Janko Samardzic
Publsiher: BoD – Books on Demand
Total Pages: 138
Release: 2018-03-21
ISBN 10: 9535138219
ISBN 13: 9789535138211
Language: EN, FR, DE, ES & NL

GABA And Glutamate Book Review:

This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 74
Release: 2011-07-05
ISBN 10: 0309212243
ISBN 13: 9780309212243
Language: EN, FR, DE, ES & NL

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System Book Review:

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Epilepsy and Neurodevelopmental Diseases

Epilepsy and Neurodevelopmental Diseases
Author: Eleonora Palma,Eleonora Aronica,Erwin van Vliet
Publsiher: Frontiers Media SA
Total Pages: 115
Release: 2020-12-09
ISBN 10: 2889661652
ISBN 13: 9782889661657
Language: EN, FR, DE, ES & NL

Epilepsy and Neurodevelopmental Diseases Book Review:

This topic has been realized in collaboration with Dr. Gabriele Ruffolo, Post Doctoral Researcher at the University of Rome (Sapienza) (ORCID ID: 0000-0002-6554-5496).

Ion and Water Transport in Cell Death

Ion and Water Transport in Cell Death
Author: Markus Ritter,Yasunobu Okada,Alexander A. Mongin,Giovanna Valenti
Publsiher: Frontiers Media SA
Total Pages: 317
Release: 2021-10-25
ISBN 10: 2889715582
ISBN 13: 9782889715589
Language: EN, FR, DE, ES & NL

Ion and Water Transport in Cell Death Book Review:

Research Awards Index

Research Awards Index
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1989
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015014022589
Language: EN, FR, DE, ES & NL

Research Awards Index Book Review:

Issues in Clinical Epileptology A View from the Bench

Issues in Clinical Epileptology  A View from the Bench
Author: Helen E. Scharfman,Paul S. Buckmaster
Publsiher: Springer
Total Pages: 339
Release: 2014-07-10
ISBN 10: 9401789142
ISBN 13: 9789401789141
Language: EN, FR, DE, ES & NL

Issues in Clinical Epileptology A View from the Bench Book Review:

This book is dedicated to Dr. Philip A. Schwartzkroin. The book has a novel format because it is not intended to be a set of reviews. Instead, it is an effort to explore important topics in the epilepsy research field. Because articles are written by leaders in the field who have years of experience and individuals with diverse expertise, articles are likely to have a long-lasting impact and be relevant for both epileptologists and neuroscientists. Authors address topics that are important, unresolved questions in the field of epilepsy research, drawing on available data from both the bench and the clinic to support their points. A given topic is addressed by one or more authors, each writing from his/her own unique perspective. For all of the individuals who have been trained or worked with Philip Schwartzkroin in the past and/or have appreciated his contributions to the epilepsy field, this volume is an excellent way to celebrate his achievements and look to the ways they have moved the field forward and continue to stimulate its growth.

Ion Channels and Disease

Ion Channels and Disease
Author: Frances M. Ashcroft
Publsiher: Academic Press
Total Pages: 481
Release: 1999-10-20
ISBN 10: 0080535216
ISBN 13: 9780080535210
Language: EN, FR, DE, ES & NL

Ion Channels and Disease Book Review:

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

Gasotransmitters novel regulators of ion channels and transporters

Gasotransmitters  novel regulators of ion channels and transporters
Author: Wolfgang G. Clauss
Publsiher: Frontiers E-books
Total Pages: 135
Release: 2013-04-23
ISBN 10: 2889191141
ISBN 13: 9782889191147
Language: EN, FR, DE, ES & NL

Gasotransmitters novel regulators of ion channels and transporters Book Review:

Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Small gaseous molecules, such as nitric oxide (NO), carbon monoxide (CO) and hydrogen sulphide (H2S), are emerging as important regulators of various cellular functions. Especially ion channels and transporters have been demonstrated to represent prominent molecular targets for those gases and are thus key factors in gas-induced cell-signalling. This Research Topic will focus on the interaction of gaseous molecules with ion channels/transporters and will address the following questions: i) Which ion channels/transporters are regulated by gases? ii) How are ion channels/transporters mechanistically regulated by gases? iii) What are cellular and physiological processes, which are triggered by the interaction of gases with ion channels/transporters?

Nonclassical Ion Channels in the Nervous System

Nonclassical Ion Channels in the Nervous System
Author: Xu Tian-le,Long-Jun Wu
Publsiher: CRC Press
Total Pages: 427
Release: 2021-08-05
ISBN 10: 1000403742
ISBN 13: 9781000403749
Language: EN, FR, DE, ES & NL

Nonclassical Ion Channels in the Nervous System Book Review:

Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.

Vitamin C in Health and Disease

Vitamin C in Health and Disease
Author: Anitra C. Carr,Jens Lykkesfeldt
Publsiher: MDPI
Total Pages: 299
Release: 2018-08-09
ISBN 10: 3038970298
ISBN 13: 9783038970293
Language: EN, FR, DE, ES & NL

Vitamin C in Health and Disease Book Review:

This book is a printed edition of the Special Issue "Vitamin C in Health and Disease" that was published in Nutrients

Ross Wilson Anatomy and Physiology in Health and Illness E Book

Ross   Wilson Anatomy and Physiology in Health and Illness E Book
Author: Anne Waugh,Allison Grant
Publsiher: Elsevier Health Sciences
Total Pages: 584
Release: 2018-07-12
ISBN 10: 0702072842
ISBN 13: 9780702072840
Language: EN, FR, DE, ES & NL

Ross Wilson Anatomy and Physiology in Health and Illness E Book Book Review:

The new edition of the hugely successful Ross and Wilson Anatomy & Physiology in Health and Illness continues to bring its readers the core essentials of human biology presented in a clear and straightforward manner. Fully updated throughout, the book now comes with enhanced learning features including helpful revision questions and an all new art programme to help make learning even easier. The 13th edition retains its popular website, which contains a wide range of ‘critical thinking’ exercises as well as new animations, an audio-glossary, the unique Body Spectrum© online colouring and self-test program, and helpful weblinks. Ross and Wilson Anatomy & Physiology in Health and Illness will be of particular help to readers new to the subject area, those returning to study after a period of absence, and for anyone whose first language isn’t English. Latest edition of the world’s most popular textbook on basic human anatomy and physiology with over 1.5 million copies sold worldwide Clear, no nonsense writing style helps make learning easy Accompanying website contains animations, audio-glossary, case studies and other self-assessment material, the unique Body Spectrum© online colouring and self-test software, and helpful weblinks Includes basic pathology and pathophysiology of important diseases and disorders Contains helpful learning features such as Learning Outcomes boxes, colour coding and design icons together with a stunning illustration and photography collection Contains clear explanations of common prefixes, suffixes and roots, with helpful examples from the text, plus a glossary and an appendix of normal biological values. Particularly valuable for students who are completely new to the subject, or returning to study after a period of absence, and for anyone whose first language is not English All new illustration programme brings the book right up-to-date for today’s student Helpful ‘Spot Check’ questions at the end of each topic to monitor progress Fully updated throughout with the latest information on common and/or life threatening diseases and disorders Review and Revise end-of-chapter exercises assist with reader understanding and recall Over 150 animations – many of them newly created – help clarify underlying scientific and physiological principles and make learning fun

Disorders of Circadian Rhythms

Disorders of Circadian Rhythms
Author: Arturo Ortega,Mario Caba,Pevet Paul
Publsiher: Frontiers Media SA
Total Pages: 105
Release: 2020-11-19
ISBN 10: 2889661318
ISBN 13: 9782889661312
Language: EN, FR, DE, ES & NL

Disorders of Circadian Rhythms Book Review:

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Basic Electrophysiological Methods

Basic Electrophysiological Methods
Author: Ellen Covey,Matt Carter
Publsiher: Oxford University Press, USA
Total Pages: 227
Release: 2015
ISBN 10: 0199939802
ISBN 13: 9780199939800
Language: EN, FR, DE, ES & NL

Basic Electrophysiological Methods Book Review:

A broad, concise, and no-nonsense guide to contemporary electrophysiological techniques, covering intracellular and extracellular recording through recording of population activity, neuropharmacology, dye imaging, voltammetry, and optogenetics.