Neurobiology of Alcohol and the Brain

Neurobiology of Alcohol and the Brain
Author: Ashok K. Singh
Publsiher: Academic Press
Total Pages: 364
Release: 2020-10-01
ISBN 10: 0128198915
ISBN 13: 9780128198919
Language: EN, FR, DE, ES & NL

Neurobiology of Alcohol and the Brain Book Review:

Neurobiology of Alcohol and the Brain addresses addiction related problems, reviewing both mechanisms and withdrawal systems surrounding alcohol addiction. Chapters discuss mechanisms of rewarding, aversive effects, alcohol’s interaction with other drugs (and ensuing adverse consequences), and current and novel treatments. Lastly, the reader is provided with examples of an experimental study that describes the possible protective effects of gold nanoparticles against alcohol addiction in rats subjected to alcohol self-administration. Provides an exhaustive overview of neurobiology of alcohol addiction, including significant recent advances Discusses the mechanisms underlying the adverse effects of alcohol-drug mixtures Includes recent experimental studies on gold nanoparticles

Neuroscience of Alcohol

Neuroscience of Alcohol
Author: Victor R. Preedy
Publsiher: Academic Press
Total Pages: 736
Release: 2019-03-19
ISBN 10: 0128131268
ISBN 13: 9780128131268
Language: EN, FR, DE, ES & NL

Neuroscience of Alcohol Book Review:

Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function Discusses alcohol use as a component of dual-use and poly addictions Outlines numerous screening and treatment strategies for alcohol misuse Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects

Neurobiology of Alcohol Dependence

Neurobiology of Alcohol Dependence
Author: Antonio Noronha,Changhai Cui,Robert Adron Harris,John C. Crabbe
Publsiher: Elsevier
Total Pages: 566
Release: 2014-05-02
ISBN 10: 0124071554
ISBN 13: 9780124071551
Language: EN, FR, DE, ES & NL

Neurobiology of Alcohol Dependence Book Review:

Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available

Addiction

Addiction
Author: Gene M. Heyman
Publsiher: Harvard University Press
Total Pages: 216
Release: 2009-10-15
ISBN 10: 0674053990
ISBN 13: 9780674053991
Language: EN, FR, DE, ES & NL

Addiction Book Review:

In a book sure to inspire controversy, Gene Heyman argues that conventional wisdom about addiction - that it is a disease, a compulsion beyond conscious control - is wrong. At the heart of Heyman's analysis is a startling view of choice and motivation that applies to all choices, not just the choice to use drugs. Heyman’s analysis of well-established but frequently ignored research leads to unexpected insights into how we make choices - from obesity to McMansionization - all rooted in our deep-seated tendency to consume too much of whatever we like best.

Alcohol

Alcohol
Author: George F. Koob,Michael A. Arends,Mandy McCracken,Michel Le Moal
Publsiher: Academic Press
Total Pages: 402
Release: 2021-07-07
ISBN 10: 0128167947
ISBN 13: 9780128167946
Language: EN, FR, DE, ES & NL

Alcohol Book Review:

A current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction is detailed in our Neurobiology of Addiction series, each volume addressing a specific area of addiction. ALCOHOL, Volume 3 in the series, explores the molecular, cellular, and neurocircuitry systems in the brain responsible for alcohol addiction using the heuristic three-stage cycle framework of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. Outlines the history and behavioral mechanism of action of alcohol relevant to the neurobiology of alcohol addiction Includes neurocircuitry, cellular, and molecular neurobiological mechanisms of alcohol addiction in each stage of the addiction cycle Explores evolving areas of research associated with all three stages of the alcohol addiction cycle, including neurobiological studies of neurodevelopmental effects of early exposure to alcohol, sleep disturbances caused by alcohol, pain interactions with alcohol, sex differences in the response to alcohol, and epigenetic/genetic interactions with alcohol.

Never Enough

Never Enough
Author: Judith Grisel
Publsiher: Anchor
Total Pages: 256
Release: 2019-02-19
ISBN 10: 0385542852
ISBN 13: 9780385542852
Language: EN, FR, DE, ES & NL

Never Enough Book Review:

A NEW YORK TIMES BESTSELLER From a renowned behavioral neuroscientist and recovering addict, a rare page-turning work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction. Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey. In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Yet they have their appeal, and Grisel draws on anecdotes both comic and tragic from her own days of using as she limns the science behind the love of various drugs, from marijuana to alcohol, opiates to psychedelics, speed to spice. With more than one in five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide, and Grisel delves with compassion into the science of this scourge. She points to what is different about the brains of addicts even before they first pick up a drink or drug, highlights the changes that take place in the brain and behavior as a result of chronic using, and shares the surprising hidden gifts of personality that addiction can expose. She describes what drove her to addiction, what helped her recover, and her belief that a “cure” for addiction will not be found in our individual brains but in the way we interact with our communities. Set apart by its color, candor, and bell-clear writing, Never Enough is a revelatory look at the roles drugs play in all of our lives and offers crucial new insight into how we can solve the epidemic of abuse.

Alcohol and the Nervous System

Alcohol and the Nervous System
Author: Edith V. Sullivan,Adolf Pfefferbaum
Publsiher: Elsevier
Total Pages: 704
Release: 2014-10-08
ISBN 10: 0444626220
ISBN 13: 9780444626226
Language: EN, FR, DE, ES & NL

Alcohol and the Nervous System Book Review:

Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism. The first focused reference specifically on alcohol and the brain Details our current understanding of how alcohol impacts the central nervous system Covers clinical and social impact of alcohol abuse disorders and the biomedical consequences of alcohol abuse Includes section on neuroimaging of neurochemical markers and brain function

Behavioral Neurobiology of Alcohol Addiction

Behavioral Neurobiology of Alcohol Addiction
Author: Wolfgang Sommer,Rainer Spanagel
Publsiher: Springer Science & Business Media
Total Pages: 727
Release: 2012-07-28
ISBN 10: 3642287204
ISBN 13: 9783642287206
Language: EN, FR, DE, ES & NL

Behavioral Neurobiology of Alcohol Addiction Book Review:

The question how alcohol alters mood states and why this may end up becoming an addiction is puzzling alcohol researchers since decades. In this volume, an assembly of highly distinguished experts and leaders in alcohol addiction research provides lucid presentations of the current knowledge and research challenges as well as interesting viewpoints on future research directions aimed to stimulate communication and convergence between clinical and preclinical researchers, and to renew interest in the vibrant field of alcohol addiction research among a wide scientifically minded audience. Five Current Topics are discussed in this volume: Neurobiological mechanisms of alcoholism, Genetics, Clinical phenotypes and their preclinical models, Brain imaging, and Translational approaches for treatment development, both pharmacological and non-pharmacological. These areas have in our opinion brought alcohol research substantially forward and influenced our thinking about how to reach our common paramount goal, namely to offer effective treatment solutions for an extensive group of patients with largely unmet medical needs.

Drugs Addiction and the Brain

Drugs  Addiction  and the Brain
Author: George F. Koob,Michael A. Arends,Michel Le Moal
Publsiher: Academic Press
Total Pages: 350
Release: 2014-07-12
ISBN 10: 0123869595
ISBN 13: 9780123869593
Language: EN, FR, DE, ES & NL

Drugs Addiction and the Brain Book Review:

Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle Actual data figures from original sources illustrating key concepts and findings Introduction to basic neuropharmacology terms and concepts Introduction to numerous animal models used to study diverse aspects of drug use. Thorough review of extant work on the neurobiology of addiction

The Science of Addiction From Neurobiology to Treatment

The Science of Addiction  From Neurobiology to Treatment
Author: Carlton K. Erickson
Publsiher: W. W. Norton & Company
Total Pages: 312
Release: 2007-02-17
ISBN 10: 9780393076226
ISBN 13: 0393076229
Language: EN, FR, DE, ES & NL

The Science of Addiction From Neurobiology to Treatment Book Review:

Runner-up winner of the Hamilton Book Author Award, this book is a comprehensive overview of the neurobiology behind addictions. Neuroscience is clarifying the causes of compulsive alcohol and drug use––while also shedding light on what addiction is, what it is not, and how it can best be treated––in exciting and innovative ways. Current neurobiological research complements and enhances the approaches to addiction traditionally taken in social work and psychology. However, this important research is generally not presented in a forthright, jargon-free way that clearly illustrates its relevance to addiction professionals. The Science of Addiction presents a comprehensive overview of the roles that brain function and genetics play in addiction. It explains in an easy-to-understand way changes in the terminology and characterization of addiction that are emerging based upon new neurobiological research. The author goes on to describe the neuroanatomy and function of brain reward sites, and the genetics of alcohol and other drug dependence. Chapters on the basic pharmacology of stimulants and depressants, alcohol, and other drugs illustrate the specific and unique ways in which the brain and the central nervous system interact with, and are affected by, each of these substances Erickson discusses current and emerging treatments for chemical dependence, and how neuroscience helps us understand the way they work. The intent is to encourage an understanding of the body-mind connection. The busy clinical practitioner will find the chapter on how to read and interpret new research findings on the neurobiological basis of addiction useful and illuminating. This book will help the almost 21.6 million Americans, and millions more worldwide, who abuse or are dependent on drugs by teaching their caregivers (or them) about the latest addiction science research. It is also intended to help addiction professionals understand the foundations and applications of neuroscience, so that they will be able to better empathize with their patients and apply the science to principles of treatment.

Neurobiology of Addiction

Neurobiology of Addiction
Author: George F. Koob,Michel Le Moal
Publsiher: Elsevier
Total Pages: 504
Release: 2005-11-11
ISBN 10: 0080497373
ISBN 13: 9780080497372
Language: EN, FR, DE, ES & NL

Neurobiology of Addiction Book Review:

Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching

Alcohol Research Health

Alcohol Research   Health
Author: Anonim
Publsiher: Unknown
Total Pages: 344
Release: 1999
ISBN 10: 1928374650XXX
ISBN 13: UCSC:32106015846345
Language: EN, FR, DE, ES & NL

Alcohol Research Health Book Review:

Addiction Neuroethics

Addiction Neuroethics
Author: Adrian Carter,Wayne Hall,Judy Illes
Publsiher: Academic Press
Total Pages: 346
Release: 2011-10-04
ISBN 10: 0123859743
ISBN 13: 9780123859747
Language: EN, FR, DE, ES & NL

Addiction Neuroethics Book Review:

Research increasingly suggests that addiction has a genetic and neurobiological basis, but efforts to translate research into effective clinical treatments and social policy needs to be informed by careful ethical analyses of the personal and social implications. Scientists and policy makers alike must consider possible unintended negative consequences of neuroscience research so that the promise of reducing the burden and incidence of addiction can be fully realized and new advances translated into clinically meaningful and effective treatments. This volume brings together leading addiction researchers and practitioners with neuroethicists and social scientists to specifically discuss the ethical, philosophical, legal and social implications of neuroscience research of addiction, as well as its translation into effective, economical and appropriate policy and treatments. Chapters explore the history of ideas about addiction, the neuroscience of drug use and addiction, prevention and treatment of addiction, the moral implications of addiction neuroscience, legal issues and human rights, research ethics, and public policy. Features outstanding and truly international scholarship, with chapters written by leading experts in neuroscience, addiction medicine, psychology and more Informs psychologists of related research in neuroscience and vice versa, giving researchers easy one-stop access to knowledge outside their area of specialty

Effects of Peri Adolescent Licit and Illicit Drug Use on the Developing CNS Part I

Effects of Peri Adolescent Licit and Illicit Drug Use on the Developing CNS Part I
Author: Anonim
Publsiher: Academic Press
Total Pages: 366
Release: 2021-10-23
ISBN 10: 0128208066
ISBN 13: 9780128208069
Language: EN, FR, DE, ES & NL

Effects of Peri Adolescent Licit and Illicit Drug Use on the Developing CNS Part I Book Review:

Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS, Volume 161 in the International Review on Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Cannabis Exposure During Adolescence: A Uniquely Sensitive Period for Neurobiological Effects, The Stoned-Age: A Systematic Review of the Neurobiological Effects of Adolescent Cannabinoid Exposure on Preclinical Animal Models, Genetic Influences Impacting Nicotine Use and Abuse During Adolescence: Insights from Human and Animal Studies, the Impact of Adolescent Nicotine Exposure on Adulthood Alcohol Consumption: The Role of Neuropeptides, and much more. Additional chapters cover The Role of Sex in the Persistent Effects of Adolescent Alcohol Exposure on Behavior and Neurobiology in Rodents, The Effects of Peri-Adolescent Alcohol Use on the Developing Hippocampus, Regulation of Glutamate Signaling in the Extended Amygdala by Adolescent Alcohol Exposure, Peri-Adolescent Binge Drinking Effects on Hippocampal Neurogenesis, Neuroepigenetic Consequences of Adolescent Ethanol Exposure, Adolescent Neuroimmunity and Its Interaction with Alcohol, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review on Neurobiology series Updated release includes the latest information on the Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing Central Nervous System

The Wiley Handbook on the Cognitive Neuroscience of Addiction

The Wiley Handbook on the Cognitive Neuroscience of Addiction
Author: Stephen J. Wilson
Publsiher: John Wiley & Sons
Total Pages: 552
Release: 2015-07-07
ISBN 10: 1118472241
ISBN 13: 9781118472248
Language: EN, FR, DE, ES & NL

The Wiley Handbook on the Cognitive Neuroscience of Addiction Book Review:

This volume provides a thorough and up-to-date synthesis of the expansive and highly influential literature from the last 30 years by bringing together contributions from leading authorities in the field, with emphasis placed on the most commonly investigated drugs of abuse. Emphasises the most commonly investigated drugs of abuse, including alcohol, cocaine, nicotine, and opiates Brings together the work of the leading authorities in all major areas of the field Provides novel coverage of cutting-edge methods for using cognitive neuroscience to advance the treatment of addiction, including real-time neurofeedback and brain stimulation methods Includes new material on emerging themes and future directions in the use of cognitive neuroscience to advance addiction science

Global Status Report on Alcohol and Health 2018

Global Status Report on Alcohol and Health 2018
Author: World Health Organization
Publsiher: World Health Organization
Total Pages: 469
Release: 2019-02-07
ISBN 10: 9241565632
ISBN 13: 9789241565639
Language: EN, FR, DE, ES & NL

Global Status Report on Alcohol and Health 2018 Book Review:

The report provides an overview of alcohol consumption and harms in relation to the UN Sustainable Development Goals (Chapter 1), presents global strategies, action plans and monitoring frameworks (Chapter 2), gives detailed information on: the consumption of alcohol in populations (Chapter 3); the health consequences of alcohol consumption (Chapter 4); and policy responses at the national level (Chapter 5). In its final Chapter 6, the imperative for reducing harmful use of alcohol in a public health perspective is presented. In addition, the report contains country profiles for WHO Member States and appendices with statistical annexes, a description of the data sources and methods used to produce the estimates and references.

The Wiley Blackwell Handbook of Forensic Neuroscience

The Wiley Blackwell Handbook of Forensic Neuroscience
Author: Anthony R. Beech,Adam J. Carter,Ruth E. Mann,Pia Rotshtein
Publsiher: John Wiley & Sons
Total Pages: 550
Release: 2018-01-26
ISBN 10: 1118650913
ISBN 13: 9781118650912
Language: EN, FR, DE, ES & NL

The Wiley Blackwell Handbook of Forensic Neuroscience Book Review:

Explores how the explosion of neuroscience-based evidence in recent years has led to a fundamental change in how forensic psychology can inform working with criminal populations. This book communicates knowledge and research findings in the neurobiological field to those who work with offenders and those who design policy for offender rehabilitation and criminal justice systems, so that practice and policy can be neurobiologically informed, and research can be enhanced. Starting with an introduction to the subject of neuroscience and forensic settings, The Wiley Blackwell Handbook of Forensic Neuroscience then offers in-depth and enlightening coverage of the neurobiology of sex and sexual attraction, aggressive behavior, and emotion regulation; the neurobiological bases to risk factors for offending such as genetics, developmental, alcohol and drugs, and mental disorders; and the neurobiology of offending, including psychopathy, antisocial personality disorders, and violent and sexual offending. The book also covers rehabilitation techniques such as brain scanning, brain-based therapy for adolescents, and compassion-focused therapy. The book itself: Covers a wide array of neuroscience research Chapters by renowned neuroscientists and criminal justice experts Topics covered include the neurobiology of aggressive behavior, the neuroscience of deception, genetic contributions to psychopathy, and neuroimaging-guided treatment Offers conclusions for practitioners and future directions for the field. The Handbook of Forensic Neuroscience is a welcome book for all researchers, practitioners, and postgraduate students involved with forensic psychology, neuroscience, law, and criminology.

Molecular Neurobiology of Addiction Recovery

Molecular Neurobiology of Addiction Recovery
Author: Kenneth Blum,John Femino,Scott Teitelbaum,John Giordano,Marlene Oscar-Berman,Mark Gold
Publsiher: Springer Science & Business Media
Total Pages: 89
Release: 2013-05-27
ISBN 10: 146147230X
ISBN 13: 9781461472308
Language: EN, FR, DE, ES & NL

Molecular Neurobiology of Addiction Recovery Book Review:

Humans are biologically programmed to seek out pleasurable experiences. These experiences are processed in the mesolimbic system, also referred to as the "reward center" of the brain, where a number of chemical messengers work in concert to provide a net release of dopamine in the Nucleus Accumbens. In some genetically predisposed individuals, addiction occurs when the mechanisms of the mesolimbic system are disrupted by the use of various drugs of abuse. Since Alcoholics Anonymous was founded in 1935, it's 12 step program of spiritual and character development has helped countless alcoholics and drug addicts curb their self-destructive behaviors. However, the program was developed at a time when comparatively little was known about the function of the brain and it has never been studied scientifically. This is the first book to take a systematic look at the molecular neurobiology associated with each of the 12 steps and to review the significant body of addiction research literature that is pertinent to the program.​

The Alcoholics

The Alcoholics
Author: Jim Thompson
Publsiher: Mulholland Books
Total Pages: 192
Release: 2012-05-01
ISBN 10: 031619588X
ISBN 13: 9780316195881
Language: EN, FR, DE, ES & NL

The Alcoholics Book Review:

Dr. Peter S. Murphy needs fifteen thousand dollars by the end of the day, or the city of Los Angeles can say goodbye to the El Healtho clinic. A recovery center for the most severe cases of alcoholism in the state -- even if no one ever does quite seem to get dry there -- El Healtho has been the bane of Dr. Murphy's existence ever since he started running it. But now that its doors are about to close forever, Dr. Murphy finds he'll do anything to keep it open. Up to and including admitting Humphrey Van Twyne III, a patient with an extremely violent past whose wealthy family has the means to keep El Healtho open for business. Sure, the man isn't exactly an alcoholic. And yes, what he really needs is to be under the care of the surgeons who performed the lobotomy that's rendered Van Twyne all but a vegetable. But the money's good -- until the rag-tag group of ne'er-do-wells at El Healtho begin to wreak havoc with Dr. Murphy's plans, and suddenly no one day has ever seemed so long. A literary precursor to One Flew Over the Cuckoo's Nest, The Alcoholics is Thompson like you've never read him before, a pitch-black, mad-cap portrait of deviant behavior that is at once darkly comic, humane and harrowing.

Alcohol and Alcoholism

Alcohol and Alcoholism
Author: John H. Hannigan,Linda P. Spear,Norman E. Spear,Charles R. Goodlett
Publsiher: Psychology Press
Total Pages: 304
Release: 1999-02
ISBN 10: 1135683999
ISBN 13: 9781135683993
Language: EN, FR, DE, ES & NL

Alcohol and Alcoholism Book Review:

This is the first volume that focuses on the lifespan neurobehavioral factors likely to determine susceptibility to alcohol abuse and its consequences. The chapters offer careful analysis of the effects of ethanol on the fetus, the infant, the adolescent, and the adult. The authors include behavioral neuroscientists and clinical neuropsychologists. Their topics range from the neurochemical and neuroanatomical consequences of prenatal alcohol to the cognitive consequences of prenatal alcohol on preschool and school-age children. The impact of genetics on sensitivity to alcohol is considered in terms of analytic tests using techniques of behavioral genetics and molecular biology. The consequences of exposure to alcohol during breastfeeding are described in experiments with human infants. The alcoholism that develops in adulthood is analyzed through the experimental study of relapse from alcohol deprivation and assessment of neuropsychological impairments and treatment for alcoholics. Drawing on extensive research that has applied techniques from molecular neurobiology and tests of learning and memory to the clinical assessment and treatment of alcoholics. The volume answers recent questions raised by the National Institute of Alcohol Abuse and Alcoholism and the National Institute of Drug Abuse about the role of early experience in susceptibility to later abuse of alcohol and other drugs. Although epidemiological studies can describe the problem, solutions in terms of mechanisms that mediate these effects will be found only with the kinds of experimentally oriented approaches the chapter authors describe.