Neuro Urology Research

Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field, discusses potential future directions and explains the latest neuroscience tools that can be used in neuro-urology research. The first section provides an overview of the circuit-based interrogation of subcortical and spinal networks involved in bladder filling and voiding. The second section discusses the translational potential of research for patients including specific chapters on the sensation of bladder stretch, bladder pain, the effects of hormones and the potential results of neurodegeneration on bladder function. The third section compares traditional and current studies determining the need for addressing or readdressing principles or adjusting dogma. Section four introduces techniques including optogenetic manipulation and calcium imaging of neural activity, and on how these methods can be applied to neuro-urology research. The fifth and final section proposes studies in directions that have remained underexplored or otherwise controversial. Perfect for all currently researching neuro-urology, this detailed understanding of the cellular and synaptic circuits that control bladder filling and voiding and of the circuitry regulating bladder function, has the potential to inform the development of newer therapeutics for treating LUTS. Conveys the importance of a deeper understanding of the basis of the neural control of bladder function to bridge gap in understanding of the neuro-urology research field Stresses and highlights the importance of fundamental research before scientific results can be applied to clinical settings Includes cutting edge neuroscience techniques like (wireless/ radiofrequency) optogenetic manipulation of cell activity, and gene profiling Summarizes the outcomes of the latest research and overview of how new findings compare with more traditional studies and clear explanations of how neuro-urology research may be applicable to treating patients with LUTS

This book introduce neurourology as an emerging interdisciplinary area that covers the basic and clinical studies of the neural control on the normal lower urinary tract and the lower/upper urinary tract dysfunction due to neuropathy disorders. It systematically describes all aspects of neurourology from the epidemiology of the neurogenic bladder; to the pathology and pathophysiology of the lower urinary tract; to the diagnosis and treatment of the neurogenic bladder by conservative therapies or surgeries. This book provides a useful resource for medical doctors, nurses and students in the field of neurourological conditions. All the topics are written by internationally recognized specialists in their field.

This book introduce neurourology as an emerging interdisciplinary area that covers the basic and clinical studies of the neural control on the normal lower urinary tract and the lower/upper urinary tract dysfunction due to neuropathy disorders. It systematically describes all aspects of neurourology from the epidemiology of the neurogenic bladder; to the pathology and pathophysiology of the lower urinary tract; to the diagnosis and treatment of the neurogenic bladder by conservative therapies or surgeries. This book provides a useful resource for medical doctors, nurses and students in the field of neurourological conditions. All the topics are written by internationally recognized specialists in their field.

This volume is a useful handbook for medical doctors involved in the diagnosis and treatment of neuro-urological problems. The first section reviews the relevant neuro-anatomy and neuro-physiology and provides a practical overview of specific neuro-urological pathologic conditions. The second section discusses the various clinical entities that can be encountered and focuses on the clinical entities neuro-urological consquences. The third section is devoted to the different diagnostic possibilities. Internationally accepted algorithms are presented and put into perspective. Section 4 deals with the triad of major clinical problems in this area: urinary (incontinence, retention and voiding dysfunction as well as upper urinary tract problems), anorectal (faecal incontinence and constipation) and sexual (erectile dysfunction and ejaculatory failure) dysfunctions. The final section covers the specific management of patients with neuro-urological problems and describes conservative and surgical treatments, providing the most recent information. Throughout, the text is accompanied by numerous illustrated case reports and discussions as well as tips and tricks based on the personal experience of the different authors.

This book provides an in-depth insight into the symptoms and symptom complexes affecting the lower urinary tract and the underlying causative conditions. The emphasis throughout is practical and clinical, with coverage of all levels of the patient pathway. In addition to the extensive guidance on diagnostic assessment and interpretation, the management of voiding and storage lower urinary tract symptoms, including incontinence, is fully described and potential complications and neurological conditions are discussed. Information is also included on relevant basic science and epidemiology. Lower Urinary Tract Symptoms in Adults: A Clinical Approach will be an ideal source of expert knowledge for practitioners in functional urology, urogynecology, and neuro-urology gerontology. .

This book is exclusively devoted to the often-challenging diagnosis, management and treatment of patients with non-neurogenic bladder dysfunction. A unique team of experts in the field report on the state of the art and the latest trends concerning overactive and underactive bladder dysfunctions, while also discussing detrusor overactivity impaired contractility. Given its scope, the book will benefit all urologists, and offers a valuable tool for professionals and physicians who care and deal with patients with non-neurogenic bladder dysfunctions.

Scientific Advances in Reconstructive Urology and Tissue Engineering is a comprehensive overview of reconstructive urology that spans male and female, pediatric, neuro-urology and trauma. Traditionally, this field has been focused solely on surgical principles with little attention to basic and translational research. However, recent advances in acellular matrices, scaffolds, stem cells and tissue engineering have changed this focus. This publication is the perfect bridge and definitive tome of the advances that will move the translational and basic science of reconstructive urology forward and allow readers to implement the findings in clinical practice. Through the use of both current case studies and future implications, the content bridges the gap from bench to bedside making it the perfect reference for translational benign urology researchers who wish to move the field of reconstructive surgery forward. Includes real-world applications of current research to help readers get rapidly up-to-speed on which research results are appropriate for immediate implementation Presents the underlying mechanism of urologic disease processes pertinent to reconstructive urology for comprehensive understanding within the field Provides independent guidance to manage specific clinical conditions while also presenting approaches that are applicable to all conditions

Emphasizing the clinical problems surrounding urogenital tract dysfunction, this up-to-date reference details the basic science, differential diagnosis, and treatment of a wide range of neurourological conditions. Covering recent advances in the neurobiology of the pelvic organs, the Handbook of Neuro-Urology reviews the neural control processes that govern pelvic organs discusses the pathogenic mechanisms behind neurological and smooth muscle disorders that produce bladder dysfunction describes the management of impaired bladder, bowel, and sexual function after brain damage and spinal cord injury examines various conditions that affect the autonomic nervous system and specifically result in bladder and sexual dysfunction investigates lower urinary tract function in the elderly suggests practical measures to manage urinary incontinence such as the use of pads, underpants, and appliances and more!

This book aims to impart all the practical knowledge required in order to evaluate and treat children with anatomical, neurological, and functional incontinence. It explains how appropriate choice of management in childhood depends first of all on a correct diagnosis, then on thorough urodynamic evaluation, and finally on sound assessment of the condition of the individual patient. The full range of relevant pathologies are considered and all of the treatment options are extensively discussed, including behavioral therapy, rehabilitation, physiotherapy, pharmacotherapy, neuromodulation, endoscopic procedures, and surgical reconstruction. Careful attention is paid to the impacts that treatments performed during childhood may have on later adult life, including on fertility and pregnancy, with a view to ensuring that the reader will be in a position to time treatments correctly, thereby avoiding adverse effects, and possess all the information needed to address the concerns of patients and their families. The book will be of value to pediatricians, urologists, nurses, physiotherapist, students, and all others with an interest in the field.

Pelvic Organ Dysfunction in Neurological Disease describes the neurological control of human bladder, bowel and sexual function and then details the dysfunctions which may arise as a consequence of various neurological diseases. Easy to read, the book will be of value to any healthcare professional managing patients in whom pelvic organ functions have been compromised by neurological disease. The book provides a structured approach to present day understanding of the neurological control of pelvic organs and the investigation and management of each type of organ dysfunction. A unique feature of this book is that it addresses the impact of specific neurological disorders on all three functions. The authors have all been associated with the Department of Uro-Neurology at the National Hospital for Neurology and Neurosurgery, London since it was established 20 years ago. This book is a timely review of their accumulated knowledge and the latest literature.

This book is aimed to bring the reader into the heart of the action of any health professional consulted for a patient with a neurogenic bladder (NB). Extensive textbooks of the NB exist but there is a lack of an actual practical guide for diagnosis and management of patients suffering from NB. This book provides a single source of information on consultation in neurourology. The text covers both urinary incontinence and retention resulting from NB dysfunction. The book also discusses complications of NB which include urinary tract infections, hydronephrosis, renal failure or autonomic dysreflexia. Sections address these clinical issues faced by physicians. This book provides a useful guide with comprehensive and practical instructions for all practitioners dealing with NB in their day-to-day clinical practice. It will serve as a valuable resource for those with a special interest in NB. The book reviews new data about diagnostic and management options. It also provides a concise yet comprehensive summary of the current NB guidelines from different societies. All chapters include the most up to date scientific and clinical information with the relevant level of clinical evidence and grade of recommendation.

The neurology of sex and bladder disorders requires specialized knowledge and represents a challenge for clinical neurologists focused on the neurological condition. Sex and bladder disorders are often related to more general neurological disorders like Parkinson’s disease and multiple sclerosis, and often the sex and bladder disorders are passed to specialists in urology. Neurology of Sexual and Bladder Disorders: Handbook of Clinical Neurology is a focused, yet comprehensive overview that provides complete tutorial reference to the science, diagnosis and treatment of sex and bladder disorders from a neurologic perspective. Comprehensive coverage of the neurology of sex and bladder disorders Details the latest techniques for the study, diagnosis and treatment of sex and bladder dysfunction from a neurological perspective A focused reference for clinical practitioners and neurology research communities

This book provides a comprehensive, state-of-the-art review of this evaluation of voiding disorders and will serve as a valuable resource for clinicians and surgeons. The book reviews the basic indications for urodynamics as well as the interpretation of basic and advanced studies with the use of clinical vignettes. In addition to step-by-step description in text, the textbook provides illustrations/photographs and tracings of different urodynamics scenarios. This atlas of urodynamics will serve as an extremely useful resource for physicians dealing with and interested in the evaluation of pelvic floor disorders and voiding dysfunction. It will provide a concise and comprehensive review of all the different types of urodynamics scenarios, while instructing its readers on how to accurately and consistently interpret these studies. All chapters are written by experts in the fields of pelvic floor disorders and voiding dysfunction.

Updated to reflect recent developments in the field, Oxford Textbook of Neurorehabilitation provides an understanding of the theoretical underpinnings of the subject along with a clear perspective on making treatment decisions on an individual basis. This is an indispensable book for those working with patients requiring neurorehabilitation.

This book is designed as a guide for management of advanced clinical scenarios encountered by the contemporary pelvic floor surgeon. It is organized by pelvic floor disorder (PFD) and covers the evaluation and treatment of urinary incontinence, fecal incontinence, and pelvic organ prolapse. Opening chapters in each section cover the fundamentals of proper and comprehensive assessment of patient PFDs, as well as the treatment options that are available for each disorder. The book then focuses on more complex and challenging situations that are becoming more frequently encountered as the number of patients being treated for PFD increases and the length of patient follow-up grows. Each chapter finally includes an expert commentary to address these new scenarios and offers a shifted approach from that required for treatment-naïve patients. Female Pelvic Medicine: Challenging Cases with Expert Commentary teaches the reader how to approach the most difficult of clinical situations in a multidisciplinary fashion.