Mouse Behavioral Testing

Mouse Behavioral Testing
Author: Douglas Wahlsten
Publsiher: Academic Press
Total Pages: 304
Release: 2010-11-25
ISBN 10: 9780123756756
ISBN 13: 0123756758
Language: EN, FR, DE, ES & NL

Mouse Behavioral Testing Book Review:

Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully

Methods of Behavior Analysis in Neuroscience

Methods of Behavior Analysis in Neuroscience
Author: Jerry J. Buccafusco
Publsiher: CRC Press
Total Pages: 352
Release: 2000-08-29
ISBN 10: 1420041819
ISBN 13: 9781420041811
Language: EN, FR, DE, ES & NL

Methods of Behavior Analysis in Neuroscience Book Review:

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

What s Wrong With My Mouse

What s Wrong With My Mouse
Author: Jacqueline N. Crawley
Publsiher: John Wiley & Sons
Total Pages: 544
Release: 2007-05-11
ISBN 10: 0470119047
ISBN 13: 9780470119044
Language: EN, FR, DE, ES & NL

What s Wrong With My Mouse Book Review:

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Mood and Anxiety Related Phenotypes in Mice

Mood and Anxiety Related Phenotypes in Mice
Author: Todd D Gould
Publsiher: Humana Press
Total Pages: 382
Release: 2011-09-02
ISBN 10: 9781617793127
ISBN 13: 1617793124
Language: EN, FR, DE, ES & NL

Mood and Anxiety Related Phenotypes in Mice Book Review:

Preclinical research related to mood and anxiety disorders relies extensively upon mouse behavioral tests and models, the use of which continues to increase as a greater number of underlying susceptibility genes are discovered, new targets for medications are identified, and clinical studies reveal novel neurobiological risk factors. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II serves as a complement to the previous volume in order to offer a comprehensive resource for the behavioral approaches that are valuable for the characterization of mood and anxiety disorder-related behaviors in mice and the techniques that are utilized in the development of effective medications. As a collection presented in the Neuromethods series, each chapter provides a brief background and review of the test or model as well as a complete and up-to-date protocol narrative. Authoritative and comprehensive, Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Volume II is an ideal resource for scientists actively pursuing or interested in establishing vital behavioral protocols in their laboratories.

Animal Models of Cognitive Impairment

Animal Models of Cognitive Impairment
Author: Edward D. Levin,Jerry J. Buccafusco
Publsiher: CRC Press
Total Pages: 400
Release: 2006-06-22
ISBN 10: 1420004336
ISBN 13: 9781420004335
Language: EN, FR, DE, ES & NL

Animal Models of Cognitive Impairment Book Review:

The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.

Rodent Models of Stroke

Rodent Models of Stroke
Author: Ulrich Dirnagl
Publsiher: Humana Press
Total Pages: 285
Release: 2010-07-08
ISBN 10: 9781607617495
ISBN 13: 1607617498
Language: EN, FR, DE, ES & NL

Rodent Models of Stroke Book Review:

In view of the numerous failures of clinical trials aimed at improving stroke therapy, the role and potential benefit of experimentally modeling focal cerebral ischemia in rodents has been debated. When methods of systematic review and metaanalyis are applied, however, it turns out that experimental models actually faithfully predicted the negative outcomes of clinical trials. In addition, thrombolysis and neuroprotection by hypothermia, first described in animal models, are key examples of treatment modalities that have made it successfully into clinical practice. In Rodent Models of Stroke, an international consortium of authors aims at critically addressing the issues on a very practical level, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. The structure and content of the book reflect both the authors’ longstanding expertise in experimental and clinical stroke research and their roles in training the scientific community in the tools of the trade. As a volume in the successful Neuromethods series, the chapters provide authoritative reviews of the most commonly used, well-honed approaches in the field today. Stimulating and easy-to-use, Rodent Models of Stroke will help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research
Author: National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research
Publsiher: National Academies Press
Total Pages: 223
Release: 2003-08-22
ISBN 10: 9780309167857
ISBN 13: 030916785X
Language: EN, FR, DE, ES & NL

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research Book Review:

Expanding on the National Research Council’s Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal’s well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Behavioral Genetics of the Mouse Volume 1 Genetics of Behavioral Phenotypes

Behavioral Genetics of the Mouse  Volume 1  Genetics of Behavioral Phenotypes
Author: Wim E. Crusio,Frans Sluyter,Robert T. Gerlai,Susanna Pietropaolo
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2013-04-25
ISBN 10: 1107355575
ISBN 13: 9781107355576
Language: EN, FR, DE, ES & NL

Behavioral Genetics of the Mouse Volume 1 Genetics of Behavioral Phenotypes Book Review:

The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

The Behavior of the Laboratory Rat

The Behavior of the Laboratory Rat
Author: Ian Q. Whishaw,Bryan Kolb
Publsiher: Oxford University Press
Total Pages: 520
Release: 2004-09-02
ISBN 10: 0198036841
ISBN 13: 9780198036845
Language: EN, FR, DE, ES & NL

The Behavior of the Laboratory Rat Book Review:

Both seasoned and beginning investigators will be amazed at the range and complexity of rat behavior as described in the 43 chapters of this volume. The behavioral descriptions are closely tied to the laboratory methods from which they were derived, thus allowing the investigator to exploit both the behavior and the methods for their own research. It will also serve as an indispensable reference for other neuroscientists, psychologist, pharmacologists, geneticists, molecular biologists, zoologists, and their students and trainees.

Animal Models of Neurological Disorders

Animal Models of Neurological Disorders
Author: Puneet Kumar Bansal,Rahul Deshmukh
Publsiher: Springer
Total Pages: 343
Release: 2018-01-17
ISBN 10: 9811059810
ISBN 13: 9789811059810
Language: EN, FR, DE, ES & NL

Animal Models of Neurological Disorders Book Review:

This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.

Psychoneuroimmunology

Psychoneuroimmunology
Author: Qing Yan
Publsiher: Humana Press
Total Pages: 405
Release: 2012-08-30
ISBN 10: 9781627030700
ISBN 13: 1627030700
Language: EN, FR, DE, ES & NL

Psychoneuroimmunology Book Review:

Psychoneuroimmunology (PNI) has developed rapidly in the last four decades. As a multidisciplinary area, PNI may provide a scientific basis for mind-body relationships toward the development of personalized and systems medicine. In Psychoneuroimmunology:Methods and Protocols, expert researchers in the field detail methods and protocols geared toward the development of integrative and individualized therapeutics in multiple dimensions from drugs to behaviors. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Psychoneuroimmunology:Methods and Protocols aids scientists in continuing to study holistic views for the translation of psychoneuroimmunology into better preventive and personalized medical practice.

Motor Activity and Movement Disorders

Motor Activity and Movement Disorders
Author: Paul Sanberg,Klaus-Peter Ossenkopp,Martin Kavaliers
Publsiher: Springer Science & Business Media
Total Pages: 370
Release: 1995-11-06
ISBN 10: 1592594697
ISBN 13: 9781592594696
Language: EN, FR, DE, ES & NL

Motor Activity and Movement Disorders Book Review:

In Motor Activity and Movement Disorders thirteen state-of-the-art articles explicate forefront research methodologies for measuring and interpreting motor activity in animals, as well as their applications to preclinical and clinical research involving motor disorders. The contributors emphasize motor asymmetries, turning behavior, and dyskinetic movements. They also present a variety of quantitative approaches designed to assess specific aspects of motor activity and illustrate numerous computerized measuring techniques that permit detailed and objective approaches to quantifying motor behavior. Motor Activity and Movement Disorders will contribute to a greater understanding of brain-behavior relationships through its focus on methodology and its application to current animal models and to human disorders.

Standards of Mouse Model Phenotyping

Standards of Mouse Model Phenotyping
Author: Martin Hrabé de Angelis,Pierre Chambon,Steve Brown
Publsiher: John Wiley & Sons
Total Pages: 358
Release: 2009-09-03
ISBN 10: 3527608702
ISBN 13: 9783527608706
Language: EN, FR, DE, ES & NL

Standards of Mouse Model Phenotyping Book Review:

This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor is Director of the German Mouse Clinic and member of the Project Committee of the German National Genome Research Network and provides here a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, he focuses on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner.

Animal Communication Networks

Animal Communication Networks
Author: P. K. McGregor
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2005-03-31
ISBN 10: 9781139443678
ISBN 13: 1139443674
Language: EN, FR, DE, ES & NL

Animal Communication Networks Book Review:

Most animal communication has evolved and now takes place in the context of a communication network, i.e. several signallers and receivers within communication range of each other. This idea follows naturally from the observation that many signals travel further than the average spacing between animals. This is self evidently true for long-range signals, but at a high density the same is true for short-range signals (e.g. begging calls of nestling birds). This book provides a current summary of research on communication networks and appraises future prospects. It combines information from studies of several taxonomic groups (insects to people via fiddler crabs, fish, frogs, birds and mammals) and several signalling modalities (visual, acoustic and chemical signals). It also specifically addresses the many areas of interface between communication networks and other disciplines (from the evolution of human charitable behaviour to the psychophysics of signal perception, via social behaviour, physiology and mathematical models).

Pre Clinical Models

Pre Clinical Models
Author: Paul C. Guest
Publsiher: Humana Press
Total Pages: 343
Release: 2019-02-04
ISBN 10: 9781493989935
ISBN 13: 1493989936
Language: EN, FR, DE, ES & NL

Pre Clinical Models Book Review:

This volume details reviews and protocols on the development and analysis of both cellular and animal-based pre-clinical models in a number of medical areas, including metabolic disorders, longevity, cancer, heart disease and psychiatric disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Pre-Clinical Models: Techniques and Protocols aims to provide methods that describe the context of specific disease or therapeutic areas.

Behavioral Genetics of the Mouse

Behavioral Genetics of the Mouse
Author: Susanna Pietropaolo,Frans Sluyter,Wim E. Crusio
Publsiher: Cambridge University Press
Total Pages: 530
Release: 2014-09-25
ISBN 10: 1107044456
ISBN 13: 9781107044456
Language: EN, FR, DE, ES & NL

Behavioral Genetics of the Mouse Book Review:

A comprehensive and critical overview of the major genetically modified mouse lines used to model human neurobehavioral disorders.

The Marshmallow Test

The Marshmallow Test
Author: Walter Mischel
Publsiher: Little, Brown Spark
Total Pages: 336
Release: 2014-09-23
ISBN 10: 0316230855
ISBN 13: 9780316230858
Language: EN, FR, DE, ES & NL

The Marshmallow Test Book Review:

Renowned psychologist Walter Mischel, designer of the famous Marshmallow Test, explains what self-control is and how to master it. A child is presented with a marshmallow and given a choice: Eat this one now, or wait and enjoy two later. What will she do? And what are the implications for her behavior later in life? The world's leading expert on self-control, Walter Mischel has proven that the ability to delay gratification is critical for a successful life, predicting higher SAT scores, better social and cognitive functioning, a healthier lifestyle and a greater sense of self-worth. But is willpower prewired, or can it be taught? In The Marshmallow Test, Mischel explains how self-control can be mastered and applied to challenges in everyday life--from weight control to quitting smoking, overcoming heartbreak, making major decisions, and planning for retirement. With profound implications for the choices we make in parenting, education, public policy and self-care, The Marshmallow Test will change the way you think about who we are and what we can be.

Mrs Frisby and the Rats of Nimh

Mrs  Frisby and the Rats of Nimh
Author: Robert C. O'Brien
Publsiher: Simon and Schuster
Total Pages: 240
Release: 2021-06-01
ISBN 10: 1665911611
ISBN 13: 9781665911610
Language: EN, FR, DE, ES & NL

Mrs Frisby and the Rats of Nimh Book Review:

Some extraordinary rats come to the aid of a mouse family in this Newbery Medal Award–winning classic by notable children’s author Robert C. O’Brien. Mrs. Frisby, a widowed mouse with four small children, is faced with a terrible problem. She must move her family to their summer quarters immediately, or face almost certain death. But her youngest son, Timothy, lies ill with pneumonia and must not be moved. Fortunately, she encounters the rats of NIMH, an extraordinary breed of highly intelligent creatures, who come up with a brilliant solution to her dilemma. And Mrs. Frisby in turn renders them a great service.

Behavioral Genetics of the Mouse Volume 1 Genetics of Behavioral Phenotypes

Behavioral Genetics of the Mouse  Volume 1  Genetics of Behavioral Phenotypes
Author: Wim E. Crusio
Publsiher: Cambridge University Press
Total Pages: 357
Release: 2013-04-25
ISBN 10: 1107034817
ISBN 13: 9781107034815
Language: EN, FR, DE, ES & NL

Behavioral Genetics of the Mouse Volume 1 Genetics of Behavioral Phenotypes Book Review:

A comprehensive review of the current state of our knowledge on the inheritance of normal behaviour in the laboratory mouse.

The Mouse in Biomedical Research

The Mouse in Biomedical Research
Author: Anonim
Publsiher: Elsevier
Total Pages: 816
Release: 2006-12-15
ISBN 10: 9780080469072
ISBN 13: 0080469078
Language: EN, FR, DE, ES & NL

The Mouse in Biomedical Research Book Review:

Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.