Morphological Mouse Phenotyping

Morphological Mouse Phenotyping
Author: Jesus Ruberte,Ana Carretero,Marc Navarro
Publsiher: Elsevier
Total Pages: 135
Release: 2017
ISBN 10: 0128128771
ISBN 13: 9780128128770
Language: EN, FR, DE, ES & NL

Morphological Mouse Phenotyping Book Review:

MORPHOLOGICAL MOUSE PHENOTYPIN

MORPHOLOGICAL MOUSE PHENOTYPIN
Author: Jesus Ruberte,Ana Carretero,Marc Navarro
Publsiher: Academic Press
Total Pages: 600
Release: 2016-12-15
ISBN 10: 9780128128053
ISBN 13: 0128128054
Language: EN, FR, DE, ES & NL

MORPHOLOGICAL MOUSE PHENOTYPIN Book Review:

Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypothesis has encouraged the development of massive global projects making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans. However, a mouse is not a man. Here we present a complete and integrative description of mouse normal morphology. This book, basically an atlas, but also containing explanatory diagrams and text, guides the reader through normal mouse anatomy, histology and imaging, and is aimed for mouse researchers as well as veterinarian and human pathologists. More than 2,200 original images showing the anatomy, histology and cellular structure of mouse organs have been specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona) In addition, correlative X-ray, Computed Tomography, Magnetic Resonance and Ultrasound images complete this integrative vision of the mouse morphology Classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, as well as histological, immunohistochemical and electron microscopy techniques have been employed to characterize the mouse morphology "

An Automated Pipeline for Phenotyping Embryonic Lethal Mice Using 3D Imaging

An Automated Pipeline for Phenotyping Embryonic Lethal Mice Using 3D Imaging
Author: Michael David Wong
Publsiher: Unknown
Total Pages: 135
Release: 2015
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1033014975
Language: EN, FR, DE, ES & NL

An Automated Pipeline for Phenotyping Embryonic Lethal Mice Using 3D Imaging Book Review:

Comparative Anatomy and Histology

Comparative Anatomy and Histology
Author: Piper M. Treuting,Suzanne M. Dintzis
Publsiher: Academic Press
Total Pages: 461
Release: 2012-01
ISBN 10: 0123813611
ISBN 13: 9780123813619
Language: EN, FR, DE, ES & NL

Comparative Anatomy and Histology Book Review:

Comparative Anatomy and Histology: A Mouse and Human Atlas is aimed at the new mouse investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse anatomy and histology using direct comparison to the human. The side by side comparison of mouse and human tissues highlight the unique biology of the mouse, which has great impact on the validation of mouse models of human disease. Print + Electronic product - E-book available on Elsevier's Expert Consult platform- through a scratch-off pin code inside the print book, customers will be able to access the full text online, perform quick searches, and download images at expertconsult.com Offers the first comprehensive source for comparing human and mouse anatomy and histology through over 600 full-color images, in one reference work Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style mouse images Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence Teaches biomedical researchers to examine the histologic changes in their mutant mice

Pathology of Genetically Engineered and Other Mutant Mice

Pathology of Genetically Engineered and Other Mutant Mice
Author: John P. Sundberg,Peter Vogel,Jerrold M. Ward
Publsiher: John Wiley & Sons
Total Pages: 496
Release: 2022-01-26
ISBN 10: 1119624576
ISBN 13: 9781119624578
Language: EN, FR, DE, ES & NL

Pathology of Genetically Engineered and Other Mutant Mice Book Review:

An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Mouse Retinal Phenotyping

Mouse Retinal Phenotyping
Author: Naoyuki Tanimoto
Publsiher: Humana Press
Total Pages: 334
Release: 2018-03-22
ISBN 10: 9781493977192
ISBN 13: 1493977199
Language: EN, FR, DE, ES & NL

Mouse Retinal Phenotyping Book Review:

The aim of this volume is to provide a wide range of techniques and aspects of mouse retinal phenotyping and characterization. Chapters guide readers through morphological and functional properties of the mouse retina and techniques for the analysis of outer to mid-retina and mid- to inner retina. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mouse Retinal Phenotyping: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Mathematical Modeling of Biological Systems Volume II

Mathematical Modeling of Biological Systems  Volume II
Author: Andreas Deutsch,Rafael Bravo de la Parra,Rob J. de Boer,Odo Diekmann,Peter Jagers,Eva Kisdi,Mirjam Kretzschmar,Petr Lansky,Hans Metz
Publsiher: Springer Science & Business Media
Total Pages: 386
Release: 2007-10-12
ISBN 10: 081764556X
ISBN 13: 9780817645564
Language: EN, FR, DE, ES & NL

Mathematical Modeling of Biological Systems Volume II Book Review:

Volume II of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout are mathematical and computational apporaches to examine central problems in the life sciences, ranging from the organization principles of individual cells to the dynamics of large populations. The chapters are thematically organized into the following main areas: epidemiology, evolution and ecology, immunology, neural systems and the brain, and innovative mathematical methods and education. The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.

Neuroanatomy of the Mouse

Neuroanatomy of the Mouse
Author: Hannsjörg Schröder,Natasha Moser,Stefan Huggenberger
Publsiher: Springer Nature
Total Pages: 350
Release: 2020-02-28
ISBN 10: 3030198987
ISBN 13: 9783030198985
Language: EN, FR, DE, ES & NL

Neuroanatomy of the Mouse Book Review:

This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories.

Mouse as a Model Organism

Mouse as a Model Organism
Author: Cord Brakebusch,Taina Pihlajaniemi
Publsiher: Springer Science & Business Media
Total Pages: 165
Release: 2011-03-29
ISBN 10: 9400707509
ISBN 13: 9789400707504
Language: EN, FR, DE, ES & NL

Mouse as a Model Organism Book Review:

Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium “Mouse as a Model Organism – From Animals to Cells”, held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described. This book will give an excellent introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It will highlight the possibilities, but also discuss the current problems and shortcomings, to give a realistic view of the current state-of-art in this fascinating field of biomedical research.

Bioprinting

Bioprinting
Author: Kenneth Douglas
Publsiher: Oxford University Press
Total Pages: 320
Release: 2021
ISBN 10: 0190943548
ISBN 13: 9780190943547
Language: EN, FR, DE, ES & NL

Bioprinting Book Review:

"Bioprinting: To Make Ourselves Anew describes how bioprinting emerged from 3D printing and details the accomplishments and challenges in bioprinting tissues of cartilage, skin, bone, muscle, neuromuscular junctions, liver, heart, lung, and kidney. It explains how scientists are attempting to provide these bioprinted tissues with a blood supply and the ability to carry nerve signals so that the tissues might be used for transplantation into persons with diseased or damaged organs. The book presents all the common terms in the bioprinting field and clarifies their meaning using plain language. The reader will learn about bioink-a bioprinting material containing living cells and supportive biomaterials. Additionally, readers will become at ease with concepts such as fugitive inks (sacrificial inks used to make channels for blood flow), extracellular matrices (the biological environment surrounding cells), decellularization (the process of isolating cells from their native environment), hydrogels (water-based substances that can substitute for the extracellular matrix), rheology (the flow properties of a bioink), bioreactors (containers to provide the environment cells need to thrive and multiply). Further vocabulary that will become familiar includes diffusion (passive movement of oxygen and nutrients from regions of high concentration to regions of low concentration), stem cells (cells with the potential to develop into different bodily cell types), progenitor cells (early descendants of stem cells), gene expression (the process by which proteins develop from instructions in our DNA), and growth factors (substances-often proteins-that stimulate cell growth, proliferation, and differentiation). The book contains an extensive glossary for quick reference"--

Pathology of the Developing Mouse

Pathology of the Developing Mouse
Author: Brad Bolon
Publsiher: CRC Press
Total Pages: 446
Release: 2015-04-24
ISBN 10: 1420070096
ISBN 13: 9781420070095
Language: EN, FR, DE, ES & NL

Pathology of the Developing Mouse Book Review:

Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Essentials of Laboratory Animal Science Principles and Practices

Essentials of Laboratory Animal Science  Principles and Practices
Author: P. Nagarajan,Ramachandra Gudde,Ramesh Srinivasan
Publsiher: Springer Nature
Total Pages: 806
Release: 2021-07-23
ISBN 10: 981160987X
ISBN 13: 9789811609879
Language: EN, FR, DE, ES & NL

Essentials of Laboratory Animal Science Principles and Practices Book Review:

This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.

Holography 3D Imaging and 3D Display

Holography  3D Imaging and 3D Display
Author: Ting-Chung Poon,Yaping Zhang,Liangcai Cao
Publsiher: MDPI
Total Pages: 364
Release: 2021-02-19
ISBN 10: 3039435957
ISBN 13: 9783039435951
Language: EN, FR, DE, ES & NL

Holography 3D Imaging and 3D Display Book Review:

Modern holographic techniques have been successfully applied in many important areas, such as 3-D inspection, 3-D microscopy, metrology, and profilometry, augmented reality, and industrial informatics. This Special Issue covers selected pieces of cutting-edge research works, ranging from low-level acquisition, to high-level analysis, processing, and manipulation of holographic information. The Special Issue also serves as a comprehensive review of existing state-of-the-art techniques in 3-D imaging and 3-D display, as well as broad insights into the future development of these disciplines. The Special Issue contains 25 papers in the field of holography, 3-D imaging, and 3-D display. All the papers underwent substantial peer review under the guidelines of Applied Sciences.

Kaufman s Atlas of Mouse Development Supplement

Kaufman   s Atlas of Mouse Development Supplement
Author: Richard Baldock,Jonathan Bard,Duncan Davidson,Gillian Morriss-Kay
Publsiher: Academic Press
Total Pages: 344
Release: 2015-09-23
ISBN 10: 0128009136
ISBN 13: 9780128009130
Language: EN, FR, DE, ES & NL

Kaufman s Atlas of Mouse Development Supplement Book Review:

Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. Provides high-resolution images for best visualization of key developmental processes and structures Offers in-depth anatomy and morphological views of organ systems Written descriptions convey developmental origins of the organ systems

Molecular and Functional Models in Neuropsychiatry

Molecular and Functional Models in Neuropsychiatry
Author: Jim J. Hagan
Publsiher: Springer Science & Business Media
Total Pages: 394
Release: 2011-04-02
ISBN 10: 3642197035
ISBN 13: 9783642197031
Language: EN, FR, DE, ES & NL

Molecular and Functional Models in Neuropsychiatry Book Review:

The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.

The Laboratory Mouse

The Laboratory Mouse
Author: Peggy J. Danneman,Mark A. Suckow,Cory Brayton
Publsiher: CRC Press
Total Pages: 256
Release: 2012-09-25
ISBN 10: 143985422X
ISBN 13: 9781439854228
Language: EN, FR, DE, ES & NL

The Laboratory Mouse Book Review:

Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a

The Guide to Investigation of Mouse Pregnancy

The Guide to Investigation of Mouse Pregnancy
Author: B. Anne Croy,Aureo T. Yamada,Francesco J. DeMayo,S. Lee Adamson
Publsiher: Academic Press
Total Pages: 832
Release: 2013-12-09
ISBN 10: 0123947944
ISBN 13: 9780123947949
Language: EN, FR, DE, ES & NL

The Guide to Investigation of Mouse Pregnancy Book Review:

The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications Describes the angiogenic tree the mother’s uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success

Human Molecular Genetics

Human Molecular Genetics
Author: Tom Strachan,Andrew Read
Publsiher: Garland Science
Total Pages: 782
Release: 2018-03-29
ISBN 10: 1136844074
ISBN 13: 9781136844072
Language: EN, FR, DE, ES & NL

Human Molecular Genetics Book Review:

Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject. The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

A Practical Guide to the Histology of the Mouse

A Practical Guide to the Histology of the Mouse
Author: Cheryl L. Scudamore
Publsiher: John Wiley & Sons
Total Pages: 248
Release: 2014-02-10
ISBN 10: 1119941202
ISBN 13: 9781119941200
Language: EN, FR, DE, ES & NL

A Practical Guide to the Histology of the Mouse Book Review:

A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation

Neurobiology of Mental Illness

Neurobiology of Mental Illness
Author: Dennis S. Charney,Eric J. Nestler,Pamela Sklar,Joseph D. Buxbaum
Publsiher: Oxford University Press
Total Pages: 1222
Release: 2013-07-04
ISBN 10: 0199934959
ISBN 13: 9780199934959
Language: EN, FR, DE, ES & NL

Neurobiology of Mental Illness Book Review:

Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.