Drug Monitoring and Clinical Chemistry

Drug Monitoring and Clinical Chemistry
Author: Georg Hempel
Publsiher: Elsevier
Total Pages: 378
Release: 2004-05-15
ISBN 10: 0080530540
ISBN 13: 9780080530543
Language: EN, FR, DE, ES & NL

Drug Monitoring and Clinical Chemistry Book Review:

Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics
Author: Georg Hempel
Publsiher: Elsevier
Total Pages: 380
Release: 2019-10-17
ISBN 10: 0444640673
ISBN 13: 9780444640673
Language: EN, FR, DE, ES & NL

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics Book Review:

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Therapeutic Drug Monitoring

Therapeutic Drug Monitoring
Author: Amitava Dasgupta
Publsiher: Academic Press
Total Pages: 468
Release: 2012-06-07
ISBN 10: 0123854687
ISBN 13: 9780123854681
Language: EN, FR, DE, ES & NL

Therapeutic Drug Monitoring Book Review:

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Therapeutic Drug Monitoring Data

Therapeutic Drug Monitoring Data
Author: Amitava Dasgupta,Matthew Krasowski
Publsiher: Academic Press
Total Pages: 382
Release: 2019-09-14
ISBN 10: 0128158506
ISBN 13: 9780128158500
Language: EN, FR, DE, ES & NL

Therapeutic Drug Monitoring Data Book Review:

Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Handbook of Drug Monitoring Methods

Handbook of Drug Monitoring Methods
Author: Amitava Dasgupta
Publsiher: Springer Science & Business Media
Total Pages: 445
Release: 2007-10-23
ISBN 10: 1588297802
ISBN 13: 9781588297808
Language: EN, FR, DE, ES & NL

Handbook of Drug Monitoring Methods Book Review:

In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

Atkinson s Principles of Clinical Pharmacology

Atkinson s Principles of Clinical Pharmacology
Author: Shiew-Mei Huang,Juan J.L. Lertora,Paolo Vicini,Arthur J. Atkinson, Jr.
Publsiher: Academic Press
Total Pages: 762
Release: 2021-10-16
ISBN 10: 0128198842
ISBN 13: 9780128198841
Language: EN, FR, DE, ES & NL

Atkinson s Principles of Clinical Pharmacology Book Review:

Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. Presents the essential knowledge for effective practice of clinical pharmacology Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology Offers an extensive regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK

Principles of Pharmacogenetics and Pharmacogenomics

Principles of Pharmacogenetics and Pharmacogenomics
Author: Russ B. Altman,David Flockhart,David B. Goldstein
Publsiher: Cambridge University Press
Total Pages: 269
Release: 2012-01-23
ISBN 10: 052188537X
ISBN 13: 9780521885379
Language: EN, FR, DE, ES & NL

Principles of Pharmacogenetics and Pharmacogenomics Book Review:

"This book is intended to introduce the field of phamacogenetics and pharmacogenomics to health care professionals. It brings together the latest informaiton about how human genetics impacts drug response phenotypes. It is written to enable the reader to undestand the current knowledge and challenges to the field"--Provided by publisher.

Clinical Challenges in Therapeutic Drug Monitoring

Clinical Challenges in Therapeutic Drug Monitoring
Author: William Clarke,Amitava Dasgupta
Publsiher: Elsevier
Total Pages: 376
Release: 2016-07-21
ISBN 10: 0128020520
ISBN 13: 9780128020524
Language: EN, FR, DE, ES & NL

Clinical Challenges in Therapeutic Drug Monitoring Book Review:

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Life Threatening Effects of Antipsychotic Drugs

Life Threatening Effects of Antipsychotic Drugs
Author: Peter Manu,Robert J. Flanagan,Kathlyn J. Ronaldson
Publsiher: Academic Press
Total Pages: 394
Release: 2016-08-16
ISBN 10: 0128033908
ISBN 13: 9780128033906
Language: EN, FR, DE, ES & NL

Life Threatening Effects of Antipsychotic Drugs Book Review:

Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects. Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness Discusses clozapine rechallenge after each of its serious adverse reactions Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy Includes data on post-mortem considerations

Pharmacogenomics in Precision Medicine

Pharmacogenomics in Precision Medicine
Author: Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang
Publsiher: Springer Nature
Total Pages: 289
Release: 2020-06-12
ISBN 10: 9811538956
ISBN 13: 9789811538957
Language: EN, FR, DE, ES & NL

Pharmacogenomics in Precision Medicine Book Review:

This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Racism Not Race

Racism  Not Race
Author: Joseph L. Graves, Jr.,Alan H. Goodman
Publsiher: Columbia University Press
Total Pages: 317
Release: 2021-12-07
ISBN 10: 0231553730
ISBN 13: 9780231553735
Language: EN, FR, DE, ES & NL

Racism Not Race Book Review:

The science on race is clear. Common categories like “Black,” “white,” and “Asian” do not represent genetic differences among groups. But if race is a pernicious fiction according to natural science, it is all too significant in the day-to-day lives of racialized people across the globe. Inequities in health, wealth, and an array of other life outcomes cannot be explained without referring to “race”—but their true source is racism. What do we need to know about the pseudoscience of race in order to fight racism and fulfill human potential? In this book, two distinguished scientists tackle common misconceptions about race, human biology, and racism. Using an accessible question-and-answer format, Joseph L. Graves Jr. and Alan H. Goodman explain the differences between social and biological notions of race. Although there are many meaningful human genetic variations, they do not map onto socially constructed racial categories. Drawing on evidence from both natural and social science, Graves and Goodman dismantle the malignant myth of gene-based racial difference. They demonstrate that the ideology of racism created races and show why the inequalities ascribed to race are in fact caused by racism. Graves and Goodman provide persuasive and timely answers to key questions about race and racism for a moment when people of all backgrounds are striving for social justice. Racism, Not Race shows readers why antiracist principles are both just and backed by sound science.

Handbook of Drug Monitoring Methods

Handbook of Drug Monitoring Methods
Author: Amitava Dasgupta
Publsiher: Springer Science & Business Media
Total Pages: 446
Release: 2007-10-05
ISBN 10: 1597450316
ISBN 13: 9781597450317
Language: EN, FR, DE, ES & NL

Handbook of Drug Monitoring Methods Book Review:

Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

Biochemical and Molecular Basis of Pediatric Disease

Biochemical and Molecular Basis of Pediatric Disease
Author: Edward C.C. Wong,Dennis J. Dietzen,Michael J. Bennett,Shannon Haymond
Publsiher: Academic Press
Total Pages: 1168
Release: 2021-05-13
ISBN 10: 0128179635
ISBN 13: 9780128179635
Language: EN, FR, DE, ES & NL

Biochemical and Molecular Basis of Pediatric Disease Book Review:

Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases. Provides a fully-updated resource with more color illustrations Focuses on the biochemical and molecular basis of disease as well as the analytical techniques Defines important differences in the pathophysiology of diseases, comparing childhood with adult

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring
Author: Amitava Dasgupta
Publsiher: John Wiley & Sons
Total Pages: 472
Release: 2012-07-02
ISBN 10: 1118347854
ISBN 13: 9781118347850
Language: EN, FR, DE, ES & NL

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring Book Review:

The tools for detecting false positives, false negatives, and interference in interactions when testing and monitoring therapeutic drug use For physicians monitoring a patient's progress, efficacy of treatment is often linked to a patient's response to medication. Determining whether a patient is taking the prescribed amount, the drug or dosage is effective, or the prescribed medication is interacting with other drugs can be determined through drug testing. Written as a guide for toxicologists, chemists, and health professionals involved in patient care, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring provides an up-to-date introduction to the tests and methodologies used in a toxicology lab as well as the sources of testing error that can lead to false positives, false negatives, and unreliable conclusions of drug abuse or under use. Covering a host of common therapeutic drugs as well as specific types of interference in immunoassays used in drug testing, the book details a number of possible testing scenarios and problems as well as solutions: False positive results in immunoassays for drugs in abuse testing Interferences in immunoassays used for monitoring anticonvulsants, tricyclic antidepressants, and digoxin False positive alcohol tests using breath analyzers and automated analyzers When a toxicology report is negative in a suspected overdose patient: the world of designer drugs Effects of drug-herb interactions on therapeutic drug monitoring Pharmacogenomics and the general principles of genetic analysis Approaches for eliminating interference/discordant specimen in therapeutic drug monitoring and drugs in abuse testing What to do in case there is no readily available method for testing Complete with easy-to-read tables and flowcharts, this book helps toxicologists, clinical chemists, clinical pathologists, and forensic pathologists develop accurate, unbiased drug monitoring and toxicology reports. Health care professionals involved in patient care, especially of critically ill patients, will find this guide indispensable in making sure lab tests are reliable enough to provide high-quality care. An indispensable handbook to the entire suite of toxicology lab tests, as well as all the possible sources of testing error, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring offers clear remedies for eliminating and preventing testing error.

Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
Author: Klara Valko
Publsiher: Elsevier
Total Pages: 612
Release: 2000-10-13
ISBN 10: 9780080541099
ISBN 13: 0080541097
Language: EN, FR, DE, ES & NL

Separation Methods in Drug Synthesis and Purification Book Review:

Separation Methods in Drug Synthesis and Purification

Pharmacogenetics Kinetics and Dynamics for Personalized Medicine

Pharmacogenetics  Kinetics  and Dynamics for Personalized Medicine
Author: David F. Kisor,Professor of Pharmacokinetics Chair Department of Pharmaceutical and Biomedical Sciences Ohio Northern University Raabe College of Pharmacy David F Kisor,Michael D. Kane,Jon E. Sprague,Jeffery N. Talbot
Publsiher: Jones & Bartlett Publishers
Total Pages: 330
Release: 2013-02-01
ISBN 10: 1449633943
ISBN 13: 9781449633943
Language: EN, FR, DE, ES & NL

Pharmacogenetics Kinetics and Dynamics for Personalized Medicine Book Review:

Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine provides a primer to understand pharmacogenetics (the study of genetic factors that influence how a drug works) in the applied context of pharmacokinetics (how the body handles a drug) and pharmacodynamics (the effects of a drug on the body). This valuable foundation illuminates how these principles and scientific advances can create optimal individual patient care, that is, personalized medicine. Through specific drug examples, this resource explores how the genetic constitution of an individual may lead to the need for an altered dose or in some cases alternative drug therapy. Real-world cases highlight the specific relationships between genetics, drug action, and the body s response as well as adverse drug reactions, altered metabolism, and drug efficacy. Ethical issues concerning pharmacogenomics and study design are also discussed in this concise overview."

The Genetics of African Populations in Health and Disease

The Genetics of African Populations in Health and Disease
Author: Muntaser E. Ibrahim,Charles N. Rotimi
Publsiher: Cambridge University Press
Total Pages: 348
Release: 2019-12-19
ISBN 10: 1107072026
ISBN 13: 9781107072022
Language: EN, FR, DE, ES & NL

The Genetics of African Populations in Health and Disease Book Review:

A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.

Individualized Drug Therapy for Patients

Individualized Drug Therapy for Patients
Author: Roger W Jelliffe,Michael Neely
Publsiher: Academic Press
Total Pages: 434
Release: 2016-11-15
ISBN 10: 0128033495
ISBN 13: 9780128033494
Language: EN, FR, DE, ES & NL

Individualized Drug Therapy for Patients Book Review:

Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient. Uses pharmacokinetic approaches as the tools with which therapy is individualized Provides examples using specific software that illustrate how best to apply these approaches and to make sense of the more sophisticated mathematical foundations upon which this book is based Incorporates clinical cases throughout to illustrate the real-world benefits of using these approaches Focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal

Topics on Drug Metabolism

Topics on Drug Metabolism
Author: James Paxton
Publsiher: BoD – Books on Demand
Total Pages: 308
Release: 2012-02-22
ISBN 10: 9535100998
ISBN 13: 9789535100997
Language: EN, FR, DE, ES & NL

Topics on Drug Metabolism Book Review:

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics
Author: Nader Rifai
Publsiher: Elsevier Health Sciences
Total Pages: 1888
Release: 2017-01-16
ISBN 10: 0323548482
ISBN 13: 9780323548489
Language: EN, FR, DE, ES & NL

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics Book Review:

The Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition provides the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests. This classic clinical chemistry reference offers encyclopedic coverage detailing everything you need to know, including: analytical criteria for the medical usefulness of laboratory tests, variables that affect tests and results, laboratory medicine, applications of statistical methods, and most importantly clinical utility and interpretation of laboratory tests. It is THE definitive reference in clinical chemistry and molecular diagnostics, now fully searchable and with quarterly content updates, podcasts, clinical cases, animations, and extended content online through Expert Consult. Analytical criteria focus on the medical usefulness of laboratory procedures. Reference ranges show new approaches for establishing these ranges — and provide the latest information on this topic. Lab management and costs gives students and chemists the practical information they need to assess costs, allowing them to do their job more efficiently and effectively. Statistical methods coverage provides you with information critical to the practice of clinical chemistry. Internationally recognized chapter authors are considered among the best in their field. Two-color design highlights important features, illustrations, and content to help you find information easier and faster. NEW! Internationally recognized chapter authors are considered among the best in their field. NEW! Expert Consult features fully searchable text, quarterly content updates, clinical case studies, animations, podcasts, atlases, biochemical calculations, multiple-choice questions, links to Medline, an image collection, and audio interviews. You will now enjoy an online version making utility of this book even greater. UPDATED! Expanded Molecular Diagnostics section with 12 chapters that focus on emerging issues and techniques in the rapidly evolving and important field of molecular diagnostics and genetics ensures this text is on the cutting edge and of the most value. NEW! Comprehensive list of Reference Intervals for children and adults with graphic displays developed using contemporary instrumentation. NEW! Standard and international units of measure make this text appropriate for any user — anywhere in the world. NEW! 22 new chapters that focus on applications of mass spectrometry, hematology, transfusion medicine, microbiology, biobanking, biomarker utility in the pharmaceutical industry and more! NEW! Expert senior editors, Nader Rifai, Carl Wittwer and Rita Horvath, bring fresh perspectives and help ensure the most current information is presented. UPDATED! Thoroughly revised and peer-reviewed chapters provide you with the most current information possible.