Mechanotransduction

Mechanotransduction
Author: Paul A. Sundaram
Publsiher: Academic Press
Total Pages: 158
Release: 2020-11-18
ISBN 10: 0128178833
ISBN 13: 9780128178836
Language: EN, FR, DE, ES & NL

Mechanotransduction Book Review:

Mechanotransduction: Cell Signaling to Cell Response covers the cell machinery responsible for the process of mechanotransduction and the manner in which cells respond to an external mechanical stimulus. The effect of mechanical stimulus on individual cells and entire tissues is discussed, with an emphasis on the practical results of this physiological process. Mechanotransduction of stem cells and cancerous cells are also covered, along with future directions in this yet nascent field. This book gives insights on basic processes that occur (or may occur) in the human body as a result of the application of mechanical stimulus. It is ideal for both biomedical engineers and biologists, and is an ideal resource for teaching. It provides a current state of conceptual and practical aspects of the field and will enable students and professionals to venture further into this incipient area which is of fundamental importance to biomedical engineering and biology fields. Covers fundamental concepts of signaling in cells as a result of mechanical stimulus Includes the physiological results of mechanical stimulus on the human body Explores the advantages of mechanical loads on the human body

Mechanotransduction

Mechanotransduction
Author: Anonim
Publsiher: Academic Press
Total Pages: 384
Release: 2014-07-29
ISBN 10: 0123983274
ISBN 13: 9780123983275
Language: EN, FR, DE, ES & NL

Mechanotransduction Book Review:

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds

Cellular Mechanotransduction

Cellular Mechanotransduction
Author: Mohammad R. K. Mofrad,Roger D. Kamm
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2009-11-23
ISBN 10: 1316139476
ISBN 13: 9781316139479
Language: EN, FR, DE, ES & NL

Cellular Mechanotransduction Book Review:

'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of biological responses it produces. This book looks at mechanotransduction in a more restricted sense, focusing on the process of stress sensing and transducing a mechanical force into a cascade of biochemical signals. This stress has become increasingly recognized as one of the primary and essential factors controlling biological functions, ultimately affecting the function of the cells, tissues, and organs. A primary goal of this broad book is also to help define the new field of mechanomics, which attempts to describe the complete mechanical state of a biological system.

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease
Author: Stefaan Verbruggen
Publsiher: Academic Press
Total Pages: 527
Release: 2018-08-09
ISBN 10: 0128129530
ISBN 13: 9780128129531
Language: EN, FR, DE, ES & NL

Mechanobiology in Health and Disease Book Review:

Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
Author: Wolfgang B. Liedtke, MD, PH.D.
Publsiher: CRC Press
Total Pages: 467
Release: 2006-09-29
ISBN 10: 1420005847
ISBN 13: 9781420005844
Language: EN, FR, DE, ES & NL

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades Book Review:

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Tissue Engineering

Tissue Engineering
Author: Clemens Van Blitterswijk,Jan De Boer
Publsiher: Academic Press
Total Pages: 896
Release: 2014-12-10
ISBN 10: 0124202101
ISBN 13: 9780124202108
Language: EN, FR, DE, ES & NL

Tissue Engineering Book Review:

Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students coming to the subject for the first time. In addition to the key topics covered in the previous edition, this update also includes new material on the regulatory authorities, commercial considerations as well as new chapters on microfabrication, materiomics and cell/biomaterial interface. Effectively reviews major foundational topics in tissue engineering in a clear and accessible fashion Includes state of the art experiments presented in break-out boxes, chapter objectives, chapter summaries, and multiple choice questions to aid learning New edition contains material on regulatory authorities and commercial considerations in tissue engineering

Mechanosensitivity and Mechanotransduction

Mechanosensitivity and Mechanotransduction
Author: Irina Kiseleva,Andre Kamkin
Publsiher: Springer Science & Business Media
Total Pages: 371
Release: 2010-11-18
ISBN 10: 904819881X
ISBN 13: 9789048198818
Language: EN, FR, DE, ES & NL

Mechanosensitivity and Mechanotransduction Book Review:

This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

T Cell Development

T Cell Development
Author: Remy Bosselut,Melanie S. Vacchio
Publsiher: Humana Press
Total Pages: 312
Release: 2016-10-28
ISBN 10: 9781493948437
ISBN 13: 1493948431
Language: EN, FR, DE, ES & NL

T Cell Development Book Review:

This volume provides simple and accessible experiment protocols to explore thymus biology. "T-Cell Development: Methods and Protocols" is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell preparation, flow cytometry analyses, and multiple aspects of thymocyte biology. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, "T-Cell Development: Methods and Protocols" aims to ensure successful results in the further study of this vital field."

Mechanosensitive Ion Channels

Mechanosensitive Ion Channels
Author: Andre Kamkin,Irina Kiseleva
Publsiher: Springer Science & Business Media
Total Pages: 382
Release: 2007-10-06
ISBN 10: 1402064268
ISBN 13: 9781402064265
Language: EN, FR, DE, ES & NL

Mechanosensitive Ion Channels Book Review:

This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.

Current Topics in Membranes

Current Topics in Membranes
Author: Anonim
Publsiher: Academic Press
Total Pages: 453
Release: 1992-01-08
ISBN 10: 9780080585109
ISBN 13: 0080585108
Language: EN, FR, DE, ES & NL

Current Topics in Membranes Book Review:

Current Topics in Membranes

Physico Chemical Control of Cell Function

Physico Chemical Control of Cell Function
Author: Cesare Gargioli,Giancarlo Forte,Alberto Rainer
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2019-10-17
ISBN 10: 2889459985
ISBN 13: 9782889459988
Language: EN, FR, DE, ES & NL

Physico Chemical Control of Cell Function Book Review:

Extracellular Matrix (ECM) has been considered for a long time merely a scaffold sustaining cell and tissue function. Despite this simplistic view shared by many, nowadays ECM and their mechanic-physical and chemical characteristic acquired a progressive larger role actively regulating cell life: survival, proliferation, gene expression and differentiation. The interplay between cells and the ECM is continuously controlled at the cell level in a dynamic way. While cells synthesize the raw components of the ECM, this in turn impacts on cell function by providing chemical, topographical and mechanical hints. Such stimuli have been proven to control several aspects of cell function, including survival, proliferation, differentiation and migration. The molecular pathways activated by cells in response to the physical cues arising from the ECM are being disclosed and thus the possibility to control cell function through materials design is becoming more realistic. Current in vitro protocols, relying in 2D cell culture system, entail reductionist approaches to the complexity of cell-ECM interaction and result in cells rapidly losing their distinctive functions in culture. Understanding and replicating the 3D microenvironmental cues affecting cell function appears as a mandatory requirement for the development of next-generation biomaterials, as well as for the establishment of more physiologically relevant and predictive in vitro models of diseases. Such an effort will require a multidisciplinary approach at the convergence of biophysics, biology, nanotechnology, and bioengineering.

Mechanosensitive Ion Channels

Mechanosensitive Ion Channels
Author: Owen P. Hamill
Publsiher: Unknown
Total Pages: 424
Release: 2007
ISBN 10: 9780121533588
ISBN 13: 0121533581
Language: EN, FR, DE, ES & NL

Mechanosensitive Ion Channels Book Review:

Membranes are essential cellular organelles. They not only define cells and other organelles, but also are critical in the cell function by selectively regulating the passage of molecules by acting as a matrix for other signaling molecules, and as conduits of information transfer between the external environment and the cell interior. This series was originally added in 1970 and has since provided a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include The Mechanical Properties of Bilayers; Molecular Dynamic Modeling of MS Channels; Structures of the Prokaryotic Mechanosensitive; Channels MscL and MscS; 3.5 Billion Years of Mechanosensory Transduction: Structure and Function of Mechanosensitive Channels in Prokaryotes; Activation of Mechanosensitive Ion Channels by Forces Transmitted through Integrins and the Cytoskeleton; Thermodynamics of Mechanosensitivity; Flexoelectricity and Mechanotransduction; Lipid Effects on Mechanosensitive Channels; Functional Interactions of the Extracellular Matrix with Mechanosensitive Channels; MSCL: The Bacterial Mechanosensitive Channel of Large Conductance; The Bacterial Mechanosensitive Channel MscS: Emerging Principles of Gating and Modulation; Structure function relations of MscS; The MscS Cytoplasmic Domain and its Conformational Changes upon the Channel Gating; Microbial TRP Channels and Their Mechanosensitivity; MSCS-Like Proteins in Plants; Delivering Force and Amplifying Signals in Plant Mechanosensing; MS Channels in Tip Growing Systems.

Molecular and Cellular Mechanobiology

Molecular and Cellular Mechanobiology
Author: Shu Chien,Adam J. Engler,Peter Yingxiao Wang
Publsiher: Springer
Total Pages: 302
Release: 2016-08-10
ISBN 10: 1493956175
ISBN 13: 9781493956173
Language: EN, FR, DE, ES & NL

Molecular and Cellular Mechanobiology Book Review:

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Collagen

Collagen
Author: Peter Fratzl
Publsiher: Springer Science & Business Media
Total Pages: 506
Release: 2008-05-10
ISBN 10: 0387739068
ISBN 13: 9780387739069
Language: EN, FR, DE, ES & NL

Collagen Book Review:

Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.

Biology and Engineering of Stem Cell Niches

Biology and Engineering of Stem Cell Niches
Author: Ajaykumar Vishwakarma,Jeffrey M Karp
Publsiher: Academic Press
Total Pages: 642
Release: 2017-03-22
ISBN 10: 0128027568
ISBN 13: 9780128027561
Language: EN, FR, DE, ES & NL

Biology and Engineering of Stem Cell Niches Book Review:

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points

Scaffolds in Tissue EngineeringMaterials Technologies and Clinical Applications

Scaffolds in Tissue EngineeringMaterials  Technologies and Clinical Applications
Author: Francesco Baino
Publsiher: BoD – Books on Demand
Total Pages: 332
Release: 2017-12-13
ISBN 10: 9535136410
ISBN 13: 9789535136415
Language: EN, FR, DE, ES & NL

Scaffolds in Tissue EngineeringMaterials Technologies and Clinical Applications Book Review:

Biomaterials are often designed to act as scaffolds, i.e., 3D porous templates that support and stimulate the growth of healthy tissue and then safely dissolve once they have performed their functions. This book provides a picture of the current state of the art in the field of scaffolds for tissue engineering, highlighting the potential associated to the latest scientific and technological advancements. The former part of the book focuses on the repair of "hard" tissues (primarily bone) by means of bioceramic/glass scaffolds, and the latter deals with the applications of polymeric scaffolds for regenerating "soft" tissues and structures including the peripheral nerve, heart, gastric mucosa and pancreas. Special emphasis is given to the challenges associated to scaffold manufacturing, biomimetic properties and cell-scaffold interactions.

Cell Signaling in Vascular Inflammation

Cell Signaling in Vascular Inflammation
Author: Jahar Bhattacharya
Publsiher: Springer Science & Business Media
Total Pages: 222
Release: 2007-11-15
ISBN 10: 1592599095
ISBN 13: 9781592599097
Language: EN, FR, DE, ES & NL

Cell Signaling in Vascular Inflammation Book Review:

A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. The book illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.

Cell Physiology Source Book

Cell Physiology Source Book
Author: Nicholas Sperelakis
Publsiher: Elsevier
Total Pages: 1235
Release: 2012-12-02
ISBN 10: 0080574556
ISBN 13: 9780080574554
Language: EN, FR, DE, ES & NL

Cell Physiology Source Book Book Review:

This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics

Molecular Mechanisms of Notch Signaling

Molecular Mechanisms of Notch Signaling
Author: Tilman Borggrefe,Benedetto Daniele Giaimo
Publsiher: Springer
Total Pages: 398
Release: 2018-07-20
ISBN 10: 3319895125
ISBN 13: 9783319895123
Language: EN, FR, DE, ES & NL

Molecular Mechanisms of Notch Signaling Book Review:

This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.

Orthodontics E Book

Orthodontics   E Book
Author: Lee W. Graber,Robert L. Vanarsdall,Katherine W. L. Vig,Greg J. Huang
Publsiher: Elsevier Health Sciences
Total Pages: 928
Release: 2016-07-15
ISBN 10: 0323444326
ISBN 13: 9780323444323
Language: EN, FR, DE, ES & NL

Orthodontics E Book Book Review:

Comprehensive, cutting-edge content prepares you for today’s orthodontics! Orthodontics: Current Principles and Techniques, 6th Edition provides evidence-based coverage of orthodontic diagnosis, planning strategies, and treatment protocols, including esthetics, genetics, temporary anchorage devices, aligners, technology-assisted biomechanics, and much more. New to this edition is an Expert Consult website using videos and additional visuals to show concepts difficult to explain with words alone. Expert Consult also adds three online-only chapters, research updates, and a fully searchable version of the text. From respected editors Lee Graber, Robert Vanarsdall, Katherine Vig, and Greg Huang, along with a veritable Who’s Who of expert contributors, this classic reference has a concise, no-nonsense approach to treatment that makes it the go-to book for orthodontic residents and practitioners! Comprehensive coverage provides a one-stop resource for the field of orthodontics, including foundational theory and the latest on the materials and techniques used in today’s practice. Experienced, renowned editors lead a team of expert, international contributors, bringing the most authoritative clinical practice and supporting science from the best and brightest in the industry. More than 3,400 images include a mixture of radiographs, full-color clinical photos, and anatomic or schematic line drawings, showing examples of treatment, techniques, and outcomes. Extensive references make it easy to look up the latest in orthodontic research and evidence-based information, and all references also appear online. Detailed, illustrated case studies show the decision-making process, showing the consequences of various treatment techniques over time. NEW! Seven all-new chapters include Orthodontic Diagnosis and Treatment Planning with Cone-Beam Computed Tomography Imaging; Upper Airway, Cranial Morphology, and Sleep Apnea; Management of Impactions; Iatrogenic Effects of Orthodontic Appliances; Minimally and Non-Invasive Approaches to Accelerate Tooth Movement; Management of Dental Luxation and Avulsion Injuries in the Permanent Dentition; and Patient Management and Motivation for the Child and Adolescent Patient. NEW! Expert Consult website includes online-only chapters, instructional videos, many references linked to PubMed, and research updates including additional case studies. UPDATED CHAPTERS include Biomechanical Considerations with Temporary Anchorage Devices, Bonding in Orthodontics, Clear Aligner Treatment, Lingual Appliance Treatment, Psychological Aspects of Diagnosis and Treatment, Clinically Relevant Aspects of Dental Materials Science in Orthodontics, The Biologic Basis of Orthodontics, and more. New co-editor Greg J. Huang is joined by new contributors who are highly regarded experts within their respective subspecialties in orthodontics.