Mechanisms of Cell Death and Opportunities for Therapeutic Development

Mechanisms of Cell Death and Opportunities for Therapeutic Development
Author: Diaqing Liao
Publsiher: Academic Press
Total Pages: 296
Release: 2021-10-26
ISBN 10: 012814209X
ISBN 13: 9780128142097
Language: EN, FR, DE, ES & NL

Mechanisms of Cell Death and Opportunities for Therapeutic Development Book Review:

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death. Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy Covers fundamental mechanisms and relevant translational research

Clinical Perspectives and Targeted Therapies in Apoptosis

Clinical Perspectives and Targeted Therapies in Apoptosis
Author: Rupinder K. Sodhi,Jitender Madan
Publsiher: Academic Press
Total Pages: 432
Release: 2020-10-15
ISBN 10: 0128157631
ISBN 13: 9780128157633
Language: EN, FR, DE, ES & NL

Clinical Perspectives and Targeted Therapies in Apoptosis Book Review:

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research. Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

Fifth Interdiciplinary Conference on Mechanisms of Cell Death and Disease

Fifth Interdiciplinary Conference on Mechanisms of Cell Death and Disease
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2004
ISBN 10: 1928374650XXX
ISBN 13: OCLC:708288571
Language: EN, FR, DE, ES & NL

Fifth Interdiciplinary Conference on Mechanisms of Cell Death and Disease Book Review:

Mechanisms of Cell Death

Mechanisms of Cell Death
Author: Cell Death Society
Publsiher: Unknown
Total Pages: 213
Release: 1999
ISBN 10: 9781573312400
ISBN 13: 1573312401
Language: EN, FR, DE, ES & NL

Mechanisms of Cell Death Book Review:

As the body of research on apoptosis grows, it paradoxically becomes simpler as the principles that define the field become more flexible and inclusive. Discussions of the role of cell death in AIDS, inflammatory disease, lung and cardiac disease, and lupus each emphasize the importance of understanding and regulating inflammation and the production of apoptotic bodies. Included in these proceedings is an in-depth review of the role of death cell genes, including intriguing studies of the existence of inhibitors of apoptosis in embryos. Many of these researchers now feel it is a combination, rather than any single gene, that activates apoptosis.

Sixth Euroconference on Mechanisms of Cell Death and Disease

Sixth     Euroconference on Mechanisms of Cell Death and Disease
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2006
ISBN 10: 1928374650XXX
ISBN 13: OCLC:708295103
Language: EN, FR, DE, ES & NL

Sixth Euroconference on Mechanisms of Cell Death and Disease Book Review:

Apoptotis Pharmacological Implications and Therapeutic Opportunities

Apoptotis  Pharmacological Implications and Therapeutic Opportunities
Author: Anonim
Publsiher: Academic Press
Total Pages: 614
Release: 1997-07-23
ISBN 10: 0080581331
ISBN 13: 9780080581330
Language: EN, FR, DE, ES & NL

Apoptotis Pharmacological Implications and Therapeutic Opportunities Book Review:

Programmed cell death (PCD) has become a topic of widespread interest and experimentation over the past decade. Written by experts in the field, Apoptosis: Pharmacological Implications and Therapeutic Opportunities concentrates on presenting an overview of PCD pathways as they are currently understood, and strives to identify important unanswered questions as well as other therapeutic possibilities suggested by recent biochemical discoveries. Understanding the biochemical pathways that participate in the cell death process has become an important goal in developmental biology, neurobiology, cardiology, and infectious disease research. The control of apoptosis has also become a major area of investigation in the field of cancer biology. Apoptosis: Pharmacological Implications and Therapeutic Opportunities contains an overview for those with a general interest in apoptosis, and provides discussions of sufficient depth to be useful for specialists in the field.

Death Receptors in Cancer Therapy

Death Receptors in Cancer Therapy
Author: Wafik S. El-Deiry
Publsiher: Springer Science & Business Media
Total Pages: 374
Release: 2007-11-15
ISBN 10: 159259851X
ISBN 13: 9781592598519
Language: EN, FR, DE, ES & NL

Death Receptors in Cancer Therapy Book Review:

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Cell Death

Cell Death
Author: Douglas R. Green
Publsiher: Unknown
Total Pages: 250
Release: 2018-09-30
ISBN 10: 9781621822141
ISBN 13: 1621822141
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Cell Death, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. This new edition contains critical new information on recent exciting advances in the field, such as new forms for cell death and important insights into the mechanisms and control of apoptosis. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.

Mechanisms of Cell Death and Approaches to Neuroprotection Disease Modification in Parkinson s Disease

Mechanisms of Cell Death and Approaches to Neuroprotection Disease Modification in Parkinson   s Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 314
Release: 2021-11-10
ISBN 10: 0323899447
ISBN 13: 9780323899444
Language: EN, FR, DE, ES & NL

Mechanisms of Cell Death and Approaches to Neuroprotection Disease Modification in Parkinson s Disease Book Review:

Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease explores the results of numerous studies surrounding in vitro and animal model evidence that looks at the impact of a-synucleinopathy on neuronal dysfunction and behavioral impairments, (ii) how research in animal models supports the development of therapeutic strategies, and (iii) how findings in animal models might relate to the disease process in humans. In this book, the author's shed light upon the complex scenario of the mechanisms of cell death and approaches to neuroprotection/disease modification in PD, both in vitro to in vivo. Along with degeneration, the pathological hallmark of PD is the presence of intraneuronal proteinaceous cytoplasmic inclusions, named Lewy Bodies (LB) that invade the whole nervous system as the disease progresses. Several fundamental discoveries have shed light upon the implication of the a-syn protein in the pathogenesis of familial and sporadic forms of PD. Other proteins also accumulate in LB, but a-syn is a major protein component of the pathological landmarks. Updates on the latest research surrounding Mechanisms of Cell Death in Parkinson’s Disease Includes In vitro and In vivo models of synucleinopathy Presents therapeutic strategies in Parkinson’s Disease

Regulated Cell Death Part A

Regulated Cell Death Part A
Author: Avi Ashkenazi,Junying Yuan,Jim Wells
Publsiher: Elsevier
Total Pages: 504
Release: 2014-06-25
ISBN 10: 0124171753
ISBN 13: 9780124171756
Language: EN, FR, DE, ES & NL

Regulated Cell Death Part A Book Review:

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Lysosomes

Lysosomes
Author: Frederick R. Maxfield,James M. Willard,Shuyan Lu
Publsiher: John Wiley & Sons
Total Pages: 544
Release: 2016-05-31
ISBN 10: 1118978307
ISBN 13: 9781118978306
Language: EN, FR, DE, ES & NL

Lysosomes Book Review:

Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development

Proteasome Inhibitors in Cancer Therapy

Proteasome Inhibitors in Cancer Therapy
Author: Julian Adams
Publsiher: Springer Science & Business Media
Total Pages: 313
Release: 2004-05-25
ISBN 10: 1592597947
ISBN 13: 9781592597949
Language: EN, FR, DE, ES & NL

Proteasome Inhibitors in Cancer Therapy Book Review:

A panel of leading academic and pharmaceutical investigators takes stock of the remarkable work that has been accomplished to date with proteasome inhibitors in cancer, and examines emerging therapeutic possibilities. The topics range from a discussion of the chemistry and cell biology of the proteasome and the rationale for proteasome inhibitors in cancer to a review of current clinical trials underway. The discussion of rationales for testing proteasome inhibitors in cancer models covers the role of the proteasome in NF-kB activation, the combining of conventional chemotherapy and radiation with proteasome inhibition, notably PS-341, new proteasome methods of inhibiting viral maturation, and the role of protesome inhibition in the treatment of AIDS. The authors also document the development of bortezomib (VelcadeTM) in Phase I clinical trials and in a multicentered Phase II clinical trials in patients with relapsed and refractory myeloma.

Programmed Cell Death The Biology and Therapeutic Implications of Cell Death

Programmed Cell Death  The Biology and Therapeutic Implications of Cell Death
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2008
ISBN 10: 1928374650XXX
ISBN 13: OCLC:760727819
Language: EN, FR, DE, ES & NL

Programmed Cell Death The Biology and Therapeutic Implications of Cell Death Book Review:

Cell Death Signaling in Cancer Biology and Treatment

Cell Death Signaling in Cancer Biology and Treatment
Author: Daniel Johnson
Publsiher: Springer Science & Business Media
Total Pages: 408
Release: 2012-11-19
ISBN 10: 1461458471
ISBN 13: 9781461458470
Language: EN, FR, DE, ES & NL

Cell Death Signaling in Cancer Biology and Treatment Book Review:

A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

Apoptosis in Cancer Pathogenesis and Anti cancer Therapy

Apoptosis in Cancer Pathogenesis and Anti cancer Therapy
Author: Christopher D. Gregory
Publsiher: Springer
Total Pages: 247
Release: 2016-08-24
ISBN 10: 3319394061
ISBN 13: 9783319394060
Language: EN, FR, DE, ES & NL

Apoptosis in Cancer Pathogenesis and Anti cancer Therapy Book Review:

This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.

Programmed Cell Death

Programmed Cell Death
Author: Hala Gali-Muhtasib,Omar Nasser Rahal
Publsiher: BoD – Books on Demand
Total Pages: 152
Release: 2020-01-15
ISBN 10: 1789847486
ISBN 13: 9781789847482
Language: EN, FR, DE, ES & NL

Programmed Cell Death Book Review:

This book incorporates developments in our understanding of cell death mechanisms and highlights recent advances in programmed cell death regulation processes. It provides the reader with the network of pathways targeted by herbal anticancer drugs and discusses the role of endoplasmic reticulum stress in cell death mechanisms in addition to highlighting the mechanisms of autophagy and its role in diseases. This book provides valuable material for researchers and for teaching postgraduate students. Emphasis on recent advances and their clinical applications offers insights to researchers that will likely lead to the development of novel therapeutic approaches.

Cell Death

Cell Death
Author: Hao Wu
Publsiher: Springer Science & Business Media
Total Pages: 272
Release: 2013-11-19
ISBN 10: 1461493021
ISBN 13: 9781461493020
Language: EN, FR, DE, ES & NL

Cell Death Book Review:

Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!

Regulated Cell Death Part B

Regulated Cell Death Part B
Author: Anonim
Publsiher: Academic Press
Total Pages: 352
Release: 2014-07-24
ISBN 10: 0128016191
ISBN 13: 9780128016190
Language: EN, FR, DE, ES & NL

Regulated Cell Death Part B Book Review:

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Protein Kinase CK2 Cellular Function in Normal and Disease States

Protein Kinase CK2 Cellular Function in Normal and Disease States
Author: Khalil Ahmed,Olaf-Georg Issinger,Ryszard Szyszka
Publsiher: Springer
Total Pages: 378
Release: 2015-03-03
ISBN 10: 3319145444
ISBN 13: 9783319145440
Language: EN, FR, DE, ES & NL

Protein Kinase CK2 Cellular Function in Normal and Disease States Book Review:

Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research. ​

Molecular Pathology

Molecular Pathology
Author: William B. Coleman,Gregory J. Tsongalis
Publsiher: Academic Press
Total Pages: 802
Release: 2017-11-09
ISBN 10: 0128027878
ISBN 13: 9780128027875
Language: EN, FR, DE, ES & NL

Molecular Pathology Book Review:

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase