Mechanical Behaviour Of Biomaterials

Combining materials science, mechanics, implant design and clinical applications, this self-contained text provides a complete grounding to the field.

A balanced mechanics-materials approach and coverage of the latest developments in biomaterials and electronic materials, the new edition of this popular text is the most thorough and modern book available for upper-level undergraduate courses on the mechanical behavior of materials. To ensure that the student gains a thorough understanding the authors present the fundamental mechanisms that operate at micro- and nano-meter level across a wide-range of materials, in a way that is mathematically simple and requires no extensive knowledge of materials. This integrated approach provides a conceptual presentation that shows how the microstructure of a material controls its mechanical behavior, and this is reinforced through extensive use of micrographs and illustrations. New worked examples and exercises help the student test their understanding. Further resources for this title, including lecture slides of select illustrations and solutions for exercises, are available online at www.cambridge.org/97800521866758.

This book describes the fundamental knowledge of mechanics and its application to biomaterials. An overivew of computer modeling in biomaterials is offered and multiple fields where biomaterials are used are reviewed with particular emphasis to the importance of the mechanical properties of biomaterials. The reader will obtain a better understanding of the current techniqus to synthesize, characterize and integrate biomaterials into the human body.

Mechanical Behaviour of Biomaterials focuses on the interface between engineering and medicine, where new insights into engineering aspects will prove to be extremely useful in their relation to the biomedical sciences and their applications. The book's main objective focuses on the mechanical behavior of biomaterials, covering key aspects, such as mechanical properties, characterization and performance. Particular emphasis is given to fatigue, creep and wear, fracture, and stress and strain relationships in biomaterials. Chapters look at both experimental and theoretical results. Readers will find this to be an essential reference for academics, biomechanical researchers, medical doctors, biologists, chemists, physicists, mechanical, biomedical and materials engineers and industrial professionals. Presents contributions from international experts Provides insights at the interface of disciplines, such as engineering and the medical and dental sciences Presents a comprehensive understanding on the mechanical properties of biomaterials Covers surface and bulk properties

Metallic Biomaterials Processing and Medical Device Manufacturing details the principles and practices of the technologies used in biomaterials processing and medical device manufacturing. The book reviews the main categories of metallic biomaterials and the essential considerations in design and manufacturing of medical devices. It bridges the gap between the designing of biomaterials and manufacturing of medical devices including requirements and standards. Main themes of the book include, manufacturing, coatings and surface modifications of medical devices, metallic biomaterials and their mechanical behaviour, degradation, testing and characterization, and quality controls, standards and FDA regulations of medical devices. The leading experts in the filed discuss the requirements, challenges, recent progresses and future research directions in the processing of materials and manufacturing of medical devices. Metallic Biomaterials Processing and Medical Device Manufacturing is ideal for those working in the disciplines of materials science, manufacturing, biomedical engineering, and mechanical engineering. Reviews key topics of biomaterials processing for medical device applications including metallic biomaterials and their mechanical behavior, degradation, testing and characterization Bridges the gap between biomaterials design and medical device manufacturing Discusses the quality controls, standards, and FDA requirements for biomaterials and medical devices

In joint replacement surgery with suboptimal bone, allograft materials are often used to achieve biological fixation of the metallic implant to the host bone and reducing the implant fixation time. The most commonly used techniques are cemented and hydroxyapatite (HA)-coated metallic implants. Typically, HA coatings are suggested for patients with better bone stock, whereas recommended implant fixation process for most other osteoporotic patients is bone cements. In general, there is a long-standing need to improve the performance of hip and other devices for longer in vivo implant lifetime that can help in reducing the number of revision surgeries, as well as minimizing physical and mental trauma to the patient. To achieve these goals, it is important to understand the mechanical and biological properties of coatings that can influence not only its short- and long-term bioactivity but also life span in vivo. Over the years, it has been recognized that the stability of a coated implant is governed by its physical and mechanical properties. A coating that separates from the implant provides no advantage over an uncoated implant and undesirable due to problems with debris materials, which can lead to osteolysis. Therefore, it is important to properly characterize the coated implants in terms of its physical and mechanical properties. In this chapter, specific details on coating characterization techniques including sample dimensions, sample preparation, experimental procedure and data interpretation are discussed. In particular, the standards and requirements of regulatory organizations are presented elucidating the significance and use of each characterization. It is important to appreciate that mechanical properties of coatings can only be determined with certain coating specification such as coating thickness. This chapter is designed even for non-experts to follow mechanical property characterizations of coatings on medical implants.

This book provides tabular and text data relating to normal and diseased tissue materials and materials used in medical devices. Comprehensive and practical for students, researchers, engineers, and practicing physicians who use implants, this book considers the materials aspects of both implantable materials and natural tissues and fluids. Examples of materials and topics covered include titanium, elastomers, degradable biomaterials, composites, scaffold materials for tissue engineering, dental implants, sterilization effects on material properties, metallic alloys, and much more. Each chapter author considers the intrinsic and interactive properties of biomaterials, as well as their appropriate applications and historical contexts. Now in an updated second edition, this book also contains two new chapters on the cornea and on vocal folds, as well as updated insights, data, and citations for several chapters.

This book is a printed edition of the Special Issue "Mechanics of Biomaterials" that was published in Materials

Despite recent advances in medical devices using other materials, metallic implants are still one of the most commercially significant sectors of the industry. Given the widespread use of metals in medical devices, it is vital that the fundamentals and behaviour of this material are understood. Metals in biomedical devices reviews the latest techniques in metal processing methods and the behaviour of this important material. Initial chapters review the current status and selection of metals for biomedical devices. Chapters in part two discuss the mechanical behaviour, degradation and testing of metals with specific chapters on corrosion, wear testing and biocompatibility of biomaterials. Part three covers the processing of metals for biomedical applications with chapters on such topics as forging metals and alloys, surface treatment, coatings and sterilisation. Chapters in the final section discuss clinical applications of metals such as cardiovascular, orthopaedic and new generation biomaterials. With its distinguished editor and team of expert contributors, Metals for biomedical devices is a standard reference for materials scientists, researchers and engineers working in the medical devices industry and academia. Reviews the latest techniques in metal processing methods including surface treatment and sterilisation Examines metal selection for biomedical devices considering biocompatibility of various metals Assesses mechanical behaviour and testing of metals featuring corrosion, fatigue and wear

How do engineering materials deform when bearing mechanical loads? To answer this crucial question, the book bridges the gap between continuum mechanics and materials science. The different kinds of material deformation are explained in detail. The book also discusses the physical processes occurring during the deformation of all classes of engineering materials and shows how these materials can be strengthened to meet the design requirements. It provides the knowledge needed in selecting the appropriate engineering material for a certain design problem. This book is both a valuable textbook and a useful reference for graduate students and practising engineers.

Biocomposites are widely used in the medical industry to repair and restore bone, tooth, cartilage skin and other tissues. Biomedical composites, provides a thorough review of the current status, recent progress and future trends in composites for biomedical applications. Part one discusses the fundamentals of biocomposites with chapters on natural composites, design and fabrication of biocomposites, and hard and soft tissue applications of biocomposites. Part two then reviews applications of biocomposites. Chapters discuss composites for bone repair, composite coatings for implants, composites for spinal implants, injectable composites and composites for tissue engineered scaffolds. Chapters in part three discuss the biocompatibility, mechanical behaviour and failure of biocomposites with such topics as cellular response, testing of biocomposites and tribology of biocomposites. Finally part four reviews the future for biocomposites with chapters on nano-structured biocomposites, developing biocomposites as scaffolds and biocomposites in tissue engineering and regenerative medicine. With its distinguished editor and team of international contributors, Biomedical composites is an essential reference to materials scientists and researchers in industry and academia, as well as all those concerned with this increasingly important field. Provides a thorough review of the current status, recent progress and future trends in composites for biomedical applications Discusses the fundamentals of biocomposites with chapters on natural composites, design and fabrication of biocomposites and their applications Chapters address composites for bone repair, spinal implants and various other applications and discuss biocompatability, mechanical behaviour and failure of biocomposites

Despite their tremendous potential, Mg and its alloys are not yet used in biomedical applications. This book aims to provide scientific insights into the challenges of the materials, and give an overview of the research regarding their mechanical properties, corrosion behaviour and biological performances. The authors intend to put the reader into the position to accurate discern the proper Mg-based material for his/her applications and to choose the proper improvement strategy to his/her cause. To this aim, the manuscript is structured as follow: in Section 2, the main challenges hampering the use of magnesium in biomedical applications and the common improvement strategies are listed. In Section 3, the most investigated Mg alloys are reported in separate sub-sections, detailing their mechanical properties, corrosion behaviour and biotoxicity. High-pure and ultra-high-pure Mg, Al-based Mg alloys, Zn-based Mg alloys, Ca-based alloys and RE-based Mg alloys have been considered. In Section 4, the alloys’ performances with respect to the challenges is summarized providing the reader with useful information and suggestions on the potentially most suited choice. Finally, in Section 5, an outlook portraying the authors’ opinion of the future development of the field will be provided. This book will allow biomedical engineers, surface scientists, material scientists, implant manufacturers and companies working on implant approval an overview of the state-of-the-art technologies adopted so far to overcome the drawbacks of Mg for biomedical applications. Particular emphasis is put on explaining the link between mechanical, corrosion and biocompatible properties of Mg and its alloys as well as their pros and cons. In doing so, the authors intend to put the reader into the position to accurate discern the proper Mg-based material for his/her applications and to choose the proper improvement strategy to his/her cause.

The ongoing process of bio-evolution has produced materials which are perfectly adapted to fulfil a specific functional role. The natural world provides us with a multitude of examples of materials with durability, strength, mechanisms of programmed self-assembly and biodegradability. The materials industry has sought to observe and appreciate the relationship between structure, properties and function of these biological materials. A multidisciplinary approach, building on recent advances at the forefront of physics, chemistry and molecular biology, has been successful in producing many synthetic structures with interesting and useful properties. Structural Biological Materials: Design and Structure-Property Relationships represents an invaluable reference in the field of biological materials science and provides an incisive view into this rapidly developing and increasingly important topic within materials science. This book focuses on the study of three sub-groups of structural biological materials: • Hard tissue engineering, focussing on cortical bone • Soft tissue engineering • Fibrous materials, particularly engineering with silk fibers. The fundamental relationship between structure and properties, and certain aspects of design and engineering, are explored in each of the sub-groups. The importance of these materials, both in their intrinsic properties and specific functions, are illustrated with relevant examples. These depict the successful integration of material properties, architecture and shape, providing a wide range of optimised designs, tailored to specific functions. Edited by Manuel Elices of the Universidad Politécnica de Madrid, Spain, this book is Volume 4 in the Pergamon Material Series.

Biomaterials: Principles and Applications offers a comprehensive review of all the major biomaterials in this rapidly growing field. In recent years, the role of biomaterials has been influenced considerably by advances in many areas of biotechnology and science, as well as advances in surgical techniques and instruments. Comprising chapters contributed by a panel of international experts, this text provides a familiarity with the uses of materials in medicine and dentistry and the rational basis for these applications. It covers such subjects as biodegradable polymeric materials and their relation to tissue engineering, biologic materials, and biomaterials applications in soft and hard tissues. Nearly one hundred figures and tables further add to the value of this book. Concise, topical, and not overly technical — no other book covers the entire field of biomaterials so succinctly in one volume.

The extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research. Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological approach and its partner with a bioengineering approach. Topics include the mechanical properties of the ECM, which outlines current knowledge of the ECM physical structure and reviewing state-of-the-art strategies to mimic its native microenvironments. The organisational characteristics of the ECM form the focus of another pair of chapters, where the collagen triple helix is discussed, followed by a review of advances in artificial reproduction of well-ordered systems using self-assembling peptides, or peptide amphiphiles. The balanced approach of this text gives it a broad appeal to those interested in the ECM from a range of backgrounds and disciplines. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.

The book presents a collection of peer-reviewed articles from the International Conference on Advances and Applications of Artificial Intelligence and Machine Learning - ICAAAIML 2020. The book covers research in artificial intelligence, machine learning, and deep learning applications in healthcare, agriculture, business, and security. This volume contains research papers from academicians, researchers as well as students. There are also papers on core concepts of computer networks, intelligent system design and deployment, real-time systems, wireless sensor networks, sensors and sensor nodes, software engineering, and image processing. This book will be a valuable resource for students, academics, and practitioners in the industry working on AI applications.

This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales – molecular, cellular, and tissue levels – sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.

Damage to the central nervous system resulting from pathological mechanical loading can occur as a result of trauma or disease. Such injuries lead to significant disability and mortality. The peripheral nervous system, while also subject to injury from trauma and disease, also transduces physiological loading to give rise to sensation, and mechanotransduction is also thought to play a role in neural development and growth. This book gives a complete and quantitative description of the fundamental mechanical properties of neural tissues, and their responses to both physiological and pathological loading. This book reviews the methods used to characterize the nonlinear viscoelastic properties of central and peripheral neural tissues, and the mathematical and sophisticated computational models used to describe this behaviour. Mechanisms and models of neural injury from both trauma and disease are reviewed from the molecular to macroscopic scale. The book provides a comprehensive picture of the mechanical and biological response of neural tissues to the full spectrum of mechanical loading to which they are exposed. This book provides a comprehensive reference for professionals involved in pre prevention of injury to the nervous system, whether this arises from trauma or disease.

"This book offers a one-stop source of information on the essentials of biomaterials and engineering, focusing on theory, advances and applications"--