Genome Editing Tools and Gene Drives

Genome Editing Tools and Gene Drives
Author: Reagan Mudziwapasi,Taylor & Francis Group,Ringisai Chekera,Clophas Zibusiso Ncube,Irvonnie Shoko,Berlinda Ncube,Thandanani Moyo,Jeffrey Godfrey Chimbo,Jemethious Dube,Farai Faustos Mashiri,Moira Amanda Mubani,Duncan Maruta,Charity Chimbo,Mpumuzi Masuku,Ryman Shoko,Rutendo Patricia Nyamusamba,Fortune Ntengwa Jomane
Publsiher: CRC Press
Total Pages: 152
Release: 2021-10-19
ISBN 10: 9780367760663
ISBN 13: 0367760665
Language: EN, FR, DE, ES & NL

Genome Editing Tools and Gene Drives Book Review:

Genome editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles, and applications - as well as the advantages and disadvantages - of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students and faculties of science at colleges and universities. This volume in the Pocket Guides to Biomedical Sciences series will help demystify these technologies. The book fills the gap between established conventional methods and the novel and exciting newly introduced tools of genome editing and gene drives. It will help young scientists understand the emerging genome editing tools and gene drives thereby promoting related research and adoption. Key Features The book extensively reviews the current genome editing tools and gene drives. Clarifies their targeting mechanisms and specificity of genome editing tools. Details many different types of natural and synthetic gene drives. Highlights concerns with gene drives and genome editing tools. Related Titles Brown, T. A. Genomes 4 (ISBN 978-0-8153-4508-4) Soh, J., et al. Genome Annotation (ISBN 978-1-4398-4117-4) Samuelsson, T. The Human Genome in Health and Disease: A Story in Four Letters (ISBN 978-0-8153-4591-6)

Advances in Animal Genomics

Advances in Animal Genomics
Author: Sukanta Mondal,Ram Lakhan Singh
Publsiher: Academic Press
Total Pages: 328
Release: 2020-11-25
ISBN 10: 0128206128
ISBN 13: 9780128206126
Language: EN, FR, DE, ES & NL

Advances in Animal Genomics Book Review:

Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches which have enabled to produce huge genomic and transcriptomic resources globally on a genome-wide scale. This book is an important resource for researchers, students, educators and professionals in agriculture, veterinary and biotechnology sciences that enables them to solve problems regarding sustainable development with the help of current innovative biotechnologies. Integrates basic and advanced concepts of animal biotechnology and presents future developments Describes current high-throughput next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches for sustainable livestock production Illustrates integrated strategies to dissect and decode the molecular and gene regulatory networks involved in complex quantitative yield and stress tolerance traits in livestock Ensures readers will gain a strong grasp of biotechnology for sustainable livestock production with its well-illustrated discussion

Targeted Genome Editing Using Site Specific Nucleases

Targeted Genome Editing Using Site Specific Nucleases
Author: Takashi Yamamoto
Publsiher: Springer
Total Pages: 205
Release: 2015-01-05
ISBN 10: 4431552278
ISBN 13: 9784431552277
Language: EN, FR, DE, ES & NL

Targeted Genome Editing Using Site Specific Nucleases Book Review:

This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.

Emerging Issues in Climate Smart Livestock Production

Emerging Issues in Climate Smart Livestock Production
Author: Sukanta Mondal,Ram Lakhan Singh
Publsiher: Academic Press
Total Pages: 528
Release: 2021-12-15
ISBN 10: 0128222662
ISBN 13: 9780128222669
Language: EN, FR, DE, ES & NL

Emerging Issues in Climate Smart Livestock Production Book Review:

Emerging Issues in Climate Smart Livestock Production: Biological Tools and Techniques furnishes a detailed reference on livestock sustainability and the role of biotechnology for creating more sustainable livestock production systems. The book is a collection of scientific techniques, including genetic engineering used to modify and improve animals, fishes, and microorganisms for human benefit. The book is particularly attractive for scientists, researchers, students, educators, and professionals in agriculture, veterinary, and biotechnology science. This book promotes several biotechnological approaches that can easily be evaluated in the field for quality assurance programs beneficial to producing livestock products and overall public health. Biotechnology has the potential to improve the productivity of animals via increased growth, carcass quality and reproduction, improved nutrition and feed utilization, improved food quality and safety, improved animal health and welfare, and reduced waste through more efficient utilization of resources. Identifies and explores biotechnological approaches for sustainable livestock and fish production Focuses on strategies for enhancing livestock and fishery productivity and sustainability Presents the latest research on modern methods and technologies

Transgenesis Techniques

Transgenesis Techniques
Author: Alan R. Clarke
Publsiher: Springer Science & Business Media
Total Pages: 351
Release: 2002
ISBN 10: 1592591787
ISBN 13: 9781592591787
Language: EN, FR, DE, ES & NL

Transgenesis Techniques Book Review:

The past decade has witnessed a spectacular explosion in both the development and the use of transgenic technologies. In Transgenesis Techniques: Principles and Protocols, Second Edition, authoritative researchers-including members of the Dolly team-take stock of these exciting developments to present a collection of readily reproducible techniques for the generation and analysis of transgenic animals, focusing on the manipulation of the mammalian genome. This second edition devotes much space to the creation of genetically modified murine strains, providing access to the germline both by conventional pronuclear injection and by retroviral and adenoviral infection. Extensive coverage is also given to the generation, maintenance, and manipulation of embryonic stem cell lineages, with protocols for both constitutive and conditional (Cre-lox or the Flp-frt systems) gene targeting. Additional chapters provide cutting-edge techniques for the cryopreservation of both male and female germlines, for the generation of transgenic sheep by nuclear transfer, and for the basic analysis of transgenic organisms. Comprehensive and highly practical, this second edition of Transgenesis Techniques: Principles and Protocols updates and expands the acclaimed first edition with a wealth of easy-to-follow cutting-edge protocols and practical tips for producing transgenic animals and analyzing their integrated transgenes.

Gene Editing

Gene Editing
Author: Yuan-Chuan Chen,Shiu-Jau Chen
Publsiher: BoD – Books on Demand
Total Pages: 108
Release: 2019-05-29
ISBN 10: 1789845084
ISBN 13: 9781789845082
Language: EN, FR, DE, ES & NL

Gene Editing Book Review:

Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed.

CRISPR Cas Systems

CRISPR Cas Systems
Author: Rodolphe Barrangou,John van der Oost
Publsiher: Springer Science & Business Media
Total Pages: 302
Release: 2012-12-13
ISBN 10: 364234657X
ISBN 13: 9783642346576
Language: EN, FR, DE, ES & NL

CRISPR Cas Systems Book Review:

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Animal Biotechnology 2

Animal Biotechnology 2
Author: Heiner Niemann,Christine Wrenzycki
Publsiher: Springer
Total Pages: 303
Release: 2018-08-01
ISBN 10: 331992348X
ISBN 13: 9783319923482
Language: EN, FR, DE, ES & NL

Animal Biotechnology 2 Book Review:

This two-volume textbook provides a comprehensive overview on the broad field of Animal Biotechnology with a special focus on livestock reproduction and breeding. The reader will be introduced to a variety of state-of-the-art technologies and emerging genetic tools and their applications in animal production. Also, ethics and legal aspects of animal biotechnology will be discussed and new trends and developments in the field will be critically assessed. The two-volume work is a must-have for graduate students, advanced undergraduates and researchers in the field of veterinary medicine, genetics and animal biotechnology. This second volume is dedicated to genetic tools in animal biotechnology such as somatic cloning, transgenic technologies and the application of stem cells in livestock breeding. Also, ethics and legal aspects are discussed.

Safety of Genetically Engineered Foods

Safety of Genetically Engineered Foods
Author: National Research Council,Institute of Medicine,Board on Agriculture and Natural Resources,Food and Nutrition Board,Board on Life Sciences,Committee on Identifying and Assessing Unintended Effects of Genetically Engineered Foods on Human Health
Publsiher: National Academies Press
Total Pages: 254
Release: 2004-07-08
ISBN 10: 9780309166157
ISBN 13: 0309166152
Language: EN, FR, DE, ES & NL

Safety of Genetically Engineered Foods Book Review:

Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.

Genome Editing Tools and Gene Drives

Genome Editing Tools and Gene Drives
Author: Reagan Mudziwapasi,Ringisai Chekera,Clophas Zibusiso Ncube,Irvonnie Shoko,Berlinda Ncube,Thandanani Moyo,Jeffrey Godfrey Chimbo,Jemethious Dube,Farai Faustos Mashiri,Moira Amanda Mubani,Duncan Maruta,Charity Chimbo,Mpumuzi Masuku,Ryman Shoko,Rutendo Patricia Nyamusamba,Fortune Ntengwa Jomane
Publsiher: CRC Press
Total Pages: 150
Release: 2021-10-19
ISBN 10: 1000463109
ISBN 13: 9781000463101
Language: EN, FR, DE, ES & NL

Genome Editing Tools and Gene Drives Book Review:

Genome-editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles and applications – as well as the advantages and disadvantages – of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students and faculties of science at colleges and universities. This volume in the Pocket Guides to Biomedical Sciences series will help demystify these technologies. The book fills the gap between established conventional methods and the novel and exciting newly introduced tools of genome editing and gene drives. It will help young scientists understand the emerging genome-editing tools and gene drives, thereby promoting related research and adoption. Key Features Extensively reviews the current genome-editing tools and gene drives Clarifies the targeting mechanisms and specificity of genome-editing tools Details many different types of natural and synthetic gene drives Highlights concerns with gene drives and genome-editing tools Related Titles Brown, T. A. Genomes 4 (ISBN 978-0-8153-4508-4) Samuelsson, T. The Human Genome in Health and Disease: A Story in Four Letters (ISBN 978-0-8153-4591-6) Soh, J., et al. Genome Annotation (ISBN 978-1-4398-4117-4)

High Throughput Phenotyping in the Genomic Improvement of Livestock

High Throughput Phenotyping in the Genomic Improvement of Livestock
Author: Fabyano Fonseca Silva,Guilherme J. M. Rosa,Gota Morota
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-08-03
ISBN 10: 2889711455
ISBN 13: 9782889711451
Language: EN, FR, DE, ES & NL

High Throughput Phenotyping in the Genomic Improvement of Livestock Book Review:

Genome Editing in Animals

Genome Editing in Animals
Author: Izuho Hatada
Publsiher: Humana Press
Total Pages: 256
Release: 2017-06-23
ISBN 10: 9781493971275
ISBN 13: 1493971271
Language: EN, FR, DE, ES & NL

Genome Editing in Animals Book Review:

This volume details protocols that can be used for generation of knockout animals. Chapters guide the reader through basic protocols for three genome editing technologies, target design tools, and specific protocols for each animal. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Genome Editing in Animals: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Animal Genomics

Animal Genomics
Author: Bhanu P. Chowdhary
Publsiher: S Karger Ag
Total Pages: 366
Release: 2003
ISBN 10: 1928374650XXX
ISBN 13: STANFORD:36105114281491
Language: EN, FR, DE, ES & NL

Animal Genomics Book Review:

This publication provides an update on the current status of gene maps in different livestock and pet/companion animal species. The findings summarized in species specific commentaries and original articles testify the rapid advances made in the field of animal genomics. Of significant interest is the fact that current investigations are providing headways for two important and exciting research fronts: targeted high-resolution mapping leading to the application of genomic information in addressing questions of economic and biological significance in animals, and the initiation of whole genome sequencing projects for some of the animal species. Like in humans and mice, this will set the stage for a new level of research and real time complex analysis of the genomes of these species. Animal Genomics signifies the beginning of a new era in this field and celebrates the achievements of the past 20 years of genomics research. It will be of special interest to researchers involved in genome analysis - both gross chromosomal as well as molecular - in various animal species, and to comparative and evolutionary geneticists.

Heritable Human Genome Editing

Heritable Human Genome Editing
Author: The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publsiher: National Academies Press
Total Pages: 238
Release: 2021-01-16
ISBN 10: 0309671132
ISBN 13: 9780309671132
Language: EN, FR, DE, ES & NL

Heritable Human Genome Editing Book Review:

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Genome Editing Applications in Animal Research

Genome Editing Applications in Animal Research
Author: Jun Song,Bradford Daigneault,Zhanjun Li,Huaqiang Yang
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-02-18
ISBN 10: 2889744426
ISBN 13: 9782889744428
Language: EN, FR, DE, ES & NL

Genome Editing Applications in Animal Research Book Review:

CRISPR in Animals and Animal Models

CRISPR in Animals and Animal Models
Author: Anonim
Publsiher: Academic Press
Total Pages: 148
Release: 2017-11-10
ISBN 10: 0128125071
ISBN 13: 9780128125076
Language: EN, FR, DE, ES & NL

CRISPR in Animals and Animal Models Book Review:

CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics of interest in this updated volume include a section on CRISPR history, The genome editing revolution, Programming CRISPR and its applications, CRISPR Delivery methods, CRISPR libraries and screening, CRISPR investigation in haploid cells, CRISPR in the generation of transgenic animals, CRISPR therapeutics, and Promising strategies and present challenges. Accessible to students and researchers alike Written by leading authorities in the field

Human Genome Editing

Human Genome Editing
Author: National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publsiher: National Academies Press
Total Pages: 328
Release: 2017-08-13
ISBN 10: 0309452880
ISBN 13: 9780309452885
Language: EN, FR, DE, ES & NL

Human Genome Editing Book Review:

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Advances in Breeding of Dairy Cattle

Advances in Breeding of Dairy Cattle
Author: Julius Van der Werf
Publsiher: Unknown
Total Pages: 659
Release: 2019
ISBN 10: 9781786762986
ISBN 13: 1786762986
Language: EN, FR, DE, ES & NL

Advances in Breeding of Dairy Cattle Book Review:

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy
Author: Fredric P. Manfredsson,Matthew J. Benskey
Publsiher: Unknown
Total Pages: 328
Release: 2019
ISBN 10: 9781493990658
ISBN 13: 1493990659
Language: EN, FR, DE, ES & NL

Viral Vectors for Gene Therapy Book Review:

This volume discusses protocols, ranging from vector production to delivery methods, used to execute gene therapy applications. Chapters are divided into four parts, and cover topics such as design, construction, and application of transcription activation-like effectors; multi-modal production of adeno-associated virus; construction of oncolytic herpes simplex virus; AAV-mediated gene delivery to the mouse liver; and intrathecal delivery of gene therapeutics by direct lumbar puncture in mice. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Viral Vectors for Gene Therapy: Methods and Protocols is a valuable resource for researchers, clinicians, and students looking to utilize viral vectors in gene therapy experiments.

Advances in Animal Biotechnology

Advances in Animal Biotechnology
Author: Birbal Singh,Gorakh Mal,Sanjeev K. Gautam,Manishi Mukesh
Publsiher: Springer
Total Pages: 562
Release: 2019-07-09
ISBN 10: 3030213099
ISBN 13: 9783030213091
Language: EN, FR, DE, ES & NL

Advances in Animal Biotechnology Book Review:

This book entitled, “Advances in Animal Biotechnology,” is a compilation of state-of-the-art in the field of Animal Biotechnology including fishery, that are not sheltered in depth in earlier publications. It offers an update on avant-garde technologies and advances in key aspects of genetic engineering, metagenomics, assisted reproduction, animal genomics, biotechnology in veterinary health, as well as the role of gut and marine microbial ecosystems in livestock and industrial development. The book is divided broadly into five different sections, viz., Gut Microbiome and Nutritional Biotechnology, Assisted Reproduction Biotechnology, Livestock Genomics, Health Biotechnology, and Animal Biotechnology in Global Perspective. The book covers the syllabi of Animal Biotechnology courses in various universities, academia and competitive examinations at various levels. Researchers, Continuing Graduates, and Academicians, Research Institutions, and Biotech Companies will be benefited from this valuable compilation of research. Its broad spectrum makes this work a valuable resource for professionals, researchers, academics and students in the field of veterinary and animal production as well as the biotechnology industry.