Lipid Signaling and Metabolism

Lipid Signaling and Metabolism
Author: James M. Ntambi
Publsiher: Academic Press
Total Pages: 566
Release: 2020-08-09
ISBN 10: 0128194057
ISBN 13: 9780128194058
Language: EN, FR, DE, ES & NL

Lipid Signaling and Metabolism Book Review:

Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others

Biochemistry of Lipids Lipoproteins and Membranes

Biochemistry of Lipids  Lipoproteins and Membranes
Author: Neale Ridgway,Roger McLeod
Publsiher: Elsevier
Total Pages: 612
Release: 2015-07-24
ISBN 10: 0444634495
ISBN 13: 9780444634498
Language: EN, FR, DE, ES & NL

Biochemistry of Lipids Lipoproteins and Membranes Book Review:

Biochemistry of Lipids: Lipoproteins and Membranes, Volume Six, contains concise chapters that cover a wide spectrum of topics in the field of lipid biochemistry and cell biology. It provides an important bridge between broad-based biochemistry textbooks and more technical research publications, offering cohesive, foundational information. It is a valuable tool for advanced graduate students and researchers who are interested in exploring lipid biology in more detail, and includes overviews of lipid biology in both prokaryotes and eukaryotes, while also providing fundamental background on the subsequent descriptions of fatty acid synthesis, desaturation and elongation, and the pathways that lead the synthesis of complex phospholipids, sphingolipids, and their structural variants. Also covered are sections on how bioactive lipids are involved in cell signaling with an emphasis on disease implications and pathological consequences. Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry References from current literature will be included in each chapter to facilitate more in-depth study Key concepts are supported by figures and models to improve reader understanding Chapters provide historical perspective and current analysis of each topic

Lipid Signaling Protocols

Lipid Signaling Protocols
Author: Banafshé Larijani,Rudiger Woscholski,Colin A. Rosser
Publsiher: Humana Press
Total Pages: 429
Release: 2014-10-30
ISBN 10: 9781627038829
ISBN 13: 1627038825
Language: EN, FR, DE, ES & NL

Lipid Signaling Protocols Book Review:

Lipid Signaling Protocols assembles in a single volume the various tools and methodologies needed by the interested investigator to unravel lipid dependent signaling and cell function. Divided into two convenient sections, the volume begins by summarizing the physical properties of hydrophobic metabolites as well as the physical methodologies used for their analysis, which leads to the second section and its selection of biological methods, focused around the most relevant lipids, their corresponding metabolizing enzymes and the recognition proteins. Following the highly successful Methods in Molecular BiologyTM series format, the chapters provide readily reproducible laboratory protocols, lists of necessary materials and reagents, and the tips on troubleshooting and avoiding known pitfalls. Contributed to by top researchers in the field, Lipid Signaling Protocols is an essential resource for both experienced and novice researchers who desire a better understanding of the application of physical methodologies in the context of lipid signaling and lipid metabolism in cell biology.

Plant Lipid Metabolism

Plant Lipid Metabolism
Author: J.C. Kader,Paul Mazliak
Publsiher: Springer Science & Business Media
Total Pages: 588
Release: 2013-04-18
ISBN 10: 9401583943
ISBN 13: 9789401583947
Language: EN, FR, DE, ES & NL

Plant Lipid Metabolism Book Review:

A collection of papers that comprehensively describe the major areas of research on lipid metabolism of plants. State-of-the-art knowledge about research on fatty acid and glycerolipid biosynthesis, isoprenoid metabolism, membrane structure and organization, lipid oxidation and degradation, lipids as intracellular and extracellular messengers, lipids and environment, oil seeds and gene technology is reviewed. The different topics covered show that modern tools of plant cellular and molecular biology, as well as molecular genetics, have been recently used to characterize several key enzymes of plant lipid metabolism (in particular, desaturases, thioesterases, fatty acid synthetase) and to isolate corresponding cDNAs and genomic clones, allowing the use of genetic engineering methods to modify the composition of membranes or storage lipids. These findings open fascinating perspectives, both for establishing the roles of lipids in membrane function and intracellular signalling and for adapting the composition of seed oil to the industrial needs. This book will be a good reference source for research scientists, advanced students and industrialists wishing to follow the considerable progress made in recent years on plant lipid metabolism and to envision the new opportunities offered by genetic engineering for the development of novel oil seeds.

Druggable Lipid Signaling Pathways

Druggable Lipid Signaling Pathways
Author: Yasuyuki Kihara
Publsiher: Springer Nature
Total Pages: 260
Release: 2020-09-07
ISBN 10: 3030506215
ISBN 13: 9783030506216
Language: EN, FR, DE, ES & NL

Druggable Lipid Signaling Pathways Book Review:

Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, became the first FDA-approved medicine as an orally bioavailable drug for treating relapsing forms of multiple sclerosis (MS). In addition to fingolimod, other drugs targeting lipid GPCRs had been developed such as latanoprost (prostaglandin F2a analogue, used for ocular hypertension and glaucoma), epoprostenol and treprostinil (prostaglandin I2 analogue, used for pulmonary arterial hypertension), montelukast and pranlukast (cysteinyl leukotriene receptor antagonist, used for asthma and allergies), etc. Novel drugs are also expected like lysophosphatidic acid (LPA) receptor antagonist for treatment of pulmonary fibrosis. Drug development targeting lipid signalling pathways are backdated to more than a century, when aspirin was synthesized and selling by Bayer, while the basic mechanism of aspirin's effects (block prostanoid synthesis by inhibiting cyclooxygenases) had not been discovered until 1970s. Nowadays, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprophen are commonly used as antipyretic analgesics and available readily over-the-counter oral drugs. Both upstream and downstream enzymes, such as phospholipase A2s and prostaglandin E synthases, respectively, are also potential therapeutic targets for inflammatory diseases. Recent studies of lipid metabolism expand the lipid biology field from pro-inflammatory lipid mediators to anti-inflammatory epoxy fatty acids (epoxyeicosatrienoic acids), and also omega-3 fatty acid-derived pro-resolving lipid mediators (lipoxin, resolvin, and neuroprotectin). These bioactive lipids, their metabolic pathways and receptors are of great interest in developing next-generation anti-inflammatory and pro-resolving drugs for a wide variety of diseases including. This book summarizes not only historical overview of lipid signaling pathways but also provides summary of cutting-edge studies that may provide some hints of novel “druggable” lipid signaling targets.

The Heterogeneity of Cancer Metabolism

The Heterogeneity of Cancer Metabolism
Author: Anne Le
Publsiher: Springer
Total Pages: 183
Release: 2018-06-26
ISBN 10: 331977736X
ISBN 13: 9783319777368
Language: EN, FR, DE, ES & NL

The Heterogeneity of Cancer Metabolism Book Review:

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

The Molecular Nutrition of Fats

The Molecular Nutrition of Fats
Author: Vinood B. Patel
Publsiher: Academic Press
Total Pages: 470
Release: 2018-10-29
ISBN 10: 0128112980
ISBN 13: 9780128112984
Language: EN, FR, DE, ES & NL

The Molecular Nutrition of Fats Book Review:

The Molecular Nutrition of Fats presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell, and their role in health and disease. Subject areas include molecular mechanisms, membranes, polymorphisms, SNPs, genomic wide analysis, genotypes, gene expression, genetic modifications and other aspects. The book is divided into three sections, providing information on the general and introductory aspects, the molecular biology of the cell, and the genetic machinery and its function. Topics discussed include lipid-related molecules, dietary lipids and lipid metabolism, high fat diets, choline, cholesterol, membranes, trans-and saturated fatty acids, and lipid rafts. Other sections provide comprehensive discussions on G protein-coupled receptors, micro RNA, transcriptomics, transcriptional factors, cholesterol, triacylglycerols, beta-oxidation, cholesteryl ester transfer, beta-oxidation, lysosomes, lipid droplets, insulin mTOR signaling and ligands, and more. Summarizes molecular nutrition in health as related to fats Discusses the impact of fats on cancer, heart disease, dementia, and respiratory and intestinal disease Includes preclinical, clinical and population studies Covers the genome, the whole body and whole communities Includes key facts, a mini dictionary of terms and summary points

Lipid signaling in plants

Lipid signaling in plants
Author: Anonim
Publsiher: Frontiers E-books
Total Pages: 135
Release: 2022
ISBN 10: 2889191486
ISBN 13: 9782889191482
Language: EN, FR, DE, ES & NL

Lipid signaling in plants Book Review:

Lipid Metabolism in Signaling Systems

Lipid Metabolism in Signaling Systems
Author: John N. Fain
Publsiher: Academic Press
Total Pages: 357
Release: 2013-10-22
ISBN 10: 1483288323
ISBN 13: 9781483288321
Language: EN, FR, DE, ES & NL

Lipid Metabolism in Signaling Systems Book Review:

Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Techniques for examining the role of phosphoinositides in signal transduction Techniques related to protein kinase C Analysis of inositol phosphates Techniques to analyze phospholipid turnover in the brain

Sphingolipid Metabolism and Cell Signaling

Sphingolipid Metabolism and Cell Signaling
Author: Anonim
Publsiher: Academic Press
Total Pages: 748
Release: 1999-11-05
ISBN 10: 9780121822125
ISBN 13: 0121822125
Language: EN, FR, DE, ES & NL

Sphingolipid Metabolism and Cell Signaling Book Review:

Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Biochemistry of Lipids Lipoproteins and Membranes

Biochemistry of Lipids  Lipoproteins and Membranes
Author: J.E. Vance,Dennis E. Vance
Publsiher: Elsevier
Total Pages: 595
Release: 1991-12-17
ISBN 10: 9780080860800
ISBN 13: 008086080X
Language: EN, FR, DE, ES & NL

Biochemistry of Lipids Lipoproteins and Membranes Book Review:

The second edition of this book on lipids, lipoprotein and membrane biochemistry has two major objectives - to provide an advanced textbook for students in these areas of biochemistry, and to summarise the field for scientists pursuing research in these and related fields. Since the first edition of this book was published in 1985 the emphasis on research in the area of lipid and membrane biochemistry has evolved in new directions. Consequently, the second edition has been modified to include four chapters on lipoproteins. Moreover, the other chapters have been extensively updated and revised so that additional material covering the areas of cell signalling by lipids, the assembly of lipids and proteins into membranes, and the increasing use of molecular biological techniques for research in the areas of lipid, lipoprotein and membrane biochemistry have been included. Each chapter of the textbook is written by an expert in the field, but the chapters are not simply reviews of current literature. Rather, they are written as current, readable summaries of these areas of research which should be readily understandable to students and researchers who have a basic knowledge of general biochemistry. The authors were selected for their abilities both as researchers and as communicators. In addition, the editors have carefully coordinated the chapters so that there is little overlap, yet extensive cross-referencing among chapters.

Lipid Signaling Protocols

Lipid Signaling Protocols
Author: Banafshé Larijani,Rudiger Woscholski,Colin A. Rosser
Publsiher: Humana Press
Total Pages: 429
Release: 2008-11-11
ISBN 10: 9781588297273
ISBN 13: 1588297276
Language: EN, FR, DE, ES & NL

Lipid Signaling Protocols Book Review:

Lipid Signaling Protocols assembles in a single volume the various tools and methodologies needed by the interested investigator to unravel lipid dependent signaling and cell function. Divided into two convenient sections, the volume begins by summarizing the physical properties of hydrophobic metabolites as well as the physical methodologies used for their analysis, which leads to the second section and its selection of biological methods, focused around the most relevant lipids, their corresponding metabolizing enzymes and the recognition proteins. Following the highly successful Methods in Molecular BiologyTM series format, the chapters provide readily reproducible laboratory protocols, lists of necessary materials and reagents, and the tips on troubleshooting and avoiding known pitfalls. Contributed to by top researchers in the field, Lipid Signaling Protocols is an essential resource for both experienced and novice researchers who desire a better understanding of the application of physical methodologies in the context of lipid signaling and lipid metabolism in cell biology.

Lipid Signaling Protocols

Lipid Signaling Protocols
Author: Banafshé Larijani,Rudiger Woscholski,Colin A. Rosser
Publsiher: Humana Press
Total Pages: 429
Release: 2008-11-11
ISBN 10: 9781588297273
ISBN 13: 1588297276
Language: EN, FR, DE, ES & NL

Lipid Signaling Protocols Book Review:

Lipid Signaling Protocols assembles in a single volume the various tools and methodologies needed by the interested investigator to unravel lipid dependent signaling and cell function. Divided into two convenient sections, the volume begins by summarizing the physical properties of hydrophobic metabolites as well as the physical methodologies used for their analysis, which leads to the second section and its selection of biological methods, focused around the most relevant lipids, their corresponding metabolizing enzymes and the recognition proteins. Following the highly successful Methods in Molecular BiologyTM series format, the chapters provide readily reproducible laboratory protocols, lists of necessary materials and reagents, and the tips on troubleshooting and avoiding known pitfalls. Contributed to by top researchers in the field, Lipid Signaling Protocols is an essential resource for both experienced and novice researchers who desire a better understanding of the application of physical methodologies in the context of lipid signaling and lipid metabolism in cell biology.

Lipid Signaling in Human Diseases

Lipid Signaling in Human Diseases
Author: Julian Gomez-Cambronero,Michael A. Frohman
Publsiher: Springer Nature
Total Pages: 336
Release: 2020-04-24
ISBN 10: 3030336689
ISBN 13: 9783030336684
Language: EN, FR, DE, ES & NL

Lipid Signaling in Human Diseases Book Review:

Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important.

Adipose Tissue Biology

Adipose Tissue Biology
Author: Michael E. Symonds
Publsiher: Springer
Total Pages: 460
Release: 2017-04-03
ISBN 10: 3319520318
ISBN 13: 9783319520315
Language: EN, FR, DE, ES & NL

Adipose Tissue Biology Book Review:

The past decade has seen an exponential increase in our knowledge and understanding of adipose tissue biology. This has coincided with the continued rise in obesity across all generations. Clearly despite substantial advances in research into adipose tissue this still has had limited impact on the on-going obesity epidemic across a majority of countries in the world. This book brings together many leading experts in the field to provide an up to date and comprehensive review of the key aspects of adipose tissue. It therefore includes chapters on evolution, development and inflammation together with a detailed review of brown and beige adipose tissue biology and their potential significance in preventing or combating obesity. These chapters are complemented by those on genetics and gender influences, together with nutrition through the life cycle. Ultimately the book provides an overview of the complexities of adipose tissue biology and the continuing challenge to combat obesity in the 21st century.

Membrane Lipid Signaling in Aging and Age Related Disease

Membrane Lipid Signaling in Aging and Age Related Disease
Author: M.P. Mattson
Publsiher: Elsevier Science
Total Pages: 236
Release: 2003-05-20
ISBN 10: 9780444512970
ISBN 13: 0444512977
Language: EN, FR, DE, ES & NL

Membrane Lipid Signaling in Aging and Age Related Disease Book Review:

The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases. This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

The Multifaceted Role of Hypoxia Inducible Factor 1 HIF1 in Lipid Metabolism

The Multifaceted Role of Hypoxia Inducible Factor 1  HIF1  in Lipid Metabolism
Author: Guomin Shen
Publsiher: Unknown
Total Pages: 135
Release: 2017
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1154176530
Language: EN, FR, DE, ES & NL

The Multifaceted Role of Hypoxia Inducible Factor 1 HIF1 in Lipid Metabolism Book Review:

Hypoxia-inducible factor 1 (HIF1) is a master transcription factor and regulates expression of a large number of genes involving many aspects of biology. In addition to HIF1's roles in glucose metabolism and angiogenesis, numerous studies have revealed an emerging role of HIF1 in controlling lipid homeostasis. In this chapter, we discuss that lipid accumulation is related to HIF1's activity in several diseases and the growing evidence demonstrating the functional importance of HIF1 in controlling lipid metabolism. The functions include lipid uptake and trafficking, fatty acid metabolism, sterol metabolism, triacylglycerol synthesis, phospholipid metabolism, lipid droplet biogenesis, and lipid signaling. Defining the role of HIF1 in lipid metabolism is crucial to understand the pathophysiology of lipid in disease and may help us to identify additional target sites for drug development. This review would shed light on our understanding of the critical role of HIF1 in lipid metabolism.

Principles of Diabetes Mellitus

Principles of Diabetes Mellitus
Author: Leonid Poretsky
Publsiher: Springer Science & Business Media
Total Pages: 784
Release: 2013-11-11
ISBN 10: 1475762607
ISBN 13: 9781475762600
Language: EN, FR, DE, ES & NL

Principles of Diabetes Mellitus Book Review:

Diabetes mellitus is a very common disease which affects approximately 150,000,000 worldwide. With its prevalence rising rapidly, diabetes continues to mystify and fascinate both practitioners and investigators by its elusive causes and multitude of This textbook is written for endocrinologists, specialists in other disciplines who treat diabetic patients, primary care physicians, housestaff and medical students. It covers, in a concise and clear manner, all aspects of the disease, from its pathogenesis on the molecular and cellular levels to its most modern therapy.

Bioactive Lipids in Health and Disease

Bioactive Lipids in Health and Disease
Author: Andres Trostchansky,Homero Rubbo
Publsiher: Springer
Total Pages: 198
Release: 2019-05-28
ISBN 10: 3030114880
ISBN 13: 9783030114886
Language: EN, FR, DE, ES & NL

Bioactive Lipids in Health and Disease Book Review:

The purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology

Sphingolipid Metabolism and Cell Signaling

Sphingolipid Metabolism and Cell Signaling
Author: Anonim
Publsiher: Elsevier
Total Pages: 688
Release: 2000-10-25
ISBN 10: 0080496695
ISBN 13: 9780080496696
Language: EN, FR, DE, ES & NL

Sphingolipid Metabolism and Cell Signaling Book Review:

This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. Its companion Volume 311 presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.