Lanzkowsky s Manual of Pediatric Hematology and Oncology

Lanzkowsky s Manual of Pediatric Hematology and Oncology
Author: Jonathan D. Fish,Jeffrey M. Lipton,Philip Lanzkowsky
Publsiher: Academic Press
Total Pages: 826
Release: 2021-06-01
ISBN 10: 0323997600
ISBN 13: 9780323997607
Language: EN, FR, DE, ES & NL

Lanzkowsky s Manual of Pediatric Hematology and Oncology Book Review:

Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Seventh Edition remains the go-to clinical manual for the treatment and management of childhood cancers and blood disorders. It is a comprehensive book on patient management, replete with algorithms and flow diagrams, and includes a new section on vascular anomalies. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the seventh edition of this successful clinical manual is entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format, again, enables readers to make accurate diagnoses and treatment decisions without having to reference larger medical textbooks. Designed to be easily readable and highly practical with over 400 illustrative tables, along with color diagrams and figures New chapter on Pediatric Vascular Anomalies New content on ‘blood avoidance’ programs to honor religious preferences Discussions of new drugs and immunological therapies for cancers, along with discussions of increasing use of cytokine stimulants for hematologic disorders Includes practical genetic evaluations providing a deeper understanding and advances in management of bone marrow failure diseases

Manual of Pediatric Hematology and Oncology

Manual of Pediatric Hematology and Oncology
Author: Philip Lanzkowsky
Publsiher: Unknown
Total Pages: 696
Release: 1995
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015017426027
Language: EN, FR, DE, ES & NL

Manual of Pediatric Hematology and Oncology Book Review:

Entirely updated to reflect modern thinking and protocols, the Manual of Pediatric Hematology and Oncology provides concise information needed for the day-to-day management of children with pediatric hematologic and oncologic diseases. The clear style allows readers to make an accurate diagnosis and permits him/her to treat patients even if they have not had extensive previous hematologic or oncologic experience. Pertinent advances in molecular genetics, cytogenetics, immunology, transplantation and biochemistry are the result of 40 years of practical experience by the author in the management of patients and incorporates various contributors who have had extensive clinical experience. * Features numerous tables, flow diagrams, protocols, and algorithms for quick access of essential clinical information necessary for the diagnosis and management of these diseases in children * Designed as a concise, easy to use guide for medical students, residents, fellows, pediatric hematologists/oncologists, pediatric nurses and nurse practitioners * Much of the practical information contained in this manual is not found in standard textbooks * Straightforward style without any redundant words or references

Handbook of Pediatric Hematology and Oncology

Handbook of Pediatric Hematology and Oncology
Author: Caroline A. Hastings,Joseph C. Torkildson,Anurag K. Agrawal
Publsiher: John Wiley & Sons
Total Pages: 378
Release: 2012-04-30
ISBN 10: 0470670886
ISBN 13: 9780470670880
Language: EN, FR, DE, ES & NL

Handbook of Pediatric Hematology and Oncology Book Review:

"This new edition of Handbook of Pediatric Hematology and Oncology: Children's Hospital & Research Center Oakland features practical guidance on how to handle common inpatient and outpatient challenges seen in pediatric hematology and oncology. Designed as a rapid reference to the latest diagnostic and therapeutic protocols, the text is short and didactic and supplemented with practical algorithms and case studies throughout. Completely revised and updated, there are brand-new chapters on subjects including bone marrow transplantation, pain management and palliative care. Comprehensive, yet concise, the handbook presents essential guidelines on the diagnosis and management of the most common pediatric blood disorders and malignancies, in addition to chemotherapeutic drug information and transfusion protocols. Designed for medical students, residents, and fellows, this user-friendly portable reference is also the perfect companion on the ward for pediatric hematology and oncology nurses."--Publisher's website.

Histiocytic Disorders

Histiocytic Disorders
Author: Oussama Abla,Gritta Janka
Publsiher: Springer
Total Pages: 392
Release: 2017-11-17
ISBN 10: 3319596322
ISBN 13: 9783319596327
Language: EN, FR, DE, ES & NL

Histiocytic Disorders Book Review:

This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses. Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.

Handbook of Pediatric Hematology and Oncology

Handbook of Pediatric Hematology and Oncology
Author: Caroline A. Hastings,Joseph C. Torkildson,Anurag K. Agrawal
Publsiher: John Wiley & Sons
Total Pages: 512
Release: 2021-02-08
ISBN 10: 1119210755
ISBN 13: 9781119210757
Language: EN, FR, DE, ES & NL

Handbook of Pediatric Hematology and Oncology Book Review:

The revised guide to the diagnosis, management, and treatment of blood disorders and cancer in children Children with blood disorders and cancer are a unique population that require specialized diagnostic considerations and management. The Handbook of Pediatric Hematology and Oncology has been designed to provide clinicians of all levels with practical guidance through an up-to-date algorithmic approach to these conditions. Assembled by a team of experts from the world-class Children's Hospital & Research Center Oakland, this updated third edition: Presents up-to-date management and treatment guidelines for the most common pediatric blood disorders and malignancies Provides an updated algorithmic approach for the diagnosis and management of the most common conditions and suggested readings Utilizes rapid-referral tables containing visual representations of symptoms, lab findings, differentials, and treatment guidance Incorporates case studies covering different hematologic and oncologic conditions, such as hemolytic anemia, sickle cell disease, hemophilia, neuroblastoma, and sarcomas of the soft tissue and bone Includes a useful formulary that lists chemotherapy agents, dosing, mechanism of action, pregnancy category, indications, and side effects Covers transfusion medicine, stem cell transplantation, management of central venous catheters, acute pain management, oncologic emergencies, and chemotherapy basics With its direct guidance and portable design, the Handbook of Pediatric Hematology and Oncology: Children's Hospital & Research Center Oakland, Third Edition, will prove an invaluable resource to medical students, trainees and residents, pediatric hematology and oncology nurses, pediatricians, and early-career providers in pediatric hematology/oncology.

Pizzo and Poplack s Pediatric Oncology

Pizzo and Poplack s Pediatric Oncology
Author: Susan M. Blaney,Lee J. Helman,Peter C. Adamson
Publsiher: LWW
Total Pages: 1352
Release: 2020-09
ISBN 10: 9781975124793
ISBN 13: 1975124790
Language: EN, FR, DE, ES & NL

Pizzo and Poplack s Pediatric Oncology Book Review:

"This authoritative reference is a comprehensive resource on the biology and genetics of childhood cancer as well as its diagnosis, multimodal treatment, as well as long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this reference provides expert guidance on state-of-the-art, multidisciplinary care for children and families"--

Pediatric Hematology Oncology in Countries with Limited Resources

Pediatric Hematology Oncology in Countries with Limited Resources
Author: Daniela Cristina Stefan,Carlos Rodriguez-Galindo
Publsiher: Springer Science & Business Media
Total Pages: 415
Release: 2013-11-18
ISBN 10: 1461438918
ISBN 13: 9781461438915
Language: EN, FR, DE, ES & NL

Pediatric Hematology Oncology in Countries with Limited Resources Book Review:

Typically, manuals of pediatric hematology-oncology are written by specialists from high-income countries, and usually target an audience with a sub-specialist level of training, often assisted by cutting-edge diagnostic and treatment facilities. However, approximately 80% of new cases of cancer in children appear in mid- and low-income countries. Almost invariably, general practitioners or general pediatricians without special training in oncology will look after children with malignancies who enter the health care system in these countries. The diagnostic facilities are usually limited, as are the treatment options. The survival figures in these conditions are somewhere below 20%, while in high-income countries they are in the range of 80% for many childhood cancers. Pediatric Hematology-Oncology in Countries with Limited Resources is the only book of its kind to provide specific guidance applicable to limited resource settings and builds up from the foundation of general practitioner or general pediatrician competence. Written and edited by leaders in the field, this manual educates physicians on the essential components of the discipline, filtered through the experience of specialists from developing countries, with immediate applicability in the specific healthcare environment in these countries.​

Pediatric Psychosocial Oncology Textbook for Multidisciplinary Care

Pediatric Psychosocial Oncology  Textbook for Multidisciplinary Care
Author: Annah N. Abrams,Anna C. Muriel,Lori Wiener
Publsiher: Springer
Total Pages: 409
Release: 2015-11-16
ISBN 10: 3319213741
ISBN 13: 9783319213743
Language: EN, FR, DE, ES & NL

Pediatric Psychosocial Oncology Textbook for Multidisciplinary Care Book Review:

This textbook walks clinicians through the psychosocial issues and challenges faced by children and adolescents with cancer and their families. Through a developmental lens, the text provides guidance and resources that will enable clinicians to understand the physical and emotional impact of the disease from diagnosis onwards, to work with families in distress, and to diagnose and treat a range of behavioral, psychological, and psychiatric issues. The book also addresses the burgeoning fields of social media, complementary therapies, palliative care, and survivorship. Among the variety of useful resources supplied are assessment tools, websites, and additional reading materials. The psychosocial issues that arise for children and their families during the course of treatment are an important yet often overlooked aspect of pediatric oncology care. The reader will find that Pediatric Psychosocial Oncology: Textbook for Multidisciplinary Care covers these issues at the forefront of clinical care in a direct and approachable way, integrating research literature with practical clinical guidance.

Practical Algorithms in Pediatric Hematology and Oncology

Practical Algorithms in Pediatric Hematology and Oncology
Author: Richard H. Sills
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 114
Release: 2003
ISBN 10: 3805574320
ISBN 13: 9783805574327
Language: EN, FR, DE, ES & NL

Practical Algorithms in Pediatric Hematology and Oncology Book Review:

This is the only comprehensive collection of algorithms which exclusively addresses hematologic and oncologic problems affecting neonates, children and adolescents. Examining clinical problems which challenge the pediatrician, general practitioner and family practice physician, each algorithm utilizes a concise, step-by-step approach based upon clues from the history, physical examination and laboratory studies. The algorithms addressing differential diagnosis clearly distinguish between the most common etiologies, those that are less frequent, and finally some that are rare but important to recognize. The 51 topics include evaluation of anemia, sickle cell anemia, thalassemia, hemolytic anemia, the bleeding child, thrombocytopenia and other platelet disorders, hemophilia, leukocyte disorders, leukemias, lymphadenopathy, splenomegaly, approaches to mass lesions in the mediastinum, abdomen, pelvis, bones and soft tissues as well as approaches to potential emergencies such as tumor lysis and superior vena cava syndromes. The oncology topics emphasize diagnostic approach and management of complications, and not the details of chemotherapy. All algorithms are presented with a page of explanatory notes and a list of selected reading. Pediatricians, family physicians and general practitioners will find this book very helpful in managing problems in their practices. Trainees in pediatric hematology will find it a useful tool in developing approaches to solve the problems they will encounter, and pediatric hematologists/oncologists will find it useful as a teaching tool.

Hematology Board Review

Hematology Board Review
Author: Francis P. Worden, MD,Rami N. Khoriaty, MD,Kathleen A. Cooney, MD,Michael W. Deininger, MD, PhD
Publsiher: Springer Publishing Company
Total Pages: 400
Release: 2018-05-28
ISBN 10: 0826137830
ISBN 13: 9780826137838
Language: EN, FR, DE, ES & NL

Hematology Board Review Book Review:

Hematology Board Review: Blueprint Study Guide and Q&A is a concise, outline-based study guide covering all topics that appear on the Hematology Certification Exam. The book includes all topics listed in the American Board of Internal Medicine (ABIM) blueprint as essential material for the exam and highlights topic areas that are often found on the test. For hematology and oncology fellows as well as practicing clinicians needing a refresher before taking MOC, this handy study guide provides succinct overviews of all blood disorders, syndromes and diseases with practice questions on the go. Each disorder or disease-based chapter provides the same structure for ease of use beginning with the epidemiology, and followed by the etiology and risk factors, signs and symptoms, diagnostic criteria, indications for treatment, prognostic factors, treatment recommendations, and special considerations. The authors provide the most accurate and up-to-date information, including well-established treatment regimens for a variety of blood disorders, including iron disorders, bone marrow failure syndromes, platelet and megakaryocytic disorders, hemostasis, thrombosis, and hematologic malignancies. Later chapters review other major subspecialty areas found on the exam including transfusion medicine and hematopoietic cell transplantation. With 200 board-style questions and answers with detailed rationales, Hematology Board Review is the go-to, quick review for any trainee preparing for initial certification and for hematologists or oncologists preparing for recertification. Key Features: Includes 200 board-style questions and answers with rationales Provides key point summaries of each topic area for quick study and easy recall Thorough coverage of hematologic malignancies, blood disorders, transfusion medicine, hematopoietic cell transplantation, and standard treatment regimens Tables providing key data and information related to staging, treatment options, and disease classifications

How It All Began

How It All Began
Author: Philip Lanzkowsky
Publsiher: Unknown
Total Pages: 506
Release: 2008-01-01
ISBN 10: 9781578645220
ISBN 13: 1578645220
Language: EN, FR, DE, ES & NL

How It All Began Book Review:

Neonatal Hematology

Neonatal Hematology
Author: Pedro A. de Alarcón,Eric J. Werner
Publsiher: Cambridge University Press
Total Pages: 480
Release: 2005-08-18
ISBN 10: 9780521780704
ISBN 13: 0521780705
Language: EN, FR, DE, ES & NL

Neonatal Hematology Book Review:

This is a practical guide to the pathogenesis, recognition and management of hematologic problems in the neonate.

The Bethesda Handbook of Clinical Oncology

The Bethesda Handbook of Clinical Oncology
Author: Jame Abraham,James L. Gulley
Publsiher: Lippincott Williams & Wilkins
Total Pages: 768
Release: 2018-04-12
ISBN 10: 1496367162
ISBN 13: 9781496367167
Language: EN, FR, DE, ES & NL

The Bethesda Handbook of Clinical Oncology Book Review:

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. The Bethesda Handbook of Clinical Oncology is a comprehensive review of the management of numerous cancer types, emphasizing practical information that can be applied in everyday, fast-moving patient care situations. With contributions from experts and scholars at the National Cancer Institute, National Institutes of Health, Cleveland Clinic, and other renowned institutions, this latest edition has been thoroughly revised with new content and continues to provide practical guidance on how to evaluate, diagnose, and treat cancer patients.

Pediatric and Neonatal Mechanical Ventilation

Pediatric and Neonatal Mechanical Ventilation
Author: Praveen Khilnani
Publsiher: JAYPEE BROTHERS MEDICAL PUBLISHERS PVT. LTD.
Total Pages: 289
Release: 2014-05-14
ISBN 10: 9350900270
ISBN 13: 9789350900277
Language: EN, FR, DE, ES & NL

Pediatric and Neonatal Mechanical Ventilation Book Review:

Pediatric Imaging Case Review Series E Book

Pediatric Imaging  Case Review Series E Book
Author: Thierry A. G. M. Huisman
Publsiher: Elsevier Health Sciences
Total Pages: 408
Release: 2010-07-01
ISBN 10: 0323082718
ISBN 13: 9780323082716
Language: EN, FR, DE, ES & NL

Pediatric Imaging Case Review Series E Book Book Review:

Pediatric Imaging: Case Review, by Thierry A.G.M. Huisman, MD, tests your ability to interpret a wide range of images seen in practice. The completely revised edition of this title in the popular Case Review series features all-new cases and superb-quality accompanying images that explore the newest imaging modalities, including the newest technology in post processing such as lung reconstruction and tractography of fibers within the brain. This complete study of pediatric imaging has been reorganized anatomically for quick reference and easy board review. This book contains approximately 200 cases—organized by difficulty—and 400 images—with questions and answers, diagnoses, commentary, references, and cross-references to Pediatric Radiology: The Requisites. Study effectively with content that mimics the format of official exams as well as the everyday clinical experience—offering highly effective preparation for certification, recertification, and practice. Distinguish between common and rare diagnoses with 200 case studies organized into ''Opening Round,'' ''Fair Game,'' and ''Challenge'' sections that present varying levels of difficulty and occurrences. Clearly see and interpret 400 high-quality, state-of-the-art images representing a wide range of clinical situations encountered in pediatric imaging. Supplement your Pediatrics board prep and get greater depth of information with easy cross-referencing to companion Get a fresh perspective from 200 new cases reflecting the most recent changes in pediatric imaging, including the newest technology in post processing such as lung reconstruction and tractography of fibers within the brain, and expert guidance from new editor Dr. Thierry Huisman, Director of Pediatric Radiology at Johns Hopkins. Spend less time searching and more time learning with easy-to-navigate chapters focused on visual identification and diagnosis, and reorganized by degree of case difficulty and then by body part within each category.

Pain in Neonates and Infants

Pain in Neonates and Infants
Author: K. J. S. Anand,B. J. Stevens,Patrick J. McGrath
Publsiher: Elsevier Health Sciences
Total Pages: 345
Release: 2007-05-04
ISBN 10: 0444520619
ISBN 13: 9780444520616
Language: EN, FR, DE, ES & NL

Pain in Neonates and Infants Book Review:

A new edition of a highly regarded text in the series on Pain Research and Clinical Management. The book is now used as a standard reference text for those working in the field of neonatology and paediatric pain assessment and management. It provides a comprehensive resource of the latest information in the field for use by both researchers and clinicians. The text is intended for use by all professionals working in the field: neonatologists; pediatricians; anestheiologists; nurses; psychologists. Multidisciplinary editorship and authorship ensuring relevancy and balance of content for all professional groups concerned. Clinically relevant and research based. Edited and written by the best known international names in the field. Covers pain management in infants up to 1 year of age as well as term and preterm neonates. Includes new chapters on: Long-term consequences of neonatal pain from animal models; Pharmacogenetics and pharmacodynamics of analgesic drugs; Neuraxial and Regional Analgesia and Anesthesia; Fetal pain and surgery; Vulnerable Populations, Palliative Care; Infant Pain in the Home and Community, Developing Countries; Health Policy and Health Economics related to Infant Pain; Complementary and Alternative Approaches to Pain in Infancy; and Future Direction.

Tendon Surgery of the Hand E Book

Tendon Surgery of the Hand E Book
Author: Jin Bo Tang,Peter C. Amadio,Jean Claude Guimberteau,James Chang
Publsiher: Elsevier Health Sciences
Total Pages: 400
Release: 2012-04-23
ISBN 10: 1455737429
ISBN 13: 9781455737420
Language: EN, FR, DE, ES & NL

Tendon Surgery of the Hand E Book Book Review:

Get the best results from the latest procedures with Tendon Surgery of the Hand, the only reference that offers comprehensive coverage of this complex and challenging area. World-renowned experts guide you through all of the newest techniques and technologies, equipping you to restore optimal function in your patients. It's your one-stop source for mastering today's best approaches to treating tendon injuries and disorders of the hand. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Successfully implement hot new repair techniques involving new suture materials, tendon sheath and pulley treatments, vascularized tendon grafts, and recent postoperative rehabilitation methods. Improve your primary flexor tendon repair and rehabilitation treatment planning based on surgical and post-surgical care principles that clearly describe successful global methods and protocols. Benefit from the collective knowledge and experience of an international group of surgeons, investigators, and therapists who offer unique and insightful techniques and advice. See how to perform key techniques with exclusive operative videos online. Access the complete contents online at expertconsult.com.

Anemia in the Young and Old

Anemia in the Young and Old
Author: Robert T. Means Jr.
Publsiher: Springer
Total Pages: 219
Release: 2018-11-13
ISBN 10: 3319964879
ISBN 13: 9783319964874
Language: EN, FR, DE, ES & NL

Anemia in the Young and Old Book Review:

This text provides a concise yet comprehensive overview of anemia in the young and old. The first section of the volume features age-specific diagnostic approaches to anemia, from the perinatal period to the elderly, with a particular emphasis on age-specific epidemiology, differential diagnosis, and testing. The second section focuses on specific anemia disorders, including inherited bone marrow failure syndromes, iron deficiency anemia, renal anemia, pure red cell anemia, and anemia of inflammation and chronic disease. Each chapter in this section revolves around a specific syndrome or group of syndromes, and addresses pathophysiology, diagnostic issues, natural history/prognosis, and treatment. Written by experts in the field, Anemia in the Young and Old: Diagnosis and Management is a valuable resource for clinicians and practitioners who treat the pediatric and elderly patient population afflicted with anemia.

The Bethesda Handbook of Clinical Hematology

The Bethesda Handbook of Clinical Hematology
Author: Griffin P Rodgers,Neal S. Young
Publsiher: Lippincott Williams & Wilkins
Total Pages: 512
Release: 2013-05-20
ISBN 10: 1451182708
ISBN 13: 9781451182705
Language: EN, FR, DE, ES & NL

The Bethesda Handbook of Clinical Hematology Book Review:

Packed with essential information on the diagnosis and treatment of blood and bone marrow disorders, "The Bethesda Handbook of Clinical Hematology, Third Edition" should be carried in the white coat pocket of the student, resident, or hematology/oncology service and in the briefcase of the internist, hospitalist, family practitioner, and pediatrician who sees patients with blood diseases. Look inside and discover...- Organization by disease category makes critical information easy to find and use.- Reader-friendly format includes tables, algorithms, meaningful figures, and bulleted lists that highlight vital facts.- Invaluable contributions from recognized experts and senior fellows bridge the gap between science and the clinical practice.- Concise coverage of the diagnosis and treatment makes the handbook ideal for quick reference, as well as for Board review! NEW to the Third Edition...- Emerging diagnostic and treatment strategies refine clinical decision-making.- Significantly revised and updated chapters describe recent advances in diagnosis and treatment of hematologic disorders. "Put this handy and portable guide to work for you and your patients...""Pick up your copy today!"

Thomas Hematopoietic Cell Transplantation 2 Volume Set

Thomas  Hematopoietic Cell Transplantation  2 Volume Set
Author: Stephen J. Forman,Robert S. Negrin,Joseph H. Antin,Frederick R. Appelbaum
Publsiher: John Wiley & Sons
Total Pages: 1416
Release: 2016-12-27
ISBN 10: 1118416007
ISBN 13: 9781118416006
Language: EN, FR, DE, ES & NL

Thomas Hematopoietic Cell Transplantation 2 Volume Set Book Review:

Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.