The Innate Immune System

The Innate Immune System
Author: Tom Monie
Publsiher: Academic Press
Total Pages: 228
Release: 2017-02-16
ISBN 10: 0081007582
ISBN 13: 9780081007587
Language: EN, FR, DE, ES & NL

The Innate Immune System Book Review:

The Innate Immune System: A Compositional and Functional Perspective focuses on the components and functionality of the innate immune system, detailing how they work in their own right, and then progressing to cover their relevance to disease and how they interface with the adaptive response. Despite the growing appreciation of the importance of the innate immune system, many classical immunology books still focus predominantly on the adaptive immune response. Not only is this unbalanced, but it fails to reflect the growing synergy between the activation and function of the innate response and the final nature of adaptive response. This book fills the gap in knowledge that is needed to fully understand and appreciate the topic. Provides a clear, but simple picture of the main principle of innate immunity and the interlink with adaptive responses Fulfills an unmet need in the area of innate immunity Gives a constructive and progressive approach to introducing and explaining the key players in the innate immune response Introduces and explains the key players in the innate immune response with a constructive and progressive approach Presents the components of the innate response and shows how these interrelated areas connect with one another from a functional perspective Enables the reader to gradually increase their level of understanding and knowledge without the risk of becoming confused, thereby ensuring they fully comprehend the integrated signaling pathways

Molecular Biology of the Cell

Molecular Biology of the Cell
Author: Bruce Alberts
Publsiher: Unknown
Total Pages: 135
Release: 2004
ISBN 10: 9780815332183
ISBN 13: 0815332181
Language: EN, FR, DE, ES & NL

Molecular Biology of the Cell Book Review:

Janeway s Immunobiology

Janeway s Immunobiology
Author: Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publsiher: Garland Science
Total Pages: 135
Release: 2010-06-22
ISBN 10: 9780815344575
ISBN 13: 0815344570
Language: EN, FR, DE, ES & NL

Janeway s Immunobiology Book Review:

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Innate Immunity

Innate Immunity
Author: Jonathan Ewbank,Eric Vivier
Publsiher: Springer Science & Business Media
Total Pages: 458
Release: 2008
ISBN 10: 1588297462
ISBN 13: 9781588297464
Language: EN, FR, DE, ES & NL

Innate Immunity Book Review:

Immunologists today are interested in all of the diverse cell-types involved in host defense and have a deeper appreciation of the importance of innate immune mechanisms as a first line of protection against pathogens. This volume thus discusses the isolation and functional characterization of cells involved in innate immunity in mouse and man, including mast cells and eosinophils. Other focuses include natural killer cells, methods in statistics, in vivo imaging, genome engineering, and mutagenesis and culture that are adapted to the study of innate immunity in these hosts. These are complemented with a series of chapters dealing with alternative models: plants, worms, mosquitoes, flies, and fish. Together, these approaches and models are being used to dissect the complex interplay between hosts and pathogens and contribute to developing strategies to help fight infection. With chapters written by experts on the cutting-edge of this technology, Innate Immunity is an essential reference for immunologists, histologists, geneticists, and molecular biologists.

Innate Immunity Resistance and Disease Promoting Principles

Innate Immunity  Resistance and Disease Promoting Principles
Author: G. Hartmann,H. Wagner
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 138
Release: 2013-06-05
ISBN 10: 3318023485
ISBN 13: 9783318023480
Language: EN, FR, DE, ES & NL

Innate Immunity Resistance and Disease Promoting Principles Book Review:

Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.

Innate Immunity

Innate Immunity
Author: Yves Carton
Publsiher: Iste Press - Elsevier
Total Pages: 324
Release: 2019-11-15
ISBN 10: 1785483080
ISBN 13: 9781785483080
Language: EN, FR, DE, ES & NL

Innate Immunity Book Review:

Innate immunity is a new branch of immunology, confirmed by three Nobel Prize winners in 2011. It is the first line of defense against pathogens and is in a way the preliminary step of adaptive immunity which occurs later, and only present in vertebrates. This book examines the way in which innate immunity was discovered in invertebrates. As a starting point, it looks at the work of Louis Pasteur on silkworm disease and the findings of Ilya Metchnikov, discoverer of phagocytosis. It also investigates André Paillot, who in 1920 demonstrated the existence of humoral immunity in insects, unrelated to the type of immunity that was initially thought to be present in all vertebrates. Finally, Innate Immunity shows how the group directed by Jules Hoffmann found strong similarities between the innate immunity response of insects and mammals. The discovery of a receptor protein in Drosophila, which is also found in humans, was what led to Jules Hoffmann being awarded the Nobel Prize in 2011. Presents the transformations experienced by the domains of innate immunity Shows the lineage of these results Bridges the gap between innate immunity of invertebrates and that of vertebrates

Innate Immunity and Inflammation

Innate Immunity and Inflammation
Author: Ruslan Medzhitov
Publsiher: Unknown
Total Pages: 240
Release: 2014-10-01
ISBN 10: 9781621820291
ISBN 13: 1621820297
Language: EN, FR, DE, ES & NL

Innate Immunity and Inflammation Book Review:

The innate immune system is rapidly activated in response to infection and injury. It is a generic rather than pathogen-specific response that recruits immune cells, promotes inflammation, and mobilizes the adaptive immune system. Excessive or chronic inflammation may cause tissue damage, so a careful balance is required to restore homeostasis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the cellular and molecular mechanisms involved in innate immunity and all types of inflammation. The contributors examine the cell types that make up the innate immune system, their use of pattern recognition receptors (e.g., Toll-like receptors) to identify pathogens and damaged tissues, and how they trigger signaling pathways that culminate in inflammation, pathogen destruction, and tissue repair. The numerous chemical signals and factors involved in innate immunity and inflammation are described, as are those that keep inflammation in check. The authors also discuss the diseases that can result when these processes go awry, such as rheumatoid arthritis and cancer. This volume is therefore a valuable reference for all immunologists, cell biologists, and medical scientists wishing to understand these protective processes and their implications for human health and disease.

Antibody Fc

Antibody Fc
Author: Margaret Ackerman,Falk Nimmerjahn
Publsiher: Academic Press
Total Pages: 358
Release: 2013-08-06
ISBN 10: 0123948185
ISBN 13: 9780123948182
Language: EN, FR, DE, ES & NL

Antibody Fc Book Review:

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system

The Innate Immune Response to Noninfectious Stressors

The Innate Immune Response to Noninfectious Stressors
Author: Massimo Amadori
Publsiher: Academic Press
Total Pages: 276
Release: 2016-02-23
ISBN 10: 0128019743
ISBN 13: 9780128019740
Language: EN, FR, DE, ES & NL

The Innate Immune Response to Noninfectious Stressors Book Review:

The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans Covers the crucial issue of the immune response to endocrine disruptors Includes immunological parameters as reporter system of environmental adaptation Provides many illustrative examples to foster reader understanding

Experimental Approaches For The Investigation Of Innate Immunity The Human Innate Immunity Handbook

Experimental Approaches For The Investigation Of Innate Immunity  The Human Innate Immunity Handbook
Author: Richard Bucala,Ruth R Montgomery
Publsiher: World Scientific
Total Pages: 180
Release: 2016-01-15
ISBN 10: 9814678740
ISBN 13: 9789814678742
Language: EN, FR, DE, ES & NL

Experimental Approaches For The Investigation Of Innate Immunity The Human Innate Immunity Handbook Book Review:

The recent explosion of information in innate immune pathways for recognition, effect or responses, and genetic regulation has given impetus to investigations into analogous pathways in the human immune response, which in turn has produced attendant insights into both normal physiology and immunopathology. This volume presents a compendium of methods and protocols for the investigation of human innate immunity with application to the study of normal immune function, immunosenescence, autoimmunity and infectious diseases. Among the topics covered are quantitative flow cytometry for Toll-like receptor expression and function; multidimensional single cell mass cytometry (CyTOF) in complex immune interactions and tumor immunity; imaging techniques such as Imagestream high resolution microscopy coupled to flow cytometry, immune cell infiltration of organotypic, biomimetic organs; high-throughput single cell secretion profiling; multiplexed transcriptomic profiling; microsatellite and microRNA methodologies, RNA interference; and the latest bioinformatics and biostatistical methodologies, including in-depth statistical modeling, genetic mapping, and systems approaches.

Autophagy Regulation of Innate Immunity

Autophagy Regulation of Innate Immunity
Author: Jun Cui
Publsiher: Springer Nature
Total Pages: 203
Release: 2019-11-14
ISBN 10: 981150606X
ISBN 13: 9789811506062
Language: EN, FR, DE, ES & NL

Autophagy Regulation of Innate Immunity Book Review:

This book discusses novel concepts and discoveries concerning the regulation of innate immunity by autophagy and autophagy-related proteins. In the past decade, there have been major advances in our understanding of the molecular mechanisms of autophagy and its physiological functions. This book highlights emerging studies on the underlying mechanisms of autophagy regulation of innate immunity, including inflammation, antiviral immunity and anti-bacterial responses and the signaling pathways that prompt or inhibit the initiation and progression of related diseases. It also offers new ideas and strategies for future drugs based on manipulating autophagy, especially selective autophagy mediated by cargo receptors. Providing a comprehensive overview of the autophagy regulation of innate immunity, it is a valuable resource for graduate students and researchers in the fields of immunology, cell biology and translational medicine.

Switching on Plant Innate Immunity Signaling Systems

Switching on Plant Innate Immunity Signaling Systems
Author: P. Vidhyasekaran
Publsiher: Springer
Total Pages: 358
Release: 2016-01-23
ISBN 10: 3319261185
ISBN 13: 9783319261188
Language: EN, FR, DE, ES & NL

Switching on Plant Innate Immunity Signaling Systems Book Review:

This book presents the ways and means to switch on plant immune signaling systems using PAMP-PIMP-PRR signaling complex for crop disease management. It also describes bioengineering approaches to develop transgenic plants expressing enhanced disease resistance using genes encoding PAMPs, PRRs and transcription factors and genes involved in generation of PIMPs/HAMPs. It also discusses recent commercial development of PAMP products to switch on plant innate immunity for crop disease management. These unique approaches have been described with more than 100 figures and illustrations and these would make this book attractive for researchers and students to buy this book.

Fundamentals of Inflammation

Fundamentals of Inflammation
Author: Charles N. Serhan,Peter A. Ward,Derek W. Gilroy
Publsiher: Cambridge University Press
Total Pages: 489
Release: 2010-04-26
ISBN 10: 0521887291
ISBN 13: 9780521887298
Language: EN, FR, DE, ES & NL

Fundamentals of Inflammation Book Review:

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.

Innate Immunity in Health and Disease

Innate Immunity in Health and Disease
Author: Shailendra K. Saxena,Hridayesh Prakash
Publsiher: BoD – Books on Demand
Total Pages: 414
Release: 2021-08-25
ISBN 10: 1838807659
ISBN 13: 9781838807658
Language: EN, FR, DE, ES & NL

Innate Immunity in Health and Disease Book Review:

The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.

Plant Innate Immunity Signals and Signaling Systems

Plant Innate Immunity Signals and Signaling Systems
Author: P. Vidhyasekaran
Publsiher: Springer Nature
Total Pages: 267
Release: 2020-04-15
ISBN 10: 9402419403
ISBN 13: 9789402419405
Language: EN, FR, DE, ES & NL

Plant Innate Immunity Signals and Signaling Systems Book Review:

The volume III of the book presents the ways and means to manipulate the signals and signaling system to enhance the expression of plant innate immunity for crop disease management. It also describes bioengineering approaches to develop transgenic plants expressing enhanced disease resistance using plant immunity signaling genes. It also discusses recent commercial development of biotechnological products to manipulate plant innate immunity for crop disease management. Engineering durable nonspecific resistance to phytopathogens is one of the ultimate goals of plant breeding. However, most of the attempts to reach this goal fail as a result of rapid changes in pathogen populations and the sheer diversity of pathogen infection mechanisms. Recently several bioengineering and molecular manipulation technologies have been developed to activate the ‘sleeping’ plant innate immune system, which has potential to detect and suppress the development of a wide range of plant pathogens in economically important crop plants. Enhancing disease resistance through altered regulation of plant immunity signaling systems would be durable and publicly acceptable. Strategies for activation and improvement of plant immunity aim at enhancing host’s capability of recognizing invading pathogens, boosting the executive arsenal of plant immunity, and interfering with virulence strategies employed by microbial pathogens. Major advances in our understanding of the molecular basis of plant immunity and of microbial infection strategies have opened new ways for engineering durable resistance in crop plants.

Oxford Textbook of Rheumatology

Oxford Textbook of Rheumatology
Author: Philip Conaghan,Chris Denton,Helen Foster,John Isaacs
Publsiher: Oxford University Press
Total Pages: 1553
Release: 2013-10
ISBN 10: 0199642486
ISBN 13: 9780199642489
Language: EN, FR, DE, ES & NL

Oxford Textbook of Rheumatology Book Review:

A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.

Current Topics in Innate Immunity II

Current Topics in Innate Immunity II
Author: John D. Lambris,George Hajishengallis
Publsiher: Springer
Total Pages: 354
Release: 2013-10-25
ISBN 10: 9781461429524
ISBN 13: 1461429528
Language: EN, FR, DE, ES & NL

Current Topics in Innate Immunity II Book Review:

Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.

Concepts of Biology

Concepts of Biology
Author: Samantha Fowler,Rebecca Roush,James Wise
Publsiher: Unknown
Total Pages: 618
Release: 2018-01-07
ISBN 10: 9789888407453
ISBN 13: 9888407457
Language: EN, FR, DE, ES & NL

Concepts of Biology Book Review:

Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.

Evolutionary Concepts in Immunology

Evolutionary Concepts in Immunology
Author: Robert Jack,Louis Du Pasquier
Publsiher: Springer
Total Pages: 145
Release: 2019-06-13
ISBN 10: 3030186679
ISBN 13: 9783030186678
Language: EN, FR, DE, ES & NL

Evolutionary Concepts in Immunology Book Review:

Immunology is a nodal subject that links many areas of biology. It permeates the biosciences, and also plays crucial roles in diagnosis and therapy in areas of clinical medicine ranging from the control of infectious and autoimmune diseases to tumour therapy. Monoclonal antibodies and small molecule modulators of immunity are major factors in the pharmaceutical industry and now constitute a multi billion dollar business. Students in these diverse areas are frequently daunted by the complexity of immunology and the astonishing array of unusual mechanisms that go to make it up. Starting from Dobzhansky’s famous slogan, “Nothing in biology makes sense except in the light of evolution”, this book will serve to illuminate how evolutionary forces shaped immunity and thus provide an explanation for how many of its counter intuitive oddities arose. By doing so it will provide a conceptual framework on which students may organise the rapidly growing flood of immunological knowledge.

Molecular Aspects of Innate and Adaptive Immunity

Molecular Aspects of Innate and Adaptive Immunity
Author: Kenneth B M Reid,Robert B Sim
Publsiher: Royal Society of Chemistry
Total Pages: 312
Release: 2008-09-29
ISBN 10: 1847558844
ISBN 13: 9781847558848
Language: EN, FR, DE, ES & NL

Molecular Aspects of Innate and Adaptive Immunity Book Review:

The understanding, at the molecular level, of the interactions between innate and adaptive arms of the immune system is currently a hot topic, particularly to those interested in immunology - especially susceptibility to infectious diseases. This book provides a survey of topics, in the area of innate and adaptive immunity, which have been researched within the MRC Immunochemistry Unit, at Oxford University, over a period of forty years. The topics include: " antibody structure - for which the first Director of the Immunochemistry Unit, Professor RR Porter, was awarded a Nobel prize in 1972 " the characterization of membrane proteins on lymphoid cells - leading to the concept of these molecules belonging to an immunoglobulin super family " the proteins of the human serum complement system - one of the body's major defences against microbial infection " the human cell -surface integrins and the hyaluronan- binding proteins, which are involved in regulation of inflammation at cell surfaces and within the extracellular matrix " the family of collectin molecules - containing distinct globular carbohydrate -binding domains linked to collagen-like regions - which play important roles in innate immunity in the lungs and bloodstream by immediate recognition and clearance of microbial pathogens Each chapter in the book gives a brief historical background to a topic and then provides a survey of recent advances in the field and are written by internationally recognised renowned experts. The theme running through the chapters is that of protein structure-function relationships - including, amongst others, descriptions of quaternary structures of large oligomeric proteins, of Factor H and C1q binding to specific ligands, and of the chemistry of the mechanism of catalysis of covalent binding of activated C3 and C4 proteins to nucleophilic groups on microbial surfaces. In several chapters excellent descriptions are given with respect to how the immune system can be recruited to combat microbial infection - via proteins of both the innate and adaptive immune systems. The book also includes notable chapters which are excellent examples of the importance of how the isolation, characterisation, protein engineering and crystallisation has resulted in a full understanding of complex protein-protein interactions involved in the recognition and triggering events of important sections of the immune system: -Structure and Function of the C1 Complex - GÚrard J. Arlaud -Chemical Engineering of Therapeutic Antibodies - George T Stevenson -Leukocyte surface proteins - purification and characterisation - A. Neil Barclay -Cell Surface Integrins - Suet-Mien Tan and S.K. Alex Law This book is aimed primarily at established senior research scientists, postdoctoral research scientists and PhD students who have an interest in proteins of the immune system. However, the wide range of immunity system topics, while staying broadly within innate/adaptive immunity will also appeal to a wider audience.