Inhaled Medicines

Inhaled Medicines
Author: Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
Publsiher: Academic Press
Total Pages: 438
Release: 2021-02-05
ISBN 10: 0128149744
ISBN 13: 9780128149744
Language: EN, FR, DE, ES & NL

Inhaled Medicines Book Review:

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

Inhaled Pharmaceutical Product Development Perspectives

Inhaled Pharmaceutical Product Development Perspectives
Author: Anthony J. Hickey
Publsiher: Elsevier
Total Pages: 110
Release: 2017-11-23
ISBN 10: 0128123362
ISBN 13: 9780128123362
Language: EN, FR, DE, ES & NL

Inhaled Pharmaceutical Product Development Perspectives Book Review:

Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future. Discusses development strategies and best practices in the context of regulatory requirements Written by a broadly qualified expert drawing on the knowledge and critical opinions of key individuals in the field Includes a foreword by Charles G. Thiel

Inhaled Medicines

Inhaled Medicines
Author: Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
Publsiher: Academic Press
Total Pages: 438
Release: 2021-01-20
ISBN 10: 0128149752
ISBN 13: 9780128149751
Language: EN, FR, DE, ES & NL

Inhaled Medicines Book Review:

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ● Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ● Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ● Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ● Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols
Author: Warren H. Finlay
Publsiher: Academic Press
Total Pages: 302
Release: 2019-06-01
ISBN 10: 0081027869
ISBN 13: 9780081027868
Language: EN, FR, DE, ES & NL

The Mechanics of Inhaled Pharmaceutical Aerosols Book Review:

The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Inhalation Aerosols

Inhalation Aerosols
Author: Anthony J. Hickey,Heidi M. Mansour
Publsiher: CRC Press
Total Pages: 417
Release: 2019-03-21
ISBN 10: 1351660519
ISBN 13: 9781351660518
Language: EN, FR, DE, ES & NL

Inhalation Aerosols Book Review:

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.

Pharmaceutical Inhalation Aerosol Technology Second Edition

Pharmaceutical Inhalation Aerosol Technology  Second Edition
Author: Anthony J. Hickey
Publsiher: CRC Press
Total Pages: 288
Release: 2003-09-03
ISBN 10: 0824756649
ISBN 13: 9780824756642
Language: EN, FR, DE, ES & NL

Pharmaceutical Inhalation Aerosol Technology Second Edition Book Review:

This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.

Pharmaceutical Inhalation Aerosol Technology Third Edition

Pharmaceutical Inhalation Aerosol Technology  Third Edition
Author: Anthony J. Hickey,Sandro R. da Rocha
Publsiher: CRC Press
Total Pages: 730
Release: 2019-03-26
ISBN 10: 042962171X
ISBN 13: 9780429621710
Language: EN, FR, DE, ES & NL

Pharmaceutical Inhalation Aerosol Technology Third Edition Book Review:

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery. Key Features: Provides a thoroughly revised and expanded reference with authoritative discussions on the physiologic,pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosols Emphasizes the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery Addresses the physics, chemistry and engineering principles while establishing disease relevance Expands the ‘technology’ focus of the original volumes to address the title more directly Offers an impressive breadth of coverage as well as an international flavour from outstanding editors and contributors

Living with Asthma Manual for teaching parents the self management of childhood asthma

Living with Asthma  Manual for teaching parents the self management of childhood asthma
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1986
ISBN 10: 1928374650XXX
ISBN 13: SRLF:EE0000095273
Language: EN, FR, DE, ES & NL

Living with Asthma Manual for teaching parents the self management of childhood asthma Book Review:

Marijuana As Medicine

Marijuana As Medicine
Author: Institute of Medicine,Janet Joy,Alison Mack
Publsiher: National Academies Press
Total Pages: 216
Release: 2000-12-30
ISBN 10: 0309065313
ISBN 13: 9780309065313
Language: EN, FR, DE, ES & NL

Marijuana As Medicine Book Review:

Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patients--as well as the people who care for them--with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and students--in short, anyone who wants to learn more about this important issue.

Inhalation Aerosols

Inhalation Aerosols
Author: Anthony J. Hickey,Heidi M. Mansour
Publsiher: CRC Press
Total Pages: 417
Release: 2019-03-21
ISBN 10: 1351660527
ISBN 13: 9781351660525
Language: EN, FR, DE, ES & NL

Inhalation Aerosols Book Review:

Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.

Inhalation Drug Delivery

Inhalation Drug Delivery
Author: Paolo Colombo,Daniela Traini,Francesca Buttini
Publsiher: John Wiley & Sons
Total Pages: 214
Release: 2013-02-11
ISBN 10: 1118354125
ISBN 13: 9781118354124
Language: EN, FR, DE, ES & NL

Inhalation Drug Delivery Book Review:

There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide. Focusing on inhalation products and specific equipment and techniques used in manufacturing and quality control, the book balances research with the industrial aspects of creating the drugs, and features a highly regarded author team with both academic and industry experience.

Inhaled Steroids in Asthma

Inhaled Steroids in Asthma
Author: Robert P. Schleimer
Publsiher: CRC Press
Total Pages: 760
Release: 2001-11-21
ISBN 10: 0203908538
ISBN 13: 9780203908532
Language: EN, FR, DE, ES & NL

Inhaled Steroids in Asthma Book Review:

This book sums up the mechanistic basis, current status, and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy, identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development. Makes connections among the underlying pharmacol

Specialised Pharmaceutical Formulation

Specialised Pharmaceutical Formulation
Author: Geoffrey D Tovey
Publsiher: Royal Society of Chemistry
Total Pages: 338
Release: 2022-05-04
ISBN 10: 1839165618
ISBN 13: 9781839165610
Language: EN, FR, DE, ES & NL

Specialised Pharmaceutical Formulation Book Review:

Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety, and stability of the final medicinal product. Regulatory and quality demands, in addition to advances in processing technologies, result in growing challenges as well as possibilities for the field. Following on from Pharmaceutical Formulation, which covered traditional dosage forms such as tablets and capsules, this volume expands upon those formulations to cover a more diverse range of less common dosage forms. Novel routes of administration are covered from inhalational, dermal and transdermal formulations to ocular, oral suspensions, vaccines and nanoparticle drug delivery. The methods through which these formulations are processed and manufactured is also covered, providing essential knowledge to ensure quality, efficiency, and acceptable costing. Specialised Pharmaceutical Formulation is an essential, up to date resource for students and researchers working in academia and in the pharmaceutical industry and will equip readers with the ability to effectively and reliably produce products which can be approved, manufactured and made available to administer to patients.

U S News World Report

U S  News   World Report
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2009
ISBN 10: 1928374650XXX
ISBN 13: STANFORD:36105063771054
Language: EN, FR, DE, ES & NL

U S News World Report Book Review:

Systemic Delivery Technologies in Anti Aging Medicine Methods and Applications

Systemic Delivery Technologies in Anti Aging Medicine  Methods and Applications
Author: Wing-Fu Lai
Publsiher: Springer Nature
Total Pages: 511
Release: 2020-10-19
ISBN 10: 3030544907
ISBN 13: 9783030544904
Language: EN, FR, DE, ES & NL

Systemic Delivery Technologies in Anti Aging Medicine Methods and Applications Book Review:

This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.

Good Cascade Impactor Practices AIM and EDA for Orally Inhaled Products

Good Cascade Impactor Practices  AIM and EDA for Orally Inhaled Products
Author: Terrence P. Tougas,Jolyon P. Mitchell,Svetlana A. Lyapustina
Publsiher: Springer Science & Business Media
Total Pages: 442
Release: 2013-04-10
ISBN 10: 1461462967
ISBN 13: 9781461462965
Language: EN, FR, DE, ES & NL

Good Cascade Impactor Practices AIM and EDA for Orally Inhaled Products Book Review:

The purpose of this publication is to introduce a new, simpler and more effective way in which to interpret pharmaceutical aerosol particle size data from orally inhaled products (OIPs). Currently, the compendial and regulatory requirements dictate the need for measurements by full resolution multi-stage cascade impactor (CI), a process that is demanding for the operator, time consuming, prone to experimental error, and challenging for method transfers from one laboratory to another. Furthermore, we shall show that the current practice of reducing information from mass-weighted aerodynamic particle size distribution (APSD) measurements through the use of CI stage groupings is not the most effective decision-making tool for OIP quality control (QC) in comparison with newly introduced, mutually-independent efficient data analysis (EDA) metrics that can be derived either from full resolution or abbreviated impactor measurements (AIM).

Asthma Management

Asthma Management
Author: Health and Administration Development Group (Aspen Publishers)
Publsiher: Jones & Bartlett Learning
Total Pages: 229
Release: 1999
ISBN 10: 9780834217058
ISBN 13: 0834217058
Language: EN, FR, DE, ES & NL

Asthma Management Book Review:

Asthma Management: Clinical Pathways, Guidelines, and Patient Educatio n is a comprehensive disease management program designed to assist cli nicians in diagnosing and effectively controlling asthma. It provides detailed guidelines on all aspects of managing asthma from the initial diagnosis in the clinical examination to the treatment strategy which may include drug therapy and lifestyle modification. This essential r esource also includes easy-to-read patient education handouts, which t each and encourage patients to comply with interventions, while becomi ng active participants in managing their chronic condition.

Field Guide to Wilderness Medicine E Book

Field Guide to Wilderness Medicine E Book
Author: Paul S. Auerbach,Benjamin B. Constance,Luanne Freer
Publsiher: Elsevier Health Sciences
Total Pages: 1000
Release: 2018-11-26
ISBN 10: 0323597564
ISBN 13: 9780323597562
Language: EN, FR, DE, ES & NL

Field Guide to Wilderness Medicine E Book Book Review:

Based on Dr. Auerbach’s renowned Wilderness Medicine text, Field Guide to Wilderness Medicine, 5th Edition, is your portable, authoritative guide to the full range of medical and emergency situations that occur in non-traditional settings. Useful for experienced physicians as well as advanced practice providers, this unique medical guide covers an indispensable range of topics in a well-illustrated, highly condensed format – in print or on any mobile device – for quick access anytime, anywhere. An easy-access presentation ensures rapid retrieval and comprehension of wilderness medical information, with "Signs and Symptoms" and "Treatment" sections, bulleted lists, and quick-reference text boxes in every chapter. All chapters are thoroughly up to date, including new information on travel medicine, medications, immunizations, and field treatment of common conditions. Step-by-step explanations from wilderness medicine experts cover the clinical presentation and treatment of a full range of wilderness emergencies and show you how to improvise with available materials. Comprehensive coverage includes dive medicine and water-related emergencies, mountain medicine and wilderness survival, global humanitarian relief and disaster medicine, high-altitude medicine, pain management, and much more. Line drawings and color plates help you quickly an accurately identify skin manifestations, plants, poisonous mushrooms, snakes, insects, and more. Useful appendices address everything from environment-specific situations to lists of essential supplies, medicines, and many additional topics of care.

National Geographic

National Geographic
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2006-12
ISBN 10: 1928374650XXX
ISBN 13: STANFORD:36105122051738
Language: EN, FR, DE, ES & NL

National Geographic Book Review:

Public Health Consequences of E Cigarettes

Public Health Consequences of E Cigarettes
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Review of the Health Effects of Electronic Nicotine Delivery Systems
Publsiher: National Academies Press
Total Pages: 774
Release: 2018-05-18
ISBN 10: 030946837X
ISBN 13: 9780309468374
Language: EN, FR, DE, ES & NL

Public Health Consequences of E Cigarettes Book Review:

Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes. Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.