Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 376
Release: 2019-10-04
ISBN 10: 0128178698
ISBN 13: 9780128178690
Language: EN, FR, DE, ES & NL

Improving the Therapeutic Ratio in Head and Neck Cancer Book Review:

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment
Author: Mitchell S. Anscher,Kristoffer Valerie
Publsiher: Springer
Total Pages: 305
Release: 2016-10-20
ISBN 10: 331945594X
ISBN 13: 9783319455945
Language: EN, FR, DE, ES & NL

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment Book Review:

This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.

Increasing the Therapeutic Ratio of Radiotherapy

Increasing the Therapeutic Ratio of Radiotherapy
Author: Philip J. Tofilon,Kevin Camphausen
Publsiher: Springer
Total Pages: 280
Release: 2016-11-21
ISBN 10: 3319408542
ISBN 13: 9783319408545
Language: EN, FR, DE, ES & NL

Increasing the Therapeutic Ratio of Radiotherapy Book Review:

Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection). Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.

Novel Therapies in Head and Neck Cancer Beyond the Horizon

Novel Therapies in Head and Neck Cancer  Beyond the Horizon
Author: Maie A. St. John,No hee Park
Publsiher: Academic Press
Total Pages: 266
Release: 2020-06-29
ISBN 10: 0128209291
ISBN 13: 9780128209295
Language: EN, FR, DE, ES & NL

Novel Therapies in Head and Neck Cancer Beyond the Horizon Book Review:

Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region

Molecular Targeted Radiosensitizers

Molecular Targeted Radiosensitizers
Author: Henning Willers,Iris Eke
Publsiher: Springer Nature
Total Pages: 364
Release: 2020-08-10
ISBN 10: 3030497011
ISBN 13: 9783030497019
Language: EN, FR, DE, ES & NL

Molecular Targeted Radiosensitizers Book Review:

Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Non melanoma Skin Cancer of the Head and Neck

Non melanoma Skin Cancer of the Head and Neck
Author: Faruque Riffat,Carsten E. Palme,Michael Veness
Publsiher: Springer
Total Pages: 201
Release: 2015-09-30
ISBN 10: 8132224973
ISBN 13: 9788132224976
Language: EN, FR, DE, ES & NL

Non melanoma Skin Cancer of the Head and Neck Book Review:

Non-melanoma skin cancer is a global public health issue. With an ever-increasing, and ageing, world population coupled with increasing numbers of immunosuppressed individuals the number of patients continues to rise. The head and neck is overwhelmingly the most frequent location for the development of a non-melanoma skin cancer and as such challenges the clinician with its complex anatomy. The importance of maintaining the aesthetics of the face and the function of the anatomy cannot be overstated, yet ultimately it is always the aim of curing a patient with the minimum of morbidity that clinicians strive for. However, the spectrum of presentations and subsequent management varies widely, ranging from patients with the ubiquitous low-risk mid-face basal cell carcinoma to those diagnosed with relatively uncommon but potentially life-threatening high-risk squamous cell carcinomas (e.g. involving metastatic lymph nodes or with perineural invasion present) and Merkel cell carcinomas.

Metronomic Chemotherapy

Metronomic Chemotherapy
Author: Guido Bocci,Giulio Francia
Publsiher: Springer
Total Pages: 295
Release: 2014-09-04
ISBN 10: 3662436043
ISBN 13: 9783662436042
Language: EN, FR, DE, ES & NL

Metronomic Chemotherapy Book Review:

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Metastases in Head and Neck Cancer

Metastases in Head and Neck Cancer
Author: Jochen A. Werner,R. Kim Davis
Publsiher: Springer Science & Business Media
Total Pages: 233
Release: 2012-12-06
ISBN 10: 3642187226
ISBN 13: 9783642187223
Language: EN, FR, DE, ES & NL

Metastases in Head and Neck Cancer Book Review:

-Richly illustrated; 109 illustrations, 57 in color -Cover a wide range of diagnostic and theraputic techniques, i.e. MRI, PET, surgical treatment, radiation therapy

Basic Radiotherapy Physics and Biology

Basic Radiotherapy Physics and Biology
Author: David S. Chang,Foster D. Lasley,Indra J. Das,Marc S. Mendonca,Joseph R. Dynlacht
Publsiher: Springer
Total Pages: 348
Release: 2014-09-19
ISBN 10: 3319068415
ISBN 13: 9783319068411
Language: EN, FR, DE, ES & NL

Basic Radiotherapy Physics and Biology Book Review:

This book is a concise and well-illustrated review of the physics and biology of radiation therapy intended for radiation oncology residents, radiation therapists, dosimetrists, and physicists. It presents topics that are included on the Radiation Therapy Physics and Biology examinations and is designed with the intent of presenting information in an easily digestible format with maximum retention in mind. The inclusion of mnemonics, rules of thumb, and reader-friendly illustrations throughout the book help to make difficult concepts easier to grasp. Basic Radiotherapy Physics and Biology is a valuable reference for students and prospective students in every discipline of radiation oncology.

PET CT in Cancer An Interdisciplinary Approach to Individualized Imaging

PET CT in Cancer  An Interdisciplinary Approach to Individualized Imaging
Author: Mohsen Beheshti,Werner Langsteger,Alireza Rezaee
Publsiher: Elsevier Health Sciences
Total Pages: 350
Release: 2017-05-25
ISBN 10: 0323496083
ISBN 13: 9780323496087
Language: EN, FR, DE, ES & NL

PET CT in Cancer An Interdisciplinary Approach to Individualized Imaging Book Review:

Edited, authored, and reviewed by an expert team of oncologists and nuclear physicians/radiologists, this one-of-a-kind title helps you make the most of the critical role PET/CT plays in cancer staging and therapeutic responses to individualized treatments. Drs. Mohsen Beheshti, Werner Langsteger, and Alireza Rezaee place an emphasis on cutting-edge research and evidence-based practice, ensuring that you’re up to date with every aspect of this fast-changing field. For each tumor entity, you’ll find authoritative discussions of background, pathology, common pattern of spread, TNM classification, clinical guidelines, discussion, evidence-based recommendations, key points, and pitfalls. Contains 130 teaching cases with high-quality PET/CT images. Presents clear, practical guidance from multiple experts across subspecialties: nuclear medicine, oncology, oncologic surgery, radiation oncology, and clinical research. Includes separate, comprehensive chapters on head and neck, lung, breast, esophageal/gastric, pancreas/neuroendocrine, colorectal, hepatobiliary, lymphoma, gynecologic, prostate, melanoma, and brain cancers. Features short reviews of clinical aspects of different cancers, primary diagnostic procedures, and recommendations regarding PET/CT from ESMO and NCCN. Helps to reveal positive outcomes or potential deficits or weaknesses in an individual plan of care, allowing for better outcomes in patient care, future cancer research, and application of radiotracers beyond 18F-FDG.

Intensity Modulated Radiation Therapy for Head and Neck Cancer

Intensity Modulated Radiation Therapy for Head and Neck Cancer
Author: K. S. Clifford Chao,Gokhan Ozyigit
Publsiher: Lippincott Raven
Total Pages: 200
Release: 2003
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015056258653
Language: EN, FR, DE, ES & NL

Intensity Modulated Radiation Therapy for Head and Neck Cancer Book Review:

The first clinical book on the hottest topic in radiation oncology, this timely teaching text offers step-by-step guidance in use of IMRT for cancers at each subsite of the head and neck. The book's high-end content gives readers the clinical decision-making expertise and technical proficiency to incorporate this state-of-the-art radiation treatment technique into practice. Unique to this text is the site-specific instruction on target determination and delineation, to ensure adequate treatment of the tumor target while sparing adjacent normal tissue. More than 250 detailed full-color and black-and-white illustrations clarify each step in clinical implementations of head and neck cancer treatment, especially IMRT. The book provides a concise, pertinent overview of the natural course, lymph node spread, diagnostic criteria, and therapeutic options for each head and neck cancer subsite. Numerous tables provide extensive summaries of the IMRT literature. Figures with succinct explanatory text demonstrate the patterns of direct tumor extension and nodal metastasis with which target volumes are determined and delineated. Clinical outcomes for patients treated with IMRT and with conventional techniques are also included.

High Risk Cutaneous Squamous Cell Carcinoma

High Risk Cutaneous Squamous Cell Carcinoma
Author: Chrysalyne D. Schmults
Publsiher: Springer
Total Pages: 255
Release: 2016-04-29
ISBN 10: 3662470810
ISBN 13: 9783662470817
Language: EN, FR, DE, ES & NL

High Risk Cutaneous Squamous Cell Carcinoma Book Review:

This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.​

Advances in the Systemic Therapy and Combined Modality Approaches for Head and Neck Cancer

Advances in the Systemic Therapy and Combined Modality Approaches for Head and Neck Cancer
Author: Athanassios Argiris,Lisa Licitra
Publsiher: Frontiers Media SA
Total Pages: 116
Release: 2020-01-22
ISBN 10: 2889633284
ISBN 13: 9782889633289
Language: EN, FR, DE, ES & NL

Advances in the Systemic Therapy and Combined Modality Approaches for Head and Neck Cancer Book Review:

Encyclopedia of Cancer

Encyclopedia of Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 1841
Release: 2018-10-12
ISBN 10: 0128124857
ISBN 13: 9780128124857
Language: EN, FR, DE, ES & NL

Encyclopedia of Cancer Book Review:

Encyclopedia of Cancer, Third Edition provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented. Comprises 180 contributions from renowned experts who present the latest in mechanisms, hallmarks of cancer, causes, prevention and control, diagnosis and therapy, pathology and genetics Presents a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health

Critical Issues in Head and Neck Oncology

Critical Issues in Head and Neck Oncology
Author: Jan B. Vermorken,Volker Budach,C. René Leemans,Jean-Pascal Machiels,Piero Nicolai,Brian O’Sullivan
Publsiher: Springer Nature
Total Pages: 373
Release: 2021-06-02
ISBN 10: 3030632342
ISBN 13: 9783030632342
Language: EN, FR, DE, ES & NL

Critical Issues in Head and Neck Oncology Book Review:

This open access book discusses the most current issues in head and neck cancer with a focus on current trends such as biomarkers, precision medicine and immunotherapy. New approaches in the diagnosis such as liquid biopsies and imaging biomarkers to predict radiotherapy toxicity as well as approaches in the surgical management of head and neck cancers are discussed. The book discusses medical and surgical approaches in both primary, recurrent and metastatic disease and also covers approaches for rare head neck cancers. Readers will learn about the latest drug developments and epidemiological aspects in cancers ranging from Head and Neck Squamous Cell Cancer to Nasopharynx cancer. Edited by a team of world leaders in Head and Neck Cancer, this volume serves as an easy reference to the head and neck oncology practitioner and provides a contemporary overview for specialists the field. The chapters are based on the latest data presented at the 7th Trends in Head and Neck Oncology Conference and reflect the most up-to-date information in the field.

Re Irradiation New Frontiers

Re Irradiation  New Frontiers
Author: Carsten Nieder,Johannes Langendijk
Publsiher: Springer
Total Pages: 364
Release: 2016-10-25
ISBN 10: 3319418254
ISBN 13: 9783319418254
Language: EN, FR, DE, ES & NL

Re Irradiation New Frontiers Book Review:

This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.

Jatin Shah s Head and Neck Surgery and Oncology E Book

Jatin Shah s Head and Neck Surgery and Oncology E Book
Author: Jatin P. Shah,Snehal G. Patel,Bhuvanesh Singh
Publsiher: Elsevier Health Sciences
Total Pages: 856
Release: 2012-02-05
ISBN 10: 0323091334
ISBN 13: 9780323091336
Language: EN, FR, DE, ES & NL

Jatin Shah s Head and Neck Surgery and Oncology E Book Book Review:

Head and Neck Surgery and Oncology, by Drs. Jatin P. Shah Snehal G. Patel, and Bhuvanesh Singh, offers you authoritative, multidisciplinary guidance on the latest diagnostic and multidisciplinary therapeutic approaches for head and neck cancer. With this medical reference book, you’ll have all the help you need to offer your patients the best possible prognoses and to optimally preserve and restore form and function. Overcome any challenge in head and neck surgery with comprehensive coverage of the scalp, skull base, paranasal sinuses, oral cavity, pharynx, larynx, cervical lymph nodes, thyroid, salivary glands, and soft tissue and bone tumors - from incidence, diagnosis, and work up through treatment planning, operative techniques, rehabilitation, and outcomes. Increase your understanding of head and neck oncology with this completely reorganized edition, presenting a uniform flow of topics, which includes the latest information on Diagnostic approaches, staging, algorithms for selection of therapy, and outcomes of treatment for head and neck tumors. Offer today’s best treatment options with outcomes of therapy data from the NCDB, institutional data from MSKCC, and evidence-based information Diagnose patients using the latest advances in radiographic imaging, diagnostic pathology and molecular biology. Take fullest advantage of every multidisciplinary management approach available including radiation oncology, medical oncology (including targeted therapies), maxillofacial prosthodontics and dental oncology, surgical procedures for salvage of recurrences after chemoradiation therapy, and rehabilitation measures to improve functional outcomes (speech, swallowing, etc.). Understand the nuances of day-to-day practical care of patients with basic operating room techniques and technology, intraoperative decisions, and post operative care for patients undergoing head and neck surgery. Know what to look for and how to proceed with sequential operative photographs of each surgical procedure and full-color artwork to demonstrate anatomical relationships. Particular emphasis is placed on surgical management of patients after chemo-radiotherapy, reflecting the changing paradigms in head and neck oncology and the special challenges that confront modern day head and neck surgeons.

Modeling for Prediction of Radiation Induced Toxicity to Improve Therapeutic Ratio in the Modern Radiation Therapy Era

Modeling for Prediction of Radiation Induced Toxicity to Improve Therapeutic Ratio in the Modern Radiation Therapy Era
Author: Ester Orlandi,Tiziana Rancati,Giuseppe Sanguineti,Claudio Fiorino,Riccardo Valdagni
Publsiher: Frontiers Media SA
Total Pages: 389
Release: 2021-07-27
ISBN 10: 2889710882
ISBN 13: 9782889710881
Language: EN, FR, DE, ES & NL

Modeling for Prediction of Radiation Induced Toxicity to Improve Therapeutic Ratio in the Modern Radiation Therapy Era Book Review:

Mitigation of Cancer Therapy Side Effects with Light

Mitigation of Cancer Therapy Side Effects with Light
Author: Raj Nair,René-Jean Bensadoun
Publsiher: Morgan & Claypool Publishers
Total Pages: 47
Release: 2016-11-01
ISBN 10: 1681741393
ISBN 13: 9781681741390
Language: EN, FR, DE, ES & NL

Mitigation of Cancer Therapy Side Effects with Light Book Review:

'Light' from low level laser therapy, through a process called photobiomodulation (PBM), has been in existence in supportive care in cancer, in particular in the management of oral mucositis (OM) in patients undergoing chemotherapy, radiation therapy and haematopoietic stem cell transplantation. In this book the authors attempt to portray the current status of the supportive care interventions that are possible with PBM using low level laser therapy (LLLT) in patients undergoing cancer treatment for solid tumours, harmatological malignancies, and head and neck cancers.

Specialist Training in Oncology E Book

Specialist Training in Oncology E Book
Author: Thankamma V Ajithkumar,Helen Hatcher
Publsiher: Elsevier Health Sciences
Total Pages: 408
Release: 2011-10-28
ISBN 10: 0723437432
ISBN 13: 9780723437437
Language: EN, FR, DE, ES & NL

Specialist Training in Oncology E Book Book Review:

This textbook of oncology is aimed at specialist registrars in the early phase of their training. The basic concepts of cancer practice is touched upon in undergraduate and junior postgraduate years, but new trainees frequently seek additional resources to boost their knowledge in the field of Oncology. This title offers a concise account of the multidisciplinary management of common cancers and cancer-related problems appropriate to doctors at the start of their careers in this specialty. The content of the book is based on latest available evidence and reflects the training guidelines. Readable and concise style, aimed at the beginner in this specialty. Well illustrated in colour with graphics, clinical photographs and radiographs. Section on research methodology. Approachable design in the ‘Specialist Training in...’ series style.