Human Embryos and Preimplantation Genetic Technologies

Human Embryos and Preimplantation Genetic Technologies
Author: E. Scott Sills,Gianpiero D. Palermo
Publsiher: Academic Press
Total Pages: 222
Release: 2019-05-01
ISBN 10: 0128167440
ISBN 13: 9780128167441
Language: EN, FR, DE, ES & NL

Human Embryos and Preimplantation Genetic Technologies Book Review:

Human Embryos and Preimplantation Genetic Technologies: Ethical, Social, and Public Policy Aspects presents the first holistic analysis of PGD and PGS as it is practiced and regulated worldwide. In addition to scientific and technical aspects, the book provides perspectives on the ethical, legal, religious, policy and social implications of global assisted reproduction technologies, including in Africa, Asia, Europe, North and South America, and Australia. Chapters cover history, ethics, feminism, family dynamics, psychological and interpersonal factors, the current state of PGD and PGS in 20 different sovereign nations and religious communities, and provide an analysis of public policy concerns and future directions. Provides an in-depth discussion of PGD and PGS as practiced and regulated worldwide Offers an accessible resource for researchers, medical professionals, patients, regulators and policymakers seeking expert opinions on PGS and PGD Contains chapters contributed by international clinicians, researchers and thought leaders in the field of assisted reproductive technology

Heritable Human Genome Editing

Heritable Human Genome Editing
Author: The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publsiher: National Academies Press
Total Pages: 238
Release: 2021-01-16
ISBN 10: 0309671132
ISBN 13: 9780309671132
Language: EN, FR, DE, ES & NL

Heritable Human Genome Editing Book Review:

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Comparative Legal Frameworks for Pre Implantation Embryonic Genetic Interventions

Comparative Legal Frameworks for Pre Implantation Embryonic Genetic Interventions
Author: Pin Lean Lau
Publsiher: Springer
Total Pages: 326
Release: 2019-08-01
ISBN 10: 3030223086
ISBN 13: 9783030223083
Language: EN, FR, DE, ES & NL

Comparative Legal Frameworks for Pre Implantation Embryonic Genetic Interventions Book Review:

This book discusses the possibilities for the use of ​international human rights law ​(and specifically, international biomedical laws related to the protection of human rights and the human genome) to provide a guiding framework for the future regulation of genetic modifications applied to human embryos and other precursor materials, when these are made with the aim of implanting a genetically altered embryo in a woman. The significance and timeliness of the work derives from the recent availability of CRISPR/​Cas9 and other gene editing tools, and from lacunae in international law regarding the legality of embryo modification with these tools and appropriate governance structures for the oversight of resulting practices. The emergence of ​improved genome editing tools like CRISPR/Cas9, holds the promise of eradicating genetic diseases in the near future. But its possible future applications with Pre-Implantation Genetic Diagnosis (PGD) raises a plethora of legal and ethical concerns about "remaking" future human beings. The work aims to address an urgent call, to embed these rising concerns about biomedical advancements into the fundamental tailoring of legal systems. Suitable regulatory approaches, coupled with careful reflection of global biomedical laws and individual constitutional systems must be explored. The Book analyzes the impact of reproductive biomedical technologies on the legal and ethical dimensions of regulatory frameworks in selected constitutional systems like the US, the UK, Australia, Malaysia and Thailand. Employing a comparative law methodology, the work reveals a dynamic intersection between legal cultures, socio-philosophical reasoning and the development of a human rights-based framework in bio-political studies. Navigating towards a truly internationalized biomedical approach to emerging technologies, it presents an understanding why a renegotiation and reinvigoration of a contemporary and "new" universal shared values system in the ​international human rights discourse is now necessary.

Born and Made

Born and Made
Author: Sarah Franklin,Celia Roberts
Publsiher: Princeton University Press
Total Pages: 283
Release: 2006-10-30
ISBN 10: 1400835429
ISBN 13: 9781400835423
Language: EN, FR, DE, ES & NL

Born and Made Book Review:

Are new reproductive and genetic technologies racing ahead of a society that is unable to establish limits to their use? Have the "new genetics" outpaced our ability to control their future applications? This book examines the case of preimplantation genetic diagnosis (PGD), the procedure used to prevent serious genetic disease by embryo selection, and the so-called "designer baby" method. Using detailed empirical evidence, the authors show that far from being a runaway technology, the regulation of PGD over the past fifteen years provides an example of precaution and restraint, as well as continual adaptation to changing social circumstances. Through interviews, media and policy analysis, and participant observation at two PGD centers in the United Kingdom, Born and Made provides an in-depth sociological examination of the competing moral obligations that define the experience of PGD. Among the many novel findings of this pathbreaking ethnography of reproductive biomedicine is the prominence of uncertainty and ambivalence among PGD patients and professionals--a finding characteristic of the emerging "biosociety," in which scientific progress is inherently paradoxical and contradictory. In contrast to much of the speculative futurology that defines this field, Born and Made provides a timely and revealing case study of the on-the-ground decision-making that shapes technological assistance to human heredity.

Human Preimplantation Embryo Selection

Human Preimplantation Embryo Selection
Author: Jacques Cohen,Kay Elder
Publsiher: CRC Press
Total Pages: 384
Release: 2007-09-26
ISBN 10: 0203089715
ISBN 13: 9780203089712
Language: EN, FR, DE, ES & NL

Human Preimplantation Embryo Selection Book Review:

The most profound dilemma in assisted reproduction to date is the inability to recognize potentially viable embryos before their replacement into the reproductive tract. Application of increasingly advanced new technology has allowed the field of embryo evaluation to evolve rapidly and dramatically over the past five years.Human Preimplantation Emb

Assisted Conception Research Ethics and Law

Assisted Conception  Research  Ethics and Law
Author: Jennifer Gunning
Publsiher: Routledge
Total Pages: 226
Release: 2017-11-01
ISBN 10: 1351723308
ISBN 13: 9781351723305
Language: EN, FR, DE, ES & NL

Assisted Conception Research Ethics and Law Book Review:

This title was first published in 2003. Assisted conception is an area where it often seems that all the ethical and legal issues have been covered and then technology advances and the discussions start all over again. The book is an anthology of papers presented during a project looking at thearaputic research in assisted conception (TRAC). It is divided into three areas addressing research, ethics and law. Each chapter begins with an overview of the issues, with the aim being to present new perspectives rather than covering old ground. The European Convention on Human rights and Biomedicine came into force on December 1, 1999. The Convention allows thearaputic research and research on spare embryos but forbid fundamental research, which may be essential to the safe development of new techniques. This also means that people may become part of an experimental process without their consent. The project brings together clinicians, embryologists, lawyers and ethicists to ascertain whether there might be a risk of infertility patients being exposed to insufficiently tested procedures and to see if there is a need for fundamental research in this area. It also looks at the legislative safeguards that exist and whether a European standard for treatment should be set.

Rethinking Reprogenetics

Rethinking Reprogenetics
Author: Inmaculada de Melo-Martín
Publsiher: Oxford University Press
Total Pages: 305
Release: 2016-11
ISBN 10: 0190460202
ISBN 13: 9780190460204
Language: EN, FR, DE, ES & NL

Rethinking Reprogenetics Book Review:

Reprogenetic technologies, which combine the power of reproductive techniques with the tools of genetic science and technology, promise prospective parents a remarkable degree of control to pick and choose the likely characteristics of their offspring. Not only can they select embryos with or without particular genetically-related diseases and disabilities but also choose embryos with non-disease related traits such as sex. Prominent authors such as Agar, Buchanan, DeGrazia, Green, Harris, Robertson, Savulescu, and Silver have flocked to the banner of reprogenetics. For them, increased reproductive choice and reduced suffering through the elimination of genetic disease and disability are just the first step. They advocate use of these technologies to create beings who enjoy longer and healthier lives, possess greater intellectual capacities, and are capable of more refined emotional experiences. Indeed, Harris and Savulescu in particular take reprogenetic technologies to be so valuable to human beings that they have insisted that their use is not only morally permissible but morally required. Rethinking Reprogenetics challenges this mainstream view with a contextualised, gender-attentive philosophical perspective. De Melo-Martín demonstrates that you do not have to be a Luddite, social conservative, or religious zealot to resist the siren song of reprogenetics. Pointing out the flawed nature of the arguments put forward by the technologies' proponents, Rethinking Reprogenetics reveals the problematic nature of the assumptions underpinning current evaluations of these technologies and offers a framework for a more critical and sceptical assessment.

Reproductive Technology

Reproductive Technology
Author: Jon Sterngass
Publsiher: Cavendish Square Publishing, LLC
Total Pages: 112
Release: 2012-01-15
ISBN 10: 160870646X
ISBN 13: 9781608706464
Language: EN, FR, DE, ES & NL

Reproductive Technology Book Review:

Allows readers to use critical thinking to create informed opinions on where they stand on the issue of reproductive technology.

Screening the Single Euploid Embryo

Screening the Single Euploid Embryo
Author: E Scott Sills
Publsiher: Springer
Total Pages: 393
Release: 2015-09-07
ISBN 10: 3319168924
ISBN 13: 9783319168920
Language: EN, FR, DE, ES & NL

Screening the Single Euploid Embryo Book Review:

Intended for readers with a background in fertility medicine as well as those less familiar with IVF, this comprehensive work presents an update on preimplantation genetic testing to enable single embryo transfer (SET). An international cast of contributors explains the treatment sequence—from ovulation induction to luteal support—aiming to transfer only one euploid embryo. Applications of molecular techniques for gamete and embryo assessment are fully detailed, with a focus on the strengths and limitations of each. In addition, expert commentary is shared across a range of regulatory challenges associated with embryo screening and cryopreservation. As access to advanced reproductive technology increases against a sharper background of healthcare reform, clinicians, economists, bioethicists and legislators alike will find this new volume relevant and highly accessible.

Human Gametes and Preimplantation Embryos

Human Gametes and Preimplantation Embryos
Author: David K. Gardner,Denny Sakkas,Emre Seli,Dagan Wells
Publsiher: Springer Science & Business Media
Total Pages: 306
Release: 2013-05-27
ISBN 10: 1461466512
ISBN 13: 9781461466512
Language: EN, FR, DE, ES & NL

Human Gametes and Preimplantation Embryos Book Review:

In recent years, the advancing science and increasing availability of assisted reproduction have given new hope to infertile couples. However, the use of IVF and ART has also led to marked increases in the number of multiple-infant live births. This poses a public health concern, as these neonates have a higher rate of pre-term delivery, compromising their survival chances and increasing their risk of lifelong disability. By optimizing the selection of gametes and embryos with high probabilities of implantation, it is possible to reduce the number of embryos transferred and, by extension, the number of high-risk multiple gestations, while maintaining or increasing pregnancy rates. Human Gametes and Preimplantation Embryos: Assessment and Diagnosis provides a broad yet concise overview of established and developing methodologies for assessment of gamete and embryo viability in assisted reproduction. This book elucidates the best practices for precisely selecting viable specimens based on morphology and cleavage rate and covers the spectrum of emerging adjunctive technologies for predicting reproductive potential. The authors present their extensive knowledge of “omics” approaches (genomics, transcriptomics, proteomics, and metabolomics), with unbiased delineation of the associated advantages and potential pitfalls. This valuable clinical resource is well suited to infertility specialists, Ob/Gyn physicians, IVF laboratory technicians, and researchers in the fields of embryology and reproductive medicine.

Contested Reproduction

Contested Reproduction
Author: John H. Evans
Publsiher: University of Chicago Press
Total Pages: 280
Release: 2010-10-15
ISBN 10: 0226222705
ISBN 13: 9780226222707
Language: EN, FR, DE, ES & NL

Contested Reproduction Book Review:

Scientific breakthroughs have led us to a point where soon we will be able to make specific choices about the genetic makeup of our offspring. In fact, this reality has arrived—and it is only a matter of time before the technology becomes widespread. Much like past arguments about stem-cell research, the coming debate over these reproductive genetic technologies (RGTs) will be both political and, for many people, religious. In order to understand how the debate will play out in the United States, John H. Evans conducted the first in-depth study of the claims made about RGTs by religious people from across the political spectrum, and Contested Reproduction is the stimulating result. Some of the opinions Evans documents are familiar, but others—such as the idea that certain genetic conditions produce a “meaningful suffering” that is, ultimately, desirable—provide a fascinating glimpse of religious reactions to cutting-edge science. Not surprisingly, Evans discovers that for many people opinion on the issue closely relates to their feelings about abortion, but he also finds a shared moral language that offers a way around the unproductive polarization of the abortion debate and other culture-war concerns. Admirably evenhanded, Contested Reproduction is a prescient, profound look into the future of a hot-button issue.

The Future of Human Nature

The Future of Human Nature
Author: Jürgen Habermas
Publsiher: John Wiley & Sons
Total Pages: 136
Release: 2014-10-15
ISBN 10: 074569411X
ISBN 13: 9780745694115
Language: EN, FR, DE, ES & NL

The Future of Human Nature Book Review:

Recent developments in biotechnology and genetic research are raising complex ethical questions concerning the legitimate scope and limits of genetic intervention. As we begin to contemplate the possibility of intervening in the human genome to prevent diseases, we cannot help but feel that the human species might soon be able to take its biological evolution in its own hands. ‘Playing God’ is the metaphor commonly used for this self-transformation of the species, which, it seems, might soon be within our grasp. In this important new book, Jürgen Habermas – the most influential philosopher and social thinker in Germany today – takes up the question of genetic engineering and its ethical implications and subjects it to careful philosophical scrutiny. His analysis is guided by the view that genetic manipulation is bound up with the identity and self-understanding of the species. We cannot rule out the possibility that knowledge of one’s own hereditary factors may prove to be restrictive for the choice of an individual’s way of life and may undermine the symmetrical relations between free and equal human beings. In the concluding chapter – which was delivered as a lecture on receiving the Peace Prize of the German Book Trade for 2001 – Habermas broadens the discussion to examine the tension between science and religion in the modern world, a tension which exploded, with such tragic violence, on September 11th.

Reproductive Genetics

Reproductive Genetics
Author: Sean Kehoe,Lyn Chitty,Tessa Homfray
Publsiher: RCOG
Total Pages: 245
Release: 2009-11
ISBN 10: 1906985162
ISBN 13: 9781906985165
Language: EN, FR, DE, ES & NL

Reproductive Genetics Book Review:

This book presents the findings of the RCOG Study Group findings on genetics underlying reproductive function.

The End of Sex and the Future of Human Reproduction

The End of Sex and the Future of Human Reproduction
Author: Henry T. Greely
Publsiher: Harvard University Press
Total Pages: 392
Release: 2016-05-30
ISBN 10: 0674728963
ISBN 13: 9780674728967
Language: EN, FR, DE, ES & NL

The End of Sex and the Future of Human Reproduction Book Review:

Within twenty, maybe forty, years most people in developed countries will stop having sex for the purpose of reproduction. Instead, prospective parents will be told as much as they wish to know about the genetic makeup of dozens of embryos, and they will pick one or two for implantation, gestation, and birth. And it will be safe, lawful, and free. In this work of prophetic scholarship, Henry T. Greely explains the revolutionary biological technologies that make this future a seeming inevitability and sets out the deep ethical and legal challenges humanity faces as a result. “Readers looking for a more in-depth analysis of human genome modifications and reproductive technologies and their legal and ethical implications should strongly consider picking up Greely’s The End of Sex and the Future of Human Reproduction...[It has] the potential to empower readers to make informed decisions about the implementation of advancements in genetics technologies.” —Dov Greenbaum, Science “[Greely] provides an extraordinarily sophisticated analysis of the practical, political, legal, and ethical implications of the new world of human reproduction. His book is a model of highly informed, rigorous, thought-provoking speculation about an immensely important topic.” —Glenn C. Altschuler, Psychology Today

Practical Preimplantation Genetic Testing

Practical Preimplantation Genetic Testing
Author: Anver Kuliev,Svetlana Rechitsky,Joe Leigh Simpson
Publsiher: Springer Nature
Total Pages: 291
Release: 2020-05-29
ISBN 10: 3030431576
ISBN 13: 9783030431570
Language: EN, FR, DE, ES & NL

Practical Preimplantation Genetic Testing Book Review:

Fully revised and updated with the most current information, the third edition of this practical clinical text covers all aspects of the rapidly advancing field of preimplantation genetic testing (PGT). Although PGT has become an established procedure for genetics and assisted reproduction practices over the last decade, its wider application has occurred after the introduction of next generation technologies in the last few years, necessitating this much-needed new edition. This will include, first of all, an update on PGT accuracy, reliability and safety, to ensure improved access to PGT for those who may benefit greatly from this technology. New content will also present progress in the primary prevention of genetic disorders, which now discusses approaches for prospective identification of at-risk PGT couples through the application of the extended gene testing panels. In fact, because of dramatic technological improvements in all aspects of PGT, most of the sections have been updated, with the addition of new sections on next generation technologies and universal PGT with combined testing for single gene and chromosomal disorders, which has previously presented a challenge. The guiding PGT strategies for different genetic disorders are presented, with emphasis on the most complicated cases that might be of special utility in the wider application PGT technologies worldwide. Additionally, a new section will be devoted to borderline indications, which will include common adult-onset conditions with genetic predisposition and non-genetic indications, expanding PGT applications to heart disease and cancer and the use of PGT for stem cell transplantation treatment of genetic and acquired disorders, where unique outcome data has become available. Combining the latest research and the most cutting-edge practice, Practical Preimplantation Genetic Testing, 3e is an excellent resource for clinical reproductive medicine specialists, genetic counselors, researchers and analysts.

In Vitro Fertilization

In Vitro Fertilization
Author: Kay Elder,Brian Dale
Publsiher: Cambridge University Press
Total Pages: 135
Release: 2010-12-02
ISBN 10: 1139492853
ISBN 13: 9781139492850
Language: EN, FR, DE, ES & NL

In Vitro Fertilization Book Review:

This fully updated new edition of a successful and popular practical guide is an indispensable account of modern in-vitro fertilization practice. Initial chapters cover theoretical aspects of gametogenesis and embryo development at the cellular and molecular level, while the latter half of the book describes the requisites for a successful IVF laboratory and the basic technologies in ART. Advanced techniques, including pre-implantation genetic diagnosis, vitrification and stem-cell technology, are comprehensively covered, providing up-to-date analyses of these groundbreaking technologies. This edition includes: • New practical techniques, including preservation of fertility for cancer patients, stem-cell biology/technology, vitrification and in-vitro maturation • A 'refresher' study review of fundamental principles of cell and molecular biology • The latest information available from animal and human research in reproductive biology Packed with a wealth of practical and scientific detail, this is a must for all IVF practitioners.

Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine

Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine
Author: Carlos Simón,Carmen Rubio
Publsiher: CRC Press
Total Pages: 193
Release: 2017-12-14
ISBN 10: 1498763316
ISBN 13: 9781498763318
Language: EN, FR, DE, ES & NL

Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine Book Review:

Different genetic diagnostic and treatment options are used worldwide to improve routine IVF procedures for the benefit of patients. This handbook updates the new genetic diagnostic technologies that have been translated to practice aiming to improve outcomes in the clinic and have a healthy baby at home. Chapters cover the use of genetic technologies in a personalized manner to unravel the possible genetic risks for the couple wishing to conceive, in terms of sperm, the embryo, the endometrium, miscarriage, and finally the fetus.


Author: José A. Horcajadas,Jaime Gosálvez
Publsiher: Academic Press
Total Pages: 425
Release: 2018-07-23
ISBN 10: 0128126760
ISBN 13: 9780128126769
Language: EN, FR, DE, ES & NL

Reproductomics Book Review:

Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine. Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data Features chapter contributions by leading international experts

Regulating Pre implantation Genetic Diagnosis

Regulating Pre implantation Genetic Diagnosis
Author: Sheila McLean,Sarah Elliston
Publsiher: Routledge
Total Pages: 250
Release: 2012
ISBN 10: 041568644X
ISBN 13: 9780415686440
Language: EN, FR, DE, ES & NL

Regulating Pre implantation Genetic Diagnosis Book Review:

The successful achievement of pregnancies following pre-implantation genetic diagnosis (PGD) was first reported in April 1990. The technology is often used for patients who are at substantial risk of conceiving a pregnancy affected by a known genetic disorder, however from this technology other more controversial uses have arisen such as HLA typing to save the life of a sibling, gender selection for social reasons, the prevention of late onset diseases, or the prevention of diseases which may be genetically predisposed to developing such as breast cancer. The technology surrounding PGD is constantly developing, giving rise to new and unexpected consequences that create fresh ethical and legal dilemmas. Featuring internationally recognized experts in the field, this book critically explores the regulation of PGD and the broader legal and ethical issues associated with it. It looks at the regulatory situation in a number of jurisdictions including New Zealand, Australia and the United Kingdom, but it also explores a number of themes of wide significance including a historical consideration of PGD and its part in the creation of the "genetic embryo" as a political tool, the over regulation of PGD and the ethical difficulties in handling additional unexpected medical information yielded by new technologies. This book will be of particular interest to academics and students of law, medicine and ethics.

The Gene Machine

The Gene Machine
Author: Bonnie Rochman
Publsiher: Scientific American / Farrar, Straus and Giroux
Total Pages: 288
Release: 2017-02-28
ISBN 10: 0374713960
ISBN 13: 9780374713966
Language: EN, FR, DE, ES & NL

The Gene Machine Book Review:

A sharp-eyed exploration of the promise and peril of having children in an age of genetic tests and interventions Is screening for disease in an embryo a humane form of family planning or a slippery slope toward eugenics? Should doctors tell you that your infant daughter is genetically predisposed to breast cancer? If tests revealed that your toddler has a genetic mutation whose significance isn’t clear, would you want to know? In The Gene Machine, the award-winning journalist Bonnie Rochman deftly explores these hot-button questions, guiding us through the new frontier of gene technology and how it is transforming medicine, bioethics, health care, and the factors that shape a family. Rochman tells the stories of scientists working to unlock the secrets of the human genome; genetic counselors and spiritual advisers guiding mothers and fathers through life-changing choices; and, of course, parents (including Rochman herself) grappling with revelations that are sometimes joyous, sometimes heartbreaking, but always profound. She navigates the dizzying and constantly expanding array of prenatal and postnatal tests, from carrier screening to genome sequencing, while considering how access to more tests is altering perceptions of disability and changing the conversation about what sort of life is worth living and who draws the line. Along the way, she highlights the most urgent ethical quandary: Is this technology a triumph of modern medicine or a Pandora’s box of possibilities? Propelled by human narratives and meticulously reported, The Gene Machine is both a scientific road map and a meditation on our power to shape the future. It is a book that gets to the very core of what it means to be human.