Allosteric Regulatory Enzymes

Allosteric Regulatory Enzymes
Author: Thomas W. Traut
Publsiher: Springer Science & Business Media
Total Pages: 250
Release: 2007-09-11
ISBN 10: 0387728910
ISBN 13: 9780387728919
Language: EN, FR, DE, ES & NL

Allosteric Regulatory Enzymes Book Review:

This book covers the most recent developments in the analysis of allosteric enzymes and provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. The book presents a complete description of all the mechanisms used for changing enzyme activity. It is extensively illustrated to clarify kinetic and regulatory properties. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.

Understanding Enzymes

Understanding Enzymes
Author: Allan Svendsen
Publsiher: CRC Press
Total Pages: 700
Release: 2016-04-27
ISBN 10: 9814669334
ISBN 13: 9789814669337
Language: EN, FR, DE, ES & NL

Understanding Enzymes Book Review:

Understanding Enzymes: Function, Design, Engineering, and Analysis focuses on the understanding of enzyme function and optimization gained in the past decade, past enzyme function analysis, enzyme engineering, and growing insights from the simulation work and nanotechnology measurement of enzymes in action in vitro or in silico. The book also presents new insights into the mechanistic function and understanding of enzyme reactions, as well as touching upon structural characteristics, including X-ray and nuclear magnetic resonance (NMR) structural methods. A major focus of the book is enzyme molecules’ dependency on dynamic and biophysical environmental impacts on their function in ensembles as well as single molecules. A wide range of readers, including academics, professionals, PhD and master’s students, industry experts, and chemists, will immensely benefit from this exclusive book.

Fundamentals of Enzyme Kinetics

Fundamentals of Enzyme Kinetics
Author: Athel Cornish-Bowden
Publsiher: Elsevier
Total Pages: 244
Release: 2014-05-20
ISBN 10: 1483161196
ISBN 13: 9781483161198
Language: EN, FR, DE, ES & NL

Fundamentals of Enzyme Kinetics Book Review:

Fundamentals of Enzyme Kinetics details the rate of reactions catalyzed by different enzymes and the effects of varying the conditions on them. The book includes the basic principles of chemical kinetics, especially the order of a reaction and its rate constraints. The text also gives an introduction to enzyme kinetics - the idea of an enzyme-substrate complex; the Michaelis-Menten equation; the steady state treatment; and the validity of its assumption. Practical considerations, the derivation of steady-state rate equations, inhibitors and activators, and two-substrate reactions are also explained. Problems after the end of each chapter have also been added, as well as their solutions at the end of the book, to test the readers' learning. The text is highly recommended for undergraduate students in biochemistry who wish to study about enzymes or focus completely on enzymology, as most of the mathematics used in this book, which have been explained in detail to remove most barriers of understanding, is elementary.

Plant Metabolic Networks

Plant Metabolic Networks
Author: Jörg Schwender
Publsiher: Springer Science & Business Media
Total Pages: 339
Release: 2009-06-12
ISBN 10: 9780387787459
ISBN 13: 0387787453
Language: EN, FR, DE, ES & NL

Plant Metabolic Networks Book Review:

Plants are the basis for human nutrition and of increasing interest for the chemical industry as a source of chemical feed stocks. Fuels derived from plant biomass will increasingly replace fossil fuels in the future. In order to increase crop productivity, design new plant products, and create new energy crops, there is need for methods of qualitative and quantitative analysis of metabolism which are able to guide the rational re-design of metabolic networks. In this book, recent advances in qualitative and quantitative analysis of metabolism are summarized to give an overview of the current state of knowledge. Principles of the analysis of network structure, flux analysis, and kinetic modeling are described. Analytical methods necessary to produce the data needed for metabolic flux analysis and for kinetic modeling are described. The analysis of larger metabolic networks is only possible by using computer assistance. Therefore each chapter of the book shall also describe software available for this purpose.

ENZYMES Catalysis Kinetics and Mechanisms

ENZYMES  Catalysis  Kinetics and Mechanisms
Author: N.S. Punekar
Publsiher: Springer
Total Pages: 562
Release: 2018-11-11
ISBN 10: 9811307857
ISBN 13: 9789811307850
Language: EN, FR, DE, ES & NL

ENZYMES Catalysis Kinetics and Mechanisms Book Review:

This enzymology textbook for graduate and advanced undergraduate students covers the syllabi of most universities where this subject is regularly taught. It focuses on the synchrony between the two broad mechanistic facets of enzymology: the chemical and the kinetic, and also highlights the synergy between enzyme structure and mechanism. Designed for self-study, it explains how to plan enzyme experiments and subsequently analyze the data collected. The book is divided into five major sections: 1] Introduction to enzymes, 2] Practical aspects, 3] Kinetic Mechanisms, 4] Chemical Mechanisms, and 5] Enzymology Frontiers. Individual concepts are treated as stand-alone chapters; readers can explore any single concept with minimal cross-referencing to the rest of the book. Further, complex approaches requiring specialized techniques and involved experimentation (beyond the reach of an average laboratory) are covered in theory with suitable references to guide readers. The book provides students, researchers and academics in the broad area of biology with a sound theoretical and practical knowledge of enzymes. It also caters to those who do not have a practicing enzymologist to teach them the subject.

Enzyme Kinetics in Drug Metabolism

Enzyme Kinetics in Drug Metabolism
Author: Swati Nagar,Upendra Argikar,Donald Tweedie
Publsiher: Humana Press
Total Pages: 538
Release: 2014-02-13
ISBN 10: 9781627037570
ISBN 13: 1627037578
Language: EN, FR, DE, ES & NL

Enzyme Kinetics in Drug Metabolism Book Review:

Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.

Fitting Models to Biological Data Using Linear and Nonlinear Regression

Fitting Models to Biological Data Using Linear and Nonlinear Regression
Author: Harvey Motulsky,Arthur Christopoulos
Publsiher: Oxford University Press
Total Pages: 352
Release: 2004-05-27
ISBN 10: 0190291397
ISBN 13: 9780190291396
Language: EN, FR, DE, ES & NL

Fitting Models to Biological Data Using Linear and Nonlinear Regression Book Review:

Most biologists use nonlinear regression more than any other statistical technique, but there are very few places to learn about curve-fitting. This book, by the author of the very successful Intuitive Biostatistics, addresses this relatively focused need of an extraordinarily broad range of scientists.

Practical Enzymology

Practical Enzymology
Author: Hans Bisswanger
Publsiher: John Wiley & Sons
Total Pages: 400
Release: 2019-11-06
ISBN 10: 3527820809
ISBN 13: 9783527820801
Language: EN, FR, DE, ES & NL

Practical Enzymology Book Review:

A practice-oriented guide to assaying more than 100 of the most important enzymes, complete with the theoretical background and specific protocols for immediate use in the biochemical laboratory. Now expanded with a new section on metal ion determination.

Physical Chemistry for the Biosciences

Physical Chemistry for the Biosciences
Author: Raymond Chang
Publsiher: University Science Books
Total Pages: 677
Release: 2005-02-11
ISBN 10: 9781891389337
ISBN 13: 1891389335
Language: EN, FR, DE, ES & NL

Physical Chemistry for the Biosciences Book Review:

This book is ideal for use in a one-semester introductory course in physical chemistry for students of life sciences. The author's aim is to emphasize the understanding of physical concepts rather than focus on precise mathematical development or on actual experimental details. Subsequently, only basic skills of differential and integral calculus are required for understanding the equations. The end-of-chapter problems have both physiochemical and biological applications.

Principles of Enzyme Kinetics

Principles of Enzyme Kinetics
Author: Athel Cornish-Bowden
Publsiher: Elsevier
Total Pages: 220
Release: 2014-05-20
ISBN 10: 1483164675
ISBN 13: 9781483164670
Language: EN, FR, DE, ES & NL

Principles of Enzyme Kinetics Book Review:

Principles of Enzyme Kinetics discusses the principles of enzyme kinetics at an intermediate level. It is primarily written for first-year research students in enzyme kinetics. The book is composed of 10 chapters. Chapter 1 provides the basic principles of enzyme kinetics with a brief discussion of dimensional analysis. Subsequent chapters cover topics on the essential characteristics of steady-state kinetics, temperature dependence, methods for deriving steady-state rate equations, and control of enzyme activity. Integrated rate equations, and introductions to the study of fast reactions and the statistical aspects of enzyme kinetics are provided as well. Chemists and biochemists will find the book invaluable.

Numerical Methods for the Life Scientist

Numerical Methods for the Life Scientist
Author: Heino Prinz
Publsiher: Springer Science & Business Media
Total Pages: 149
Release: 2011-08-06
ISBN 10: 9783642208201
ISBN 13: 3642208207
Language: EN, FR, DE, ES & NL

Numerical Methods for the Life Scientist Book Review:

Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.

The Molecules of Life

The Molecules of Life
Author: Kuriyan, John,Konforti, Boyana,Wemmer, David
Publsiher: W.W. Norton & Company
Total Pages: 1008
Release: 2012-07-25
ISBN 10: 0815341881
ISBN 13: 9780815341888
Language: EN, FR, DE, ES & NL

The Molecules of Life Book Review:

This textbook provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. It is particularly suitable for students planning to enter the pharmaceutical industry. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.

Cellular Energy Metabolism and its Regulation

Cellular Energy Metabolism and its Regulation
Author: Gerard Meurant
Publsiher: Elsevier
Total Pages: 293
Release: 2012-12-02
ISBN 10: 0323138764
ISBN 13: 9780323138765
Language: EN, FR, DE, ES & NL

Cellular Energy Metabolism and its Regulation Book Review:

Cellular Energy Metabolism and Its Regulation examines the metabolic and molecular aspects of living organisms. Beginning with a discussion of evolutionary design and its close analogy with human design, it emphasizes the notion that evolution is a process of functional design, and that the characteristics of an organism, whether morphological or molecular, were selected because of functional advantage to the organism's ancestors. Thus, the study of an enzyme, a reaction, or a sequence can be biologically relevant only if its position in the hierarchy of function is kept in mind. This book deals with some aspects of metabolism from that point of view. The key concepts discussed include the conservation of solvent capacity and energy; functional stoichiometric coupling and metabolic prices; adenylate control and the adenylate energy charge; aspects of enzyme behavior that appear to be related to metabolic control; interactions between metabolic sequences; and the adenylate energy charge in intact cells. This book was designed for graduate students in biochemistry, physiology, microbiology, and related fields. However, it may also be useful to senior undergraduate students and more advanced workers who have a direct or peripheral interest in energy metabolism. It assumes a general familiarity with the material covered in a standard biochemistry textbook as well as some knowledge of such related areas as genetics.

Physical Chemistry for the Chemical and Biological Sciences

Physical Chemistry for the Chemical and Biological Sciences
Author: Raymond Chang
Publsiher: University Science Books
Total Pages: 1018
Release: 2000-05-12
ISBN 10: 9781891389061
ISBN 13: 1891389068
Language: EN, FR, DE, ES & NL

Physical Chemistry for the Chemical and Biological Sciences Book Review:

Hailed by advance reviewers as "a kinder, gentler P. Chem. text," this book meets the needs of an introductory course on physical chemistry, and is an ideal choice for courses geared toward pre-medical and life sciences students. Physical Chemistry for the Chemical and Biological Sciences offers a wealth of applications to biological problems, numerous worked examples and around 1000 chapter-end problems.

Enzyme Kinetics

Enzyme Kinetics
Author: Irwin H. Segel
Publsiher: Wiley-Interscience
Total Pages: 992
Release: 1993-05-06
ISBN 10:
ISBN 13: UVA:X002628791
Language: EN, FR, DE, ES & NL

Enzyme Kinetics Book Review:

Covers enzyme kinetics from its most elementary aspects to such modern subjects as steady-state, multi-reactant kinetics and isotope exchange. Offers an understanding of the behavior of enzyme systems and the diagnostic tools used to characterize them and determine kinetic mechanisms. Illustrates and explains current subjects such as cumulative, concerted and cooperative feedback inhibition and metal ion activation.

Introduction to Modeling Biological Cellular Control Systems

Introduction to Modeling Biological Cellular Control Systems
Author: Weijiu Liu
Publsiher: Springer Science & Business Media
Total Pages: 272
Release: 2012-04-26
ISBN 10: 8847024900
ISBN 13: 9788847024908
Language: EN, FR, DE, ES & NL

Introduction to Modeling Biological Cellular Control Systems Book Review:

This textbook contains the essential knowledge in modeling, simulation, analysis, and applications in dealing with biological cellular control systems. In particular, the book shows how to use the law of mass balance and the law of mass action to derive an enzyme kinetic model - the Michaelis-Menten function or the Hill function, how to use a current-voltage relation, Nernst potential equilibrium equation, and Hodgkin and Huxley's models to model an ionic channel or pump, and how to use the law of mass balance to integrate these enzyme or channel models into a complete feedback control system. The book also illustrates how to use data to estimate parameters in a model, how to use MATLAB to solve a model numerically, how to do computer simulations, and how to provide model predictions. Furthermore, the book demonstrates how to conduct a stability and sensitivity analysis on a model.

Enzyme Kinetics

Enzyme Kinetics
Author: Hans Bisswanger
Publsiher: John Wiley & Sons
Total Pages: 320
Release: 2017-06-22
ISBN 10: 3527806474
ISBN 13: 9783527806478
Language: EN, FR, DE, ES & NL

Enzyme Kinetics Book Review:

Now in full color for a more intuitive learning experience, this new edition of the long-selling reference also features a number of new developments in methodology and the application of enzyme kinetics. Starting with a description of ligand binding equilibria, the experienced author goes on to discuss simple and complex enzyme reactions in kinetic terms. Special cases such as membrane-bound and immobilized enzymes are considered, as is the influence of external conditions, such as temperature and pH value. The final part of the book then covers a range of widely used measurement methods and compares their performance and scope of application. With its unique mix of theory and practical advice, this is an invaluable aid for teaching as well as for experimental work.

Nonlinear Regression Analysis and Its Applications

Nonlinear Regression Analysis and Its Applications
Author: Douglas M Bates,Douglas M. Bates,Donald G. Watts
Publsiher: Wiley-Interscience
Total Pages: 365
Release: 2007-04-23
ISBN 10:
ISBN 13: UCSD:31822034586008
Language: EN, FR, DE, ES & NL

Nonlinear Regression Analysis and Its Applications Book Review:

Provides a presentation of the theoretical, practical, and computational aspects of nonlinear regression. There is background material on linear regression, including a geometrical development for linear and nonlinear least squares.

Regulation of Tissue Oxygenation

Regulation of Tissue Oxygenation
Author: Roland Pittman
Publsiher: Biota Publishing
Total Pages: 100
Release: 2011-03-01
ISBN 10: 1615041788
ISBN 13: 9781615041787
Language: EN, FR, DE, ES & NL

Regulation of Tissue Oxygenation Book Review:

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO in their vicinity falls to a critical level of about 1 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO. In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved. Table of Contents: Introduction / The Circulatory System and Oxygen Transport / The Respiratory System and Oxygen Transport / Oxygen Transport / Chemical Regulation of Respiration / Tissue Gas Transport / Oxygen Transport in Normal and Pathological Situations: Defects and Compensations / Matching Oxygen Supply to Oxygen Demand / Exercise and Hemorrhage / Measurement of Oxygen / Summary / References / Biography

Enzymes

Enzymes
Author: Robert A. Copeland
Publsiher: John Wiley & Sons
Total Pages: 416
Release: 2004-04-07
ISBN 10: 0471461857
ISBN 13: 9780471461852
Language: EN, FR, DE, ES & NL

Enzymes Book Review:

Fully updated and expanded-a solid foundation for understandingexperimental enzymology. This practical, up-to-date survey is designed for a broadspectrum of biological and chemical scientists who are beginning todelve into modern enzymology. Enzymes, Second Editionexplains the structural complexities of proteins and enzymes andthe mechanisms by which enzymes perform their catalytic functions.The book provides illustrative examples from the contemporaryliterature to guide the reader through concepts and data analysisprocedures. Clear, well-written descriptions simplify the complexmathematical treatment of enzyme kinetic data, and numerouscitations at the end of each chapter enable the reader to accessthe primary literature and more in-depth treatments of specifictopics. This Second Edition of Enzymes: A Practical Introductionto Structure, Mechanism, and Data Analysis features refinedand expanded coverage of many concepts, while retaining theintroductory nature of the book. Important new featuresinclude: A new chapter on protein-ligand binding equilibria Expanded coverage of chemical mechanisms in enzyme catalysisand experimental measurements of enzyme activity Updated and refined discussions of enzyme inhibitors andmultiple substrate reactions Coverage of current practical applications to the study ofenzymology Supplemented with appendices providing contact information forsuppliers of reagents and equipment for enzyme studies, as well asa survey of useful Internet sites and computer software forenzymatic data analysis, Enzymes, Second Edition isthe ultimate practical guide for scientists and students inbiochemical, pharmaceutical, biotechnical, medicinal, andagricultural/food-related research.