Hematopoietic Cell Transplantation for Malignant Conditions

Hematopoietic Cell Transplantation for Malignant Conditions
Author: Qaiser Bashir,Mehdi Hamadani
Publsiher: Elsevier Health Sciences
Total Pages: 438
Release: 2019-02-14
ISBN 10: 0323568033
ISBN 13: 9780323568036
Language: EN, FR, DE, ES & NL

Hematopoietic Cell Transplantation for Malignant Conditions Book Review:

Get a quick, expert overview of hematologic and non-hematologic malignancies for which hematopoietic cell transplantation is a treatment option. Drs. Qaiser Bashir and Mehdi Hamadani provide easy-to-find information on basic science of hematopoietic cell transplantation, pharmacology, workflows and procedures, possible complications and side effects, in addition to the role of HCT in conjunction with clinical cellular therapy. Discusses high-dose chemotherapeutic regimens and radiation therapy, patient and donor selection and workup, as well as other key aspects of hematopoietic cell transplantation. Includes practical information on complications, infectious disease, and special populations such as patients with HIV infection. Consolidates today’s available information in this fast-changing area into one convenient resource.

Hematopoietic Stem Cell Transplantation in Clinical Practice

Hematopoietic Stem Cell Transplantation in Clinical Practice
Author: Jennifer G. Treleaven,A. John Barrett
Publsiher: Elsevier Health Sciences
Total Pages: 568
Release: 2008-09-02
ISBN 10: 0702033537
ISBN 13: 9780702033537
Language: EN, FR, DE, ES & NL

Hematopoietic Stem Cell Transplantation in Clinical Practice Book Review:

A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. Has a practical, accessible approach with free use of algorithms, list tables. Aimed at the whole transplant team - this is an interdisciplinary field. International contributor team with editors in the UK and USA. Illustrated in colour throughout.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation
Author: Jennifer Treleaven,Austin John Barrett
Publsiher: Churchill Livingstone
Total Pages: 555
Release: 2009
ISBN 10: 9780443101472
ISBN 13: 0443101477
Language: EN, FR, DE, ES & NL

Hematopoietic Stem Cell Transplantation Book Review:

A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. Has a practical, accessible approach with free use of algorithms, list tables. Aimed at the whole transplant team - this is an interdisciplinary field. International contributor team with editors in the UK and USA. Illustrated in colour throughout.

The European Blood and Marrow Transplantation Textbook for Nurses

The European Blood and Marrow Transplantation Textbook for Nurses
Author: Michelle Kenyon,Aleksandra Babic
Publsiher: Springer
Total Pages: 311
Release: 2018-03-14
ISBN 10: 3319500260
ISBN 13: 9783319500263
Language: EN, FR, DE, ES & NL

The European Blood and Marrow Transplantation Textbook for Nurses Book Review:

This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.

Pediatric Hematopoietic Stem Cell Transplantation

Pediatric Hematopoietic Stem Cell Transplantation
Author: Ronald M. Kline
Publsiher: CRC Press
Total Pages: 640
Release: 2006-07-19
ISBN 10: 9780824724450
ISBN 13: 0824724453
Language: EN, FR, DE, ES & NL

Pediatric Hematopoietic Stem Cell Transplantation Book Review:

Hematopoietic stem cell transplantation (HSCT) is currently utilized as a treatment option for a variety of life-threatening conditions affecting children and young adults including leukemia, lymphoma, neuroblastoma, brain tumors, inherited immune deficiency syndromes, blood disorders, and inherited metabolic diseases. This expertly written reference provides current information on methods and outcomes in a wide range of pediatric diseases, using a variety of HSCT approaches. It guides the pediatric professional in the proper execution and understanding of HSCT, and provides illustrative discussions of the hematopoietic and immune systems, clear outlines of current chemotherapy regimens, and expert guidance on each phase of stem cell transplantation and management, including patient evaluation and recovery.

Stem Cell Transplantation for Hematologic Malignancies

Stem Cell Transplantation for Hematologic Malignancies
Author: Robert J. Soiffer
Publsiher: Springer Science & Business Media
Total Pages: 486
Release: 2004-01-29
ISBN 10: 1592597335
ISBN 13: 9781592597338
Language: EN, FR, DE, ES & NL

Stem Cell Transplantation for Hematologic Malignancies Book Review:

A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation.

Handbook of Stem Cell Transplantation and Cellular Therapy Management

Handbook of Stem Cell Transplantation and Cellular Therapy Management
Author: Edwin P. Alyea, III, MD,Vincent T. Ho, MD,Brett E. Glotzbecker, MD,Prashant Nageshwar, MD, PhD
Publsiher: Springer Publishing Company
Total Pages: 250
Release: 2020-09-29
ISBN 10: 0826139949
ISBN 13: 9780826139948
Language: EN, FR, DE, ES & NL

Handbook of Stem Cell Transplantation and Cellular Therapy Management Book Review:

Handbook of Stem Cell Transplantation and Cellular Therapy Management provides an evidence-based practical guide for clinicians and practitioners who treat cancer patients with these challenging and innovative techniques. The handbook begins with chapters on autologous transplantation for myeloma and lymphoma and allogenic transplantation for leukemia, lymphoma, and myelodysplastic syndrome. Further chapters cover the standards of care for managing adverse events related to acute graft-versus-host disease, chronic graft-versus-host disease, infections of bacterial, fungal, and viral nature, lymphoproliferative disease, pulmonary complications, renal complications, and more clinical issues. Concluding chapters address new CAR T-cell therapies, including their mechanisms of action, indications, and unique associated toxicities, in addition to a chapter dedicated to biostatistics and clinical trials. Throughout the book, extensive tables, flow diagrams, and other figures highlight, simplify, and illustrate key concepts. Written by experienced clinicians at the world-renowned Dana Farber Cancer Center and Harvard Medical School in Boston as well as leading experts at other institutions, this stem cell transplantation handbook combines the clinical knowledge, expertise and practical application of these potential life-saving cell therapies in one quick, point-of-care reference. With real-world clinical vignettes interwoven among the chapters, this handbook is an essential resource for anyone managing patients being treated with stem cell transplantation or cellular therapies. Key Features: Provides latest insights and recommendations for managing challenging treatment complications and adverse events Consolidates key information such as diagnosis criteria, disease staging, common complications, and more using detailed tables and diagrams Shares real-world clinical vignette examples, which provide insight into clinical assessment, treatment, and management Emphasizes patient management and best practices Discusses short- and long-term risks for stem cell transplantation and cellular therapy

Allogeneic Immunotherapy for Malignant Diseases

Allogeneic Immunotherapy for Malignant Diseases
Author: John Barrett,Yin-Zhen Jiang
Publsiher: CRC Press
Total Pages: 408
Release: 2000-01-27
ISBN 10: 0824746767
ISBN 13: 9780824746766
Language: EN, FR, DE, ES & NL

Allogeneic Immunotherapy for Malignant Diseases Book Review:

This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic solid tumors! Written by over 40 world renowned experts in the field and containing more than 1450 references for in-depth exploration of the subject, Allogeneic Immunotherapy for Malignant Diseases investigates the capacity of the donor-and the host-to destroy residual leukemia cells by allogeneic immune reaction determines how to direct immune reactions against hematopoietic malignancies safely reveals which other malignant conditions may be responsive to allogeneic-mediated graft-versus-tumor reactions covers the mechanisms that contribute to the development of responses to minor histocompatibility complex (mHC) molecules focuses on the biology of effector cells and their role in mediating GVL reactions in chronic myeloid leukemia (CML) summarizes the putative impact of human mHag on the GVL effect in bone marrow transplantation (BMT) addresses the potential and limitations of oncogene-based immunotherapy examines ways to isolate and control the GVL component of allograft immunity discusses efforts to develop specific anti-leukemic T-cell immunotherapy and more! Attributing the curative effect of allogeneic stem cell transplantation to the GVL or GVT effect, Allogeneic Immunotherapy for Malignant Diseases is an indispensable reference for hematologists, clinical oncologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, residents, and medical school students in these disciplines.

The Comprehensive Cancer Center

The Comprehensive Cancer Center
Author: Mahmoud Aljurf,Navneet S. Majhail,Mickey B.C. Koh,Mohamed A. Kharfan-Dabaja,Nelson J. Chao
Publsiher: Springer
Total Pages: 193
Release: 2021-10-29
ISBN 10: 9783030820510
ISBN 13: 3030820513
Language: EN, FR, DE, ES & NL

The Comprehensive Cancer Center Book Review:

This open access book provides a valuable resource for hospitals, institutions, and health authorities worldwide in their plans to set up and develop comprehensive cancer care centers. The development and implementation of a comprehensive cancer program allows for a systematic approach to evidence-based strategies of prevention, early detection, diagnosis, treatment, and palliation. Comprehensive cancer programs also provide a nexus for the running of clinical trials and implementation of novel cancer therapies with the overall aim of optimizing comprehensive and holistic care of cancer patients and providing them with the best opportunity to improve quality of life and overall survival. This book's self-contained chapter format aims to reinforce the critical importance of comprehensive cancer care centers while providing a practical guide for the essential components needed to achieve them, such as operational considerations, guidelines for best clinical inpatient and outpatient care, and research and quality management structures. Intended to be wide-ranging and applicable at a global level for both high and low income countries, this book is also instructive for regions with limited resources. The Comprehensive Cancer Center: Development, Integration, and Implementation is an essential resource for oncology physicians including hematologists, medical oncologists, radiation oncologists, surgical oncologists, and oncology nurses as well as hospitals, health departments, university authorities, governments and legislators.

Rare Hematological Malignancies

Rare Hematological Malignancies
Author: Stephen M. Ansell
Publsiher: Springer Science & Business Media
Total Pages: 434
Release: 2007-11-17
ISBN 10: 0387737448
ISBN 13: 9780387737447
Language: EN, FR, DE, ES & NL

Rare Hematological Malignancies Book Review:

This hugely practical work will be a bible in the pocket of hematologists and other practitioners everywhere, covering as it does malignant hematologic diseases that physicians will only occasionally see. It provides accurate, up-to-date information on the disease biology as well as practical recommendations concerning disease management. Information concerning these diseases, and particularly regarding their management, can be extremely difficult to find. Not any more.

Allogeneic Stem Cell Transplantation

Allogeneic Stem Cell Transplantation
Author: Hillard M. Lazarus,Mary J. Laughlin
Publsiher: Springer Science & Business Media
Total Pages: 881
Release: 2010-03-02
ISBN 10: 1597454788
ISBN 13: 9781597454780
Language: EN, FR, DE, ES & NL

Allogeneic Stem Cell Transplantation Book Review:

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Holland Frei Cancer Medicine

Holland Frei Cancer Medicine
Author: Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publsiher: John Wiley & Sons
Total Pages: 2008
Release: 2017-03-13
ISBN 10: 1119000831
ISBN 13: 9781119000839
Language: EN, FR, DE, ES & NL

Holland Frei Cancer Medicine Book Review:

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Nijkamp and Parnham s Principles of Immunopharmacology

Nijkamp and Parnham s Principles of Immunopharmacology
Author: Michael J. Parnham,Frans P. Nijkamp,Adriano G. Rossi
Publsiher: Springer Nature
Total Pages: 888
Release: 2019-12-10
ISBN 10: 3030108112
ISBN 13: 9783030108113
Language: EN, FR, DE, ES & NL

Nijkamp and Parnham s Principles of Immunopharmacology Book Review:

Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.

Allogeneic Immunotherapy for Malignant Diseases

Allogeneic Immunotherapy for Malignant Diseases
Author: John Barrett,Yin-Zhen Jiang
Publsiher: CRC Press
Total Pages: 408
Release: 2000-01-27
ISBN 10: 9781135548261
ISBN 13: 1135548269
Language: EN, FR, DE, ES & NL

Allogeneic Immunotherapy for Malignant Diseases Book Review:

This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic solid tumors! Written by over 40 world renowned experts in the field and containing more than 1450 references for in-depth exploration of the subject, Allogeneic Immunotherapy for Malignant Diseases investigates the capacity of the donor-and the host-to destroy residual leukemia cells by allogeneic immune reaction determines how to direct immune reactions against hematopoietic malignancies safely reveals which other malignant conditions may be responsive to allogeneic-mediated graft-versus-tumor reactions covers the mechanisms that contribute to the development of responses to minor histocompatibility complex (mHC) molecules focuses on the biology of effector cells and their role in mediating GVL reactions in chronic myeloid leukemia (CML) summarizes the putative impact of human mHag on the GVL effect in bone marrow transplantation (BMT) addresses the potential and limitations of oncogene-based immunotherapy examines ways to isolate and control the GVL component of allograft immunity discusses efforts to develop specific anti-leukemic T-cell immunotherapy and more! Attributing the curative effect of allogeneic stem cell transplantation to the GVL or GVT effect, Allogeneic Immunotherapy for Malignant Diseases is an indispensable reference for hematologists, clinical oncologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, residents, and medical school students in these disciplines.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation
Author: Michael R. Bishop
Publsiher: Springer Science & Business Media
Total Pages: 589
Release: 2009-09-25
ISBN 10: 9780387785806
ISBN 13: 0387785809
Language: EN, FR, DE, ES & NL

Hematopoietic Stem Cell Transplantation Book Review:

The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.

Thomas Hematopoietic Cell Transplantation 2 Volume Set

Thomas  Hematopoietic Cell Transplantation  2 Volume Set
Author: Stephen J. Forman,Robert S. Negrin,Joseph H. Antin,Frederick R. Appelbaum
Publsiher: John Wiley & Sons
Total Pages: 1416
Release: 2016-12-27
ISBN 10: 1118416007
ISBN 13: 9781118416006
Language: EN, FR, DE, ES & NL

Thomas Hematopoietic Cell Transplantation 2 Volume Set Book Review:

Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.

Blood and Marrow Transplant Handbook

Blood and Marrow Transplant Handbook
Author: Richard T. Maziarz,Susan Schubach Slater
Publsiher: Unknown
Total Pages: 135
Release: 2015
ISBN 10: 9783319138336
ISBN 13: 3319138332
Language: EN, FR, DE, ES & NL

Blood and Marrow Transplant Handbook Book Review:

This updated and expanded edition developed by the Blood and Marrow Stem Cell Transplant team at Oregon Health & Science University Knight Cancer Institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant patients. Spanning the timeline from the initial consultation throughout the transplant process, this handbook includes indications for transplantation and donor selection, treatment guidelines for addressing complications during and after transplant, and recommendations for long-term follow up care. Concise, comprehensive, and easy-to-use, Blood and Marrow Transplant Handbook, 2nd Edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers who care for transplant patients, and also residents, fellows, and other trainees.

The EBMT Handbook

The EBMT Handbook
Author: Nicolaus Kröger,Mohamad Mohty,Carlo Dufour
Publsiher: Unknown
Total Pages: 688
Release: 2020-10-08
ISBN 10: 9781013273674
ISBN 13: 1013273672
Language: EN, FR, DE, ES & NL

The EBMT Handbook Book Review:

This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Oncologic Critical Care

Oncologic Critical Care
Author: Joseph L. Nates,Kristen J. Price
Publsiher: Springer
Total Pages: 2099
Release: 2019-10-30
ISBN 10: 9783319745879
ISBN 13: 3319745875
Language: EN, FR, DE, ES & NL

Oncologic Critical Care Book Review:

This major reference work is the most comprehensive resource on oncologic critical care. The text reviews all significant aspects of oncologic ICU practices, with a particular focus on challenges encountered in the diagnosis and management of the critically ill cancer patient population. Comprised of over 140 chapters, the text explores such topics as the organization and management of an oncologic ICU, diseases and complications encountered in the oncologic ICU, multidisciplinary care, surgical care, transfusion medicine, special patient populations, critical care procedures, ethics, pain management, and palliative care. Written by worldwide experts in the field, Oncologic Critical Care is a valuable resource for intensivists, advance practice providers, nurses, and other healthcare providers, that will help close significant knowledge and educational gaps within the realm of medical care for critically ill cancer patients.

Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Advances in Allogeneic Hematopoietic Stem Cell Transplantation
Author: Richard K. Burt,Mary M. Brush
Publsiher: Springer Science & Business Media
Total Pages: 440
Release: 2000-02-29
ISBN 10: 9780792377146
ISBN 13: 0792377141
Language: EN, FR, DE, ES & NL

Advances in Allogeneic Hematopoietic Stem Cell Transplantation Book Review:

The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).