Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation  Cancer and Cancer Therapy
Author: G V Sherbet
Publsiher: Elsevier
Total Pages: 368
Release: 2011-07-12
ISBN 10: 0123878209
ISBN 13: 9780123878205
Language: EN, FR, DE, ES & NL

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy Book Review:

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation  Cancer and Cancer Therapy
Author: Gajanan V. Sherbet
Publsiher: Unknown
Total Pages: 368
Release: 2011-07-28
ISBN 10: 9780323165310
ISBN 13: 0323165311
Language: EN, FR, DE, ES & NL

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy Book Review:

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research

Growth Factors and their Receptors in Cancer Metastasis

Growth Factors and their Receptors in Cancer Metastasis
Author: Wen G. Jiang,K. Matsumoto,T. Nakamura
Publsiher: Springer Science & Business Media
Total Pages: 303
Release: 2006-04-11
ISBN 10: 0306483998
ISBN 13: 9780306483998
Language: EN, FR, DE, ES & NL

Growth Factors and their Receptors in Cancer Metastasis Book Review:

about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation  Cancer and Cancer Therapy
Author: Gajanan V. Sherbet
Publsiher: Elsevier
Total Pages: 347
Release: 2011
ISBN 10: 0123878195
ISBN 13: 9780123878199
Language: EN, FR, DE, ES & NL

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy Book Review:

Annotation G.V. Sherbet provides insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. The book focuses on the relationships and convergence of growth factors and their receptors in development and pathogenesis.

Holland Frei Cancer Medicine

Holland Frei Cancer Medicine
Author: Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publsiher: John Wiley & Sons
Total Pages: 2008
Release: 2017-03-10
ISBN 10: 111900084X
ISBN 13: 9781119000846
Language: EN, FR, DE, ES & NL

Holland Frei Cancer Medicine Book Review:

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Genetic Recombination in Cancer

Genetic Recombination in Cancer
Author: Gajanan V. Sherbet
Publsiher: Elsevier
Total Pages: 264
Release: 2003-07-24
ISBN 10: 9780080521909
ISBN 13: 0080521908
Language: EN, FR, DE, ES & NL

Genetic Recombination in Cancer Book Review:

Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells * Examines the role of genetic recombination in cancer including cancer invasion and metastasis * Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers

Therapeutic Strategies in Cancer Biology and Pathology

Therapeutic Strategies in Cancer Biology and Pathology
Author: Gajanan V. Sherbet
Publsiher: Elsevier
Total Pages: 310
Release: 2013-07-26
ISBN 10: 0124165907
ISBN 13: 9780124165908
Language: EN, FR, DE, ES & NL

Therapeutic Strategies in Cancer Biology and Pathology Book Review:

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. Identifies molecular targets and their accessibility for therapeutic intervention Provides information on biological features of tumor development and dissemination Background information provided for each topic

Insulin Like Growth Factors

Insulin Like Growth Factors
Author: Douglas Yee
Publsiher: IOS Press
Total Pages: 124
Release: 2003
ISBN 10: 9781586034092
ISBN 13: 158603409X
Language: EN, FR, DE, ES & NL

Insulin Like Growth Factors Book Review:

Over the past five years there has been an explosion of "targeted therapies" for cancer treatment. In most cases, these therapies have been based on pre-clinical data showing that specific molecules play an important role in regulating the malignant phenotype. In breast cancer, there is compelling rationale that such targeted strategies should be successful. Targeting of estrogen receptor ? (ER?) has proven to be a successful way to reduce breast cancer risk, decrease the risk of death and recurrence in an adjuvant setting, and remains the first choice of treatment for advanced disease. With this success, it is hoped that other molecular pathways could also be successfully exploited. This publication reviews the role of the insulin-like growth factors (IGFs) in breast cancer. Over 100 years ago George Beatson made an intuitive leap connecting breast cancer therapy with ovarian function He removed the ovaries from a premenopausal woman with breast cancer; he reasoned that ovarian function regulated normal mammary gland function, therefore the ovaries may influence the malignant phenotype. Other discussion included cover the function of IGF action in the normal mammary gland using mouse model systems where expression and function can be manipulated and the patterns of expression of the IGFs, their binding proteins, and their receptors in the normal gland.

The Genetics of Cancer

The Genetics of Cancer
Author: Gajanan V. Sherbet,M. S. Lakshmi
Publsiher: Academic Press
Total Pages: 338
Release: 1997-06-22
ISBN 10: 9780080542485
ISBN 13: 0080542484
Language: EN, FR, DE, ES & NL

The Genetics of Cancer Book Review:

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Clonal evolution of the metastasis phenotype Cell Cycle regulation Apoptosis in tumour growth and metastasis Angiogenesis in cancer Cell surface glycoproteins and their receptors Proteinases and their inhibitors in cancer invasion Oncogenes and cancer metastasis Developmental genes Tumour suppressor genes Metastasis suppressor genes Dominant metastasis-associated genes

Molecular Approach to Cancer Management

Molecular Approach to Cancer Management
Author: Gajanan V. Sherbet
Publsiher: Academic Press
Total Pages: 352
Release: 2017-06-15
ISBN 10: 0128128976
ISBN 13: 9780128128978
Language: EN, FR, DE, ES & NL

Molecular Approach to Cancer Management Book Review:

Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy. Covers all relevant topics with a defined aim of targeted therapy Encompasses the basic aspects of cancer invasion and metastasis Discusses signaling systems operating in normal cells and their deregulation in cancer cells Directs attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach

Oxford Textbook of Oncology

Oxford Textbook of Oncology
Author: David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
Publsiher: Oxford University Press
Total Pages: 832
Release: 2016-01-28
ISBN 10: 0191065110
ISBN 13: 9780191065118
Language: EN, FR, DE, ES & NL

Oxford Textbook of Oncology Book Review:

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics

Fibroblast Growth Factors  Biology And Clinical Application   Fgf Biology And Therapeutics
Author: Simons Michael
Publsiher: World Scientific
Total Pages: 284
Release: 2016-12-27
ISBN 10: 981314338X
ISBN 13: 9789813143388
Language: EN, FR, DE, ES & NL

Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics Book Review:

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states. Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches. With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments — endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer. It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.

Blood Cell Biochemistry

Blood Cell Biochemistry
Author: Anthony D. Whetton,John Gordon
Publsiher: Springer Science & Business Media
Total Pages: 419
Release: 1996-08-31
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015041066294
Language: EN, FR, DE, ES & NL

Blood Cell Biochemistry Book Review:

Volume 7 explores the role of receptors and growth factors in the control of hematopoiesis and the immune system. This work features color plates and numerous illustrations.

Cooperation of Liver Cells in Health and Disease

Cooperation of Liver Cells in Health and Disease
Author: Z. Kmiec
Publsiher: Springer Science & Business Media
Total Pages: 151
Release: 2013-06-29
ISBN 10: 3642565530
ISBN 13: 9783642565533
Language: EN, FR, DE, ES & NL

Cooperation of Liver Cells in Health and Disease Book Review:

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

The Effects of Insulin Like Growth Factors on Human G292 Osteosarcoma Cells

The Effects of Insulin Like Growth Factors on Human G292 Osteosarcoma Cells
Author: Thabet AlHousami
Publsiher: Unknown
Total Pages: 135
Release: 2017
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1000614132
Language: EN, FR, DE, ES & NL

The Effects of Insulin Like Growth Factors on Human G292 Osteosarcoma Cells Book Review:

Introduction: Osteosarcoma is the most common bone sarcoma in children and adolescents. It is an aggressive primary bone cancer recognized by abnormal cell proliferation and function. The insulin-like growth factor (IGF) system plays an integral role in the growth, differentiation, and developmental processes, and is involved in various physiological and pathological events. The IGF system consists of IGF I and II, their cell surface receptors and insulin-like growth factor binding proteins (IGFBP). IGF-binding proteins (IGFBPs) are important modulators of IGF signaling. IGF-II is a potent mitogen whose deregulation is linked to diverse pathologies and plays a role in tumorigenesis, development of different types of cancers such as liver, breast and prostate cancers, metastasis and resistance to existing forms of cancer therapy. Chromeceptin is a synthetic small molecule that induces expression of IGF inhibitory genes.^It has been shown that chromeceptin inhibits insulin-induced adipogenesis and decreases the growth and viability of hepatocellular carcinoma cells that overexpress IGF-II. The involvement of IGF-II and IGFBP1 in cancer suggests that the analysis of their regulation may provide us with a better understanding of human cancers and new therapeutic approaches. Aim of the study: To study the effect of IGF-II on the activity of human G292 osteosarcoma cells, focusing both on the effects of endogenous and exogenous IGF-II levels. In addition, to study the role of IGFBPs and chromeceptin on G292 osteosarcoma cell activity. Material and Methods: The MTT assay was used to assess the activity of G292 (Clone A141B1) human osteosarcoma cells. Growth activity was analyzed after various periods of incubation in serum-free media. Enzyme-linked Immunosorbent Assays (ELISA) were used to detect the endogenous levels of IGF-II and IGFBP1 in the treated G292 human osteosarcoma cells. Result: Our experimental results show that chromeceptin plays a significant role in the activity of G292 osteosarcoma cells, since chromeceptin alone decreased cell activity of G292 osteosarcoma cells compared to the control group. With the concentrations of IGF-II added exogenously, very small effects were observed under the conditions studied. G292 cells appear to thrive in serum free medium and to be dependent in an autocrine manner on IGF-II and paracrine effects of this growth factor are minimal. In addition, we tested the effects of chromeceptin on IGFBP-1 in G292 cells and observed significant decreases in IGF-II levels. At concentrations that had significant effects on G292 cell activity and IGF-II levels, chromeceptin produced small, but significant increases in IGFBP1 levels. Conclusions: Our studies with the drug, chromeceptin, presented here strongly suggest a role of endogenous IGF-II in cell activity of G292 human osteosarcoma cells with a role of IGFBP-1 in this process as well. In general, our studies on the involvement of IGF-II in the human G292 osteosarcoma cell suggest that the further analysis of IGF-II regulation may lead to a better understanding of human bone cancers and possible new cancer therapies.

Insulin like Growth Factor Receptor Signalling

Insulin like Growth Factor Receptor Signalling
Author: Derek Leroith,Walter Zumkeller,Robert C. Baxter
Publsiher: Springer Science & Business Media
Total Pages: 524
Release: 2003-07-31
ISBN 10: 9780306478468
ISBN 13: 0306478463
Language: EN, FR, DE, ES & NL

Insulin like Growth Factor Receptor Signalling Book Review:

Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis
Author: Padma V. Devarajan,Prajakta Dandekar,Anisha A. D'Souza
Publsiher: Springer Nature
Total Pages: 560
Release: 2019-11-09
ISBN 10: 3030291685
ISBN 13: 9783030291686
Language: EN, FR, DE, ES & NL

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis Book Review:

This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.

Signal Transduction in Cancer

Signal Transduction in Cancer
Author: David A. Frank
Publsiher: Springer Science & Business Media
Total Pages: 357
Release: 2006-04-18
ISBN 10: 0306481588
ISBN 13: 9780306481581
Language: EN, FR, DE, ES & NL

Signal Transduction in Cancer Book Review:

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Growth Factors and Their Receptors

Growth Factors and Their Receptors
Author: Russell Ross,Antony Burgess,Tony Hunter
Publsiher: Alan R. Liss
Total Pages: 319
Release: 1989
ISBN 10: 1928374650XXX
ISBN 13: UCAL:B4532484
Language: EN, FR, DE, ES & NL

Growth Factors and Their Receptors Book Review:

EGFR Signaling Networks in Cancer Therapy

EGFR Signaling Networks in Cancer Therapy
Author: John D. Haley,William John Gullick
Publsiher: Springer Science & Business Media
Total Pages: 395
Release: 2009-03-01
ISBN 10: 1597453560
ISBN 13: 9781597453561
Language: EN, FR, DE, ES & NL

EGFR Signaling Networks in Cancer Therapy Book Review:

The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.