GPCR Signaling in Cancer

GPCR Signaling in Cancer
Author: Arun K. Shukla
Publsiher: Academic Press
Total Pages: 312
Release: 2020-02
ISBN 10: 0128202300
ISBN 13: 9780128202302
Language: EN, FR, DE, ES & NL

GPCR Signaling in Cancer Book Review:

GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more. G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics.

Trafficking of GPCRs

Trafficking of GPCRs
Author: Guangyu Wu
Publsiher: Academic Press
Total Pages: 328
Release: 2015-06-05
ISBN 10: 0128029552
ISBN 13: 9780128029558
Language: EN, FR, DE, ES & NL

Trafficking of GPCRs Book Review:

G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms. Written by future leaders in the pain field Covers a wide range of targets Contains provocative ideas about GPCR trafficking

G Protein Coupled Receptors in Immune Response and Regulation

G Protein Coupled Receptors in Immune Response and Regulation
Author: Anonim
Publsiher: Academic Press
Total Pages: 398
Release: 2017-09-23
ISBN 10: 0128124040
ISBN 13: 9780128124048
Language: EN, FR, DE, ES & NL

G Protein Coupled Receptors in Immune Response and Regulation Book Review:

G Protein-Coupled Receptors in Immune Response and Regulation, Volume 136 presents emerging concepts related to the role of GPCRs in immune response and regulation. Users will find updated chapters on a variety of topics, including Beta-adrenergic signaling in the onset and progression of asthma, the Emerging roles of Regulators of G protein signaling (RGS) proteins in the immune system, information on Kinin receptors in immune response and pathogenic infections, and sections on GPCR signaling in C. elegans and its implications in immune response, GPCR Kinases in Inflammatory response and signaling, and GRK2 in Inflammation: Regulation of T cell receptors and IgE signaling. Chapters in this book discuss not only the well-known aspects of GPCR signaling in immunology, but also presents many emerging paradigms that have not yet been reported in classical textbooks. Each chapter presents a forward-looking discussion, providing a glimpse of the tremendous potential associated with the specific receptor systems discussed. Brings together contributions from leading experts in the area of GPCR biology Discusses current paradigms and the future potential of understanding GPCR signaling in immune response and regulation Presents the first of its kind book to focus on specific GPCR systems in various aspects of immunology, all brought together in one volume

G Protein Coupled Receptors

G Protein Coupled Receptors
Author: Anonim
Publsiher: Academic Press
Total Pages: 332
Release: 2019-01-05
ISBN 10: 0128151080
ISBN 13: 9780128151082
Language: EN, FR, DE, ES & NL

G Protein Coupled Receptors Book Review:

G-Protein-Coupled Receptors, Part B, 2nd Edition, Volume 149, the latest release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers Optical Approaches for Visualization of Arrestin Binding to Muscarinic Receptors, Luciferase Reporter Assay for Unlocking Ligand-mediated Signaling of GPCRs, Assays to Measure GPCR Dependent Cellular Migration, Characterization of the Frizzled GPCRs, Binding Assays for Bradykinin and Angiotensin Receptors, Detection of Misfolded Rhodopsin Aggregates in Cells, Measuring GPCR Ubiquitination and Trafficking, Culture of Primary Neurons and its Use in Studying GPCR Trafficking, and much more. Covers the increasingly appreciated cell biology field of G-protein-coupled receptors Includes both established and new technologies Contributed by experts in the field

GPCR Molecular Pharmacology and Drug Targeting

GPCR Molecular Pharmacology and Drug Targeting
Author: Annette Gilchrist
Publsiher: John Wiley & Sons
Total Pages: 544
Release: 2010-12-10
ISBN 10: 9781118035177
ISBN 13: 1118035178
Language: EN, FR, DE, ES & NL

GPCR Molecular Pharmacology and Drug Targeting Book Review:

G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.

G Protein Coupled Receptors in Drug Discovery

G Protein Coupled Receptors in Drug Discovery
Author: Kenneth H. Lundstrom,Mark L. Chiu
Publsiher: CRC Press
Total Pages: 376
Release: 2005-07-11
ISBN 10: 1420028219
ISBN 13: 9781420028218
Language: EN, FR, DE, ES & NL

G Protein Coupled Receptors in Drug Discovery Book Review:

The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs

Pharmacology of G Protein Coupled Receptors

Pharmacology of G Protein Coupled Receptors
Author: S. J. Enna
Publsiher: Academic Press
Total Pages: 391
Release: 2011
ISBN 10: 0123859522
ISBN 13: 9780123859525
Language: EN, FR, DE, ES & NL

Pharmacology of G Protein Coupled Receptors Book Review:

G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones. In addition, emerging drug targets such as receptor families for fatty acids, carboxylic acids, lipid mediators, etc. are included. Final chapters cover novel mechanisms of signal regulation through PDZ domains and RGS proteins. This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists

The G Protein Coupled Receptors Handbook

The G Protein Coupled Receptors Handbook
Author: Lakshmi A. Devi
Publsiher: Springer Science & Business Media
Total Pages: 412
Release: 2008-03-01
ISBN 10: 1592599192
ISBN 13: 9781592599196
Language: EN, FR, DE, ES & NL

The G Protein Coupled Receptors Handbook Book Review:

A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.

Fundamentals of Medical Physiology Ebook

Fundamentals of Medical Physiology Ebook
Author: Harminder Singh,Itika Singh
Publsiher: Elsevier Health Sciences
Total Pages: 746
Release: 2018-07-05
ISBN 10: 8131254100
ISBN 13: 9788131254103
Language: EN, FR, DE, ES & NL

Fundamentals of Medical Physiology Ebook Book Review:

Enhanced learning in the form of animations for functioning of organ systems

Monitoring endogenous GPCRs lessons for drug design

Monitoring endogenous GPCRs  lessons for drug design
Author: Dominique Massotte
Publsiher: Unknown
Total Pages: 135
Release: 2015-10-07
ISBN 10: 2889196518
ISBN 13: 9782889196517
Language: EN, FR, DE, ES & NL

Monitoring endogenous GPCRs lessons for drug design Book Review:

G protein-coupled receptors (GPCRs) are integral membrane proteins forming the fourth largest superfamily in the human genome. Many of these receptors play key physiological roles and several pathologies have been associated with receptor functional abnormalities. GPCRs therefore represent important goals for drug design in pharmaceutical companies since they constitute the target of about one third of the drugs currently on the market. However, endogenous GPCRs are most often difficult to study because of a lack of tools to target them specifically and single out their response to physiological or drug-elicited stimulations. Hence, studies mostly focused on recombinant receptors expressed in a variety of cellular models that do not always closely reflect the receptor natural environment and often deal with levels of expression exceeding by far physiological ranges. Recent technological developments combining for example genetically modified animals and advanced imaging approaches have improved our ability to visualize endogenous GPCRs. To date, trailing receptor activation, subsequent intracellular redistribution, changes in signaling cascade up to integrated response to a drug-elicited stimulation is at hand though the impact of a physiological challenge on receptor dynamics remains a major issue. Data however suggest that the receptor may embrace a different fate depending on the type of stimulation in particular if sustained or repeated. This suggests that current drugs may only partially mimic the genuine response of the receptor and may explain, at least in part, their secondary effects. Commonalities and specificities between physiological and drug-induced activation can thus represent valuable guidelines for the design of future drugs.

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors
Author: Anonim
Publsiher: Academic Press
Total Pages: 488
Release: 2012-12-02
ISBN 10: 012394791X
ISBN 13: 9780123947918
Language: EN, FR, DE, ES & NL

Oligomerization and Allosteric Modulation in G Protein Coupled Receptors Book Review:

In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments in the field

G Protein Coupled Receptors Modeling and Simulation

G Protein Coupled Receptors   Modeling and Simulation
Author: Marta Filizola
Publsiher: Springer Science & Business Media
Total Pages: 228
Release: 2013-10-25
ISBN 10: 9400774230
ISBN 13: 9789400774230
Language: EN, FR, DE, ES & NL

G Protein Coupled Receptors Modeling and Simulation Book Review:

G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors. Luckily, there has been a steady increase of high-resolution crystal structures of these receptors since 2007, and this information, integrated with dynamic inferences from computational and experimental methods, holds great potential for the discovery of new, improved drugs. This book, which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the second part of the book. The third part reports recent progress in rational ligand discovery and mathematical modeling, whereas the fourth part provides an overview of bioinformatics tools and resources that are available for GPCRs.

Pharmacology for Health Professionals ebook

Pharmacology for Health Professionals ebook
Author: Bronwen Bryant,Kathleen Knights
Publsiher: Elsevier Health Sciences
Total Pages: 1166
Release: 2014-12-19
ISBN 10: 0729581713
ISBN 13: 9780729581714
Language: EN, FR, DE, ES & NL

Pharmacology for Health Professionals ebook Book Review:

Perfect for: Undergraduate Health science, Paramedic science, Nursing, Midwifery, Podiatry and Optometry students. Pharmacology for Health Professionals 4th Edition provides a comprehensive introduction to fundamental pharmacology principles and concepts. The fourth edition has been fully updated and revised to reflect the most up-to-date information on the clinical use of drugs, Australian and New Zealand scheduling, drug legislation and ethics. • Anatomy and physiology integrated throughout • Discipline-specific information integrated throughout and additional resources provided via Evolve • Key drug information at your fingertips: Drug Monographs, Drug Interactions Tables, Clinical Interest Boxes and key terms and abbreviations • End-of-chapter review exercises to test your understanding. • Evolve resources for both lecturer and student. • New and updated Drug Monographs describing important aspects of drugs and drug groups • Updated tables outlining detailed drug interactions occurring with major drug groups • Recent changes in the pharmacological management of major conditions • New Clinical Interest Boxes, including current New Zealand specific and pharmacological treatment of common diseases and conditions • Referencing most up-to-date reviews of drugs and major disease management • Guidelines for clinical choice and use of drugs • Enhanced information on the use of complementary and alternative medicine (CAM) modalities, with a focus on interactions between drugs and CAM therapies • Improved internal design for ease of navigation.

Protein Crystallography

Protein Crystallography
Author: Gwyndaf Evans,Konstantinos Beis
Publsiher: Royal Society of Chemistry
Total Pages: 225
Release: 2018-06-21
ISBN 10: 1782627286
ISBN 13: 9781782627289
Language: EN, FR, DE, ES & NL

Protein Crystallography Book Review:

Protein crystallography has become vital to further understanding the structure and function of many complex biological systems. In recent years, structure determination has progressed tremendously however the quality of crystals and data sets can prevent the best results from being obtained. With contributions from world leading researchers whose software are used worldwide, this book provides a coherent approach on how to handle difficult crystallographic data and how to assess its quality. The chapters will cover all key aspects of protein crystallography, from instrumentation and data processing through to model building. This book also addresses challenges that protein crystallographers will face such as dealing with data from microcrystals and multi protein complexes. This book is ideal for both academics and researchers in industry looking for a comprehensive guide to protein crystallography.

Regulators of G Protein Signaling

Regulators of G Protein Signaling
Author: Anonim
Publsiher: Elsevier
Total Pages: 480
Release: 2004-11-25
ISBN 10: 0080497268
ISBN 13: 9780080497266
Language: EN, FR, DE, ES & NL

Regulators of G Protein Signaling Book Review:

Regulators of G Protein Signaling, Part A is an in-depth treatment of G-Protein Signaling, and will cover general methods of analysis of RGS protein analysis, including Expression and post-translational modification, Assays of GAP activity and allosteric control, Electrophysiological methods and RGS-insensitive Ga subunits, Mouse models of RGS protein action, Methods of RGS protein inhibition, and G-protein regulators of model organisms. Table of Contents Expression and post-translational modification Assays of GAP activity and allosteric control Electrophysiological methods and RGS-insenstitive Ga subunits Mouse Models of RGS protein action Methods of RGS protein inhibition G-protein regulators of model organisms

G Protein Coupled Receptor Dimers

G Protein Coupled Receptor Dimers
Author: Katharine Herrick-Davis,Graeme Milligan,Giuseppe Di Giovanni
Publsiher: Springer
Total Pages: 501
Release: 2017-08-31
ISBN 10: 3319601741
ISBN 13: 9783319601748
Language: EN, FR, DE, ES & NL

G Protein Coupled Receptor Dimers Book Review:

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

G Protein Coupled Receptors

G Protein Coupled Receptors
Author: Anonim
Publsiher: Academic Press
Total Pages: 480
Release: 2013-01-24
ISBN 10: 0123918731
ISBN 13: 9780123918734
Language: EN, FR, DE, ES & NL

G Protein Coupled Receptors Book Review:

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high throughput assays for identification of pharmacoperone drugs. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high-throughput assays for identifying pharmacoperone drugs

Chemical and Synthetic Biology Approaches to Understand Cellular Functions Part C

Chemical and Synthetic Biology Approaches to Understand Cellular Functions   Part C
Author: Anonim
Publsiher: Academic Press
Total Pages: 308
Release: 2020-02-10
ISBN 10: 0128191295
ISBN 13: 9780128191293
Language: EN, FR, DE, ES & NL

Chemical and Synthetic Biology Approaches to Understand Cellular Functions Part C Book Review:

Chemical and Synthetic Biology Approaches to Understand Cellular Functions - Part C, Volume 633, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial. This release includes sections on Next generation probes for molecular imaging in cells, Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein, Converting avidin to bind ligands other than biotin, especially steroids, Chemoenzymatic Labeling Strategy, Engineered Siderophores, Small molecules to inhibit bacterial population behavior, NMR tube bioreactor, Small molecule controlled RAS activation system, Small molecule regulated Cas9, the Design and application of synthetic receptors, and much more. Contains the authority of authors who are leaders in their field Provides a comprehensive source on new methods and research in enzymology

Rang Dale s Pharmacology

Rang   Dale s Pharmacology
Author: Humphrey P. Rang,Maureen M. Dale,James M. Ritter,Rod J. Flower,Graeme Henderson
Publsiher: Elsevier Health Sciences
Total Pages: 792
Release: 2011-04-14
ISBN 10: 0702045047
ISBN 13: 9780702045042
Language: EN, FR, DE, ES & NL

Rang Dale s Pharmacology Book Review:

Rang & Dale’s Pharmacology provides you with all the knowledge you need to get through your pharmacology course and beyond. Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson present a clear and accessible approach to the analysis of therapeutic agents at the cellular and molecular level through detailed diagrams, full-color illustrations, and pedagogical features. Find and cross-reference information quickly using a color-coded layout that makes navigation easy. Effectively understand and review key concepts through detailed diagrams and full-color illustrations that clarify even the most complex concepts. Reinforce your learning with key points boxes and clinical uses boxes that highlight crucial information and clinical applications. Apply current best practices and clinical applications through thoroughly updated and revised drug information. Stay current with the latest developments in the field thanks to major updates in chapters such as How Drugs Act; Amino Acid Transmitters; Analgesic Drugs; Antidepressant Drugs; and Drug Addiction, Dependence & Abuse. Tap into comprehensive content tailored to your courses with new and reorganized chapters on Host Defense; Inflammatory Mediators; Pharmacogenetics, Pharmacogenomics & Personalized Medicine; Hydroxytoptomine & The Pharmacy of Migraine; and Purines.

G Protein Coupled Receptor Screening Assays

G Protein Coupled Receptor Screening Assays
Author: Sofia Aires M. Martins,Duarte Miguel F. Prazeres
Publsiher: Humana
Total Pages: 327
Release: 2021-06-05
ISBN 10: 9781071612200
ISBN 13: 1071612204
Language: EN, FR, DE, ES & NL

G Protein Coupled Receptor Screening Assays Book Review:

This fully updated edition targets not only those assays directly involved in the discovery of GPCR-active compounds but also those involved in cell-based experiments designed to study physiological responses. Whether coming from academia or industry, or being an experienced researcher or a newcomer to the field, the reader will find accessible methods and protocols that cover the latest developments on receptor purification, molecular biology, recombinant engineering, and analytical techniques that enable the real time monitoring of the complex GPCR signaling cascade and identification of potential drug targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, G Protein-Coupled Receptor Screening Assays: Methods and Protocols, Second Edition aims to provide the tools necessary to contribute to the advancement of GPCR research and discovery and ultimately lead to the availability of innovative and more efficient drugs.