Glioblastoma Resistance to Chemotherapy Molecular Mechanisms and Innovative Reversal Strategies

Glioblastoma Resistance to Chemotherapy  Molecular Mechanisms and Innovative Reversal Strategies
Author: Ramasamy Paulmurugan,Tarik F. Massoud
Publsiher: Academic Press
Total Pages: 828
Release: 2021-06-25
ISBN 10: 0128215682
ISBN 13: 9780128215685
Language: EN, FR, DE, ES & NL

Glioblastoma Resistance to Chemotherapy Molecular Mechanisms and Innovative Reversal Strategies Book Review:

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

New Targeting in The Reversal of Resistant Glioblastomas

New Targeting in The Reversal of Resistant Glioblastomas
Author: Ali Syed Arbab
Publsiher: Academic Press
Total Pages: 202
Release: 2021-03-05
ISBN 10: 0128232765
ISBN 13: 9780128232767
Language: EN, FR, DE, ES & NL

New Targeting in The Reversal of Resistant Glioblastomas Book Review:

New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies. This book helps readers rethink treatment strategies to successfully fight glioblastomas. It is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field. Explains the effect of bone marrow derived cells on the development of resistance to clinically practiced therapies Provides information on the availability of alternate therapies for recurrent glioblastoma when standard practices have failed Discusses targeting tumor microenvironment using available FDA approved drugs as an alternative treatment strategy for glioblastoma

Overcoming Drug Resistance in Gynecologic Cancers

Overcoming Drug Resistance in Gynecologic Cancers
Author: Anonim
Publsiher: Academic Press
Total Pages: 388
Release: 2021-08-11
ISBN 10: 0128243007
ISBN 13: 9780128243008
Language: EN, FR, DE, ES & NL

Overcoming Drug Resistance in Gynecologic Cancers Book Review:

Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory and clinic. The book discusses topics such as lifestyle, nutrition and risk of gynecologic cancers, the financial impact of drug resistance, chemosensitizing agents and targeted therapies in cervical, endometrial and ovarian cancer, immunotherapy to overcome drug resistance, and genetic polymorphisms in gynecologic cancers. Additionally, it discusses ethnic and racial health disparity perspectives and future developments in chemosensitizing activities to reverse drug resistance in gynecologic cancers. It is a valuable resource for cancer researchers, oncologists, clinicians and other biomedical field members who are interested in new approaches to improve chemotherapy outcome in patients with gynecologic cancers. Provides a comprehensive resource with all the details needed for readers to understand and follow information Encompasses schematics, diagrams and flow charts in all chapters to help readers easily follow critical information Presents tables and figures especially developed to summarize the information with appropriate statistical rigor and to show details of clinical specimens such as pathological, radiological characteristics, and/or laboratory biomarkers

Epigenetic Regulation in Overcoming Chemoresistance

Epigenetic Regulation in Overcoming Chemoresistance
Author: Chunfu Wu,Lihui Wang
Publsiher: Academic Press
Total Pages: 144
Release: 2021-06-26
ISBN 10: 012823685X
ISBN 13: 9780128236857
Language: EN, FR, DE, ES & NL

Epigenetic Regulation in Overcoming Chemoresistance Book Review:

Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA methyltransferase inhibitors (DNMTi), Histone deacetylases inhibitors (HDACi), Histone lysine demethylases inhibitors (HDMi), Histone lysine methyltransferases inhibitors (HMTi) and drugs regulating the microRNA, long non-coding RNA (lncRNA) or RNA methylation. Finally, recent and future developments of the field of epigenetic regulation are explored. This is a valuable resource for cancer researchers, clinicians, graduate students and several members of biomedical field who are interested in learning about epigenetic regulation methods to reverse chemo-resistance in cancers. Presents detailed diagrams of the mechanisms of epigenetic regulation for easy consult Encompasses multiple clinical trial summary diagrams to help readers quickly and clearly get information from clinical trials Provides future perspectives in each section to inspire readers to use epigenetic regulation to overcome chemo-resistance

Cancer Drug Resistance

Cancer Drug Resistance
Author: Beverly A. Teicher
Publsiher: Springer Science & Business Media
Total Pages: 617
Release: 2007-11-09
ISBN 10: 1597450359
ISBN 13: 9781597450355
Language: EN, FR, DE, ES & NL

Cancer Drug Resistance Book Review:

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Alternative Mechanisms of Multidrug Resistance in Cancer

Alternative Mechanisms of Multidrug Resistance in Cancer
Author: John A. Kellen
Publsiher: Springer Science & Business Media
Total Pages: 281
Release: 2012-12-06
ISBN 10: 1461598524
ISBN 13: 9781461598527
Language: EN, FR, DE, ES & NL

Alternative Mechanisms of Multidrug Resistance in Cancer Book Review:

Nullius in verba. . . Truth will be tested not by words. Horace (Epistles) Few read introductions except for book reviewers, who want to take a shortcut and avoid reading the book itself. However, tradition requires that the preface make public why the book was written at all (this is not supposed to include powerful reasons such as augmenting the ego of the editor and authors). Frequently, the inflationary tendency to publish in verbose length is in conflict with market forces and interest. No doubt, multidrug resistance is a "fashionable" topic, but there are many fashions displayed on the cat-walk of scientific literature. One can rationalize that the forces driving our concern with multi drug resistance reflect the frustration of pharmaceutical companies and oncologists alike: as soon as a new anticancer drug enters clinical trials, cancer cells start eluding extinction with their elaborate and successful mechanisms. Many grants have been awarded and spent, only to confirm the futility of our efforts to defeat this cellular Darwinism. Our medical and scientific training makes it hard, if not impossible, to accept that the survival of a malignant cell, alone or as part of a tissue, is part of the continuance of life. Since exposure to noxious and lethal substances is unavoidable, cells have been forced to develop a multitude of mechanisms to prevent entry or accelerate exit of such materials from intracellular space.

Handbook of Brain Tumor Chemotherapy

Handbook of Brain Tumor Chemotherapy
Author: Herbert B. Newton
Publsiher: Elsevier
Total Pages: 586
Release: 2005-12-19
ISBN 10: 9780080455938
ISBN 13: 008045593X
Language: EN, FR, DE, ES & NL

Handbook of Brain Tumor Chemotherapy Book Review:

Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including “targeted agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease. Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy. Provides the most up to date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics, for the treatment of brain tumors Broadly appeals to anyone interested in the field of Neuro-Oncology and in the treatment of patients with brain tumors Useful to clinicians interested in a thorough overview of the use of chemotherapy in patients with a broad range of brain tumors as well as serving as a source of background information to basic scientists and pharmaceutical researchers with an interest in the molecular therapeutics of brain tumors

Brain Tumors

Brain Tumors
Author: Amit Agrawal,Luis Rafael Moscote-Salazar
Publsiher: BoD – Books on Demand
Total Pages: 248
Release: 2018-08-22
ISBN 10: 1789235561
ISBN 13: 9781789235562
Language: EN, FR, DE, ES & NL

Brain Tumors Book Review:

We all know that the field of neuro-oncology is heterogeneous and under continuous development with the addition of new knowledge and information on a regular basis. The present book "Brain Tumor - An Update" is an attempt to share the personal experiences of experts who are involved in neuro-oncology-related research. Through this book, the authors share their experiences and provide details about the pathophysiology, neuroimaging approaches, and management options, and how to go about decision-making in patients with brain tumors. We hope that the valuable contributions from the authors shall facilitate understanding about brain tumors. I am grateful to all the authors who have contributed their tremendous expertise, and I would like to acknowledge the outstanding support of Ms. Danijela Sakic, Author Service Manager, IntechOpen Science, who collaborated tirelessly in crafting this book.

Topics on Drug Metabolism

Topics on Drug Metabolism
Author: James Paxton
Publsiher: BoD – Books on Demand
Total Pages: 308
Release: 2012-02-22
ISBN 10: 9535100998
ISBN 13: 9789535100997
Language: EN, FR, DE, ES & NL

Topics on Drug Metabolism Book Review:

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging
Author: M. A. Hayat
Publsiher: Academic Press
Total Pages: 430
Release: 2016-12-28
ISBN 10: 0128094273
ISBN 13: 9780128094273
Language: EN, FR, DE, ES & NL

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Book Review:

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

A Clinician s Guide to Integrative Oncology

A Clinician s Guide to Integrative Oncology
Author: Kylie O'Brien,Avni Sali
Publsiher: Springer
Total Pages: 331
Release: 2017-07-24
ISBN 10: 3319566326
ISBN 13: 9783319566320
Language: EN, FR, DE, ES & NL

A Clinician s Guide to Integrative Oncology Book Review:

This book is the definitive guide for oncologists, general medical practitioners and other healthcare professionals with an interest in integrative oncology. Guiding you on how to conduct the “ultimate consultation” from an integrative medicine perspective, this text is a valuable educational tool, presenting the latest evidence-based approaches to managing the cancer patient, as well as anecdotes and practical recommendations from Dr. Sali’s decades of clinical experience as a leading expert in integrative oncology. Topics include the role of mind-body medicine in cancer, stress reduction, diet, sleep, sunshine and Vitamin D, exercise, vitamins and other supplements, supportive complementary medicines including Chinese herbal medicine and acupuncture, and innovative investigative and treatment technologies. Written by two clinicians who are also educators and researchers, A Clinician's Guide to Integrative Oncology provides practical, evidence-based information and patient advice that clinicians can put into practice immediately.

Management of Adult Glioma in Nursing Practice

Management of Adult Glioma in Nursing Practice
Author: Ingela Oberg
Publsiher: Springer
Total Pages: 314
Release: 2019-01-04
ISBN 10: 331976747X
ISBN 13: 9783319767475
Language: EN, FR, DE, ES & NL

Management of Adult Glioma in Nursing Practice Book Review:

This contributed book focuses on the nursing care and considerations for the most common type of malignant brain tumours – gliomas, out of the 150 different types of brain tumours . The reader will gain specialist knowledge in understanding the disease trajectory of malignant gliomas and gain a deeper understanding of the presenting symptoms and varying treatment options of this highly malignant tumour. High grade malignant gliomas impact significantly on prognosis, with an average life expectancy of 18-24 months from diagnosis, given maximum treatment options including surgery, chemotherapy and radiotherapy. This book takes you through all current treatment options with their associated risks and intended benefits. Brain tumours affect not just the patient, but their family and carers too and this important aspect of holistic nursing care is not to be overlooked. This book encompasses first hand experiences of both a brain tumour patient living with a glioma and aspects from a carer. The structure of this book follows a typical patient pathway from presenting signs / symptoms through to MDT (multidisciplinary team) discussions to surgical techniques and radiological investigations, right through to chemotherapy, radiotherapy and palliative care including end of life care. It provides a distinct overview of the holistic needs spectrum encompassing the entire patient journey and equips the reader with learning objectives set at every chapter. Although this book is primarily aimed at Nurses working at ward level within neuro-oncology, this book is also intended to benefit professionals new to the field of specialist nursing – in particular those working with adult brain tumours and neuro-oncology.

Genome Stability

Genome Stability
Author: Igor Kovalchuk,Olga Kovalchuk
Publsiher: Academic Press
Total Pages: 760
Release: 2021-07-17
ISBN 10: 0323856802
ISBN 13: 9780323856805
Language: EN, FR, DE, ES & NL

Genome Stability Book Review:

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Hypoxia and Cancer Metastasis

Hypoxia and Cancer Metastasis
Author: Daniele M. Gilkes
Publsiher: Springer
Total Pages: 160
Release: 2019-06-14
ISBN 10: 3030127346
ISBN 13: 9783030127343
Language: EN, FR, DE, ES & NL

Hypoxia and Cancer Metastasis Book Review:

The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.

Molecular Advances in Diagnosis and Treatment of CNS Tumors

Molecular Advances in Diagnosis and Treatment of CNS Tumors
Author: Liam Chen,Ming-Tseh Lin,Zhaohui Zhang
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-12-09
ISBN 10: 2889661644
ISBN 13: 9782889661640
Language: EN, FR, DE, ES & NL

Molecular Advances in Diagnosis and Treatment of CNS Tumors Book Review:

Advances in DNA Repair

Advances in DNA Repair
Author: Clark Chen
Publsiher: BoD – Books on Demand
Total Pages: 496
Release: 2015-11-18
ISBN 10: 9535122096
ISBN 13: 9789535122098
Language: EN, FR, DE, ES & NL

Advances in DNA Repair Book Review:

This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair.

Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy
Author: Kenneth K.W. To,William C.S. Cho
Publsiher: Academic Press
Total Pages: 458
Release: 2020-07-29
ISBN 10: 0128199032
ISBN 13: 9780128199039
Language: EN, FR, DE, ES & NL

Drug Repurposing in Cancer Therapy Book Review:

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Neuro Oncology of CNS Tumors

Neuro Oncology of CNS Tumors
Author: Jörg-Christian Tonn,Manfred Westphal,J. T. Rutka,S.A. Grossman
Publsiher: Springer Science & Business Media
Total Pages: 706
Release: 2006-01-16
ISBN 10: 3540312609
ISBN 13: 9783540312604
Language: EN, FR, DE, ES & NL

Neuro Oncology of CNS Tumors Book Review:

Diagnosis and treatment modalities for neuro-oncologic diseases have made considerable advances in recent years. There is hardly a segment of the field of solid tumours that is experiencing such dynamic development with regard to basic scientific findings and clinical results. In the present book the world's leading experts have compiled the current practice-relevant knowledge of neuro-oncologic deseases. The book's clear structure and the uniform presentation of all chapters make this volume a valuable reference, especially for practice-oriented activities, allowing swift access to information about current treatment standards. Hence it will be of great value to both clinicians and researchers.

Onco Nephrology E Book

Onco Nephrology E Book
Author: Kevin W. Finkel,Mark Anthony Perazella,Eric P Cohen
Publsiher: Elsevier Health Sciences
Total Pages: 608
Release: 2019-07-02
ISBN 10: 0323549616
ISBN 13: 9780323549615
Language: EN, FR, DE, ES & NL

Onco Nephrology E Book Book Review:

Kidney disease and cancer are frequent comorbidities that require specialized knowledge and expertise from both the nephrologist and the oncologist. Written by three pioneers in this growing subspecialty, Onco-Nephrology provides authoritative, definitive coverage of the mechanism and management of these two life-threatening diseases. This unique, single-volume resource covers current protocols and recommends management therapies to arrest kidney failure and allow oncologic treatments to continue and succeed. Addresses acute and chronic kidney diseases that develop from a variety of cancers. This includes direct kidney injury from the malignancy, paraneoplastic effects of the cancer, and various cancer agents used to treat the malignancy. Discusses key issues regarding kidney disease in patients with cancer, including conventional chemotherapeutic regimens and new novel therapies (targeted agents and immunotherapies) or the malignancies themselves that may promote kidney injury; patients with chronic kidney disease who acquire cancer unrelated to renal failure; and kidney transplantation, which has been shown to carry an increased risk of cancer. Contains dedicated chapters for each class of the conventional chemotherapeutic agents, targeted cancer agents, and cancer immunotherapies including the basic science, pathogenic mechanisms of injury, clinical manifestations, and treatment. Includes special chapters devoted to the individual classes of chemotherapies that relate to kidney disease for quick reference. Discusses increasingly complex problems due to more numerous and specialized anti-cancer drugs, as well as increased survival rates for both cancer and renal failure requiring long-term patient care. Covers anti-VEGF (antivascular endothelial growth factor) agents and cancer immunotherapies – treatments that are being recognized for adverse kidney effects. Utilizes a clear, logical format based on the ASN Core Curriculum for Onco-Nephrology, making this reference an excellent tool for board review, as well as a practical resource in daily practice.

Novel Therapies in Head and Neck Cancer Beyond the Horizon

Novel Therapies in Head and Neck Cancer  Beyond the Horizon
Author: Maie A. St. John,No hee Park
Publsiher: Academic Press
Total Pages: 266
Release: 2020-06-29
ISBN 10: 0128209291
ISBN 13: 9780128209295
Language: EN, FR, DE, ES & NL

Novel Therapies in Head and Neck Cancer Beyond the Horizon Book Review:

Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region