Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 288
Release: 2020-04-08
ISBN 10: 0128178205
ISBN 13: 9780128178201
Language: EN, FR, DE, ES & NL

Genome Plasticity in Health and Disease Book Review:

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

Epigenetics of Lifestyle

Epigenetics of Lifestyle
Author: Marcelina Párrizas,Rosa Gasa,Perla Kaliman
Publsiher: Bentham Science Publishers
Total Pages: 174
Release: 2012-09-07
ISBN 10: 1608052990
ISBN 13: 9781608052998
Language: EN, FR, DE, ES & NL

Epigenetics of Lifestyle Book Review:

Recent advances in the fields of genomics and bioinformatics have made it increasingly clear that genetic sequence alone cannot explain how the genome regulates the development and function of complex multicellular organisms both in health and disease. This inference has led to the expansion of epigenetics as a discipline. Epigenetics refers to the way in which the environment in the wide sense participates in the regulation of gene expression. Several studies show that the well-known beneficial role of a healthy lifestyle over a number of pathologies or as a pre-emptive therapy is at least in part exerted through epigenetic mechanisms, thus giving rise to a new paradigm of preventive medicine based on the concept of genetic plasticity. In Epigenetics of Lifestyle, several contributors provide a comprehensive view of how various facets of lifestyle, including nutrition, exercise, stress, addiction or social interactions, affect chromatin (the combination of DNA and proteins that make up the contents of a cell nucleus) - resulting in profound and long-lasting changes in gene function. In summary, Epigenetics of Lifestyle is a fresh approach towards epigenetics and presents the reader with significant research findings in epigenetics and lifestyle studies. This volume is a simplified source of information for both undergraduate and working professionals interested in lifestyle medicine and life sciences in general.

Explaining Health Across the Sciences

Explaining Health Across the Sciences
Author: Jonathan Sholl,Suresh I.S. Rattan
Publsiher: Springer Nature
Total Pages: 555
Release: 2020-08-28
ISBN 10: 3030526631
ISBN 13: 9783030526634
Language: EN, FR, DE, ES & NL

Explaining Health Across the Sciences Book Review:

This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final part looks at more clinical or practical perspectives. It thereby gathers, across 30 chapters, diverse perspectives from the broad fields of evolutionary and systems biology, immunology, and biogerontology, more specific areas such as odontology, cardiology, neurology, and public health, as well as philosophical reflections on mental health, sexuality, authenticity and medical theories. The overarching aim is to inform, inspire and encourage intellectuals from various disciplines to assess whether explanations in these disparate fields and across biological levels can be sufficiently systematized and unified to clarify the complexity of health. It will be particularly useful for medical graduates, philosophy graduates and research professionals in the life sciences and general medicine, as well as for upper-level graduate philosophy of science students.

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease
Author: Michel Neidhart
Publsiher: Academic Press
Total Pages: 552
Release: 2015-08-11
ISBN 10: 0127999205
ISBN 13: 9780127999203
Language: EN, FR, DE, ES & NL

DNA Methylation and Complex Human Disease Book Review:

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

Goldman Cecil Medicine E Book

Goldman Cecil Medicine E Book
Author: Lee Goldman,Andrew I. Schafer
Publsiher: Elsevier Health Sciences
Total Pages: 2972
Release: 2019-08-16
ISBN 10: 0323550878
ISBN 13: 9780323550871
Language: EN, FR, DE, ES & NL

Goldman Cecil Medicine E Book Book Review:

To be the best doctor you can be, you need the best information. For more than 90 years, what is now called Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature. But Goldman-Cecil Medicine is not just a textbook. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier’s full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information. More than 400 chapters authored by a veritable "Who’s Who" of modern medicine A practical, templated organization with an emphasis on evidence-based references Thousands of algorithms, figures, and tables that make its information readily accessible Supplemented by over 1500 board-style questions and answers to help you prepare for certification and recertification examinations

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry
Author: Anonim
Publsiher: Academic Press
Total Pages: 564
Release: 2020-08-26
ISBN 10: 0128210184
ISBN 13: 9780128210185
Language: EN, FR, DE, ES & NL

Quadruplex Nucleic Acids As Targets For Medicinal Chemistry Book Review:

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series

Tandem Repeat Polymorphisms

Tandem Repeat Polymorphisms
Author: Anthony J. Hannan
Publsiher: Springer Science & Business Media
Total Pages: 208
Release: 2013-07-30
ISBN 10: 1461454344
ISBN 13: 9781461454342
Language: EN, FR, DE, ES & NL

Tandem Repeat Polymorphisms Book Review:

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distributions have the potential to greatly influence functional diversity and disease susceptibility. Recent discoveries in this expanding field are critically reviewed and discussed in a range of subsequent chapters, with a focus on the role of TRPs and their various gene products in evolution, development, diverse molecular and cellular processes, brain function and disease.

Genome Plasticity and Infectious Diseases

Genome Plasticity and Infectious Diseases
Author: Jörg Hacker,Ulrich Dobrindt,Reinhard Kurth
Publsiher: American Society for Microbiology Press
Total Pages: 391
Release: 2012-03-22
ISBN 10: 1555817084
ISBN 13: 9781555817084
Language: EN, FR, DE, ES & NL

Genome Plasticity and Infectious Diseases Book Review:

Comprehensive examination of the current understanding of pathogen adaptation and microevolution. • Introduces the rapidly evolving field of genome plasticity, presents the latest research findings, and explores the relevance of these findings to infection and infection control. • Compiles and analyzes current investigations on the genome fluidity of pathogenic microbes. • Explores bacteria, viruses, fungi, and parasites from the aspect of host genome plasticity and its impact on infection.

Early Life Adversity s Impact on Brain and Body Understanding Disrupted Circuits to Identify Preventive Strategies

Early Life Adversity   s Impact on Brain and Body  Understanding Disrupted Circuits to Identify Preventive Strategies
Author: Andreas Menke,Annamaria Cattaneo,Christiaan H. Vinkers
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-07-01
ISBN 10: 2889669610
ISBN 13: 9782889669615
Language: EN, FR, DE, ES & NL

Early Life Adversity s Impact on Brain and Body Understanding Disrupted Circuits to Identify Preventive Strategies Book Review:

The Plasticity of Sex

The Plasticity of Sex
Author: Marianne J. Legato
Publsiher: Academic Press
Total Pages: 318
Release: 2020-05-19
ISBN 10: 0128159693
ISBN 13: 9780128159699
Language: EN, FR, DE, ES & NL

The Plasticity of Sex Book Review:

The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior provides a comprehensive view on the development of human sexuality. As there has been a crescendo of interest over the past several decades about the nature and diversity of human sexuality, this reference brings the evidence-based research into one place. The emergence of issues surrounding gender identity, genital ambivalence and the transition from one sex to another is striking, with the public and treating physicians alike clamoring for an evidence-based, comprehensive treatment of human sexuality and all its variations. This is a must-have reference for biomedical researchers in endocrinology, neuroscience, development biology, medical students, residents, and practicing physicians from all medical areas. Winner of the 2021 PROSE Award in Biomedicine from the Association of American Publishers! Discusses the role of biology in gender identity from research in genetics, endocrinology and neuroscience Addresses important health disparities and how to address them when treating the transgender patient Reviews evidence-based information on the biological basis and impact of environmental and hormonal factors at different life stages Outlines schema for treating variations in the sexuality and sexual function of the individual patient

Human Retrotransposons in Health and Disease

Human Retrotransposons in Health and Disease
Author: Gael Cristofari
Publsiher: Springer
Total Pages: 330
Release: 2017-01-06
ISBN 10: 3319483447
ISBN 13: 9783319483443
Language: EN, FR, DE, ES & NL

Human Retrotransposons in Health and Disease Book Review:

This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.

Evolution in Health and Disease

Evolution in Health and Disease
Author: Stephen C. Stearns,Jacob C. Koella
Publsiher: Oxford University Press
Total Pages: 374
Release: 2008
ISBN 10: 9780199207459
ISBN 13: 0199207453
Language: EN, FR, DE, ES & NL

Evolution in Health and Disease Book Review:

This work explores and analyses the ways in which our ancient genes contend with, and influence, modern human life. It offers coverage of the points of contact between evolutionary biology and medical science.

Genomic Elements in Health Disease and Evolution

Genomic Elements in Health  Disease and Evolution
Author: Kyriacos Felekkis,Konstantinos Voskarides
Publsiher: Springer
Total Pages: 315
Release: 2015-09-30
ISBN 10: 1493930702
ISBN 13: 9781493930708
Language: EN, FR, DE, ES & NL

Genomic Elements in Health Disease and Evolution Book Review:

Over 98% of the human genome contains non-coding DNA sequences. For many years molecular biologists referred to this component of the genome as the “junk” DNA since it does not code for any “useful” protein product. Over the last years this notion changed significantly as scientists discovered that a large part of this DNA contains various genomic elements that have important roles in cell physiology. Genomic elements such as non-coding RNAs, transposons, splicing RNAs, DNA repeats and others were shown to play a significant role in regulating gene expression. In addition, all these elements were implicated to contribute in the pathogenesis or progression of various human diseases. In this book, the editor will attempt to describe all these genomic elements that constitute the junk DNA of the genome. For every genomic element, the physiologic role in the organism, its role in evolution and any possible involvement in human diseases will be discussed. Additionally, interaction between these elements in normal or pathologic condition will be discussed. Since a large amount of new knowledge is generated daily in regards to these genomic elements, this book will attempt to combine all the information in a single publication that can serve as a reference for future studies. The first part will discuss RNA elements such as microRNAs, long non-coding RNAs, piRNAs and splicing RNAs. The second part of the book will deal with transposons, retrotransposons and DNA transposons. Finally the third part of the book will discuss DNA elements that include DNA repeats, conserved non-coding sequences, distal genomic elements, introns, pseudogenes, CpG islands and telomeres. For miRNAs and CNVs a separate chapter will be dedicated to their role in human diseases since an extensive amount of information exists about these two elements.

The Oxford Handbook of Evolutionary Medicine

The Oxford Handbook of Evolutionary Medicine
Author: Martin Brüne,Wulf Schiefenhövel
Publsiher: Oxford University Press
Total Pages: 992
Release: 2019-01-31
ISBN 10: 0192506781
ISBN 13: 9780192506788
Language: EN, FR, DE, ES & NL

The Oxford Handbook of Evolutionary Medicine Book Review:

Medicine is grounded in the natural sciences, among which biology stands out with regard to the understanding of human physiology and conditions that cause dysfunction. Ironically though, evolutionary biology is a relatively disregarded field. One reason for this omission is that evolution is deemed a slow process. Indeed, macroanatomical features of our species have changed very little in the last 300,000 years. A more detailed look, however, reveals that novel ecological contingencies, partly in relation to cultural evolution, have brought about subtle changes pertaining to metabolism and immunology, including adaptations to dietary innovations, as well as adaptations to the exposure to novel pathogens. Rapid pathogen evolution and evolution of cancer cells cause major problems for the immune system to find adequate responses. In addition, many adaptations to past ecologies have turned into risk factors for somatic disease and psychological disorder in our modern worlds (i.e. mismatch), among which epidemics of autoimmune diseases, cardiovascular diseases, diabetes and obesity, as well as several forms of cancer stand out. In addition, depression, anxiety and other psychiatric conditions add to the list. The Oxford Handbook of Evolutionary Medicine is a compilation of cutting edge insights into the evolutionary history of ourselves as a species, and how and why our evolved design may convey vulnerability to disease. Written in a classic textbook style emphasising physiology and pathophysiology of all major organ systems, the Oxford Handbook of Evolutionary Medicine will be valuable for students as well as scholars in the fields of medicine, biology, anthropology and psychology.

Pan genomics Applications Challenges and Future Prospects

Pan genomics  Applications  Challenges  and Future Prospects
Author: Debmalya Barh,Siomar C. Soares,Sandeep Tiwari,Vasco Azevedo
Publsiher: Academic Press
Total Pages: 474
Release: 2020-03-06
ISBN 10: 0128170778
ISBN 13: 9780128170779
Language: EN, FR, DE, ES & NL

Pan genomics Applications Challenges and Future Prospects Book Review:

Pan-genomics: Applications, Challenges, and Future Prospects covers current approaches, challenges and future prospects of pan-genomics. The book discusses bioinformatics tools and their applications and focuses on bacterial comparative genomics in order to leverage the development of precise drugs and treatments for specific organisms. The book is divided into three sections: the first, an "overview of pan-genomics and common approaches, brings the main concepts and current approaches on pan-genomics research; the second, “case studies in pan-genomics, thoroughly discusses twelve case, and the last, “current approaches and future prospects in pan-multiomics , encompasses the developments on omics studies to be applied on bacteria related studies. This book is a valuable source for bioinformaticians, genomics researchers and several members of biomedical field interested in understanding further bacterial organisms and their relationship to human health. Covers the entire spectrum of pangenomics, highlighting the use of specific approaches, case studies and future perspectives Discusses current bioinformatics tools and strategies for exploiting pangenomics data Presents twelve case studies with different organisms in order to provide the audience with real examples of pangenomics applicability

Developmental Origins of Health and Disease

Developmental Origins of Health and Disease
Author: Peter Gluckman,Mark Hanson
Publsiher: Cambridge University Press
Total Pages: 542
Release: 2006-04-20
ISBN 10: 9780521847438
ISBN 13: 0521847435
Language: EN, FR, DE, ES & NL

Developmental Origins of Health and Disease Book Review:

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Genetics and Evolution of Infectious Diseases

Genetics and Evolution of Infectious Diseases
Author: Michel Tibayrenc
Publsiher: Elsevier
Total Pages: 686
Release: 2017-01-12
ISBN 10: 0128001534
ISBN 13: 9780128001530
Language: EN, FR, DE, ES & NL

Genetics and Evolution of Infectious Diseases Book Review:

Genetics and Evolution of Infectious Diseases, Second Edition, discusses the constantly evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world. Students in public health, biomedical professionals, clinicians, public health practitioners, and decisions-makers will find valuable information in this book that is relevant to the control and prevention of neglected and emerging worldwide diseases that are a major cause of global morbidity, disability, and mortality. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases during the last century, in recent decades the world has witnessed a worldwide human immunodeficiency virus (HIV) pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. The economic, social, and political burden of infectious diseases is most evident in developing countries which must confront the dual burden of death and disability due to infectious and chronic illnesses. Takes an integrated approach to infectious diseases Includes contributions from leading authorities Provides the latest developments in the field of infectious disease

From Molecules to Minds

From Molecules to Minds
Author: Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publsiher: National Academies Press
Total Pages: 90
Release: 2008-11-07
ISBN 10: 9780309178457
ISBN 13: 0309178452
Language: EN, FR, DE, ES & NL

From Molecules to Minds Book Review:

Neuroscience has made phenomenal advances over the past 50 years and the pace of discovery continues to accelerate. On June 25, 2008, the Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders hosted more than 70 of the leading neuroscientists in the world, for a workshop titled "From Molecules to Minds: Challenges for the 21st Century." The objective of the workshop was to explore a set of common goals or "Grand Challenges" posed by participants that could inspire and rally both the scientific community and the public to consider the possibilities for neuroscience in the 21st century. The progress of the past in combination with new tools and techniques, such as neuroimaging and molecular biology, has positioned neuroscience on the cusp of even greater transformational progress in our understanding of the brain and how its inner workings result in mental activity. This workshop summary highlights the important issues and challenges facing the field of neuroscience as presented to those in attendance at the workshop, as well as the subsequent discussion that resulted. As a result, three overarching Grand Challenges emerged: How does the brain work and produce mental activity? How does physical activity in the brain give rise to thought, emotion, and behavior? How does the interplay of biology and experience shape our brains and make us who we are today? How do we keep our brains healthy? How do we protect, restore, or enhance the functioning of our brains as we age?

Environmental Epigenetics

Environmental Epigenetics
Author: L. Joseph Su,Tung-chin Chiang
Publsiher: Springer
Total Pages: 321
Release: 2015-05-18
ISBN 10: 1447166787
ISBN 13: 9781447166788
Language: EN, FR, DE, ES & NL

Environmental Epigenetics Book Review:

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

New Horizons in Health

New Horizons in Health
Author: National Research Council,Division of Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Future Directions for Behavioral and Social Sciences Research at the National Institutes of Health
Publsiher: National Academies Press
Total Pages: 224
Release: 2001-03-09
ISBN 10: 0309072964
ISBN 13: 9780309072960
Language: EN, FR, DE, ES & NL

New Horizons in Health Book Review:

New Horizons in Health discusses how the National Institutes of Health (NIH) can integrate research in the social, behavioral, and biomedical sciences to better understand the causes of disease as well as interventions that promote health. It outlines a set of research priorities for consideration by the Office of Behavioral and Social Sciences Research (OBSSR), with particular attention to research that can support and complement the work of the National Institutes of Health. By addressing the range of interactions among social settings, behavioral patterns, and important health concerns, it highlights areas of scientific opportunity where significant investment is most likely to improve nationalâ€"and globalâ€"health outcomes. These opportunities will apply the knowledge and methods of the behavioral and social sciences to contemporary health needs, and give attention to the chief health concerns of the general public.