Genes Environment and Alzheimer s Disease

Genes  Environment and Alzheimer s Disease
Author: Orly Lazarov,Giuseppina Tesco
Publsiher: Academic Press
Total Pages: 448
Release: 2016-02-25
ISBN 10: 0128028858
ISBN 13: 9780128028858
Language: EN, FR, DE, ES & NL

Genes Environment and Alzheimer s Disease Book Review:

Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Genes Environment and Alzheimer s Disease

Genes  Environment and Alzheimer s Disease
Author: Orly Lazarov
Publsiher: Academic Press
Total Pages: 350
Release: 2016-03-01
ISBN 10: 9780128028513
ISBN 13: 0128028513
Language: EN, FR, DE, ES & NL

Genes Environment and Alzheimer s Disease Book Review:

Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer's disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer's disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer's disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Cognitive Enhancement

Cognitive Enhancement
Author: Shira Knafo,César Venero
Publsiher: Academic Press
Total Pages: 392
Release: 2014-12-20
ISBN 10: 0124171257
ISBN 13: 9780124171251
Language: EN, FR, DE, ES & NL

Cognitive Enhancement Book Review:

Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors addresses the gap that exists in research on the topic, gathering multidisciplinary knowledge and tools that help the reader understand the basics of cognitive enhancement. It also provides assistance in designing procedures and pharmacological approaches to further the use of novel cognitive enhancers, a field that offers potential benefit to a variety of populations, including those with neurologic and psychiatric disorders, mild aging-related cognitive impairment, and those who want to improve intellectual performance. The text builds on our knowledge of the molecular/cellular basis of cognitive function, offering the technological developments that may soon enhance cognition. Separate sections cover enhancement drugs, environmental conditions, and genetic factors in terms of both human and animal studies, including both healthy/young and aging/diseased individuals. Provides a multidisciplinary knowledge, enabling a further understanding of cognitive enhancement Offers coverage of the pharmacologic, environmental, and genetic factors relevant to the topic Discusses cognitive enhancement from the perspective of both healthy and diseased or aging populations Topics are discussed in terms of both human and animal studies

Behavior Genetics of Cognition Across the Lifespan

Behavior Genetics of Cognition Across the Lifespan
Author: Deborah Finkel,Chandra A. Reynolds
Publsiher: Springer Science & Business Media
Total Pages: 300
Release: 2013-07-09
ISBN 10: 1461474477
ISBN 13: 9781461474470
Language: EN, FR, DE, ES & NL

Behavior Genetics of Cognition Across the Lifespan Book Review:

Along with psychopathology, cognition has been one of the primary phenotypic focal points of the field of behavior genetics since its inception. Francis Galton’s 1874 examination of eminent families in Britain was among the earliest attempts to investigate whether cognitive achievements run in families. This volume presents current methodologies for understanding cognitive abilities that move beyond the outdated nature vs. nurture paradigm. Recent advances in both collection and statistical modeling of twin data, particularly longitudinal twin data, make this an especially advantageous moment to produce a work that presents a collection of the groundbreaking research on cognitive abilities across the lifespan. This volume presents an overview of the current state of quantitative and molecular genetic investigations into the many facets of cognitive performance and functioning across the lifespan.​

The Relationship Between Some Genetic and Environmental Factors in the Etiology of Alzheimer s Disease

The Relationship Between Some Genetic and Environmental Factors in the Etiology of Alzheimer s Disease
Author: Susan Janse van Rensburg
Publsiher: Unknown
Total Pages: 324
Release: 1993
ISBN 10: 1928374650XXX
ISBN 13: OCLC:61034725
Language: EN, FR, DE, ES & NL

The Relationship Between Some Genetic and Environmental Factors in the Etiology of Alzheimer s Disease Book Review:

Aging

Aging
Author: Cindy S. Bergeman
Publsiher: SAGE Publications
Total Pages: 159
Release: 1997-04-30
ISBN 10: 1452249857
ISBN 13: 9781452249858
Language: EN, FR, DE, ES & NL

Aging Book Review:

Why do people age differently? Gerontological research has indicated that there are large individual differences in personality, cognitive functioning, physical health, psychological well-being and quality of life in old age. This book explores this variability. Following an overview of family, adoption and twin studies of genetic and environmental influences on ageing, the author examines such topics as: longevity and health research; cognitive functioning, personality and psychopathology; and social support, life events and family environment measures. The book concludes with a summary of finding from gerontological behavioural genetics.

Neurodegeneration From Genetics to Molecules

Neurodegeneration  From Genetics to Molecules
Author: Victoria Campos-Peña,Marco Antonio Meraz-Ríos,Rosalinda Guevara-Guzmán,Karla Guadalupe Carvajal
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2016-11-15
ISBN 10: 2889450201
ISBN 13: 9782889450206
Language: EN, FR, DE, ES & NL

Neurodegeneration From Genetics to Molecules Book Review:

Chronic degenerative diseases are one of the major public health problems, particularly those affecting the nervous system. They are characterized by the degeneration of specific cell populations that include several pathologies which contribute significantly to morbidity and mortality in the elderly population. Therefore, in recent years, the study of neuroscience has gained significant importance. Most of these neurodegenerative disorders are the result of a complex interaction between genetic and environmental factors that generate progression and can even determine its severity. The presence of mutations in genes as LRRK2, SNCA, PARK7, PARK2 or PINK1 is associated with Parkinson's disease. Mutations in genes such as APP, PS1 and PS2 are associated with familial Alzheimer's disease; while HTT gene mutations are the cause of Huntington's disease. In most cases, this condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. It is known that these mutations can also alter the proteins function; however, it has not yet been possible to fully understand how some genetic changes cause the disease or influence the risk of developing these disorders. Most symptoms seen in these conditions occurs when specific nerve cells are damaged or die generating a loss in brain communication. Also many of these mutations generate aggregation of intracellular or extracellular proteins affecting cell function and eventually causing neuronal death. It is unclear whether the presence of these aggregates play an important role in nerve cell death during the development of neurodegenerative diseases, or if they are simply part of the response of cells to the disease. Other mutations affect the mitochondrial function generating alterations in energy production and promoting the formation of unstable molecules such as free radicals. Under normal conditions, the harmful effects caused by free radicals, are offset within the cell. However, in pathological conditions, the presence of mutations can alter this process by allowing the accumulation of radicals and damaging or killing cells. On the other hand, we also know that these diseases may not have a direct genetic component, thus, the study of sporadic type neurodegenerative diseases is much more complex. Histopathological lesions as well as the cellular and molecular alterations are generally indistinguishable from familial cases. For this reason, it is important to understand the genetic and molecular mechanisms associated with this type of pathologies. In this sense, this issue aims to understand the molecular processes that occur in the brain, and how these are influenced by the environment, genetics and behavior.

Challenging Genetic Determinism

Challenging Genetic Determinism
Author: Louis Maheu,Roderick A. Macdonald
Publsiher: McGill-Queen's Press - MQUP
Total Pages: 319
Release: 2011-08-23
ISBN 10: 0773537805
ISBN 13: 9780773537804
Language: EN, FR, DE, ES & NL

Challenging Genetic Determinism Book Review:

Compelling essays on understanding the interplay of genes in society.

Review of Selected Genetic and Environmental Risk Factors for Alzheimer Disease

Review of Selected Genetic and Environmental Risk Factors for Alzheimer Disease
Author: Marc W. Gordon
Publsiher: Unknown
Total Pages: 96
Release: 2000
ISBN 10: 1928374650XXX
ISBN 13: OCLC:48854831
Language: EN, FR, DE, ES & NL

Review of Selected Genetic and Environmental Risk Factors for Alzheimer Disease Book Review:

Alzheimer s Disease

Alzheimer s Disease
Author: Caroline McNeil
Publsiher: DIANE Publishing
Total Pages: 60
Release: 1997
ISBN 10: 9780788137938
ISBN 13: 078813793X
Language: EN, FR, DE, ES & NL

Alzheimer s Disease Book Review:

This report was written for people who are interested in research on Alzheimer's disease. Briefly covers the following areas of research: neurotransmitters, the proteins, the genes, environmental suspects, the calcium hypothesis, metabolism, cognitive markers, biological markers, caregiving, managing symptoms, potential biomedical treatments, and much more. Technical terms are defined in the glossary. Each chapter ends with a list of review articles and other materials that provide more detail on other studies mentioned in the text. Illustrated.

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease
Author: J. Robin Harris
Publsiher: Springer Science & Business Media
Total Pages: 650
Release: 2012-12-09
ISBN 10: 9400754167
ISBN 13: 9789400754164
Language: EN, FR, DE, ES & NL

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease Book Review:

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.

Understanding Racial and Ethnic Differences in Health in Late Life

Understanding Racial and Ethnic Differences in Health in Late Life
Author: National Research Council,Division of Behavioral and Social Sciences and Education,Committee on Population,Panel on Race, Ethnicity, and Health in Later Life
Publsiher: National Academies Press
Total Pages: 184
Release: 2004-09-08
ISBN 10: 9780309165860
ISBN 13: 0309165865
Language: EN, FR, DE, ES & NL

Understanding Racial and Ethnic Differences in Health in Late Life Book Review:

As the population of older Americans grows, it is becoming more racially and ethnically diverse. Differences in health by racial and ethnic status could be increasingly consequential for health policy and programs. Such differences are are not simply a matter of education or ability to pay for health care. For instance, Asian Americans and Hispanics appear to be in better health, on a number of indicators, than White Americans, despite, on average, lower socioeconomic status. The reasons are complex, including possible roles for such factors as selective migration, risk behaviors, exposure to various stressors, patient attitudes, and geographic variation in health care. This volume, produced by a multidisciplinary panel, considers such possible explanations for racial and ethnic health differentials within an integrated framework. It provides a concise summary of available research and lays out a research agenda to address the many uncertainties in current knowledge. It recommends, for instance, looking at health differentials across the life course and deciphering the links between factors presumably producing differentials and biopsychosocial mechanisms that lead to impaired health.

Alzheimer s Disease

Alzheimer s Disease
Author: Inga Zerr
Publsiher: BoD – Books on Demand
Total Pages: 372
Release: 2015-07-01
ISBN 10: 9535121375
ISBN 13: 9789535121374
Language: EN, FR, DE, ES & NL

Alzheimer s Disease Book Review:

There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.

Environmental Factors in Neurodegenerative Diseases

Environmental Factors in Neurodegenerative Diseases
Author: Anonim
Publsiher: Academic Press
Total Pages: 290
Release: 2017-09-19
ISBN 10: 0128127651
ISBN 13: 9780128127650
Language: EN, FR, DE, ES & NL

Environmental Factors in Neurodegenerative Diseases Book Review:

Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson’s disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government

Genetic and Environmental Factors Affecting Alzheimer s Disease Pathogenic Mechanism

Genetic and Environmental Factors Affecting Alzheimer s Disease Pathogenic Mechanism
Author: Letizia Polito
Publsiher: Unknown
Total Pages: 135
Release: 2012
ISBN 10: 1928374650XXX
ISBN 13: OCLC:806196055
Language: EN, FR, DE, ES & NL

Genetic and Environmental Factors Affecting Alzheimer s Disease Pathogenic Mechanism Book Review:

Alzheimer's disease (AD) is the leading cause of senile dementia and the current lack of effective treatments provides a strong incentive for an improved therapeutic strategy. In particular, non-pharmacological treatments, such as calorie restriction (CR), were shown to be useful in delaying or preventing AD onset. This has given insight into the molecular pathways involved. Sirtuins (SIRTl-7) are evolutionary conserved enzymes that modulate life expectancy in simple organisms. In mammals, sirtuins are involved in pathways linked to age-related -.- - diseases, such as AD. In particular, they seem to be the molecular effectors of some beneficial effects mediated by external stimuli such as CR and physical activity. This thesis aims at investigating, for the first time, the involvement of all 7 sirtuins in AD. The relevance of sirtuin gene variation to AD risk was assessed by a combined mutation screening and case-control genetic study design. Sirtuin expression levels were also assessed in a transgenic mouse model of AD (APP23 mice) and within the application of a non-pharmacological approach (environmental enrichment-EE). Finally, the possible role of SIRTl in AD pathogenesis was better elucidated through in vitro studies. Overall, in vitro studies confirmed the neuroprotective role of SIRTl activator resveratrol in etiopathological contexts related to AD. Moreover, genetic studies have highlighted SIRT2 could be involved in modulating AD etiology. In particular, a common polymorphism in SIRT2 could be a weak genetic risk factor for AD. Finally, in vivo studies confirmed the beneficial effects of an EE protocol in delaying AD onset. However, despite sirtuin involvement in other environmental paradigms, no apparent modulation was registered under EE.

Principles of Psychiatric Genetics

Principles of Psychiatric Genetics
Author: John I. Nurnberger, Jr,Wade Berrettini
Publsiher: Cambridge University Press
Total Pages: 402
Release: 2012-09-13
ISBN 10: 0521896495
ISBN 13: 9780521896498
Language: EN, FR, DE, ES & NL

Principles of Psychiatric Genetics Book Review:

A comprehensive, up-to-date resource providing information about genetic influences on disorders of behavior.

Gene Environment Transactions in Developmental Psychopathology

Gene Environment Transactions in Developmental Psychopathology
Author: Patrick H. Tolan,Bennett L. Leventhal
Publsiher: Springer
Total Pages: 301
Release: 2017-04-29
ISBN 10: 3319492276
ISBN 13: 9783319492278
Language: EN, FR, DE, ES & NL

Gene Environment Transactions in Developmental Psychopathology Book Review:

This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.

Genetics and Mental Illness

Genetics and Mental Illness
Author: L.L. Hall
Publsiher: Springer Science & Business Media
Total Pages: 226
Release: 2013-06-29
ISBN 10: 1489901701
ISBN 13: 9781489901705
Language: EN, FR, DE, ES & NL

Genetics and Mental Illness Book Review:

''Refreshing and informative....describe[s] the new complex research tools, directions and interpretations in a lucid and understandable fashion.'' --- Lancet, North American edition ''Beautifully crafted...The most significant contribution of this book involves its integration of areas that are not typically considered in genetic overviews.'' --- American Scientist, 1998 ''This book does an extraordinary job of making sense out of the many complex and controversial issues surrounding psychiatric genetics...It is worth the price.'' --- Journal of Genetic Counseling, Vol. 6, No. 3, 1997 This collection of essays clearly examines the complex nature of mental illness, focusing on the theory and state of the art of psychiatric genetics. This insightful volume is the first to present the diverse viewpoints of investigators, policy analysts, and psychiatric patients. Contributors explore the roles of genes in mental illness and describe various clinical, ethical, and social implications of psychiatric genetics. Additional discussions include trends in psychiatric genetic research, nature versus nurture in behavioral genetics, basic statistical principles of linkage analysis, and the many social domains relevant to psychiatric genetics.

Neurology in Clinical Practice

Neurology in Clinical Practice
Author: Walter George Bradley
Publsiher: Unknown
Total Pages: 2545
Release: 2004
ISBN 10: 9780750674690
ISBN 13: 0750674695
Language: EN, FR, DE, ES & NL

Neurology in Clinical Practice Book Review:

New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Uday Kishore
Publsiher: BoD – Books on Demand
Total Pages: 640
Release: 2013-05-15
ISBN 10: 9535110888
ISBN 13: 9789535110880
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Review:

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.