Gene Environment Interactions

Gene Environment Interactions
Author: Moyra Smith
Publsiher: Academic Press
Total Pages: 424
Release: 2020-01-24
ISBN 10: 0128196130
ISBN 13: 9780128196137
Language: EN, FR, DE, ES & NL

Gene Environment Interactions Book Review:

Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population. Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies Illuminates environmental factors affecting disease-gene etiology and treatment Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine

Gene Environment Interactions in Psychiatry

Gene Environment Interactions in Psychiatry
Author: Bart Ellenbroek,Ji Un Youn
Publsiher: Academic Press
Total Pages: 366
Release: 2016-07-26
ISBN 10: 012801783X
ISBN 13: 9780128017838
Language: EN, FR, DE, ES & NL

Gene Environment Interactions in Psychiatry Book Review:

Gene-Environment Interactions in Psychiatry: Nature, Nurture, Neuroscience begins with the basic aspects of gene–environment studies, such as basic genetics, principles of animals modeling, and the basic processes of how environmental factors affect brain and behavior, with part two describing the most important psychiatric disorders in detail. Each chapter has a similar structure that includes a general description of the disorder that is followed by an analysis of the role of genes and how they are affected by environmental factors. Each chapter ends with a description of the most relevant animal models, again focusing on gene–environment interactions. The book concludes with a critical evaluation of the current research and an outlook for the (possible) future, offering a vignette into the fascinating world of nature, nurture, and neuroscience. Written to provide in-depth basic knowledge on gene–environment interactions for graduate students, postgraduate students, clinicians, and scientists Includes descriptions of the major psychiatric disorders Provides detailed descriptions of animal models and basic genetic information Presents well-illustrated color figures to explain complex features in a simple manner

Gene Environment Interaction Analysis

Gene Environment Interaction Analysis
Author: Sumiko Anno
Publsiher: CRC Press
Total Pages: 212
Release: 2016-03-30
ISBN 10: 9814669644
ISBN 13: 9789814669641
Language: EN, FR, DE, ES & NL

Gene Environment Interaction Analysis Book Review:

Gene–environment (G × E) interaction analysis is a statistical method for clarifying G × E interactions applicable to a phenotype or a disease that is the result of interactions between genes and the environment. This book is the first to deal with the theme of G × E interaction analysis. It compiles and details cutting-edge research in bioinformatics and computational biology and will appeal to anyone involved in bioinformatics and computational biology.

Gene Environment Interactions

Gene Environment Interactions
Author: Lucio G. Costa,David L. Eaton
Publsiher: John Wiley & Sons
Total Pages: 576
Release: 2005-12-16
ISBN 10: 0471758035
ISBN 13: 9780471758037
Language: EN, FR, DE, ES & NL

Gene Environment Interactions Book Review:

Understanding the play between heredity and environment, andrelating it to disease causation, is the task of ecogenetics.Gene-Environment Interactions: Fundamentals of Ecogenetics presentsthe first comprehensive survey of this discipline, reflecting itsrelationship with toxicology, epidemiology, pharmacology, publichealth, and other medical and biological fields. Divided into four sections, the text elucidates key basic andadvanced topics: * Section 1 covers fundamentals, including the history of thediscipline, a discussion of the molecular laboratory toolscurrently available to assess genotypes, using such measurements inmolecular epidemiology studies, and the statistical issues involvedin their analysis. * Section 2 focuses on a number of key genetic polymorphismsrelevant for ecogenetics, including enzymes of phase I and phase IImetabolism, enzymes involved in DNA repair, as well as receptorsand ion channels. This highlights characteristics of selected,widely studied genotypic/phenotypic differences, and allowsdiscussion of how given genetic variations can influence responsesto exogenous chemicals. * Section 3 examines gene-environment interactions through adisease-based approach, addressing how genetic polymorphisms caninfluence susceptibility to various diseases. Chapters coverimportant disease conditions such as various types of cancer,neurodegenerative diseases, cardiovascular disease, chronicpulmonary diseases, infectious diseases, diabetes, andobesity. * The final section discusses the ethical, legal, and social issuesthat arise when investigating and evaluating genetic polymorphismsin human populations, as well as the impact of ecogenetics on riskassessment, regulatory policies, and medicine and publichealth. Packed with clear examples illustrating concepts, as well asnumerous tables and figures, Gene-Environment Interactions:Fundamentals of Ecogenetics is a unique resource for a wide rangeof physicians, students, and other specialists.

Environmental Epigenetics

Environmental Epigenetics
Author: L. Joseph Su,Tung-chin Chiang
Publsiher: Springer
Total Pages: 321
Release: 2015-05-18
ISBN 10: 1447166787
ISBN 13: 9781447166788
Language: EN, FR, DE, ES & NL

Environmental Epigenetics Book Review:

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Gene Environment Interactions in Developmental Psychopathology

Gene Environment Interactions in Developmental Psychopathology
Author: Kenneth A. Dodge,Michael Rutter
Publsiher: Guilford Press
Total Pages: 305
Release: 2011-09-01
ISBN 10: 1609181905
ISBN 13: 9781609181901
Language: EN, FR, DE, ES & NL

Gene Environment Interactions in Developmental Psychopathology Book Review:

Bringing together foremost experts, this book reviews groundbreaking gene–environment research and explores implications for clinical practice, prevention, and public policy. Presented is cutting-edge work on the interplay of genetic factors and childhood experiences in the development of mental disorders such as depression, conduct disorder, and schizophrenia. Essential topics include what scientists currently know about "susceptibility genes"; the mechanisms by which maltreatment and other stressors interact with biological susceptibilities across development; and factors that make certain children more resilient than others. Future directions for personalizing treatment and prevention efforts, thus making them more effective, are discussed.

Beyond Our Genes

Beyond Our Genes
Author: Raffaele Teperino
Publsiher: Springer Nature
Total Pages: 266
Release: 2020-01-24
ISBN 10: 3030352137
ISBN 13: 9783030352134
Language: EN, FR, DE, ES & NL

Beyond Our Genes Book Review:

The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.

Genes Behavior and the Social Environment

Genes  Behavior  and the Social Environment
Author: Institute of Medicine,Board on Health Sciences Policy,Committee on Assessing Interactions Among Social, Behavioral, and Genetic Factors in Health
Publsiher: National Academies Press
Total Pages: 384
Release: 2006-12-07
ISBN 10: 0309101964
ISBN 13: 9780309101967
Language: EN, FR, DE, ES & NL

Genes Behavior and the Social Environment Book Review:

Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.

Cancer and the Environment

Cancer and the Environment
Author: Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine
Publsiher: National Academies Press
Total Pages: 161
Release: 2002-09-01
ISBN 10: 030908475X
ISBN 13: 9780309084758
Language: EN, FR, DE, ES & NL

Cancer and the Environment Book Review:

The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Handbook of Statistical Methods for Case Control Studies

Handbook of Statistical Methods for Case Control Studies
Author: Ørnulf Borgan,Norman Breslow,Nilanjan Chatterjee,Mitchell H. Gail,Alastair Scott,Chris J. Wild
Publsiher: CRC Press
Total Pages: 536
Release: 2018-06-27
ISBN 10: 1351650122
ISBN 13: 9781351650120
Language: EN, FR, DE, ES & NL

Handbook of Statistical Methods for Case Control Studies Book Review:

Handbook of Statistical Methods for Case-Control Studies is written by leading researchers in the field. It provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, as well as a review of classical principles and methods. The handbook is designed to serve as a reference text for biostatisticians and quantitatively-oriented epidemiologists who are working on the design and analysis of case-control studies or on related statistical methods research. Though not specifically intended as a textbook, it may also be used as a backup reference text for graduate level courses. Book Sections Classical designs and causal inference, measurement error, power, and small-sample inference Designs that use full-cohort information Time-to-event data Genetic epidemiology About the Editors Ørnulf Borgan is Professor of Statistics, University of Oslo. His book with Andersen, Gill and Keiding on counting processes in survival analysis is a world classic. Norman E. Breslow was, at the time of his death, Professor Emeritus in Biostatistics, University of Washington. For decades, his book with Nick Day has been the authoritative text on case-control methodology. Nilanjan Chatterjee is Bloomberg Distinguished Professor, Johns Hopkins University. He leads a broad research program in statistical methods for modern large scale biomedical studies. Mitchell H. Gail is a Senior Investigator at the National Cancer Institute. His research includes modeling absolute risk of disease, intervention trials, and statistical methods for epidemiology. Alastair Scott was, at the time of his death, Professor Emeritus of Statistics, University of Auckland. He was a major contributor to using survey sampling methods for analyzing case-control data. Chris J. Wild is Professor of Statistics, University of Auckland. His research includes nonlinear regression and methods for fitting models to response-selective data.

Epigenomics in Health and Disease

Epigenomics in Health and Disease
Author: Mario Fraga,Agustin Fernandez Fernandez
Publsiher: Academic Press
Total Pages: 328
Release: 2015-10-12
ISBN 10: 0128004967
ISBN 13: 9780128004968
Language: EN, FR, DE, ES & NL

Epigenomics in Health and Disease Book Review:

Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics. Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysis Includes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging

Gene Environment Transactions in Developmental Psychopathology

Gene Environment Transactions in Developmental Psychopathology
Author: Patrick H. Tolan,Bennett L. Leventhal
Publsiher: Springer
Total Pages: 301
Release: 2017-04-29
ISBN 10: 3319492276
ISBN 13: 9783319492278
Language: EN, FR, DE, ES & NL

Gene Environment Transactions in Developmental Psychopathology Book Review:

This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.

The Wiley Encyclopedia of Personality and Individual Differences Personality Processes and Individuals Differences

The Wiley Encyclopedia of Personality and Individual Differences  Personality Processes and Individuals Differences
Author: Annamaria Di Fabio,Donald H. Saklofske,Con Stough
Publsiher: John Wiley & Sons
Total Pages: 592
Release: 2020-11-03
ISBN 10: 1119795257
ISBN 13: 9781119795254
Language: EN, FR, DE, ES & NL

The Wiley Encyclopedia of Personality and Individual Differences Personality Processes and Individuals Differences Book Review:

Volume 3, Personality Processes and Individuals Differences of The Wiley Encyclopedia of Personality and Individual Differences The Encyclopedia of Personality and Individual Differences (EPID) is organized into four volumes that look at the many likenesses and differences between individuals. Each of these four volumes focuses on a major content area in the study of personality psychology and individuals' differences. The first volume, Models and Theories, surveys the significant classic and contemporary viewpoints, perspectives, models, and theoretical approaches to the study of personality and individuals' differences (PID). The second volume on Measurement and Assessment examines key classic and modern methods and techniques of assessment in the study of PID. Volume III, titled Personality Processes and Individuals Differences, covers the important traditional and current dimensions, constructs, and traits in the study of PID. The final volume discusses three major categories: clinical contributions, applied research, and cross-cultural considerations, and touches on topics such as culture and identity, multicultural identities, cross-cultural examinations of trait structures and personality processes, and more. Each volume contains approximately 100 entries on personality and individual differences written by a diverse international panel of leading psychologists Covers significant classic and contemporary personality psychology models and theories, measurement and assessment techniques, personality processes and individuals differences, and research Provides a comprehensive and in-depth overview of the field of personality psychology The Encyclopedia of Personality and Individual Differences is an important resource for all psychology students and professionals engaging in the study and research of personality.

Nature and Nurture

Nature and Nurture
Author: Cynthia Garcia Coll,Elaine L. Bearer,Richard M. Lerner
Publsiher: Psychology Press
Total Pages: 280
Release: 2014-04-04
ISBN 10: 1135628971
ISBN 13: 9781135628970
Language: EN, FR, DE, ES & NL

Nature and Nurture Book Review:

What does it mean to find a gene or set of genes that are associated with ADHD, schizophrenia, or autism? Could we eradicate such diseases from our species through gene therapy? Is it possible to eradicate from our genome the genetic material that predisposes us to be too aggressive, too shy, less intelligent, or not active enough? Who has the political power and/or moral authority to make these decisions? The premise of Nature and Nurture is that the complexity of the transactions between nature and nurture--between genes and the environment from the cellular to the cultural level--make these questions incredibly complex and in need of careful attention by educators, scientists, the public, and policymakers. A product of the conference held at Brown University in 2001, this book suggests that genes and environments work together interactively in a complex and closely intertwined fashion. The contributors to this book--biologists, psychologists, psychiatrists, and economists--present knowledge that enables research and application to transcend the traditional question of whatever variance or significance is attributed to genetics versus environment in the development of a particular behavioral trait. This book presents a variety of views on the current status of knowledge about the ways in which dynamic, developmental, mutually interactive systems in the genetic and environmental domains operate. The chapters represent contributions from different perspectives.

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide
Author: Yogesh Dwivedi
Publsiher: CRC Press
Total Pages: 482
Release: 2012-06-25
ISBN 10: 143983881X
ISBN 13: 9781439838815
Language: EN, FR, DE, ES & NL

The Neurobiological Basis of Suicide Book Review:

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

The Science of Expertise

The Science of Expertise
Author: David Z. Hambrick,Guillermo Campitelli,Brooke N. Macnamara
Publsiher: Routledge
Total Pages: 468
Release: 2017-09-22
ISBN 10: 1351624830
ISBN 13: 9781351624831
Language: EN, FR, DE, ES & NL

The Science of Expertise Book Review:

Offering the broadest review of psychological perspectives on human expertise to date, this volume covers behavioral, computational, neural, and genetic approaches to understanding complex skill. The chapters show how performance in music, the arts, sports, games, medicine, and other domains reflects basic traits such as personality and intelligence, as well as knowledge and skills acquired through training. In doing so, this book moves the field of expertise beyond the duality of "nature vs. nurture" toward an integrative understanding of complex skill. This book is an invaluable resource for researchers and students interested in expertise, and for professionals seeking current reviews of psychological research on expertise.

Genetic Effects on Environmental Vulnerability to Disease

Genetic Effects on Environmental Vulnerability to Disease
Author: Sir Michael J. Rutter
Publsiher: Wiley
Total Pages: 232
Release: 2008-10-20
ISBN 10: 9780470777800
ISBN 13: 047077780X
Language: EN, FR, DE, ES & NL

Genetic Effects on Environmental Vulnerability to Disease Book Review:

Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss: How epidemiological cohort studies can better integrate physiological (mechanistic) measures; How best to characterise subjects’ vulnerability versus resilience by moving beyond single genetic polymorphisms; How gene hunters can benefit from recruiting samples selected for known exposures; How environmental pathogens can be used as tools for gene hunting; How to deal with potential spurious (statistical) interactions, and How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).

Gene environment Interactions in Genetic Epidemiology

Gene environment Interactions in Genetic Epidemiology
Author: Christine Marie Spinka
Publsiher: Unknown
Total Pages: 135
Release: 2005
ISBN 10: 1928374650XXX
ISBN 13: OCLC:59132642
Language: EN, FR, DE, ES & NL

Gene environment Interactions in Genetic Epidemiology Book Review:

Gene-environment interactions are an area of increasing interest in complex human diseases. The first step in any study of the interactions between genes and the environment involves identifying genes which influence the trait of interest. In this dissertation, a new method for using the information in complex pedigrees to perform a joint linkage disequilibrium and linkage mapping of quantitative trait loci is developed. Subsequently, methods are needed to determine the interaction, if any, between these genes and environmental risk factors. Many of these factors, such as weight or age, are continuous and little is known about their distributions. Thus, we introduce a new method for estimating the gene-environment interaction parameters in a logistic regression for the case-control study design. In doing so, we make the assumption that in the underlying population, the distributions of the genetic factors and the environmental covariates are independent. Additionally, we treat the environmental parameters nonparametricly, utilizing the profile likelihood. Furthermore, the methodology we develop is also general enough to be used on many different types of genetic information, including haplotypes, and can accommodate missing genotype data. The method is also extended to allow analysis in the presence of population stratification or genotype misclassification. We show that the standard errors of parameter estimates using our method are smaller than those found using complete data only. These methods are illustrated using simulations and are applied to a real data set exploring the interaction between genotype and environment in disease risk.

Genotype X Environment Interactions

Genotype X Environment Interactions
Author: Paolo Annicchiarico
Publsiher: Food & Agriculture Org.
Total Pages: 136
Release: 2002
ISBN 10: 9789251048702
ISBN 13: 9251048703
Language: EN, FR, DE, ES & NL

Genotype X Environment Interactions Book Review:

The projected increase in world population levels and the subsequent rise in food demand represents a huge challenge for agricultural production systems worldwide. This publication examines the opportunities and challenges raised by the use of plant genetic resources and highlights the contribution that data from multi-environment yield trials can provide for the definition of adaptation strategies and yield stability targets in plant breeding programmes. It contains a case study about a durum wheat crop programme in Algeria, and also includes a CD-ROM with data from IRRISTAT, a programme developed by the International Rice Research Institute (IRRI).

The Routledge Handbook of Social Work and Addictive Behaviors

The Routledge Handbook of Social Work and Addictive Behaviors
Author: Audrey L. Begun,Margaret M. Murray
Publsiher: Routledge
Total Pages: 644
Release: 2020-04-16
ISBN 10: 0429515138
ISBN 13: 9780429515132
Language: EN, FR, DE, ES & NL

The Routledge Handbook of Social Work and Addictive Behaviors Book Review:

The Routledge Handbook of Social Work and Addictive Behaviors is a definitive resource about addictive behaviors, emphasizing substance misuse, gambling, and problematic technology use. Contents address their prevalence in various communities and populations globally, theories related to their origins and etiology, and what is currently known about effective intervention strategies, education, and research. Social work’s biopsychosocial, lifespan, and person-in-environment perspectives underpin the book contents which are applicable to a wide range of professional and social science disciplines. Contents are divided into five sections: The scope and nature of addictive behavior and related problems Addictive behavior across the lifespan and specific populations Interventions to prevent and address addictive behavior and related problems Issues frequently co-occurring with addictive behavior Moving forward This handbook provides students, practitioners, and scholars with a strong focus on cutting-edge high-quality research. With contributions from a global interdisciplinary team of leading scholars, this handbook is relevant to readers from social work, public health, psychology, education, sociology, criminal justice, medicine, nursing, human services, and health professions.