Gap Junctions in the Brain

Gap Junctions in the Brain
Author: Ekrem Dere
Publsiher: Academic Press
Total Pages: 304
Release: 2012-12-12
ISBN 10: 0124159273
ISBN 13: 9780124159273
Language: EN, FR, DE, ES & NL

Gap Junctions in the Brain Book Review:

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants. Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants

Gap Junctions in the Brain

Gap Junctions in the Brain
Author: Ekrem Dere
Publsiher: Academic Press
Total Pages: 290
Release: 2012
ISBN 10: 012415901X
ISBN 13: 9780124159013
Language: EN, FR, DE, ES & NL

Gap Junctions in the Brain Book Review:

Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions associated with mutations in single gap junction connexion genes, making it applicable to clinicians doing translational research. Finally, it includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants. Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants

Gap Junctions in the Nervous System

Gap Junctions in the Nervous System
Author: David C. Spray,Rolf Dermietzel
Publsiher: Springer
Total Pages: 317
Release: 2013-11-13
ISBN 10: 9783662219379
ISBN 13: 3662219379
Language: EN, FR, DE, ES & NL

Gap Junctions in the Nervous System Book Review:

A Cytoplasm Connexon or Hemichannel Cytoplasm external loop I - P. M. N-Termlnus Fig. 1. 1. Topology of gap junction channels. (A) Cap junction channels, extending from the cytoplasm of one cell to the cytoplasm of another, are formed by two connexons or hemichannels connected across extracellular space. (B) Each connexon is formed from six connexin subunits, each having four membrane-spanning domains and both amino and carboxyl termini within the cytoplasm. External/oops (I and II} are believed to provide the high affinity interactions between the hemichannels. 4 Gap }unctions in the Nervous System P-region of voltage sensitive nonjunctional molecules; these contributed disulfide 9 channels. And Delmar's group has ob bridges are presumably involved in intra tained evidence that intracellular acidifi connexin and inter-EL loop tertiary struc cation may result in a conformational ture. An old observation that should be change analogous to the ball and chain repeated stoichiometrically with modern techniques is that gap junction channels model of inactivation of voltage gated ionic can be split into connexons or hemi channels, whereby the carboxyl terminal channels using hyperosmotic disaccharide portion of connexin43 binds to CL, closing 23 solutions again implying that linkage is the channel. Higher order structure of the channel not covalent. is believed to consist of six connexins form ing the hemichannel or connexon in a 3.

Gap Junctions in the Nervous System

Gap Junctions in the Nervous System
Author: David C. Spray,Rolf Dermietzel
Publsiher: Springer Science & Business Media
Total Pages: 317
Release: 2013-06-29
ISBN 10: 3662219352
ISBN 13: 9783662219355
Language: EN, FR, DE, ES & NL

Gap Junctions in the Nervous System Book Review:

This book deals with the types of gap junction proteins (connexins) and their distribution within the nervous system, the physiological properties of channels formed of each connexin, and the role of gap junction channels in functions of normal and pathological brain and peripheral nerve. Although glial tissue is emphasized, additional groups of chapters deal with neurons in the central nervous system and with the retina.

Gap Junctions in the Nervous System

Gap Junctions in the Nervous System
Author: David C. Spray,Rolf Dermietzel
Publsiher: Oxford University Press
Total Pages: 344
Release: 1996
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015038171727
Language: EN, FR, DE, ES & NL

Gap Junctions in the Nervous System Book Review:

Gap Junctions in the Brain

Gap Junctions in the Brain
Author: Colin R. Green
Publsiher: Unknown
Total Pages: 159
Release: 1998
ISBN 10: 1928374650XXX
ISBN 13: OCLC:313546633
Language: EN, FR, DE, ES & NL

Gap Junctions in the Brain Book Review:

Connexins The Gap Junction Proteins

Connexins  The Gap Junction Proteins
Author: Dr. Mahboob Ul Hussain
Publsiher: Springer
Total Pages: 93
Release: 2014-08-06
ISBN 10: 8132219198
ISBN 13: 9788132219194
Language: EN, FR, DE, ES & NL

Connexins The Gap Junction Proteins Book Review:

Gap-junction proteins, connexins are important cellular entities that regulate various facets of cellular physiology. The connexins constitute large family of proteins. The present book provides basic overview about various aspects of connexin proteins. The book has tried to touch the fundamental aspects of connexin family. This book will be useful to broad audience that includes under-and post-graduate students, research scholars, clinicians, etc. The reference section at the end of the book will be helpful for those who seek to know deeper details about this family of proteins.

Gap Junctions in Development and Disease

Gap Junctions in Development and Disease
Author: Elke Winterhager
Publsiher: Springer Science & Business Media
Total Pages: 279
Release: 2005-12-06
ISBN 10: 3540286217
ISBN 13: 9783540286219
Language: EN, FR, DE, ES & NL

Gap Junctions in Development and Disease Book Review:

Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.

Gap Junctions

Gap Junctions
Author: E.L. Hertzberg
Publsiher: Elsevier
Total Pages: 407
Release: 2000-01-10
ISBN 10: 9780762305995
ISBN 13: 0762305991
Language: EN, FR, DE, ES & NL

Gap Junctions Book Review:

The objective in editing this volume was twofold: to provide a reasoned overview of the field as well as to furnish one that provided this overview within the context of the intellectual boundaries of those who initially attempted to define the purview of gap junction research. The latter objective has been realized by selecting the topics for review in this volume. The former objective was achieved by securing the cooperation of leaders in their fields as chapter co-authors.

The Function and Regulation of Gap Junctions in Astrocytes

The Function and Regulation of Gap Junctions in Astrocytes
Author: Mark Alexander Ozog
Publsiher: Unknown
Total Pages: 378
Release: 2002
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1069390209
Language: EN, FR, DE, ES & NL

The Function and Regulation of Gap Junctions in Astrocytes Book Review:

Molecular Biology of the Cell

Molecular Biology of the Cell
Author: Bruce Alberts
Publsiher: Unknown
Total Pages: 135
Release: 2004
ISBN 10: 9780815332183
ISBN 13: 0815332181
Language: EN, FR, DE, ES & NL

Molecular Biology of the Cell Book Review:

Gap Junctions Hemichannels and Pannexons New Implications in Neuroplasticity and Neuroinflammation

Gap Junctions  Hemichannels and Pannexons  New Implications in Neuroplasticity and Neuroinflammation
Author: Juan Andrés Orellana,Eliseo A. Eugenin,Pablo José Sáez
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-02-01
ISBN 10: 2889742180
ISBN 13: 9782889742189
Language: EN, FR, DE, ES & NL

Gap Junctions Hemichannels and Pannexons New Implications in Neuroplasticity and Neuroinflammation Book Review:

Connexin30 Expression in Astrocytes Co localization with Connexin43 at Gap Junctions and Late Developmental Appearance in Rat Brain

Connexin30  Expression in Astrocytes  Co localization with Connexin43 at Gap Junctions  and Late Developmental Appearance in Rat Brain
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1911
ISBN 10: 1928374650XXX
ISBN 13: OCLC:654222374
Language: EN, FR, DE, ES & NL

Connexin30 Expression in Astrocytes Co localization with Connexin43 at Gap Junctions and Late Developmental Appearance in Rat Brain Book Review:

Evidence has been presented (Nagy et al., 1997a) that in addition to connexin43, astrocytes express a second connexin, suggested to be connexin30 (Cx30), a recently discovered member of the family of gap junction proteins. A Cx30 specific antibody was developed and used to confirm this observation using Western blots and immunohistochemical techniques. On Western blots, this antibody detected a 30,000 mol. wt protein in rat, mouse, cat and human brain. It did not exhibit cross-reaction with connexin43 (Cx43), connexin26 (Cx26), or any other known connexins expressed in brain. Immunohistochemically, Cx30 was localized to astrocytes, at gap junctions of these cells, and on the astrocytic side of gap junctions between astrocytes and oligodendrocytes. Double labeling revealed co-expression of Cx30 with Cx43 at astrocytic gap junctions. The punctate immunolabeling patterns of these two connexins was similar, but differences were evident. In contrast to regional Cx43 expression, diencephalic and hindbrain areas showed a greater expression of Cx30 than did forebrain areas. Subcortical perivascular astrocytic endfeet were more heavily labeled for Cx30. White matter tracts such as corpus callosum, internal capsule, and anterior commissure were devoid of Cx30 labeling. During development, Cx30 was not detected until about 15 days postnatal. These results indicate that Cx30 is expressed in gray matter, but not in white matter astrocytes, the distribution of Cx30 is highly heterogeneous in gray matter, it is co-localized with Cx43 at astrocytic gap junctions where it forms homotypic or heterotypic junctions, and its emergence is delayed until late brain maturation. The results suggest that astrocytic Cx30 expression at regional and cellular levels is subject to regulation in adult brain as well as during brain development.

Cell Cell Channels

Cell Cell Channels
Author: František Baluška,Dieter Volkmann,Peter W. Barlow
Publsiher: Springer Science & Business Media
Total Pages: 321
Release: 2007-08-10
ISBN 10: 0387469575
ISBN 13: 9780387469577
Language: EN, FR, DE, ES & NL

Cell Cell Channels Book Review:

he biological sciences are dominated by the idea that cells are the functionally autonomous, physically separated, discrete units of life. TThis concept was propounded in the 19th century by discoveries of the cellular structuring of both plants and animals. Moreover, the ap parent autonomy of unicellular eukaryotes, as well as the cellular basis of the mammalian brain (an organ whose anatomy for a long while defied attempts to validate the idea of the cellular nature of its neurons), seemed to provide the final conclusive evidence for the completeness of *cell theory', a theory which has persisted in an almost dogmatic form up to the present day. However, it is very obvious that there are numerous observations which indicate that it is not the cells which serve as the basic units of biological life but that this property falls to some other, subcellular assemblage. To deal with this intricate problem concerning the fundamental unit of living matter, we proposed the so-called Cell Body concept which, in fact, devel ops an exceedingly original idea proposed by Julius Sachs at the end of the 19th century. In the case of eukaryotic cells, DNA-enriched nuclei are intimately associated with a microtubular cytoskeleton. In this configuration—as a Cell Body—these two items comprise the fundamental functional and struc tural unit of eukaryotic living matter. The Cell Body seems to be inherent to all cells in all organisms.

Gap Junctions in Development and Disease

Gap Junctions in Development and Disease
Author: Elke Winterhager
Publsiher: Springer Science & Business Media
Total Pages: 312
Release: 2005-07-19
ISBN 10: 9783540261568
ISBN 13: 3540261567
Language: EN, FR, DE, ES & NL

Gap Junctions in Development and Disease Book Review:

The main objective of Gap Junctions in Development and Disease is to describe the molecular events that cause impairments in development and disease. Communication between cells via intercellular channels, so called gap junctions, appears to be essential for certain developmental processes and appropriate organ function. Starting with a comprehensive review of the various mouse and human genes encoding the channel-forming protein connexin, further chapters describe the most important connexin mutations that lead to diseases such as hereditary deafness and female infertility in humans. Erroneous signaling mediated via connexin-protein interactions, thought to be responsible for disfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in mice and men, is also addressed. Although the question why some of the mutations in gap-junction proteins lead to a specific phenotype remains to be answered, the reviews in this book give an intriguing outlook on the future direction of this research field.

Discovering the Brain

Discovering the Brain
Author: National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publsiher: National Academies Press
Total Pages: 194
Release: 1992-01-01
ISBN 10: 0309045290
ISBN 13: 9780309045292
Language: EN, FR, DE, ES & NL

Discovering the Brain Book Review:

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brain--an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attention--and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniques--what various technologies can and cannot tell us--and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakers--and many scientists as well--with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Gap Junction Channels and Hemichannels

Gap Junction Channels and Hemichannels
Author: Donglin Bai,Juan C. Sáez
Publsiher: CRC Press
Total Pages: 305
Release: 2016-07-25
ISBN 10: 9781498738620
ISBN 13: 1498738621
Language: EN, FR, DE, ES & NL

Gap Junction Channels and Hemichannels Book Review:

Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and hemichannel research has recently exploded and became one of the most active areas of cell biology. Numerous novel approaches and techniques have been developed, but there is no single book dedicated to the unique techniques and protocols employed for the research on these large pore channels. This book fills the gap and focuses on protocols, approaches and reviews of gap junction channels and connexin hemichannels. It will be a useful reference for graduate students, postdoctoral fellows and researchers. Anyone with an interest in gap junction channels and hemichannels will need this summary of state-of-the-art techniques and protocols.

The Role of Gap Junctions in Brain Glucose Deprivation and Glucose Reperfusion

The Role of Gap Junctions in Brain Glucose Deprivation and Glucose Reperfusion
Author: Sonia Sugumar
Publsiher: Unknown
Total Pages: 135
Release: 2014
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1032926385
Language: EN, FR, DE, ES & NL

The Role of Gap Junctions in Brain Glucose Deprivation and Glucose Reperfusion Book Review:

Modeling in the Neurosciences

Modeling in the Neurosciences
Author: R.R. Poznanski
Publsiher: Routledge
Total Pages: 366
Release: 2019-01-22
ISBN 10: 1351430963
ISBN 13: 9781351430968
Language: EN, FR, DE, ES & NL

Modeling in the Neurosciences Book Review:

With contributions from more than 40 renowned experts, Modeling in the Neurosciences: From Ionic Channels to Neural Networks is essential for those interested in neuronal modeling and quantitative neiroscience. Focusing on new mathematical and computer models, techniques and methods, this monograph represents a cohesive and comprehensive treatment

Cortical Oscillations in Health and Disease

Cortical Oscillations in Health and Disease
Author: Roger Traub, MD,Miles Whittington, PhD
Publsiher: Oxford University Press
Total Pages: 135
Release: 2010-05-12
ISBN 10: 019971150X
ISBN 13: 9780199711505
Language: EN, FR, DE, ES & NL

Cortical Oscillations in Health and Disease Book Review:

This book first reviews the case that brain oscillations not only are important for cognition, as long suspected, but also play a part in the expression of signs and symptoms of neuropsychiatric disorders. The cellular mechanisms of many of the clinically relevant oscillations have been studied by the authors and their colleagues, using in vitro slice methods as well as detailed computer simulations. A surprising insight is that gap junctions between principal neurons play an absolutely critical role in so many types of oscillation in neuronal populations; oscillations are not just the result of properties of individual neurons and their synaptic connections. Furthermore, the way in which gap junctions produce oscillations in the cortex is novel, involving as it does global properties of networks, rather than just the time constants of membrane currents. This insight has implications for therapeutics as well as for our understanding of normal brain functions.