Epigenetics of Exercise and Sports

Epigenetics of Exercise and Sports
Author: Stuart Raleigh
Publsiher: Academic Press
Total Pages: 320
Release: 2021-07-13
ISBN 10: 0128209372
ISBN 13: 9780128209370
Language: EN, FR, DE, ES & NL

Epigenetics of Exercise and Sports Book Review:

Epigenetics of Exercise and Sports: Concepts, Methods, and Current Research explains fundamental epigenetic processes and how these are altered by exercise and sports. After a brief review of fundamental epigenetic biology, this all-new volume in the Translational Epigenetics series offers step-by-step instruction in how epigenetic factors are investigated for their influence over exercise related traits of human physiology, disease, and injury. The current state of knowledge in the field and recent findings are discussed in-depth, illuminating how exercise and sports performance may epigenetically modify our physiology, disease and injury risks, and how this knowledge can be applied in personalized exercise approaches, diagnostics, and treatment. This book also explores the shortcomings of explaining exercise related phenomena using only genomics and traditional biochemical techniques, setting the scene for a paradigm shift in exercise biology. In addition, over a dozen international specialists contribute chapters on exercise and sports epigenetics, and their influence over metabolism, obesity, aging, immunity, and neurological disease, as well as the epigenetic impacts of concussions and sports doping. A concluding chapter discusses ongoing themes in the field and outlooks for future research. Thoroughly examines fundamental concepts in exercise and sports epigenetics, methods for new research, and known impacts for human physiology, disease, and clinical outcomes Discusses exercise and sports epigenetics in relation to metabolism, obesity, aging, immunity, and neurological disease, concussion, and sports doping, among other topics Includes preliminary information on exercise epigenetics and covid-19 infection Features chapter contributions from international experts in the field

Sports Exercise and Nutritional Genomics

Sports  Exercise  and Nutritional Genomics
Author: Debmalya Barh,Ildus I. Ahmetov
Publsiher: Academic Press
Total Pages: 606
Release: 2019-08-25
ISBN 10: 0128163402
ISBN 13: 9780128163405
Language: EN, FR, DE, ES & NL

Sports Exercise and Nutritional Genomics Book Review:

Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions is the first reference volume to offer a holistic examination of omics-driven advances across different aspects of exercise and sports physiology, biochemistry, sports medicine, psychology, anthropology, and sports nutrition; and highlighting the opportunities towards advance personalized training and athlete health management. More than 70 international experts from 14 countries have discussed key exercise and sport-related themes through the prism of genomics, epigenomics, transcriptomics, proteomics, metabolomics, telomere biology, talent in sport, individual differences in response to regular physical activity, that in the future may empower coaches, sports physicians, fitness experts, genetic counselors, and translational scientists to employ various omics data and approaches in improving health and physical performance of people participating in sports and exercise activities. Contributors address current knowledge of genetic influence on athletic performance, individual responses to exercise training, as well as the genetics of musculoskeletal phenotypes, exercise-related injuries, flexibility, and neurodegenerative disorders in athletes. Finally, performance-related and psychological traits associated with epigenetic, transcriptomic and metagenomic biomarkers are also considered, along with nutritional and pharmacogenomic aids in sports medicine and personalized nutrition. Effectively synthesizes key themes across molecular aspects of exercise and sports sciences Provides a knowledge base for future translation of omics solutions to talent identification, individualized training, and nutrition Features contributions from international experts (researchers and clinicians) in the subject area

Routledge Handbook of Sport and Exercise Systems Genetics

Routledge Handbook of Sport and Exercise Systems Genetics
Author: J. Timothy Lightfoot,Monica J. Hubal,Stephen M. Roth
Publsiher: Routledge
Total Pages: 514
Release: 2019-03-14
ISBN 10: 1351380168
ISBN 13: 9781351380164
Language: EN, FR, DE, ES & NL

Routledge Handbook of Sport and Exercise Systems Genetics Book Review:

Technological advances over the last two decades have placed genetic research at the forefront of sport and exercise science. It provides potential answers to some of contemporary sport and exercise’s defining issues and throws up some of the area’s most challenging ethical questions, but to date, it has rested on a fragmented and disparate literature base. The Routledge Handbook of Sport and Exercise Systems Genetics constitutes the most authoritative and comprehensive reference in this critical area of study, consolidating knowledge and providing a framework for interpreting future research findings. Taking an approach which covers single gene variations, through genomics, epigenetics, and proteomics, to environmental and dietary influences on genetic mechanisms, the book is divided into seven sections. It examines state-of-the-art genetic methods, applies its approach to physical activity, exercise endurance, muscle strength, and sports performance, and discusses the ethical considerations associated with genetic research in sport and exercise. Made up of contributions from some of the world’s leading sport and exercise scientists and including chapters on important topical issues such as gene doping, gender testing, predicting sport performance and injury risk, and using genetic information to inform physical activity and health debates, the handbook is a vital addition to the sport and exercise literature. It is an important reference for any upper-level student, researcher, or practitioner working in the genetics of sport and exercise or exercise physiology, and crucial reading for any social scientist interested in the ethics of sport.

Exercise Biochemistry

Exercise Biochemistry
Author: Vassilis Mougios
Publsiher: Human Kinetics
Total Pages: 496
Release: 2019-02-04
ISBN 10: 1492572691
ISBN 13: 9781492572695
Language: EN, FR, DE, ES & NL

Exercise Biochemistry Book Review:

Exercise Biochemistry brings an admittedly difficult and technical subject to life. Extremely user- and student-friendly, it is written in conversational style by Vassilis Mougios, who poses and then answers questions as if in conversation with a student. Mougios does an excellent job of making the information interesting by using simple language without compromising scientific accuracy and content. He also uses ample analogies, related works of art, and numerous illustrations to drive home his points for readers. The result is that Exercise Biochemistry is a highly informative and illuminating text on the effects of exercise on molecular-level functioning. It presents the basics of biochemistry as well as in-depth coverage of exercise biochemistry. The book uses key terms, sidebars, and questions and problems posed at the end of each chapter to facilitate learning. It also covers metabolism, endocrinology, and assessment all in one volume, unlike other exercise biochemistry books. In exploring all of these topics, Exercise Biochemistry makes the case for exercise biochemistry to have a stand-alone textbook. In fact, this book will encourage more universities to introduce exercise biochemistry courses to their curricula. Having the necessary topics of basic biochemistry in a single volume will facilitate the work of both instructors and students. Exercise Biochemistry will also be useful to graduate students in sport science who have not been formally introduced to exercise biochemistry during their undergraduate programs. Additionally, it can supplement exercise physiology textbooks with its coverage of the molecular basis of physiological processes. This book is also for physical education and sport professionals who have an interest in how the human body functions during and after exercise. And this book is addressed to health scientists who are interested in the transformations in human metabolism brought about by physical activity. The book is organized in four parts. Part I introduces readers to biochemistry basics, including chapters on metabolism, proteins, nucleic acids and gene expression, and carbohydrates and lipids. Part II consists of two chapters that explore neural control of movement and muscle contraction. The essence of the book is found in part III, which details exercise metabolism in its six chapters. Included are chapters on carbohydrate, lipid, and protein metabolism in exercise; compounds of high phosphoryl transfer potential; effects of exercise on gene expression; and integration of exercise metabolism. In part IV, the author focuses on biochemical assessment of people who exercise, with chapters on iron status, metabolites, and enzymes and hormones. Simple biochemical tests are provided to assess an athlete's health and performance. Exercise Biochemistry is a highly readable book that serves as a source for understanding how exercise changes bodily functions. The text is useful for both students and practitioners alike.

Molecular Exercise Physiology

Molecular Exercise Physiology
Author: Henning Wackerhage
Publsiher: Routledge
Total Pages: 338
Release: 2014-02-24
ISBN 10: 1136477020
ISBN 13: 9781136477027
Language: EN, FR, DE, ES & NL

Molecular Exercise Physiology Book Review:

Molecular Exercise Physiology: An Introduction is the first student-friendly textbook to be published on this key topic in contemporary sport and exercise science. It introduces sport and exercise genetics and the molecular mechanisms by which exercise causes adaptation. The text is linked to real life sport and exercise science situations such as ‘what makes people good at distance running?’, ‘what DNA sequence variations code for a high muscle mass?’ or ‘by what mechanisms does exercise improve type2 diabetes?’ The book includes a full range of useful features, such as summaries, definitions of key terms, guides to further reading, review questions, personal comments by molecular exercise pioneers (Booth, Bouchard) and leading research in the field, as well as descriptions of research methods. A companion website offers interactive and downloadable resources for both student and lecturers. Structured around central themes in sport and exercise science, such as nutrition, endurance training, resistance training, exercise & chronic disease and ageing, this book is the perfect foundation around which to build a complete upper-level undergraduate or postgraduate course on molecular exercise physiology.

Research Methods in Physical Activity and Health

Research Methods in Physical Activity and Health
Author: Stephen R. Bird
Publsiher: Routledge
Total Pages: 348
Release: 2018-12-19
ISBN 10: 1351656767
ISBN 13: 9781351656764
Language: EN, FR, DE, ES & NL

Research Methods in Physical Activity and Health Book Review:

Physical activity is vital for good health. It has an established strong evidence base for its positive effects on functional capacity, reducing the risk of many chronic diseases, and promoting physical, mental and social well-being. Furthermore, these benefits are evident across a diversity of ages, groups and populations. The need for these benefits in current societies means that exercise practitioners, professional bodies, institutions, health authorities and governments require high quality evidence to establish appropriate exercise guidelines, implementation strategies and effective exercise prescription at individual, group and population levels. Research Methods in Physical Activity and Health is the first book to comprehensively present the issues associated with physical activity and health research and outline methods available along with considerations of the issues associated with these methods and working with particular groups. The book outlines the historical and scientific context of physical activity and health research before working through the full research process, from generating literature reviews and devising a research proposal, through selecting a research methodology and quantifying physical activity and outcome measures, to disseminating findings. Including a full section on conducting research studies with special populations, the book includes chapters on: Observational and cross-sectional studies; Interviews, questionnaires and focus groups; Qualitative and quantitative research methods; Epidemiological research methods; Physical activity interventions and sedentary behaviour; and Working with children, older people, indigenous groups, LGBTI groups, and those with physical and mental health issues. Research Methods in Physical Activity and Health is the only book to approach the full range of physical activity research methods from a health perspective. It is essential reading for any undergraduate student conducting a research project or taking applied research modules in physical activity and health, graduate students of epidemiology, public health, exercise psychology or exercise physiology with a physical activity and health focus, or practicing researchers in the area.

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics
Author: Shuai Li,John Hopper
Publsiher: Academic Press
Total Pages: 374
Release: 2021-08-31
ISBN 10: 0128209526
ISBN 13: 9780128209523
Language: EN, FR, DE, ES & NL

Twin and Family Studies of Epigenetics Book Review:

Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field

Genetic and Epigenetic Modulation of Cell Functions by Physical Exercise

Genetic and Epigenetic Modulation of Cell Functions by Physical Exercise
Author: Italia Di Liegro
Publsiher: MDPI
Total Pages: 170
Release: 2020-05-12
ISBN 10: 3039284800
ISBN 13: 9783039284801
Language: EN, FR, DE, ES & NL

Genetic and Epigenetic Modulation of Cell Functions by Physical Exercise Book Review:

From an evolutionary perspective, our species has relied upon physical activity for most of its history to survive and has had to escape from predators, to scavenge for food, and to use physique to work or build necessary means for everyday life. Physical activity has been part of our evolution and progress since the very beginning and, consequently, our entire body has been programmed to be active physically. In the last 20 years, scientific research has increasingly shown that our ancient survival principle has beneficial effects not only on the cells and organs involved in physical activities but on the metabolism of the entire organism, influencing the homeostasis and integration of all bodily functions, likely stimulating the production of hormones and other regulatory molecules, with each affecting vital signalling pathways. Most of the web of factors involved in molecular signalling upon exercise are suspected to be centrally controlled by the brain, which has been reported to be deeply modified by physical activity. Such complexity requires a multifaceted approach to shed light on the molecular interactions that occur between physical activity and its outcome at a cellular level.

Medical Epigenetics

Medical Epigenetics
Author: Anonim
Publsiher: Academic Press
Total Pages: 970
Release: 2021-08-27
ISBN 10: 0128243260
ISBN 13: 9780128243268
Language: EN, FR, DE, ES & NL

Medical Epigenetics Book Review:

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Organized from system disorders to multi-system disorders that involve epigenetic aberrations Examines the role of epigenetics in precision medicine

Genetics and Sports

Genetics and Sports
Author: M. Posthumus,M. Collins
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 124
Release: 2016-06-10
ISBN 10: 3318030112
ISBN 13: 9783318030112
Language: EN, FR, DE, ES & NL

Genetics and Sports Book Review:

This second edition of Genetics and Sports expands on topics previously discussed in an attempt to create an integrated and holistic understanding of the field of sports genomics. It is an update on technologies and on the role of genetics in training, performance, injury, and other exercise-related phenotypes. Ethical concerns and the importance of counselling before and after genetic testing are also addressed. It is increasingly important to understand the field of genetics and sports because of the potential to use and misuse information. All exercise scientists, sport and exercise clinicians, athletes, and coaches need to be adequately informed to ensure that genetic information is accurately and properly used. Genetics and Sports is, therefore, highly recommended to all of these groups.

Genome Stability

Genome Stability
Author: Igor Kovalchuk,Olga Kovalchuk
Publsiher: Academic Press
Total Pages: 760
Release: 2021-07-17
ISBN 10: 0323856802
ISBN 13: 9780323856805
Language: EN, FR, DE, ES & NL

Genome Stability Book Review:

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Nutrition and Epigenetics

Nutrition and Epigenetics
Author: Emily Ho,Frederick Domann
Publsiher: CRC Press
Total Pages: 422
Release: 2014-10-16
ISBN 10: 1482203820
ISBN 13: 9781482203820
Language: EN, FR, DE, ES & NL

Nutrition and Epigenetics Book Review:

Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process. This pivotal text: Documents the epigenetic effect of antioxidants and their health benefits Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging Illustrates that the epigenetic origins of disease occur in early (fetal) development Synthesizes the data regarding nutrient and epigenomic interactions Nutrition and Epigenetics highlights the interactions among nutrients, epigenetics, and health, providing an essential resource for scientists and clinical researchers interested in nutrition, aging, and metabolic diseases.

Exercise Genomics

Exercise Genomics
Author: Linda S. Pescatello,Stephen M. Roth
Publsiher: Springer Science & Business Media
Total Pages: 268
Release: 2011-03-23
ISBN 10: 1607613557
ISBN 13: 9781607613558
Language: EN, FR, DE, ES & NL

Exercise Genomics Book Review:

Exercise Genomics encompasses the translation of exercise genomics into preventive medicine by presenting a broad overview of the rapidly expanding research examining the role of genetics and genomics within the areas of exercise performance and health-related physical activity. Leading researchers from a number of the key exercise genomics research groups around the world have been brought together to provide updates and analysis on the key discoveries of the past decade, as well as lend insights and opinion about the future of exercise genomics, especially within the contexts of translational and personalized medicine. Clinicians, researchers and health/fitness professionals will gain up-to-date background on the key findings and critical unanswered questions across several areas of exercise genomics, including performance, body composition, metabolism, and cardiovascular disease risk factors. Importantly, basic information on genomics, research methods, and statistics are presented within the context of exercise science to provide students and professionals with the foundation from which to fully engage with the more detailed chapters covering specific traits. Exercise Genomics will be of great value to health/fitness professionals and graduate students in kinesiology, public health and sports medicine desiring to learn more about the translation of exercise genomics into preventive medicine.

Basic Exercise Physiology

Basic Exercise Physiology
Author: Moran S. Saghiv,Michael S. Sagiv
Publsiher: Springer Nature
Total Pages: 582
Release: 2020-08-26
ISBN 10: 3030488063
ISBN 13: 9783030488062
Language: EN, FR, DE, ES & NL

Basic Exercise Physiology Book Review:

This book reviews the assessment of human performance and the role of different exercise modes both in a laboratory and clinical setting. Details of how to successfully perform basic laboratory procedures for exercise training in health and disease, as well as how to apply non-invasive measurements in exercise physiology are provided. Chapters cover how to appropriately use a range of measures in assessing pulmonary function, anaerobic function and oxygen uptake. Techniques for cardiopulmonary rehabilitation and the mechanisms associated with thermoregulation are also described. Interactive exercises enable readers to easily assimilate key concepts and develop a thorough understanding of the topic. Basic Exercise Physiology provides both trainees and professional healthcare staff interested in exercise physiology with a detailed and practically applicable resource on the topic.

Sport and Exercise Science

Sport and Exercise Science
Author: Matjaz Merc
Publsiher: BoD – Books on Demand
Total Pages: 124
Release: 2018-02-07
ISBN 10: 9535137948
ISBN 13: 9789535137948
Language: EN, FR, DE, ES & NL

Sport and Exercise Science Book Review:

Professional and semiprofessional sports as well as excessive amateur exercise inevitably lead to some degree of musculoskeletal injury once in a sportsman's career. Some injuries are represented as chronic injuries, which can result in irreversible long-term tissue changes and deformities. The subject of this book is to represent the up-to-date knowledge about etiology, pathogenesis, diagnosis, management, and prevention of chronic injuries or sport-related long-term changes in locomotor system.

Exercise Sport and Bioanalytical Chemistry

Exercise  Sport  and Bioanalytical Chemistry
Author: Anthony C Hackney
Publsiher: Elsevier
Total Pages: 136
Release: 2016-03-14
ISBN 10: 0128096918
ISBN 13: 9780128096918
Language: EN, FR, DE, ES & NL

Exercise Sport and Bioanalytical Chemistry Book Review:

A new volume in the Emerging Issues in Analytical Chemistry series, Exercise, Sport, and Bioanalytical Chemistry: Principles and Practice focuses on the basic and applied aspects of energy metabolism in humans. Concise and scientific, yet intelligible to the nonscientist, the book consists of two parts. Part I, Introduction: Basics and Background, provides the biochemistry necessary to understand the rest of the book and describes analytical processes and results as an aid to grasping the science. Part II, Applications: Knowledge into Practice, explores measurement techniques for metabolism, energy expenditure of various activities, techniques that enhance expenditure, metabolic adaptation, foods and drugs that enhance expenditure, and the role of bioanalytical chemistry in future research in exercise and sport. Discussion of the benefits of exercise and practices for improving the capacity to perform exercise is illustrated by many useful and entertaining examples. This volume allows readers to come away with a grasp of the scientific concepts, how they are manifested in research techniques, and how the results of research can be applied in the real world of public health and personal development. The Emerging Issues in Analytical Chemistry series is published in partnership with RTI International and edited by Brian F. Thomas. Please be sure to check out our other featured volumes: Thomas, Brian F. and ElSohly, Mahmoud. The Analytical Chemistry of Cannabis: Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations, 9780128046463, December 2015. Tanna, Sangeeta and Lawson, Graham. Analytical Chemistry for Assessing Medication Adherence, 9780128054635, April 2016. Rao, Vikram, Knight, Rob, and Stoner, Brian. Sustainable Shale Oil and Gas: Analytical Chemistry, Biochemistry, and Geochemistry Methods, 9780128103890, forthcoming September 2016. Farsalinos, Konstantinos, et al. Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles, 9780128112410, forthcoming November 2016. Provides readers with the fundamental biochemistry and some elements of the physiology behind physical activity/exercise and describes the analytical techniques used to elucidate the science Written in clear, concise, compelling prose that is neither simplistic to scientists nor too sophisticated for a large, diverse global audience A one-page Close-Up in each chapter illustrates key topics to catch, engage, entertain, and create a novel synthesis of thought

Skeletal Muscle Circulation

Skeletal Muscle Circulation
Author: Ronald J. Korthuis
Publsiher: Morgan & Claypool Publishers
Total Pages: 131
Release: 2011
ISBN 10: 1615041834
ISBN 13: 9781615041831
Language: EN, FR, DE, ES & NL

Skeletal Muscle Circulation Book Review:

The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References

The Encyclopaedia of Sports Medicine Genetic and Molecular Aspects of Sports Performance

The Encyclopaedia of Sports Medicine  Genetic and Molecular Aspects of Sports Performance
Author: Claude Bouchard,Eric P. Hoffman
Publsiher: John Wiley & Sons
Total Pages: 424
Release: 2011-08-02
ISBN 10: 1444348299
ISBN 13: 9781444348293
Language: EN, FR, DE, ES & NL

The Encyclopaedia of Sports Medicine Genetic and Molecular Aspects of Sports Performance Book Review:

This is the latest volume in the IOC Encyclopaedia of Sports Medicine series, summarizing the evidence from all relevant sources on the genetic and molecular basis of sports and other human physical performance. The initial chapters address the basic science of genomics and genetics and the regulation of gene expression. Additional chapters provide authoritative information on the genetics of complex performance phenotypes, the contributions of small animal research, family and twin studies, and ethnic comparisons. A final section addresses the issue of the contribution of specific genes and molecular markers as related to endurance, strength and power, and responsiveness to specific conditioning programs. This latest volume in the Encyclopaedia of Sports Medicine Series from the Medical Commission of the International Olympic Committee is a must for sports and exercise scientists who require a thorough guide to the most cutting edge science in this expanding field.

Optimal Mobility and Function across the Lifespan

Optimal Mobility and Function across the Lifespan
Author: Ronald F. Zernicke,David Arthur Hart
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-03-12
ISBN 10: 2889665933
ISBN 13: 9782889665938
Language: EN, FR, DE, ES & NL

Optimal Mobility and Function across the Lifespan Book Review:

Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics
Author: José Luis García-Giménez
Publsiher: Academic Press
Total Pages: 696
Release: 2015-12-07
ISBN 10: 0128019212
ISBN 13: 9780128019214
Language: EN, FR, DE, ES & NL

Epigenetic Biomarkers and Diagnostics Book Review:

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies