Genetics and Etiology of Down Syndrome

Genetics and Etiology of Down Syndrome
Author: Subrata Dey
Publsiher: Unknown
Total Pages: 342
Release: 2011
ISBN 10: 9789535164609
ISBN 13: 9535164600
Language: EN, FR, DE, ES & NL

Genetics and Etiology of Down Syndrome Book Review:

This book provides a concise yet comprehensive source of current information on Down syndrome. Research workers, scientists, medical graduates and paediatricians will find it an excellent source for reference and review. This book has been divided into four sections, beginning with the Genetics and Etiology and ending with Prenatal Diagnosis and Screening. Inside, you will find state-of-the-art information on: 1. Genetics and Etiology 2. Down syndrome Model 3. Neurologic, Urologic, Dental & Allergic disorders 4. Prenatal Diagnosis and Screening Whilst aimed primarily at research workers on Down syndrome, we hope that the appeal of this book will extend beyond the narrow confines of academic interest and be of interest to a wider audience, especially parents and relatives of Down syndrome patients.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
Author: J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Publsiher: Academic Press
Total Pages: 374
Release: 2012-12-31
ISBN 10: 0123944058
ISBN 13: 9780123944054
Language: EN, FR, DE, ES & NL

Epigenetic Regulation in the Nervous System Book Review:

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide
Author: Yogesh Dwivedi
Publsiher: CRC Press
Total Pages: 482
Release: 2012-06-25
ISBN 10: 143983881X
ISBN 13: 9781439838815
Language: EN, FR, DE, ES & NL

The Neurobiological Basis of Suicide Book Review:

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Epigenetic Mechanisms in Neural Plasticity

Epigenetic Mechanisms in Neural Plasticity
Author: Daniel Ortuño-Sahagún,Reinhard Schliebs,Merce Pallàs
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2019-09-20
ISBN 10: 2889630005
ISBN 13: 9782889630004
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms in Neural Plasticity Book Review:

Neural plasticity is a unique and adaptive feature of nervous system, which allows neurons to reorganize their interactions in response to a stimulation (intrinsic or extrinsic) to maintain their function. For these reasons, epigenetics emerges as a potential field for developing strategies to modulate changes in pathological situation because extrinsic factors and pharmacological tools can modify neural functioning in organisms during their life. Diet, exercise, environmental aspects, stressors or drugs are available to alter those mechanisms. Epigenetic involves certain molecular signaling pathways, as DNA methylation and histone acetylation and deacetylation, and the emerging non-coding small RNA, mainly microRNA, as a commanders of a number of translation processes. As most of molecular nervous cell alterations, epigenetic mechanisms play an important role in neural plasticity. This eBook collects the burgeoning advances in epigenetic mechanisms, focusing on new insights into cellular and molecular neurobiological mechanisms that underlie brain functioning in health and pathological conditions. Contributions go from basic cellular mechanism to therapeutic opportunities to tackle the challenges on nervous central system development and neurodegeneration.

Epigenetics Brain and Behavior

Epigenetics  Brain and Behavior
Author: Paolo Sassone Corsi,Yves Christen
Publsiher: Springer Science & Business Media
Total Pages: 163
Release: 2012-08-28
ISBN 10: 3642279120
ISBN 13: 9783642279126
Language: EN, FR, DE, ES & NL

Epigenetics Brain and Behavior Book Review:

What lies at the heart of neuronal plasticity? Accumulating evidence points to epigenetics. This word originally indicated potentially heritable modifications in gene expression that do not involve changes in DNA sequence. Today this definition is much less strict, and epigenetic control is thought to include DNA methylation, histone modifications, histone variants, microRNA metabolic pathways and non-histone proteins modifications. Thus, while neuronal plasticity is rightly thought to be intimately associated to genomic control, it is critical to appreciate that there is much more to the genome than DNA sequence. Recent years have seen spectacular advances in the field of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigenetic regulation to brain functions has been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molecular mechanisms implicated in epigenetic control and how these may operate in concert. It will be critical to unravel how specificity is achieved. Importantly, specific modifications seem to mediate both developmental processes and adult brain functions, such as synaptic plasticity and memory. Many aspects of the research in neurosciences and endocrinology during the upcoming decade will be dominated by the deciphering of epigenetic control. This book constitutes a compendium of the most updated views in the field.

Epigenetic Mechanisms of Neurogenesis in the Developing Neocortex

Epigenetic Mechanisms of Neurogenesis in the Developing Neocortex
Author: Magdalena Götz,Wieland B. Huttner,Mareike Albert
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-11-30
ISBN 10: 288971778X
ISBN 13: 9782889717781
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms of Neurogenesis in the Developing Neocortex Book Review:

DNA Modifications in the Brain

DNA Modifications in the Brain
Author: Timothy W Bredy
Publsiher: Academic Press
Total Pages: 180
Release: 2016-12-23
ISBN 10: 0128017813
ISBN 13: 9780128017814
Language: EN, FR, DE, ES & NL

DNA Modifications in the Brain Book Review:

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease. Provides a comprehensive overview of the many facets of DNA modifications Discusses the impact of this dynamic epigenetic mechanism across brain development and lifespan at behavioral, cognitive, molecular and genetic levels Contains contributions by influential leaders in the field Edited by a Neuroscientist to further promote synthesis between epigenetics, neuroscience, and clinical relevance

Epigenetics in Psychiatry

Epigenetics in Psychiatry
Author: Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publsiher: Academic Press
Total Pages: 846
Release: 2021-08-16
ISBN 10: 0128235780
ISBN 13: 9780128235782
Language: EN, FR, DE, ES & NL

Epigenetics in Psychiatry Book Review:

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Genetic and Epigenetic Mechanisms in Down Syndrome Brain

Genetic and Epigenetic Mechanisms in Down Syndrome Brain
Author: Jie Lu
Publsiher: Unknown
Total Pages: 135
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1154267950
Language: EN, FR, DE, ES & NL

Genetic and Epigenetic Mechanisms in Down Syndrome Brain Book Review:

Genetic and Epigenetic Mechanisms in Down Syndrome Brain.

Regulation of Gene Expression in the Nervous System

Regulation of Gene Expression in the Nervous System
Author: Anna Maria Giuffrida Stella,Jean de Vellis,J. Regino Perez-Polo
Publsiher: Wiley-Liss
Total Pages: 504
Release: 1990-07-19
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015018477763
Language: EN, FR, DE, ES & NL

Regulation of Gene Expression in the Nervous System Book Review:

Offers an up-to-date account of the latest research findings concerned with the regulatory mechanisms of gene expression in neuronal and glial cells under different conditions. The book explores the cellular and neurobiological aspects of important phenomena of the nervous system and its role in health, disease and injury. Contributions from prominent scientists in the field address a variety of specific topics concerned with gene expression in the nervous system--from growth, hormonal and trophic factors to neural tissue reactions in injury or aging.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
Author: Jeremy J. Day,J. David Sweatt
Publsiher: Elsevier Inc. Chapters
Total Pages: 374
Release: 2012-12-31
ISBN 10: 0128058404
ISBN 13: 9780128058404
Language: EN, FR, DE, ES & NL

Epigenetic Regulation in the Nervous System Book Review:

Behavioral Neurogenomics

Behavioral Neurogenomics
Author: Elisabeth B. Binder,Torsten Klengel
Publsiher: Springer Nature
Total Pages: 259
Release: 2019-12-12
ISBN 10: 3030312658
ISBN 13: 9783030312657
Language: EN, FR, DE, ES & NL

Behavioral Neurogenomics Book Review:

This book provides a unique overview on the most recent developments in initially diverse areas of behavioral genomic research that now start to intertwine to provide more detailed insights into the complex nature of behavior in health and disease. It focuses on our current understanding of genetic and epigenetic mechanisms of brain function and how they contribute to the complex formation of behavioral traits and psychiatric disorders. Readers experience diverse perspectives of the contributing authors starting from the genetic viewpoint and the effort to establish functional connection between genetic variants and behavioral phenotypes. Particular attention is given to the broad spectrum of epigenetic mechanisms and behavior. The chapter 'Role of MicoRNAs in Anxiety and Anxiety-Related Disorders' is available open access under a CC BY 4.0 license at link.springer.com

Epigenetic Epidemiology

Epigenetic Epidemiology
Author: Karin B. Michels
Publsiher: Springer Science & Business Media
Total Pages: 448
Release: 2012-01-02
ISBN 10: 9400724950
ISBN 13: 9789400724952
Language: EN, FR, DE, ES & NL

Epigenetic Epidemiology Book Review:

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

The Epigenetics of Suicide

The Epigenetics of Suicide
Author: Benoit Labonté
Publsiher: Unknown
Total Pages: 135
Release: 2013
ISBN 10: 1928374650XXX
ISBN 13: OCLC:922058836
Language: EN, FR, DE, ES & NL

The Epigenetics of Suicide Book Review:

"Suicide is a problem resulting from the interaction between several factors. Among these factors, early-life adversity, characterized by child sexual and physical abuse as well as parental neglect, is one of the strongest risk factors for depression and suicidal behaviors. While it is clear that child abuse increases the risk for depression and suicide, the mechanisms mediating these effects are still unknown. Recent evidences suggest that epigenetic mechanisms may be involved in mediating the effects of early-life adversity on behavior. Early-life stress in animals has been shown to alter DNA methylation in genes regulatory regions what, in turn, has been associated with changes in gene expression and behavioral modifications. Importantly, similar changes have been reported in several genes in the human brain. However, although epigenetic modifications have been found in several genes, the extent of epigenetic changes induced by early-life adversity is still unknown and their impacts on increasing suicide risk are unclear. This thesis aims at expanding our understanding of suicide by investigating one potential mechanism by which early-life adversity may increase vulnerability to mood disorders and suicide, namely epigenetic regulation of gene expression. We first expanded our characterization of DNA methylation alterations induced by early and adult-life stress in the regulatory regions of the glucocorticoid receptor gene which is one of the most consistent alterations associated with stress, depression and suicidal behaviors. We then opted for a genome-wide characterization of DNA methylation alterations found in the brains of suicide completers with and without a history of child abuse using microarray analyses focusing on gene promoters throughout the genome. Our findings revealed several DNA methylation alterations in genes with known roles on behavioral regulation and identified several new genes and networks which may be specifically altered by early-life adversity. We also characterized the functional impact of these alterations on gene expression and promoter transcriptional activity. Overall, this work identifies and characterizes the molecular mechanisms by which environment induces behavioral changes conferring vulnerability toward mood disorders and suicidal behaviors. " --

Genetic and Epigenetic Mechanisms Underpinning Vulnerability to Developing Psychiatric Disorders

Genetic and Epigenetic Mechanisms Underpinning Vulnerability to Developing Psychiatric Disorders
Author: Elena Martín-García,Patrick E. Williams,Noèlia Fernàndez-Castillo
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-07-06
ISBN 10: 2889765156
ISBN 13: 9782889765157
Language: EN, FR, DE, ES & NL

Genetic and Epigenetic Mechanisms Underpinning Vulnerability to Developing Psychiatric Disorders Book Review:

Epigenetic Mechanisms of Gene Regulation

Epigenetic Mechanisms of Gene Regulation
Author: Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publsiher: Unknown
Total Pages: 692
Release: 1996
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015047449171
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms of Gene Regulation Book Review:

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

APA Handbook of Comparative Psychology

APA Handbook of Comparative Psychology
Author: Josep Call
Publsiher: American Psychological Association (APA)
Total Pages: 135
Release: 2017-01
ISBN 10: 9781433823480
ISBN 13: 1433823489
Language: EN, FR, DE, ES & NL

APA Handbook of Comparative Psychology Book Review:

Epigenetics of Aging

Epigenetics of Aging
Author: Trygve O. Tollefsbol
Publsiher: Springer Science & Business Media
Total Pages: 469
Release: 2009-11-11
ISBN 10: 1441906398
ISBN 13: 9781441906397
Language: EN, FR, DE, ES & NL

Epigenetics of Aging Book Review:

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Epigenetic Mechanisms and Their Involvement in Rare Diseases

Epigenetic Mechanisms and Their Involvement in Rare Diseases
Author: Mojgan Rastegar,Dag H. Yasui
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-10-20
ISBN 10: 2889715140
ISBN 13: 9782889715145
Language: EN, FR, DE, ES & NL

Epigenetic Mechanisms and Their Involvement in Rare Diseases Book Review:

The Impact of Aversive Caregiving on DNA Methylation in Blood and the Prefrontal Cortex

The Impact of Aversive Caregiving on DNA Methylation in Blood and the Prefrontal Cortex
Author: Hannah Duffy
Publsiher: Unknown
Total Pages: 59
Release: 2020
ISBN 10: 1928374650XXX
ISBN 13: 9798678105868
Language: EN, FR, DE, ES & NL

The Impact of Aversive Caregiving on DNA Methylation in Blood and the Prefrontal Cortex Book Review:

Aversive caregiving causes epigenetic alterations that may lead to neurological and behavioral problems later in life. These issues presumably originate in the brain, and, as such, epigenetic changes within the brain would appear to be the most relevant to better understand the origin of and possible alleviation of these issues. However, it is difficult to study epigenetics in the brain in living humans, so many researchers rely on epigenetic alterations in peripheral tissues to be an indication of aberrant epigenetic mechanisms within the brain. The reliability of using such epigenetic changes in the periphery as a proxy for that of the brain is still largely unknown. Rodent models provide a much-needed mechanism of testing whether epigenetic alterations in peripheral tissues like blood mirror that of the brain. The current study used a rodent model to examine changes in DNA methylation at two regions (exons IV and IX) of the Brain-derived neurotrophic factor (Bdnf) gene in both the prefrontal cortex and blood following aversive caregiving. DNA methylation increased in response to aversive caregiving at exons IV and IX in both the prefrontal cortex and blood. Despite the similar group trends in both tissues in response to aversive caregiving, no correlations were found between DNA methylation in the brain and the blood. Data overall indicate that Bdnf DNA methylation in the blood and brain tissue is similarly responsive to early-life experiences, but the correlational analyses suggest that this relationship varies at the individual subject level.