Enzyme Active Sites and their Reaction Mechanisms

Enzyme Active Sites and their Reaction Mechanisms
Author: Harry Morrison
Publsiher: Academic Press
Total Pages: 280
Release: 2020-12-02
ISBN 10: 0128231947
ISBN 13: 9780128231944
Language: EN, FR, DE, ES & NL

Enzyme Active Sites and their Reaction Mechanisms Book Review:

Enzyme Active Sites and their Reaction Mechanisms provides a one-stop reference on how enzymes "work." Here, Dr. Harry Morrison, PhD and Professor Emeritus at Purdue University, provides a detailed overview of the origin and function of forty enzymes, the chemical details of their active sites, their mechanisms of action, and associated cofactors. The enzymes featured highlight a step forward, along with possible areas of application, thus supporting new research in academic and industrial labs. Each chapter is written in a clear format, including a brief summary of enzyme function and structure, a detailed description of their mechanisms of action and associated co-factors. Offers a comprehensive, biochemical understanding of enzyme mechanisms and their reaction sites Supports new research in academic, medical and industrial labs, connecting discoveries powered by recent advances in technology and experimental approaches to areas of application Features short, carefully structured, actionable chapters on various enzyme classes, thus allowing for easy-use and searchability

Enzymatic Reaction Mechanisms

Enzymatic Reaction Mechanisms
Author: Perry A. Frey,Adrian D. Hegeman
Publsiher: Oxford University Press
Total Pages: 848
Release: 2007-01-27
ISBN 10: 0199880743
ISBN 13: 9780199880744
Language: EN, FR, DE, ES & NL

Enzymatic Reaction Mechanisms Book Review:

Books dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.

Mechanisms of Catalysis

Mechanisms of Catalysis
Author: Anonim
Publsiher: Academic Press
Total Pages: 459
Release: 1991-01-28
ISBN 10: 9780080865966
ISBN 13: 0080865968
Language: EN, FR, DE, ES & NL

Mechanisms of Catalysis Book Review:

The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Molecular Biology of the Cell

Molecular Biology of the Cell
Author: Bruce Alberts
Publsiher: Unknown
Total Pages: 135
Release: 2004
ISBN 10: 9780815332183
ISBN 13: 0815332181
Language: EN, FR, DE, ES & NL

Molecular Biology of the Cell Book Review:

Enzymes

Enzymes
Author: Robert A. Copeland
Publsiher: John Wiley & Sons
Total Pages: 416
Release: 2004-04-07
ISBN 10: 0471461857
ISBN 13: 9780471461852
Language: EN, FR, DE, ES & NL

Enzymes Book Review:

Fully updated and expanded-a solid foundation for understandingexperimental enzymology. This practical, up-to-date survey is designed for a broadspectrum of biological and chemical scientists who are beginning todelve into modern enzymology. Enzymes, Second Editionexplains the structural complexities of proteins and enzymes andthe mechanisms by which enzymes perform their catalytic functions.The book provides illustrative examples from the contemporaryliterature to guide the reader through concepts and data analysisprocedures. Clear, well-written descriptions simplify the complexmathematical treatment of enzyme kinetic data, and numerouscitations at the end of each chapter enable the reader to accessthe primary literature and more in-depth treatments of specifictopics. This Second Edition of Enzymes: A Practical Introductionto Structure, Mechanism, and Data Analysis features refinedand expanded coverage of many concepts, while retaining theintroductory nature of the book. Important new featuresinclude: A new chapter on protein-ligand binding equilibria Expanded coverage of chemical mechanisms in enzyme catalysisand experimental measurements of enzyme activity Updated and refined discussions of enzyme inhibitors andmultiple substrate reactions Coverage of current practical applications to the study ofenzymology Supplemented with appendices providing contact information forsuppliers of reagents and equipment for enzyme studies, as well asa survey of useful Internet sites and computer software forenzymatic data analysis, Enzymes, Second Edition isthe ultimate practical guide for scientists and students inbiochemical, pharmaceutical, biotechnical, medicinal, andagricultural/food-related research.

Enzymes Involved in Glycolysis Fatty Acid and Amino Acid Biosynthesis Active Site Mechanism and Inhibition

Enzymes Involved in Glycolysis  Fatty Acid and Amino Acid Biosynthesis  Active Site Mechanism and Inhibition
Author: Marco Brito-Arias
Publsiher: Bentham Science Publishers
Total Pages: 334
Release: 2020-09-01
ISBN 10: 9811460884
ISBN 13: 9789811460883
Language: EN, FR, DE, ES & NL

Enzymes Involved in Glycolysis Fatty Acid and Amino Acid Biosynthesis Active Site Mechanism and Inhibition Book Review:

Multidisciplinary research involving crystallography, kinetic studies, molecular docking, genetics and other techniques in biochemistry has yielded a wealth of knowledge about the reaction mechanisms in cellular processes. This knowledge has allowed researchers to understand, in a better way, the normal functioning of the cell process, which is used as a reference point for learning about and preventing or correcting pathologies that cause diseases. This enzymology reference is a thorough compendium about reaction mechanisms occurring between the major enzymes related to the biosynthetic pathways of 3 important types of biological compounds – 6-carbon carbohydrates, fatty acids and amino acids – and their substrates, cofactors and residues. Readers will gain an understanding of the interaction between substrates or ligands with specific amino acid residues in biosynthetic enzymes. This understanding builds a foundation for learning about the biochemistry of different inhibitors used in the treatment of several diseases such as cancer, infectious diseases, and metabolic syndrome alterations such as diabetes and obesity. Enzymes covered in the book include aldolases, isomerases, kinases, mutases, synthases, dehydrogenases, reductases, transferases, hydrolases, lyases among others, all of which are wide spread in biochemical transformations. This reference, with its insights on common biochemical enzymes serves as a handy guide for students, researchers and professionals involved academia or industry related to pharmaceutical development, healthcare, food chemistry and other disciplines.

Structural and Functional Aspects of Enzyme Catalysis

Structural and Functional Aspects of Enzyme Catalysis
Author: H. Eggerer,R. Huber
Publsiher: Springer Science & Business Media
Total Pages: 218
Release: 2012-12-06
ISBN 10: 3642817386
ISBN 13: 9783642817380
Language: EN, FR, DE, ES & NL

Structural and Functional Aspects of Enzyme Catalysis Book Review:

Enzymes perform the executive role in growth, energy conversion, and repair of a living organism. Their activity is adjusted to their en vironment within the cell, being turned off, switched on, or finely tuned by specific metabolites according to demands at the physiologi cal level. Each enzyme discovered in the long history of enzymology has revealed its own individuality. Even closely related members of a family differ in specificity, stability or regulatory properties. Despite these, at first sight overwhelming aspects of individuality, common factors of enzymic reactions have been recognized. Enzymes are stereospecific catalysts even when a nonspecific process would yield the same product. Knowledge of the detailed stereochemistry of an enzymic reaction helps to deduce reaction mechanisms and to ob tain insight into the specific binding of substrates at the active site. This binding close to catalytically competent groups is related to the enormous speed of enzyme-catalyzed reactions. The physical ba sis of rate-enhancement is understood in principle and further exploit ed in the design of small organic receptor molecules as model enzymes. These aspects of enzyme catalysis are discussed in Session 1. Session 2 emphasizes the dynamic aspects of enzyme substrate inter action. Substrate must diffuse from solution space to the enzyme's surface. This process is influenced and can be greatly facilitated by certain electrostatic propterties of enzymes. The dynamic events during catalysis are studied by relaxation kinetics or NMR techniques.

Introduction to Enzyme and Coenzyme Chemistry

Introduction to Enzyme and Coenzyme Chemistry
Author: T. D. H. Bugg
Publsiher: John Wiley & Sons
Total Pages: 280
Release: 2012-05-29
ISBN 10: 1118348990
ISBN 13: 9781118348994
Language: EN, FR, DE, ES & NL

Introduction to Enzyme and Coenzyme Chemistry Book Review:

Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

Enzyme Kinetics Catalysis and Control

Enzyme Kinetics  Catalysis and Control
Author: Daniel L. Purich
Publsiher: Elsevier
Total Pages: 920
Release: 2010-06-16
ISBN 10: 0123809258
ISBN 13: 9780123809254
Language: EN, FR, DE, ES & NL

Enzyme Kinetics Catalysis and Control Book Review:

Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions

Chemistry 2e

Chemistry 2e
Author: Paul Flowers,Klaus Theopold,Richard Langley,Edward J. Neth,William R. Robinson
Publsiher: Unknown
Total Pages: 135
Release: 2019-02-14
ISBN 10: 9781947172623
ISBN 13: 194717262X
Language: EN, FR, DE, ES & NL

Chemistry 2e Book Review:

New Trends in Enzyme Catalysis and Biomimetic Chemical Reactions

New Trends in Enzyme Catalysis and Biomimetic Chemical Reactions
Author: Gertz I. Likhtenshtein
Publsiher: Springer Science & Business Media
Total Pages: 230
Release: 2007-05-08
ISBN 10: 0306481103
ISBN 13: 9780306481109
Language: EN, FR, DE, ES & NL

New Trends in Enzyme Catalysis and Biomimetic Chemical Reactions Book Review:

"This book is a view of enzyme catalysis by a physico-chemist with long-term experience in the investigation of structure and action mechanism of biological catalysts. This book is not intended to provide an exhaustive survey of each topic but rather a discussion of their theoretical and experimental background, and recent developments. The literature of enzyme catalysis is so vast and many scientists have made important contribution in the area, that it is impossible in the space allowed for this book to give a representative set of references. The author has tried to use reviews, and general principles of articles. He apologizes to those he has not been able to include. . ... The monograph is intended for scientists working on enzyme catalysis and adjacent areas such as chemical modeling of biological processes, homogeneous catalysis, biomedical research and biotechnology. The book can be use as a subsidiary manual for instructors, graduate and undergraduate students of university biochemistry and chemistry departments."--Pages ix-x.

Comprehensive Natural Products II

Comprehensive Natural Products II
Author: Anonim
Publsiher: Elsevier
Total Pages: 7388
Release: 2010-03-05
ISBN 10: 0080453821
ISBN 13: 9780080453828
Language: EN, FR, DE, ES & NL

Comprehensive Natural Products II Book Review:

This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas among the established natural products research community—which includes chemists, biochemists, biologists, botanists, and pharmacologists Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats Includes 100% new content, with more than 6,000 figures (1/3 of these in color) and 40,000 references to the primary literature, for a thorough examination of the field Highlights new research and innovations concerning living organisms and their distinctive role in our understanding and improvement of human health, genomics, ecology/environment, and more Adds to the rich body of work that is the first edition, which will be available for the first time in a convenient online format giving researchers complete access to authoritative Natural Products content

The Organic Chemistry of Enzyme catalyzed Reactions

The Organic Chemistry of Enzyme catalyzed Reactions
Author: Richard B. Silverman
Publsiher: Academic Press
Total Pages: 717
Release: 2002
ISBN 10: 0126437319
ISBN 13: 9780126437317
Language: EN, FR, DE, ES & NL

The Organic Chemistry of Enzyme catalyzed Reactions Book Review:

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

Enzyme Inhibition and Bioapplications

Enzyme Inhibition and Bioapplications
Author: Rakesh Sharma
Publsiher: BoD – Books on Demand
Total Pages: 332
Release: 2012-05-09
ISBN 10: 953510585X
ISBN 13: 9789535105855
Language: EN, FR, DE, ES & NL

Enzyme Inhibition and Bioapplications Book Review:

Enzyme Inhibition and Bioapplications is a concise book on applied methods of enzymes used in drug testing. The present volume will serve the purpose of applied drug evaluation methods in research projects, as well as relatively experienced enzyme scientists who might wish to develop their experiments further. Chapters are arranged in the order of basic concepts of enzyme inhibition and physiological basis of cytochromes followed by new concepts of applied drug therapy; reliability analysis; and new enzyme applications from mechanistic point of view.

Enzyme Inhibitors and Activators

Enzyme Inhibitors and Activators
Author: Murat Şentürk
Publsiher: BoD – Books on Demand
Total Pages: 268
Release: 2017-03-29
ISBN 10: 9535130579
ISBN 13: 9789535130574
Language: EN, FR, DE, ES & NL

Enzyme Inhibitors and Activators Book Review:

Over the recent years, medicinal chemistry has become responsible for explaining interactions of chemical molecule processes such that many scientists in the life sciences from agronomy to medicine are engaged in medicinal research. This book contains an overview focusing on the research area of enzyme inhibitor and activator, enzyme-catalyzed biotransformation, usage of microbial enzymes, enzymes associated with programmed cell death, natural products as potential enzyme inhibitors, protease inhibitors from plants in insect pest management, peptidases, and renin-angiotensin system. The book provides an overview on basic issues and some of the recent developments in medicinal science and technology. Especially, emphasis is devoted to both experimental and theoretical aspect of modern medicine. The primary target audience for the book includes students, researchers, chemists, molecular biologists, medical doctors, pharmacologists, and professionals who are interested in associated areas. The textbook is written by international scientists with expertise in biochemistry, enzymology, molecular biology, and genetics, many of which are active in biochemical and pharmacological research. I would like to acknowledge the authors for their contribution to the book. We hope that the textbook will enhance the knowledge of scientists in the complexities of some medical approaches; it will stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications of pharmacology.

An Introduction to Biochemical Reaction Mechanisms

An Introduction to Biochemical Reaction Mechanisms
Author: James N. Lowe,Lloyd L. Ingraham
Publsiher: Prentice Hall
Total Pages: 145
Release: 1974
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015001646895
Language: EN, FR, DE, ES & NL

An Introduction to Biochemical Reaction Mechanisms Book Review:

Enzymatic Reaction Mechanisms

Enzymatic Reaction Mechanisms
Author: Perry A. Frey,Adrian D. Hegeman
Publsiher: Oxford University Press
Total Pages: 848
Release: 2007-01-27
ISBN 10: 9780195352740
ISBN 13: 0195352742
Language: EN, FR, DE, ES & NL

Enzymatic Reaction Mechanisms Book Review:

Books dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.

Enzymes and Their Inhibitors

Enzymes and Their Inhibitors
Author: H. John Smith,Claire Simons
Publsiher: CRC Press
Total Pages: 328
Release: 2004-11-29
ISBN 10: 0203414586
ISBN 13: 9780203414583
Language: EN, FR, DE, ES & NL

Enzymes and Their Inhibitors Book Review:

Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibitors: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, functions, mechanisms, and kinetics of enzymes, including their use as disease markers, analytical reagents, and in industrial processes. Subsequent chapters discuss the different types of enzyme inhibitors and the principles involved in developing them into effective drugs. This outstanding text, also valuable as a professional reference, will be useful to all students of pharmacology and medicinal chemistry.

Computational Methods for Analysis and Redesign of Enzyme Active Sites

Computational Methods for Analysis and Redesign of Enzyme Active Sites
Author: Geoffrey Ryan Nosrati
Publsiher: Unknown
Total Pages: 147
Release: 2012
ISBN 10: 1928374650XXX
ISBN 13: OCLC:827230857
Language: EN, FR, DE, ES & NL

Computational Methods for Analysis and Redesign of Enzyme Active Sites Book Review:

The rational design of enzymes and understanding of enzyme mechanisms both present a tremendous challenge in terms of both computational and experimental methodologies. In this work, we review the current state-of-the-art techniques in enzyme design and present a new computational method for active site redesign, called SABER (Selection of Active/Binding sites for Enzyme Redesign). This program was used to analyze both an existing enzyme redesign from the literature, o-succinyl benzoate synthase, and to predict new scaffolds that might be redesigned function similarly to a designed Kemp elimination enzyme. The logic behind the program is discussed in detail with examples taken from the code. Next, SABER was applied to the problem of predicting catalytic functionality in enzyme active sites. This methodology was used to analyze the active sites from two well-studied enzyme families, the serine proteases and the tyrosine phosphatases, and was found to predict catalytic function with high accuracy. It was then used to analyze the active site of orotidine 5'-monophosphate decarboxylase, an enzyme with an unknown mechanism, and used to support of an imminium-based mechanism of catalysis. Finally, a very challenging rational enzyme design process to catalyze an aromatic Claisen rearrangement is discussed. This led to the design and synthesis of six enzymes, none of which showed any rate acceleration versus the background reaction. During this work, an aromatic Claisen substrate that rearranges rapidly in water was discovered and characterized. This was used to highlight the difficulties in both the enzyme design process and in prediction of hydrogen-bond catalyzed reaction rates in water.

Theory and Experiment in Electrocatalysis

Theory and Experiment in Electrocatalysis
Author: Perla B. Balbuena,Venkat R. Subramanian
Publsiher: Springer Science & Business Media
Total Pages: 578
Release: 2010-11-02
ISBN 10: 1441955941
ISBN 13: 9781441955944
Language: EN, FR, DE, ES & NL

Theory and Experiment in Electrocatalysis Book Review:

This review volume highlights advances in both theoretical and experimental techniques and points out both the progress made and the challenges to overcome in the near future. The topics cover a broad spectrum going from surface characterization, investigation of thermodynamics and kinetics mechanistic pathways, electrochemical experiments and theory, multi-scale modeling applied to synthesis and growth processes such as electrodeposition, and corrosion reactions arising from the nanosize of electrocatalysts that affect their lifetime and activity.