Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

Physiologically Based Pharmacokinetic  PBPK  Modeling and Simulations
Author: Sheila Annie Peters
Publsiher: John Wiley & Sons
Total Pages: 450
Release: 2012-02-17
ISBN 10: 1118140303
ISBN 13: 9781118140307
Language: EN, FR, DE, ES & NL

Physiologically Based Pharmacokinetic PBPK Modeling and Simulations Book Review:

The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand development. Comprised of two parts, the book first provides adetailed and systematic treatment of the principles behindphysiological modeling of pharmacokinetic processes,inter-individual variability, and drug interactions for smallmolecule drugs and biologics. The second part looks in greaterdetail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for abrief overview of the field as well as those who need more detail,the book includes a range of important learning aids. Featuringend-of-chapter keywords for easy reference—a valuable assetfor general or novice readers without a PBPK background—alongwith an extensive bibliography for those looking for furtherinformation, Physiologically- Based Pharmacokinetic (PBPK) Modelingand Simulations is the essential single-volume text on one of thehottest topics in the pharmaceutical sciences today.

Physiologically Based Pharmacokinetic PBPK Modeling

Physiologically Based Pharmacokinetic  PBPK  Modeling
Author: Jeffrey W. Fisher,Jeffery Gearhart,Zhoumeng Lin
Publsiher: Academic Press
Total Pages: 346
Release: 2020-05-20
ISBN 10: 0128196823
ISBN 13: 9780128196823
Language: EN, FR, DE, ES & NL

Physiologically Based Pharmacokinetic PBPK Modeling Book Review:

Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more. Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research Authored by expert editors and contributors who are among the best PBPK modelers in the world

Pharmacokinetic Pharmacodynamic Modeling and Simulation

Pharmacokinetic Pharmacodynamic Modeling and Simulation
Author: Peter L. Bonate
Publsiher: Springer Science & Business Media
Total Pages: 618
Release: 2011-07-01
ISBN 10: 1441994858
ISBN 13: 9781441994851
Language: EN, FR, DE, ES & NL

Pharmacokinetic Pharmacodynamic Modeling and Simulation Book Review:

This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.

Mathematical Modeling of Pharmacokinetic Data

Mathematical Modeling of Pharmacokinetic Data
Author: DavidW.A. Bourne
Publsiher: Routledge
Total Pages: 152
Release: 2018-05-02
ISBN 10: 1351433253
ISBN 13: 9781351433259
Language: EN, FR, DE, ES & NL

Mathematical Modeling of Pharmacokinetic Data Book Review:

A concise guide to mathematical modeling and analysis of pharmacokinetic data, this book contains valuable methods for maximizing the information obtained from given data. It is an ideal resource for scientists, scholars, and advanced students.

Clinical Anesthesia 7e Print Ebook with Multimedia

Clinical Anesthesia  7e  Print   Ebook with Multimedia
Author: Paul Barash,Bruce F. Cullen,Robert K. Stoelting,Michael Cahalan,Christine M. Stock,Rafael Ortega
Publsiher: Lippincott Williams & Wilkins
Total Pages: 1880
Release: 2013-02-07
ISBN 10: 1469830272
ISBN 13: 9781469830278
Language: EN, FR, DE, ES & NL

Clinical Anesthesia 7e Print Ebook with Multimedia Book Review:

Clinical Anesthesia, Seventh Edition covers the full spectrum of clinical options, providing insightful coverage of pharmacology, physiology, co-existing diseases, and surgical procedures. This classic book is unmatched for its clarity and depth of coverage. *This version does not support the video and update content that is included with the print edition. Key Features: • Formatted to comply with Kindle specifications for easy reading • Comprehensive and heavily illustrated • Full color throughout • Key Points begin each chapter and are labeled throughout the chapter where they are discussed at length • Key References are highlighted • Written and edited by acknowledged leaders in the field • New chapter on Anesthesia for Laparoscopic and Robotic Surgery Whether you’re brushing up on the basics, or preparing for a complicated case, the digital version will let you take the content wherever you go.

Clinical Anesthesia 7e Ebook without Multimedia

Clinical Anesthesia  7e  Ebook without Multimedia
Author: Paul Barash,Bruce F. Cullen,Robert K. Stoelting,Michael Cahalan,M. Christine Stock,Rafael Ortega
Publsiher: Lippincott Williams & Wilkins
Total Pages: 1880
Release: 2013-03-01
ISBN 10: 1469830248
ISBN 13: 9781469830247
Language: EN, FR, DE, ES & NL

Clinical Anesthesia 7e Ebook without Multimedia Book Review:

Clinical Anesthesia, Seventh Edition covers the full spectrum of clinical options, providing insightful coverage of pharmacology, physiology, co-existing diseases, and surgical procedures. This classic book is unmatched for its clarity and depth of coverage. *This version does not support the video and update content that is included with the print edition. Key Features: • Formatted to comply with Kindle specifications for easy reading • Comprehensive and heavily illustrated • Full color throughout • Key Points begin each chapter and are labeled throughout the chapter where they are discussed at length • Key References are highlighted • Written and edited by acknowledged leaders in the field • New chapter on Anesthesia for Laparoscopic and Robotic Surgery Whether you’re brushing up on the basics, or preparing for a complicated case, the digital version will let you take the content wherever you go.

Modeling in Biopharmaceutics Pharmacokinetics and Pharmacodynamics

Modeling in Biopharmaceutics  Pharmacokinetics and Pharmacodynamics
Author: Panos Macheras,Athanassios Iliadis
Publsiher: Springer Science & Business Media
Total Pages: 444
Release: 2006-04-26
ISBN 10: 0387319107
ISBN 13: 9780387319100
Language: EN, FR, DE, ES & NL

Modeling in Biopharmaceutics Pharmacokinetics and Pharmacodynamics Book Review:

This book presents a novel modeling approach to biopharamceutics, pharmacokinetics and pharmacodynamic phenomena. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. Throughout, many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling
Author: Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III
Publsiher: John Wiley & Sons
Total Pages: 420
Release: 2005-06-14
ISBN 10: 0471478776
ISBN 13: 9780471478775
Language: EN, FR, DE, ES & NL

Physiologically Based Pharmacokinetic Modeling Book Review:

A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book presents an overview of the underlying principles of PBPKmodel development. Then it provides a compendium of PBPK modelinginformation, including historical development, specific modelingchallenges, and current practices for: * Halogenated Alkanes * Halogenated Alkenes * Alkene and Aromatic Compounds * Reactive Vapors in the Nasal Cavity * Alkanes, Oxyhydrocarbons, and Related Compounds * Pesticides and Persistent Organic Pollutants * Dioxin and Related Compounds * Metals and Inorganic Compounds * Drugs * Antineoplastic Agents * Perinatal Transfer * Mixtures * Dermal Exposure Models In addition to pinpointing specific information, readers canexplore diverse modeling techniques and applications. Anauthoritative reference for toxicologists, ecotoxicologists, riskassessors, regulators, pharmacologists, pharmacists, and graduatestudents in pharmacokinetics and toxicology, Physiologically-BasedPharmacokinetic Modeling compiles information from leaders in thefield and discusses future directions for PBPK modeling.

Clinical Anesthesia

Clinical Anesthesia
Author: Paul G. Barash
Publsiher: Lippincott Williams & Wilkins
Total Pages: 1808
Release: 2017-04-10
ISBN 10: 1496337018
ISBN 13: 9781496337016
Language: EN, FR, DE, ES & NL

Clinical Anesthesia Book Review:

Where experts turn for definitive answers! Clinical Anesthesia covers the full spectrum of clinical issues and options in anesthesiology, providing insightful coverage of pharmacology, physiology, co-existing diseases, and surgical procedures. Unmatched in its clarity and depth of coverage as well as its robust multimedia features, this classic clinical reference brings you the very latest essential knowledge in the field, equipping you to effectively apply today’s standards of care and make optimal clinical decisions on behalf of your patients.

Essential Pharmacokinetics

Essential Pharmacokinetics
Author: Thorsteinn Loftsson
Publsiher: Academic Press
Total Pages: 178
Release: 2015-03-25
ISBN 10: 0128014911
ISBN 13: 9780128014912
Language: EN, FR, DE, ES & NL

Essential Pharmacokinetics Book Review:

Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes Illustrates how to write and evaluate drug registration files

Pharmacometrics

Pharmacometrics
Author: Ene I. Ette,Paul J. Williams
Publsiher: John Wiley & Sons
Total Pages: 1216
Release: 2013-03-14
ISBN 10: 1118679512
ISBN 13: 9781118679517
Language: EN, FR, DE, ES & NL

Pharmacometrics Book Review:

Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. The pharmaceutical industry is integrating pharmacometrics into its drug development program, but there is a lack of and need for experienced pharmacometricians since fewer and fewer academic programs exist to train them. Pharmacometrics: The Science of Quantitative Pharmacology lays out the science of pharmacometrics and its application to drug development, evaluation, and patient pharmacotherapy, providing a comprehensive set of tools for the training and development of pharmacometricians. Edited and written by key leaders in the field, this flagship text on pharmacometrics: Integrates theory and practice to let the reader apply principles and concepts. Provides a comprehensive set of tools for training and developing expertise in the pharmacometric field. Is unique in including computer code information with the examples. This volume is an invaluable resource for all pharmacometricians, statisticians, teachers, graduate and undergraduate students in academia, industry, and regulatory agencies.

Pharmacokinetic Evaluation and Modeling of Clinically Significant Drug Metabolites

Pharmacokinetic Evaluation and Modeling of Clinically Significant Drug Metabolites
Author: Constantin Mircioiu,Momir Mikov,Victor A. Voicu,Adrian Nicolescu,Valentina Anuta
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-07-14
ISBN 10: 2889710432
ISBN 13: 9782889710430
Language: EN, FR, DE, ES & NL

Pharmacokinetic Evaluation and Modeling of Clinically Significant Drug Metabolites Book Review:

69th AACC Annual Scientific Meeting Abstract eBook

69th AACC Annual Scientific Meeting Abstract eBook
Author: American Association for Clinical Chemistry
Publsiher: CTI Meeting Technology
Total Pages: 135
Release: 2017-06-30
ISBN 10: 1928374650XXX
ISBN 13: 9182736450XXX
Language: EN, FR, DE, ES & NL

69th AACC Annual Scientific Meeting Abstract eBook Book Review:

Toxicokinetics and Risk Assessment

Toxicokinetics and Risk Assessment
Author: John C. Lipscomb,Edward V. Ohanian
Publsiher: CRC Press
Total Pages: 361
Release: 2016-04-19
ISBN 10: 1000612139
ISBN 13: 9781000612134
Language: EN, FR, DE, ES & NL

Toxicokinetics and Risk Assessment Book Review:

Toxicokinetics in Risk Assessment discusses the noncancer risk assessment process and its reliance on uncertainty factors in order to facilitate the continued study and refinement of the scientific basis for health risk assessment. This text clearly demonstrates the application of physiologically-based pharmacokinetic (PBPK) modeling in human healt

Computational Pharmacokinetics

Computational Pharmacokinetics
Author: Anders Kallen
Publsiher: CRC Press
Total Pages: 184
Release: 2007-07-19
ISBN 10: 9781420060669
ISBN 13: 142006066X
Language: EN, FR, DE, ES & NL

Computational Pharmacokinetics Book Review:

Being that pharmacokinetics (PK) is the study of how the body handles various substances, it is not surprising that PK plays an important role in the early development of new drugs. However, the clinical research community widely believes that mathematics in some way blurs the true meaning of PK. Demonstrating that quite the opposite is true, Computational Pharmacokinetics outlines the fundamental concepts and models of PK from a mathematical perspective based on clinically relevant parameters. After an introductory chapter, the book presents a noncompartmental approach to PK and discusses the numerical analysis of PK data, including a description of an absorption process through numerical deconvolution. The author then builds a simple physiological model to better understand PK volumes and compares this model to other methods. The book also introduces compartmental models, discusses their limitations, and creates a general-purpose type of model. The final chapter looks at the relationship between drug concentration and effect, known as PK/pharmacodynamics (PD) modeling. With both a solid discussion of theory and the use of practical examples, this book will enable readers to thoroughly grasp the computational factors of PK modeling.

Basic Pharmacokinetics and Pharmacodynamics

Basic Pharmacokinetics and Pharmacodynamics
Author: Sara E. Rosenbaum
Publsiher: John Wiley & Sons
Total Pages: 576
Release: 2016-12-27
ISBN 10: 1119143152
ISBN 13: 9781119143154
Language: EN, FR, DE, ES & NL

Basic Pharmacokinetics and Pharmacodynamics Book Review:

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Clinical Anesthesia Fundamentals Ebook without Multimedia

Clinical Anesthesia Fundamentals  Ebook without Multimedia
Author: Paul G. Barash,Bruce F. Cullen,Robert K. Stoelting,Michael Cahalan,M. Christine Stock,Rafael Ortega,Sam R. Sharar
Publsiher: Lippincott Williams & Wilkins
Total Pages: 912
Release: 2015-04-28
ISBN 10: 1496310845
ISBN 13: 9781496310842
Language: EN, FR, DE, ES & NL

Clinical Anesthesia Fundamentals Ebook without Multimedia Book Review:

From the popular and highly respected Clinical Anesthesia family of titles comes a new resource that clearly and simply explains the core concepts of anesthesiology that you need to know. From physiology and pharmacology to anatomy and system-based anesthesia, it uses full-color graphics, easy-to-read tables, and clear, concise text to convey the essential principles of the field.

Perinatal and Neonatal Infections An Issue of Clinics in Perinatology EBook

Perinatal and Neonatal Infections  An Issue of Clinics in Perinatology EBook
Author: Joseph B. Cantey,Andi Shane
Publsiher: Elsevier Health Sciences
Total Pages: 240
Release: 2021-06-03
ISBN 10: 0323757065
ISBN 13: 9780323757065
Language: EN, FR, DE, ES & NL

Perinatal and Neonatal Infections An Issue of Clinics in Perinatology EBook Book Review:

In this issue of Clinics in Perinatology, guest editors Joseph B. Cantey and Andi Shane bring their considerable expertise to the topic of Perinatal and Neonatal Infections. Provides in-depth, clinical reviews on Perinatal and Neonatal Infections, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Handbook of Pharmacokinetic Pharmacodynamic Correlation

Handbook of Pharmacokinetic Pharmacodynamic Correlation
Author: Hartmut Derendorf,Guenther Hochhaus
Publsiher: CRC Press
Total Pages: 483
Release: 2019-06-04
ISBN 10: 1000005909
ISBN 13: 9781000005905
Language: EN, FR, DE, ES & NL

Handbook of Pharmacokinetic Pharmacodynamic Correlation Book Review:

First published in 1995: Combining the established disciplines of pharmacokinetics (PK), the relationship between drug concentration and time, and pharmacodynamics (PD), the relationship between drug effects and concentration, this handbook examines the relevant relationship between drug effects and time.

Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

Physiologically Based Pharmacokinetic  PBPK  Modeling and Simulations
Author: Sheila Annie Peters
Publsiher: John Wiley & Sons
Total Pages: 624
Release: 2021-09-30
ISBN 10: 1119497795
ISBN 13: 9781119497790
Language: EN, FR, DE, ES & NL

Physiologically Based Pharmacokinetic PBPK Modeling and Simulations Book Review:

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations The first book dedicated to the emerging field of physiologically based pharmacokinetic modeling (PBPK) Now in its second edition, Physiologically Based Pharmacokinetic (PBPK) Modelling and Simulations: Principles, Methods, and Applications in the Pharma Industry remains the premier reference book throughout the rapidly growing PBPK user community. Using clear and concise language, author Sheila Annie Peters connects theory with practice as she explores the vast potential of PBPK modeling for improving drug discovery and development. This fully updated new edition covers key developments in the field of PBPK modelling and simulations that have emerged in recent years. A brand-new section provides case studies in different application areas of PBPK modelling, including drug-drug interaction, genetic polymorphism, renal impairment, and pediatric extrapolation. Additional chapters address topics such as model-informed drug development (MIDD) and expose readers to a wide range of current applications in the field. Throughout the book, substantially revised chapters simplify complex topics and offer a balanced view of both the opportunities and challenges of PBPK modelling. Providing timely and comprehensive coverage of one of the most exciting new areas of pharmaceutical science, this book: Describes the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics Features a wealth of new figures and case studies of the applications of PBPK modelling along the value chain in drug discovery and development Reflects the latest regulatory guidelines on the reporting of PBPK modelling analysis Includes access to a new companion website containing code, datasets, explanations of case examples in the text, and discussion of key developments in the field Contains a brief overview of the field, end-of-chapter keywords for easy reference, and an extensive bibliography Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry, Second Edition is an indispensable single-volume resource for beginning and intermediate practitioners across the pharmaceutical sciences in both industry and academia.