Dynemicin A Uncialamycin and Analogues

Dynemicin A  Uncialamycin and Analogues
Author: Daniel Best,Mickael Jean,Pierre Van De Weghe
Publsiher: Elsevier
Total Pages: 144
Release: 2016-06-14
ISBN 10: 0081010869
ISBN 13: 9780081010860
Language: EN, FR, DE, ES & NL

Dynemicin A Uncialamycin and Analogues Book Review:

Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds

Asymmetric Phase Transfer Catalysis

Asymmetric Phase Transfer Catalysis
Author: Keiji Maruoka
Publsiher: John Wiley & Sons
Total Pages: 228
Release: 2008-03-31
ISBN 10: 9783527318421
ISBN 13: 3527318429
Language: EN, FR, DE, ES & NL

Asymmetric Phase Transfer Catalysis Book Review:

Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author: Atta-ur-Rahman
Publsiher: Elsevier
Total Pages: 468
Release: 2018-08-08
ISBN 10: 0444640592
ISBN 13: 9780444640598
Language: EN, FR, DE, ES & NL

Studies in Natural Products Chemistry Book Review:

Studies in Natural Products Chemistry, Volume 58, covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Microbes in Microbial Communities

Microbes in Microbial Communities
Author: Raghvendra Pratap Singh,Geetanjali Manchanda,Kaushik Bhattacharjee,Hovik Panosyan
Publsiher: Springer Nature
Total Pages: 370
Release: 2022-01-01
ISBN 10: 9811656177
ISBN 13: 9789811656170
Language: EN, FR, DE, ES & NL

Microbes in Microbial Communities Book Review:

The book overviews the complex interactions amongst the microbes and their possible applications. Emphasis has been made to include a wide spectrum of experimental and theoretical contributions from eminent researchers in the field. Microbial communities are the assemblages of microorganisms of various species which live together in the same environment and continuously interact with each other. The microbial cells in communities display unique phenotypes that affect the survival and reproduction of other cells present around them. These phenotypes constitute the social adaptations that drive the interactions between microbial cells. The interactions, further determine the productivity, stability and the ability of community to resist the environmental perturbations. These microbial communities live with extremely competitive niche and fight for their survival and genetic persistence. But they frequently appear in niche with multifaceted and interactive webs rather than the planktonic nature. This can be within the same species or with different species, or even with diverse genera and families. It either a competitive winner community whereas the “weaker” strain goes extinct or a competitor that coexist with their metabolic secretory potentials or a separator that assigned their own community territorial niches. Sometimes, it can be neutral or tritagonist. These microbial associations within the microbiome provides the foundation for diverse forms of microbial ecology and determined the applied perspectives for agriculture, clinical and industrial sectors. This book will be useful to postgraduate students, researchers from academic as well as industry working in the field of microbial exploration with keen interest in survival factors and mechanism of their survival by various ecological and functional strategies.

Biphasic Chemistry and The Solvent Case

Biphasic Chemistry and The Solvent Case
Author: Jean-Philippe Goddard,Max Malacria,Cyril Ollivier
Publsiher: John Wiley & Sons
Total Pages: 230
Release: 2020-02-05
ISBN 10: 1786305097
ISBN 13: 9781786305091
Language: EN, FR, DE, ES & NL

Biphasic Chemistry and The Solvent Case Book Review:

Biphasic Chemistry and The Solvent Case examines recent improvements in reaction conditions, in order to affirm the role of chemistry in the sustainable field. This book shows that those who work within the chemistry industry support limits for the use of toxic or flammable solvents, since it reduces the purifications to simple filtrations. Thanks to commercial scavengers, solid phase syntheses are now available to all. Fluorine biphasic catalysis enables extremely efficient catalyst recycling and has a high applicability potential at the industrial level. This book also reviews the many studies that have shown that water is a solvent of choice for most synthetic reactions. Particular traits can be obtained and the effects on thermodynamics make it possible to operate at lower temperatures, thereby achieving energy savings. Finally the great diversity of application of the reactions without solvents is illustrated.

Analytical Determination of Nicotine and Related Compounds and their Metabolites

Analytical Determination of Nicotine and Related Compounds and their Metabolites
Author: J.W. Gorrod,P. Jacob III
Publsiher: Elsevier
Total Pages: 772
Release: 1999-11-02
ISBN 10: 9780080525518
ISBN 13: 0080525512
Language: EN, FR, DE, ES & NL

Analytical Determination of Nicotine and Related Compounds and their Metabolites Book Review:

This book provides for the first time a single comprehensive source of information on the analytical chemistry of nicotine and related alkaloids. The editors have brought together scientists from academia and the tobacco industry to describe the state-of-the-art of the chemistry and analytical methods for measurement of nicotine. Both the scope and detail of the book are impressive. Chapters describe the history, pharmacology and toxicology of nicotine, the biosynthesis of nicotine and other alkaloids in the tobacco plant, the general chemistry of nicotine and the analytical methodologies that have been used to measure nicotine and related alkaloids in biological specimens, in tobacco and pharmaceutical products and in tobacco smoke. There is also a comprehensive review of the chemistry and toxicology of nicotine-derived nitrosamines, an important class of tobacco carcinogens.

Cytotoxic Payloads for AntibodyDrug Conjugates

Cytotoxic Payloads for AntibodyDrug Conjugates
Author: David E Thurston,Paul J M Jackson
Publsiher: Royal Society of Chemistry
Total Pages: 480
Release: 2019-07-11
ISBN 10: 1788018451
ISBN 13: 9781788018456
Language: EN, FR, DE, ES & NL

Cytotoxic Payloads for AntibodyDrug Conjugates Book Review:

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

Building a Practical Information Security Program

Building a Practical Information Security Program
Author: Jason Andress,Mark Leary
Publsiher: Syngress
Total Pages: 202
Release: 2016-11-01
ISBN 10: 0128020881
ISBN 13: 9780128020883
Language: EN, FR, DE, ES & NL

Building a Practical Information Security Program Book Review:

Building a Practical Information Security Program provides users with a strategic view on how to build an information security program that aligns with business objectives. The information provided enables both executive management and IT managers not only to validate existing security programs, but also to build new business-driven security programs. In addition, the subject matter supports aspiring security engineers to forge a career path to successfully manage a security program, thereby adding value and reducing risk to the business. Readers learn how to translate technical challenges into business requirements, understand when to "go big or go home," explore in-depth defense strategies, and review tactics on when to absorb risks. This book explains how to properly plan and implement an infosec program based on business strategy and results. Provides a roadmap on how to build a security program that will protect companies from intrusion Shows how to focus the security program on its essential mission and move past FUD (fear, uncertainty, and doubt) to provide business value Teaches how to build consensus with an effective business-focused program

Catalytic Cascade Reactions

Catalytic Cascade Reactions
Author: Peng-Fei Xu,Wei Wang
Publsiher: John Wiley & Sons
Total Pages: 440
Release: 2013-11-11
ISBN 10: 1118016025
ISBN 13: 9781118016022
Language: EN, FR, DE, ES & NL

Catalytic Cascade Reactions Book Review:

Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency. Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition-metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research. Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Brønsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes Application of transition-metal catalyzed cascade reactions in natural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascade reactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth. Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade processes. Moreover, it sets the stage for the development of new catalytic cascade reactions and their applications.

Active Pharmaceutical Ingredients in Synthesis

Active Pharmaceutical Ingredients in Synthesis
Author: Anthony J. Burke,Carolina Silva Marques,Nicholas J. Turner,Gesine J. Hermann
Publsiher: John Wiley & Sons
Total Pages: 456
Release: 2018-11-28
ISBN 10: 3527342419
ISBN 13: 9783527342419
Language: EN, FR, DE, ES & NL

Active Pharmaceutical Ingredients in Synthesis Book Review:

Presents the most effective catalytic reactions in use today, with a special focus on process intensification, sustainability, waste reduction, and innovative methods This book demonstrates the importance of efficient catalytic transformations for producing pharmaceutically active molecules. It presents the key catalytic reactions and the most efficient catalytic processes, including their significant advantages over compared previous methods. It also places a strong emphasis on asymmetric catalytic reactions, process intensification (PI), sustainability and waste mitigation, continuous manufacturing processes as enshrined by continuous flow catalysis, and supported catalysis. Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development offers chapters covering: Catalysis and Prerequisites for the Modern Pharmaceutial Industry Landscape; Catalytic Process Design - The Industrial Perspective; Hydrogenation, Hydroformylation and Other Reductions; Oxidation; ; Catalytic Addition Reactions; Catalytic Cross-Coupling Reactions; Catalytic Metathesis Reactions; Catalytic Cycloaddition Reactions: Coming Full-Circle; Catalytic Cyclopropanation Reactions; Catalytic C-H insertion Reactions; Phase Transfer Catalysis; and Biocatalysis. -Provides the reader with an updated clear view of the current state of the challenging field of catalysis for API production -Focuses on the application of catalytic methods for the synthesis of known APIs -Presents every key reaction, including Diels-Alder, CH Insertions, Metal-catalytic coupling-reactions, and many more -Includes recent patent literature for completeness Covering a topic of great interest for synthetic chemists and R&D researchers in the pharmaceutical industry, Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development is a must-read for every synthetic chemist working with APIs.

Molecules That Changed the World

Molecules That Changed the World
Author: K. C. Nicolaou,Tamsyn Montagnon
Publsiher: Wiley-VCH
Total Pages: 385
Release: 2008-03-17
ISBN 10: 9783527309832
ISBN 13: 3527309837
Language: EN, FR, DE, ES & NL

Molecules That Changed the World Book Review:

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Here, the best-selling author and renowned researcher, K. C. Nicolaou, presents around 40 natural products that all have an enormous impact on our everyday life. Printed in full color throughout with a host of pictures, this book is written in the author's very enjoyable and distinct style, such that each chapter is full of interesting and entertaining information on the facts, stories and people behind the scenes. Molecules covered span the healthy and useful, as well as the much-needed and extremely toxic, including Aspirin, urea, camphor, morphine, strychnine, penicillin, vitamin B12, Taxol, Brevetoxin and quinine. A veritable pleasure to read.

Classics in Total Synthesis

Classics in Total Synthesis
Author: K. C. Nicolaou,E. J. Sorensen
Publsiher: John Wiley & Sons
Total Pages: 821
Release: 1996-04-11
ISBN 10: 3527292314
ISBN 13: 9783527292318
Language: EN, FR, DE, ES & NL

Classics in Total Synthesis Book Review:

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

Comprehensive Natural Products III

Comprehensive Natural Products III
Author: Anonim
Publsiher: Elsevier
Total Pages: 4238
Release: 2020-07-22
ISBN 10: 0081026919
ISBN 13: 9780081026915
Language: EN, FR, DE, ES & NL

Comprehensive Natural Products III Book Review:

Comprehensive Natural Products III, Third Edition, updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Computational Organic Chemistry

Computational Organic Chemistry
Author: Steven M. Bachrach
Publsiher: John Wiley & Sons
Total Pages: 632
Release: 2014-03-03
ISBN 10: 1118671228
ISBN 13: 9781118671221
Language: EN, FR, DE, ES & NL

Computational Organic Chemistry Book Review:

The Second Edition demonstrates how computational chemistry continues to shed new light on organic chemistry The Second Edition of author Steven Bachrach’s highly acclaimed Computational Organic Chemistry reflects the tremendous advances in computational methods since the publication of the First Edition, explaining how these advances have shaped our current understanding of organic chemistry. Readers familiar with the First Edition will discover new and revised material in all chapters, including new case studies and examples. There’s also a new chapter dedicated to computational enzymology that demonstrates how principles of quantum mechanics applied to organic reactions can be extended to biological systems. Computational Organic Chemistry covers a broad range of problems and challenges in organic chemistry where computational chemistry has played a significant role in developing new theories or where it has provided additional evidence to support experimentally derived insights. Readers do not have to be experts in quantum mechanics. The first chapter of the book introduces all of the major theoretical concepts and definitions of quantum mechanics followed by a chapter dedicated to computed spectral properties and structure identification. Next, the book covers: Fundamentals of organic chemistry Pericyclic reactions Diradicals and carbenes Organic reactions of anions Solution-phase organic chemistry Organic reaction dynamics The final chapter offers new computational approaches to understand enzymes. The book features interviews with preeminent computational chemists, underscoring the role of collaboration in developing new science. Three of these interviews are new to this edition. Readers interested in exploring individual topics in greater depth should turn to the book’s ancillary website www.comporgchem.com, which offers updates and supporting information. Plus, every cited article that is available in electronic form is listed with a link to the article.

Selenium in Natural Products Synthesis

Selenium in Natural Products Synthesis
Author: K. C. Nicolaou,N. A. Petasis
Publsiher: Cis
Total Pages: 328
Release: 1984
ISBN 10: 1928374650XXX
ISBN 13: UCSD:31822001671486
Language: EN, FR, DE, ES & NL

Selenium in Natural Products Synthesis Book Review:

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy
Author: Loutfy H. Madkour
Publsiher: Academic Press
Total Pages: 650
Release: 2019-08-27
ISBN 10: 0128197781
ISBN 13: 9780128197783
Language: EN, FR, DE, ES & NL

Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book Review:

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Natural and Synthetic Biomedical Polymers

Natural and Synthetic Biomedical Polymers
Author: Sangamesh Kumbar,Cato Laurencin,Meng Deng
Publsiher: Newnes
Total Pages: 420
Release: 2014-01-21
ISBN 10: 0123972906
ISBN 13: 9780123972903
Language: EN, FR, DE, ES & NL

Natural and Synthetic Biomedical Polymers Book Review:

Polymers are important and attractive biomaterials for researchers and clinical applications due to the ease of tailoring their chemical, physical and biological properties for target devices. Due to this versatility they are rapidly replacing other classes of biomaterials such as ceramics or metals. As a result, the demand for biomedical polymers has grown exponentially and supports a diverse and highly monetized research community. Currently worth $1.2bn in 2009 (up from $650m in 2000), biomedical polymers are expected to achieve a CAGR of 9.8% until 2015, supporting a current research community of approximately 28,000+. Summarizing the main advances in biopolymer development of the last decades, this work systematically covers both the physical science and biomedical engineering of the multidisciplinary field. Coverage extends across synthesis, characterization, design consideration and biomedical applications. The work supports scientists researching the formulation of novel polymers with desirable physical, chemical, biological, biomechanical and degradation properties for specific targeted biomedical applications. Combines chemistry, biology and engineering for expert and appropriate integration of design and engineering of polymeric biomaterials Physical, chemical, biological, biomechanical and degradation properties alongside currently deployed clinical applications of specific biomaterials aids use as single source reference on field. 15+ case studies provides in-depth analysis of currently used polymeric biomaterials, aiding design considerations for the future

Handbook of Heterocyclic Chemistry

Handbook of Heterocyclic Chemistry
Author: Alan R. Katritzky
Publsiher: Elsevier
Total Pages: 568
Release: 2017-01-31
ISBN 10: 1483293424
ISBN 13: 9781483293424
Language: EN, FR, DE, ES & NL

Handbook of Heterocyclic Chemistry Book Review:

Provides a one-volume overall picture of the largest of the classical divisions of organic chemistry, suitable for the graduate or advanced undergraduate student, as well as for research workers, both specialists in the field and those engaged in another discipline and requiring knowledge of heterocyclic chemistry. It represents Volume 9 of Comprehensive Heterocyclic Chemistry and utilizes the general chapters which appear in the 8-volume work. The highly systematic coverage given to the subject makes this the most authoritative one-volume account of modern heterocyclic chemistry available.

Biosynthesis of Heterocycles

Biosynthesis of Heterocycles
Author: Patrizia Diana,Girolamo Cirrincione
Publsiher: John Wiley & Sons
Total Pages: 784
Release: 2015-01-30
ISBN 10: 1118960424
ISBN 13: 9781118960424
Language: EN, FR, DE, ES & NL

Biosynthesis of Heterocycles Book Review:

This book describes biosynthetic methods to synthesize heterocycliccompounds, offering a guide for the development of new drugs basedon natural products. The authors explain the role of naturalproducts in chemistry and their formation along with importantanalytical methods and techniques for working withheterocycles. • Covers methods and techniques: isotopic labelling,enzymes and mutants, and pathway identification • Provides a thorough resource of informationspecifically on heterocyclic natural products and their practicalbiosynthetic relevance • Explains the role of natural products in chemistry andtheir formation • Discusses gene cluster identification and the use ofbiogenetic engineering in pharmaceutical application

Naturally Occurring Quinones IV

Naturally Occurring Quinones IV
Author: R.H. Thomson
Publsiher: Springer Science & Business Media
Total Pages: 746
Release: 1997
ISBN 10: 9780751402483
ISBN 13: 0751402486
Language: EN, FR, DE, ES & NL

Naturally Occurring Quinones IV Book Review:

The earlier volumes of this series have long been regarded by chemists as classics of their type, providing accurate and reliable information compiled by one of the world's leading figures in the field. Detailed and authoritative reviews of the chemistry and characterisation of the naturally occuring quinones reported during the last 10 years are provided in this fourth volume which describes more than 900 new compounds.