Disease Pathways

Disease Pathways
Author: Anastasia P. Nesterova,Anton Yuryev,Eugene A. Klimov,Maria Zharkova,Maria Shkrob,Natalia V. Ivanikova,Sergey Sozin,Vladimir Sobolev
Publsiher: Elsevier
Total Pages: 732
Release: 2019-10-18
ISBN 10: 0128170875
ISBN 13: 9780128170878
Language: EN, FR, DE, ES & NL

Disease Pathways Book Review:

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Signaling Pathways in Liver Diseases

Signaling Pathways in Liver Diseases
Author: Jean-Francois Dufour,Pierre-Alain Clavien
Publsiher: John Wiley & Sons
Total Pages: 520
Release: 2015-08-24
ISBN 10: 1118663365
ISBN 13: 9781118663363
Language: EN, FR, DE, ES & NL

Signaling Pathways in Liver Diseases Book Review:

Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: Autophagy Notch Pathway P13K/PTEN Signaling in Liver Diseases Sirtuins Hepcidin and Iron Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis Oxidative Stress and Signaling in the Liver. Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

Precision Medicine and the Reinvention of Human Disease

Precision Medicine and the Reinvention of Human Disease
Author: Jules J. Berman
Publsiher: Academic Press
Total Pages: 398
Release: 2018-01-26
ISBN 10: 0128143940
ISBN 13: 9780128143940
Language: EN, FR, DE, ES & NL

Precision Medicine and the Reinvention of Human Disease Book Review:

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Advancing Genomics for Rare Disease Diagnosis and Therapy Development

Advancing Genomics for Rare Disease Diagnosis and Therapy Development
Author: Zhichao Liu,Weida Tong,Tieliu Shi,Mike Mikailov,Ruth Roberts
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-12-08
ISBN 10: 2889661628
ISBN 13: 9782889661626
Language: EN, FR, DE, ES & NL

Advancing Genomics for Rare Disease Diagnosis and Therapy Development Book Review:

Signal Transduction Pathways Mechanisms and Diseases

Signal Transduction  Pathways  Mechanisms and Diseases
Author: Ari Sitaramayya
Publsiher: Springer Science & Business Media
Total Pages: 437
Release: 2009-12-02
ISBN 10: 3642021123
ISBN 13: 9783642021121
Language: EN, FR, DE, ES & NL

Signal Transduction Pathways Mechanisms and Diseases Book Review:

Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

Communities in Action

Communities in Action
Author: National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on Community-Based Solutions to Promote Health Equity in the United States
Publsiher: National Academies Press
Total Pages: 582
Release: 2017-04-27
ISBN 10: 0309452961
ISBN 13: 9780309452960
Language: EN, FR, DE, ES & NL

Communities in Action Book Review:

In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.

Neurobiology of Huntington s Disease

Neurobiology of Huntington   s Disease
Author: Donald C. Lo,Robert E. Hughes
Publsiher: CRC Press
Total Pages: 338
Release: 2010-07-02
ISBN 10: 1420008250
ISBN 13: 9781420008258
Language: EN, FR, DE, ES & NL

Neurobiology of Huntington s Disease Book Review:

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Improving Healthcare Quality in Europe Characteristics Effectiveness and Implementation of Different Strategies

Improving Healthcare Quality in Europe Characteristics  Effectiveness and Implementation of Different Strategies
Author: OECD,World Health Organization
Publsiher: OECD Publishing
Total Pages: 135
Release: 2019-10-17
ISBN 10: 9264805907
ISBN 13: 9789264805903
Language: EN, FR, DE, ES & NL

Improving Healthcare Quality in Europe Characteristics Effectiveness and Implementation of Different Strategies Book Review:

This volume, developed by the Observatory together with OECD, provides an overall conceptual framework for understanding and applying strategies aimed at improving quality of care. Crucially, it summarizes available evidence on different quality strategies and provides recommendations for their implementation. This book is intended to help policy-makers to understand concepts of quality and to support them to evaluate single strategies and combinations of strategies.

Clinical Pathways In Vitreoretinal Disease

Clinical Pathways In Vitreoretinal Disease
Author: Scott M. Steidl,Mary Elizabeth Hartnett
Publsiher: Thieme
Total Pages: 524
Release: 2011-01-01
ISBN 10: 1604064587
ISBN 13: 9781604064582
Language: EN, FR, DE, ES & NL

Clinical Pathways In Vitreoretinal Disease Book Review:

Vitreoretinal disease is the leading cause of severe vision loss in most developed countries. This all-encompassing new book is designed to enhance diagnosis and treatment of retinal pathology as you proceed from initial finding to differential diagnosis and treatment. Using evidence-based medicine to develop management strategies and featuring pathway diagrams and decision-making trees, the book links specific symptoms to the appropriate diagnosis and most effective treatment. A top team of retinal specialists have come together to create this pace-setting reference, covering everything from retinal detachment and hemorrhage, to pigmented lesions and noninfectious inflammation. Chapters are uniquely arranged by presenting symptom instead of diagnosis, allowing you to find material quickly and easily. Key features of this valuable book:Broad coverage of all important topics, including both pediatric and adult retinal diseasesClinical decision-making trees and pathway diagrams offering a yes-or-no approach to diagnosis and treatmentBeneficial question and answer format provides clarity and explanations for specific problemsHelpful table of contents organized by presenting symptomCLINICAL PATHWAY IN VITREORETINAL DISEASE is essential for all retina specialists, general ophthalmologists, and residents who treat severe vision loss. It offers the valuable information needed to reach an accurate diagnosis and provide optimal patient care. The book also serves as an excellent text for retina and general ophthalmology courses.

What Your Doctor May Not Tell You about Heart Disease

What Your Doctor May Not Tell You about Heart Disease
Author: Mark Houston
Publsiher: Grand Central Life & Style
Total Pages: 320
Release: 2012-02-06
ISBN 10: 1455506532
ISBN 13: 9781455506538
Language: EN, FR, DE, ES & NL

What Your Doctor May Not Tell You about Heart Disease Book Review:

Coronary heart disease has long been the number one killer in this country, and for decades, we have been told about five basic risk factors: elevated cholesterol, high blood pressure, diabetes, obesity, and smoking. But the truth is that heart disease is much more complex-- with close to 400 risk factors! In this innovative guide, Dr. Mark Houston helps readers discover the causes of heart disease, how to prevent and treat its debilitating effects via nutrition, nutritional supplements, exercise, weight management, and lays to rest to various myths (cholesterol is not the primary cause) based on scientific studies and medical publications. Readers will also learn how to indentify the risk factors most likely to endager them and construct an arsenal of non-pharmacological preventitive strategies that can counteract this most deadly disease.

Polypharmacology

Polypharmacology
Author: Zhiguo Wang,Baofeng Yang
Publsiher: Springer Nature
Total Pages: 870
Release: 2022-08-01
ISBN 10: 3031049985
ISBN 13: 9783031049989
Language: EN, FR, DE, ES & NL

Polypharmacology Book Review:

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.

How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease
Author: Anonim
Publsiher: U.S. Government Printing Office
Total Pages: 728
Release: 2010
ISBN 10: 1928374650XXX
ISBN 13: UCSD:31822037817723
Language: EN, FR, DE, ES & NL

How Tobacco Smoke Causes Disease Book Review:

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Microbial Metabolism and Disease

Microbial Metabolism and Disease
Author: Elena L. Paley
Publsiher: Academic Press
Total Pages: 306
Release: 2021-03-13
ISBN 10: 0323884466
ISBN 13: 9780323884464
Language: EN, FR, DE, ES & NL

Microbial Metabolism and Disease Book Review:

Microbiome Metabolic Pathways and Disease provides insight into the interaction of microbial metabolic pathways in the human body and the impact these can have on a variety of diseases. By analyzing these pathways the book seeks to investigate how these metabolic processes can be targeted and manipulated in order to treat various disorders and diseases. Topics covered in the book include microbial shikimate pathways, protein biosynthesis, tryptophan metabolites, microbiome metabolic engineering, fecal microbiota transplantation, and virulence factors. Additionally, a variety of conditions are covered, such as disorders associated with metabolic syndromes, serotonin syndromes, Alzheimer’s disease, and Covid-19, providing a detailed overview of how metabolic pathways of microbiome can impact health and disease in the human body. Explores microbial metabolic pathways in the human body and implications for disease Investigates specific steps involved in metabolic reactions in the human microbiome, including shikimate pathways and tryptophan pathways Considers a variety of diseases and disorders, such as Alzheimer’s disease, metabolic syndromes, Crohn’s disease and Covid-19 Includes analysis of various amino acids and enzymes in microbial and human cells and how these can impact health

Role of Inflammation in Neurodegenerative Diseases

Role of Inflammation in Neurodegenerative Diseases
Author: Maya Koronyo-Hamaoui,Sally Ann Frautschy,Jorge Ivan Alvarez
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-07-13
ISBN 10: 2889765628
ISBN 13: 9782889765621
Language: EN, FR, DE, ES & NL

Role of Inflammation in Neurodegenerative Diseases Book Review:

Dietary Modulation of Cell Signaling Pathways

Dietary Modulation of Cell Signaling Pathways
Author: Zigang Dong,Young-Joon Surh
Publsiher: CRC Press
Total Pages: 504
Release: 2008-09-26
ISBN 10: 9780849381492
ISBN 13: 0849381495
Language: EN, FR, DE, ES & NL

Dietary Modulation of Cell Signaling Pathways Book Review:

A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Dietary Modulation of Cell Signaling Pathways reviews some of these findings, focusing on nutrient-gene interactions with particular emphasis on the intracellular signaling network. Explore a Pivotal Function for Maintaining Homeostasis The book addresses the dietary modulation of particular gene expression systems and highlights the underlying molecular and cellular mechanisms that involve upstream signaling molecules, such as kinases and transcription factors in the context of their therapeutic potential. It describes nutrients’ actions on the activation of an antioxidant and inflammatory transcription factor and the induction of their target gene expression. Provides a Mechanistic Understanding of the Action of Dietary Components Comprehensively covering dietary modulation of cell signaling, leading experts provide information on state-of-the-art research in their own specialty. For those working in the fields of dietary components, molecular mechanisms, and health benefits, this book presents a useful tool for mechanistic understanding of the action of dietary components.

The Identification and Characterization of the Hydrolethalus Syndrome Gene HYLS1 on 11q24

The Identification and Characterization of the Hydrolethalus Syndrome Gene  HYLS1  on 11q24
Author: Lisa Marja-Lanyi Mee
Publsiher: Unknown
Total Pages: 236
Release: 2005
ISBN 10: 1928374650XXX
ISBN 13: UCLA:L0091226514
Language: EN, FR, DE, ES & NL

The Identification and Characterization of the Hydrolethalus Syndrome Gene HYLS1 on 11q24 Book Review:

Coronary Artery Disease

Coronary Artery Disease
Author: Angelo Squeri
Publsiher: BoD – Books on Demand
Total Pages: 272
Release: 2012-03-16
ISBN 10: 953510344X
ISBN 13: 9789535103448
Language: EN, FR, DE, ES & NL

Coronary Artery Disease Book Review:

Coronary Artery disease is one of the leading causes of death in industrialized countries and is responsible for one out of every six deaths in the United States. Remarkably, coronary artery disease is also largely preventable. The biggest challenge in the next years is to reduce the incidence of coronary artery disease worldwide. A complete knowledge of the mechanisms responsible for the development of ischaemic heart disease is an essential prerequisite to a better management of this pathology improving prevention and therapy. This book has been written with the intention of providing new concepts about coronary artery disease pathogenesis that may link various aspects of the disease, going beyond the traditional risk factors.

Recent Advances in Parkinson s Disease

Recent Advances in Parkinson s Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 574
Release: 2020-04-02
ISBN 10: 0444642617
ISBN 13: 9780444642615
Language: EN, FR, DE, ES & NL

Recent Advances in Parkinson s Disease Book Review:

Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields

OECD Reviews of Public Health Latvia A Healthier Tomorrow

OECD Reviews of Public Health  Latvia A Healthier Tomorrow
Author: OECD
Publsiher: OECD Publishing
Total Pages: 168
Release: 2020-12-22
ISBN 10: 926461964X
ISBN 13: 9789264619647
Language: EN, FR, DE, ES & NL

OECD Reviews of Public Health Latvia A Healthier Tomorrow Book Review:

Latvia sees high rates of obesity, smoking and alcohol consumption. In turn, this results in a high incidence of preventable diseases, such as heart disease, diabetes and many cancers. This puts a burden on a health system which is already operating on a very tight budget as compared to other OECD countries.

Drugs

Drugs
Author: Rick Ng
Publsiher: John Wiley & Sons
Total Pages: 560
Release: 2015-04-13
ISBN 10: 1118907221
ISBN 13: 9781118907221
Language: EN, FR, DE, ES & NL

Drugs Book Review:

The third edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the manufacturing processes for pharmaceutical products. Concise and easy to read, Drugs: From Discovery to Approval, Third Edition quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs. The third edition incorporates the latest developments and updates in the pharmaceutical community, provides more comprehensive coverage of topics, and includes more materials and case studies suited to college and university use. Biotechnology is a dynamic field with changes across R&D, clinical trials, manufacturing and regulatory processes, and the third edition of the text provides timely updates for those in this rapidly growing field.