Disease Modifying Targets in Neurodegenerative Disorders

Disease Modifying Targets in Neurodegenerative Disorders
Author: Veerle Baekelandt,Evy Lobbestael
Publsiher: Academic Press
Total Pages: 320
Release: 2017-03-31
ISBN 10: 012805266X
ISBN 13: 9780128052662
Language: EN, FR, DE, ES & NL

Disease Modifying Targets in Neurodegenerative Disorders Book Review:

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress Summarizes how patients are treated today, providing a glance at future disease management Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists Written and peer reviewed by outstanding scientists in their respective fields

Molecular Targets in Protein Misfolding and Neurodegenerative Disease

Molecular Targets in Protein Misfolding and Neurodegenerative Disease
Author: Pierfausto Seneci
Publsiher: Academic Press
Total Pages: 314
Release: 2014-10-07
ISBN 10: 0128004991
ISBN 13: 9780128004999
Language: EN, FR, DE, ES & NL

Molecular Targets in Protein Misfolding and Neurodegenerative Disease Book Review:

Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

Neuroprotection in Alzheimer s Disease

Neuroprotection in Alzheimer s Disease
Author: Illana Gozes
Publsiher: Academic Press
Total Pages: 342
Release: 2016-12-30
ISBN 10: 0128037121
ISBN 13: 9780128037126
Language: EN, FR, DE, ES & NL

Neuroprotection in Alzheimer s Disease Book Review:

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Drug Design and Discovery in Alzheimer s Disease

Drug Design and Discovery in Alzheimer   s Disease
Author: Atta-ur-Rahman,Muhammad Iqbal Choudhary
Publsiher: Elsevier
Total Pages: 784
Release: 2015-06-27
ISBN 10: 0128039604
ISBN 13: 9780128039601
Language: EN, FR, DE, ES & NL

Drug Design and Discovery in Alzheimer s Disease Book Review:

Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

TDP 43 and Neurodegeneration

TDP 43 and Neurodegeneration
Author: Vijay Kumar,Manoj Kumar Jaiswal
Publsiher: Academic Press
Total Pages: 270
Release: 2021-10-23
ISBN 10: 0128204400
ISBN 13: 9780128204405
Language: EN, FR, DE, ES & NL

TDP 43 and Neurodegeneration Book Review:

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside

New Paradigms in Neuroscience and Related Targets for Drug Discovery

New Paradigms in Neuroscience and Related Targets for Drug Discovery
Author: Salvatore Salomone
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-07-02
ISBN 10: 2889638200
ISBN 13: 9782889638208
Language: EN, FR, DE, ES & NL

New Paradigms in Neuroscience and Related Targets for Drug Discovery Book Review:

Molecular Mechanisms of Neurodegenerative Diseases

Molecular Mechanisms of Neurodegenerative Diseases
Author: Marie-Francoise Chesselet
Publsiher: Springer Science & Business Media
Total Pages: 410
Release: 2000-10-19
ISBN 10: 1592590063
ISBN 13: 9781592590063
Language: EN, FR, DE, ES & NL

Molecular Mechanisms of Neurodegenerative Diseases Book Review:

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
Author: Adeboye Adejare
Publsiher: Academic Press
Total Pages: 316
Release: 2016-09-20
ISBN 10: 0128028114
ISBN 13: 9780128028117
Language: EN, FR, DE, ES & NL

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders Book Review:

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

Biometals in Neurodegenerative Diseases

Biometals in Neurodegenerative Diseases
Author: Anthony R. White,Michael Aschner,Lucio G. Costa,Ashley I. Bush
Publsiher: Academic Press
Total Pages: 462
Release: 2017-04-28
ISBN 10: 0128045639
ISBN 13: 9780128045633
Language: EN, FR, DE, ES & NL

Biometals in Neurodegenerative Diseases Book Review:

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets Written for academic researchers, clinicians and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Uday Kishore
Publsiher: BoD – Books on Demand
Total Pages: 640
Release: 2013-05-15
ISBN 10: 9535110888
ISBN 13: 9789535110880
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Review:

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

Alzheimer s Disease

Alzheimer s Disease
Author: Renee D. Wegrzyn,Alan S. Rudolph
Publsiher: CRC Press
Total Pages: 298
Release: 2012-04-26
ISBN 10: 1439827087
ISBN 13: 9781439827086
Language: EN, FR, DE, ES & NL

Alzheimer s Disease Book Review:

In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer’s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer’s Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores: The basis of AD and the role of Aβ oligomers in development of disease Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies In vivo imaging diagnostic approaches Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.

Emerging Drugs and Targets for Multiple Sclerosis

Emerging Drugs and Targets for Multiple Sclerosis
Author: Ana Martinez
Publsiher: Royal Society of Chemistry
Total Pages: 333
Release: 2019-06-28
ISBN 10: 1788014502
ISBN 13: 9781788014502
Language: EN, FR, DE, ES & NL

Emerging Drugs and Targets for Multiple Sclerosis Book Review:

Multiple sclerosis (MS) is a complex disease with a presumed autoimmune aetiology and few current effective treatments. Disease modifying therapies focus on the altering the natural course of relapsing and remitting MS, targeting the inflammatory response. Other targets involve tacking the cause of the disease – demyelination of axons through remyelination therapies. Due to several recent breakthroughs in the understanding of the pathophysiology of MS new targets for remyelination and immunomodulation are rapidly emerging. This book provides a comprehensive overview of drug discovery and development for the molecular basis of the disease, from new targets to drugs currently in clinical development, cellular and animal disease models to biomarkers for diagnosis and assessment in clinical trials. Emerging Drugs and Targets for Multiple Sclerosis is an ideal reference for any student or researcher interested in drug development for neurodegenerative diseases, autoimmune diseases and MS in particular.

Neurodegenerative Disorders as Systemic Diseases

Neurodegenerative Disorders as Systemic Diseases
Author: Keiji Wada
Publsiher: Springer
Total Pages: 304
Release: 2015-10-21
ISBN 10: 4431545417
ISBN 13: 9784431545415
Language: EN, FR, DE, ES & NL

Neurodegenerative Disorders as Systemic Diseases Book Review:

This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.

Emerging Drugs and Targets for Alzheimer s Disease

Emerging Drugs and Targets for Alzheimer s Disease
Author: Ana Martinez
Publsiher: Unknown
Total Pages: 668
Release: 2010-05-07
ISBN 10: 9781849730457
ISBN 13: 1849730458
Language: EN, FR, DE, ES & NL

Emerging Drugs and Targets for Alzheimer s Disease Book Review:

A comprehensive 2-volume complete set that collects some of the most promising examples of new drugs currently under pharmaceutical development that will reach the Alzheimer's drug market over the next few years as disease-modifying therapeutics.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Nagehan Ersoy Tunalı
Publsiher: BoD – Books on Demand
Total Pages: 178
Release: 2021-01-20
ISBN 10: 1838801499
ISBN 13: 9781838801496
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Review:

Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

Neuroprotection

Neuroprotection
Author: Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret
Publsiher: BoD – Books on Demand
Total Pages: 348
Release: 2020-11-26
ISBN 10: 1838804390
ISBN 13: 9781838804398
Language: EN, FR, DE, ES & NL

Neuroprotection Book Review:

Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease
Author: Pierfausto Seneci
Publsiher: Academic Press
Total Pages: 260
Release: 2015-01-12
ISBN 10: 9780128019443
ISBN 13: 0128019441
Language: EN, FR, DE, ES & NL

Chemical Modulators of Protein Misfolding and Neurodegenerative Disease Book Review:

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer's and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents. • Written to provide comprehensive coverage of neurodegenerative disease-modifying compounds; • Provides discipline-specific chapters that cover medicinal chemistry and clinical applications; • Provides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorder; • Coverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery.

Neurons

Neurons
Author: Gonzalo Emiliano Aranda Abreu,María Elena Hernández Aguilar
Publsiher: BoD – Books on Demand
Total Pages: 128
Release: 2019-02-20
ISBN 10: 1789851238
ISBN 13: 9781789851236
Language: EN, FR, DE, ES & NL

Neurons Book Review:

The brain is the most complex structure that exists in the universe, consisting of neurons whose function is to receive information through dendrites and transmit information through the axon. In neurosciences one of the main problems that exists are neurodegenerative diseases for which until now there has been no cure. This book is mainly focused on updating the information on the signaling process carried out in the development of axons. Topics such as axon guidance and its interaction with the extracellular matrix are discussed. Other important topics are semaphorins and their relationship with neurodegenerative diseases, and the neurobiology of the gap junction in the dorsal root ganglion. Finally, the topic of bioelectrical interfaces destined to regenerate damaged nerves is covered. The information in this book will be very important both for researchers who work with these issues and doctoral students who are involved in neuroscience.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Daniela Galimberti,Elio Scarpini
Publsiher: Springer Science & Business
Total Pages: 253
Release: 2014-04-23
ISBN 10: 144716380X
ISBN 13: 9781447163800
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Review:

This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis. Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields.

Vessel Based Imaging Techniques

Vessel Based Imaging Techniques
Author: Chun Yuan,Thomas S. Hatsukami,Mahmud Mossa-Basha
Publsiher: Springer Nature
Total Pages: 356
Release: 2019-10-10
ISBN 10: 3030252493
ISBN 13: 9783030252496
Language: EN, FR, DE, ES & NL

Vessel Based Imaging Techniques Book Review:

This book provides comprehensive information on new and existing vessel imaging techniques, with the intention of improving diagnosis, treatment, and prevention of vascular and related diseases. In recent years, vessel wall imaging has expanded greatly into other beds (such as the intracranial and peripheral arteries) and many of the techniques available for evaluation and diagnosis have only previously been published in research papers. This book bridges that gap for clinicians, applying cutting edge research to their everyday practice. The first six sections of the book are centered around individual vessel beds. These chapters will teach clinicians the multi-modality imaging techniques available to image these vessels and related pathology with a focus on new imaging tools and techniques. The final two sections of the book will offer a more comprehensive technical background aimed at imaging scientists for the imaging techniques used and the relationship of blood flow and modeling to disease monitoring and prevention. This is an ideal guide for radiologists and imaging scientists looking to learn the latest techniques in vessel imaging.