Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products
Author: Goutam Brahmachari
Publsiher: Elsevier
Total Pages: 332
Release: 2016-10-11
ISBN 10: 0128096926
ISBN 13: 9780128096925
Language: EN, FR, DE, ES & NL

Discovery and Development of Antidiabetic Agents from Natural Products Book Review:

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Discovery and Development of Anti inflammatory Agents from Natural Products

Discovery and Development of Anti inflammatory Agents from Natural Products
Author: Goutam Brahmachari
Publsiher: Elsevier
Total Pages: 332
Release: 2019-07-11
ISBN 10: 0128169931
ISBN 13: 9780128169933
Language: EN, FR, DE, ES & NL

Discovery and Development of Anti inflammatory Agents from Natural Products Book Review:

Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases. Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases Offers an authoritative source of information on the industrial application of natural products for medicinal purposes

Inflammation and Natural Products

Inflammation and Natural Products
Author: Sreeraj Gopi,Augustine Amalraj,Ajaikumar B. Kunnumakkara,Sabu Thomas
Publsiher: Academic Press
Total Pages: 462
Release: 2021-01-19
ISBN 10: 0128192194
ISBN 13: 9780128192191
Language: EN, FR, DE, ES & NL

Inflammation and Natural Products Book Review:

Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries. Increases the knowledge of anti-inflammatory activities of natural products and their mechanism of action Provides a new perspective and forward-thinking ideas to researchers, the scientific community and industry Intensifies the understanding of synergistic action of biologically active naturally occurring molecules and their biological activities against inflammation

Natural Products and Drug Discovery

Natural Products and Drug Discovery
Author: Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi
Publsiher: Elsevier
Total Pages: 776
Release: 2018-02-16
ISBN 10: 0081021046
ISBN 13: 9780081021040
Language: EN, FR, DE, ES & NL

Natural Products and Drug Discovery Book Review:

Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

Handbook on Drugs from Natural Sources

Handbook on Drugs from Natural Sources
Author: H. Panda
Publsiher: ASIA PACIFIC BUSINESS PRESS Inc.
Total Pages: 480
Release: 2010-10-01
ISBN 10: 8178331330
ISBN 13: 9788178331331
Language: EN, FR, DE, ES & NL

Handbook on Drugs from Natural Sources Book Review:

Natural products have played an important role throughout the world in treating and preventing human diseases. Natural product medicines have come from various materials including terrestrial plants, terrestrial microorganisms, organisms etc. Historical experiences with plants as therapeutic tools have helped to introduce single chemical entries in modern medicine. About 40% of the drugs used are derived from natural sources. Most are pure substances which are isolated from various organisms & used directly or after chemical modification. Natural products will continue to be important in three areas of drug discovery: as targets for production by biotechnology as a source of new lead compounds of novel chemical structure and as the active ingredients of useful treatments derived from traditional systems. Biotechnology will contribute more new natural products for medicinal use. Plants provide a fertile source of natural products many of which are clinically important medicinal agents. Natural products have traditionally provided most of the drugs in use. Despite the achievements of synthetic chemistry and the advances towards rational drug design, natural products continue to be essential in providing medicinal compounds and as starting points for the development of synthetic analogues. With the increasing power of screening programs and the increasing interest in the reservoir of untested natural products, many future drug developments will be based, at least in part, on natural products. The major contents of the book are plant products produced in cell culture , application of genetic engineering to the production of pharmaceuticals , anti transpirants and plant growth regulators based , the potential and the problems of marine natural products, marine sterols, plants as a source of anti-inflammatory substances, anti hepatotoxic principles in oriental medicinal plants, immune stimulants of fungi and higher plants, amanita muscaria in medicinal chemistry, ergot alkaloids and their derivatives in medicinal chemistry and therapy, development of drugs from cannabinoids, etc. This book contains development of new drugs from plants, work on some Thai medicinal plants, plant growth based on Jasmonates, marine sterols, bleomycin and its derivatives, drugs from cannabinoids, bioactive compounds from nature, fungi and higher plants, biological active compounds from British Marine, microbial phytotoxins as herbicides and many more. This book will be very helpful to its readers, upcoming entrepreneurs, scientists, existing industries, technical institutions, druggist etc.

Drug Discovery and Development

Drug Discovery and Development
Author: Ramarao Poduri
Publsiher: Springer Nature
Total Pages: 522
Release: 2021-02-15
ISBN 10: 9811555346
ISBN 13: 9789811555343
Language: EN, FR, DE, ES & NL

Drug Discovery and Development Book Review:

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Anti Inflammatory Drug Discovery

Anti Inflammatory Drug Discovery
Author: Jeremy I. Levin,Stefan Laufer
Publsiher: Royal Society of Chemistry
Total Pages: 528
Release: 2012
ISBN 10: 1849734135
ISBN 13: 9781849734134
Language: EN, FR, DE, ES & NL

Anti Inflammatory Drug Discovery Book Review:

A comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and a key reference for those interested in the prosecution of modern drug discovery programs directed at anti-inflammatory mechanisms of action.

Discovery and Development of Neuroprotective Agents from Natural Products

Discovery and Development of Neuroprotective Agents from Natural Products
Author: Goutam Brahmachari
Publsiher: Elsevier
Total Pages: 490
Release: 2017-05-18
ISBN 10: 0128097698
ISBN 13: 9780128097694
Language: EN, FR, DE, ES & NL

Discovery and Development of Neuroprotective Agents from Natural Products Book Review:

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Drug Discovery and Development

Drug Discovery and Development
Author: Omboon Vallisuta,Suleiman Olimat
Publsiher: BoD – Books on Demand
Total Pages: 330
Release: 2015-06-03
ISBN 10: 9535121286
ISBN 13: 9789535121282
Language: EN, FR, DE, ES & NL

Drug Discovery and Development Book Review:

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Marine Anti inflammatory Agents 2020

Marine Anti inflammatory Agents 2020
Author: Donatella Degl’Innocenti,Marzia Vasarri
Publsiher: MDPI
Total Pages: 112
Release: 2021-05-18
ISBN 10: 3036507884
ISBN 13: 9783036507880
Language: EN, FR, DE, ES & NL

Marine Anti inflammatory Agents 2020 Book Review:

This Special Issue covers original and innovative basic research regarding the anti-inflammatory potential of several classes of secondary metabolites (i.e., polyphenols, phytosterols, proteoglycans, and polysaccharides) in manifestations of acute and chronic inflammation in both in vitro and in vivo experimental models.

The Role of Natural Products in Drug Discovery

The Role of Natural Products in Drug Discovery
Author: J. Mulzer,R. Bohlmann
Publsiher: Springer Science & Business Media
Total Pages: 351
Release: 2013-04-17
ISBN 10: 3662040425
ISBN 13: 9783662040423
Language: EN, FR, DE, ES & NL

The Role of Natural Products in Drug Discovery Book Review:

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Lead Molecules from Natural Products

Lead Molecules from Natural Products
Author: Anonim
Publsiher: Elsevier
Total Pages: 448
Release: 2006-07-07
ISBN 10: 9780080459332
ISBN 13: 0080459331
Language: EN, FR, DE, ES & NL

Lead Molecules from Natural Products Book Review:

Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered. The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations. * Explains the effects of plant extracts on gene expression profiling. * Details medicinal plant research from around the world * Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.

Bioassay Methods in Natural Product Research and Drug Development

Bioassay Methods in Natural Product Research and Drug Development
Author: Lars Bohlin,Jan G. Bruhn
Publsiher: Springer Science & Business Media
Total Pages: 203
Release: 2012-12-06
ISBN 10: 9401148104
ISBN 13: 9789401148108
Language: EN, FR, DE, ES & NL

Bioassay Methods in Natural Product Research and Drug Development Book Review:

Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Exploration of Natural Product Leads for Multitarget Based Treatment of Cancer Computational to Experimental Journey

Exploration of Natural Product Leads for Multitarget Based Treatment of Cancer   Computational to Experimental Journey
Author: Rajeev K. Singla,Marcus Scotti,Supratik Kar
Publsiher: Frontiers Media SA
Total Pages: 249
Release: 2022-03-14
ISBN 10: 2889746860
ISBN 13: 9782889746866
Language: EN, FR, DE, ES & NL

Exploration of Natural Product Leads for Multitarget Based Treatment of Cancer Computational to Experimental Journey Book Review:

Official Gazette of the United States Patent and Trademark Office

Official Gazette of the United States Patent and Trademark Office
Author: Anonim
Publsiher: Unknown
Total Pages: 380
Release: 1993
ISBN 10: 1928374650XXX
ISBN 13: PSU:000066191131
Language: EN, FR, DE, ES & NL

Official Gazette of the United States Patent and Trademark Office Book Review:

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author: David M. Pereira,Patrícia Valentão,Paula B. Andrade
Publsiher: Elsevier Inc. Chapters
Total Pages: 538
Release: 2013-06-25
ISBN 10: 0128084723
ISBN 13: 9780128084724
Language: EN, FR, DE, ES & NL

Studies in Natural Products Chemistry Book Review:

Marine organisms have been increasingly regarded as excellent sources of new drugs for human therapeutics due to their remarkable chemistry, which, in turn, is reflected in their wide range of biological applications, including cancer, inflammation, infection, and pain. In the past 20 years, several new drugs have been discovered, some of them with novel pharmacological targets and the first sea-derived approved medicines are now paving their way into the market. In this chapter, we will focus on small-molecule drugs obtained from marine animals (sponges, gorgonians, mollusks, echinoderms) for the treatment of inflammation. The distribution of these compounds by different taxonomical families will be discussed, as well as the state-of-the-art regarding their structure–activity relationship. The most important chemical classes will be presented, such as terpenes, alkaloids, among others. The most important molecular targets, including phospholipase A2 (PLA2), cyclooxygenases (COXs), nitric oxide synthase (NOS), and NF-κB will be discussed.

Medicinal Plants of South Asia

Medicinal Plants of South Asia
Author: Muhammad Asif Hanif,Haq Nawaz,Muhammad Mumtaz Khan,Hugh J. Byrne
Publsiher: Elsevier
Total Pages: 768
Release: 2019-09-14
ISBN 10: 0081026609
ISBN 13: 9780081026601
Language: EN, FR, DE, ES & NL

Medicinal Plants of South Asia Book Review:

Medicinal Plants of South Asia: Novel Sources for Drug Discovery provides a comprehensive review of medicinal plants of this region, highlighting chemical components of high potential and applying the latest technology to reveal the underlying chemistry and active components of traditionally used medicinal plants. Drawing on the vast experience of its expert editors and authors, the book provides a contemporary guide source on these novel chemical structures, thus making it a useful resource for medicinal chemists, phytochemists, pharmaceutical scientists and everyone involved in the use, sales, discovery and development of drugs from natural sources. Provides comprehensive reviews of 50 medicinal plants and their key properties Examines the background and botany of each source before going on to discuss underlying phytochemistry and chemical compositions Links phytochemical properties with pharmacological activities Supports data with extensive laboratory studies of traditional medicines

Natural Products as Source of Molecules with Therapeutic Potential

Natural Products as Source of Molecules with Therapeutic Potential
Author: Valdir Cechinel Filho
Publsiher: Springer
Total Pages: 531
Release: 2018-12-07
ISBN 10: 3030005453
ISBN 13: 9783030005450
Language: EN, FR, DE, ES & NL

Natural Products as Source of Molecules with Therapeutic Potential Book Review:

This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.

Drug Repurposing

Drug Repurposing
Author: Farid A. Badria
Publsiher: BoD – Books on Demand
Total Pages: 234
Release: 2020-12-02
ISBN 10: 1839685204
ISBN 13: 9781839685200
Language: EN, FR, DE, ES & NL

Drug Repurposing Book Review:

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

Terpenes and Terpenoids

Terpenes and Terpenoids
Author: Shagufta Perveen,Areej Al-Taweel
Publsiher: BoD – Books on Demand
Total Pages: 154
Release: 2018-12-19
ISBN 10: 1789847761
ISBN 13: 9781789847765
Language: EN, FR, DE, ES & NL

Terpenes and Terpenoids Book Review:

Terpenes belong to the diverse class of chemical constituents isolated from materials found in nature (plants, fungi, insects, marine organisms, plant pathogens, animals and endophytes). These metabolites have simple to complex structures derived from Isopentyl diphosphate (IPP), dimethyl allyl diphosphate (DMAPP), mevalonate and deoxyxylulose biosynthetic pathways. Terpenes play a very important role in human health and have significant biological activities (anticancer, antimicrobial, anti-inflammatory, antioxidant, antiallergic, skin permeation enhancer, anti-diabetic, immunomodulatory, anti-insecticidal). This book gives an overview and highlights recent research in the phytochemical and biological understanding of terpenes and terpenoid and explains the most essential functions of these kinds of secondary metabolites isolated from natural sources.