Diabetic Neuropathy

Diabetic Neuropathy identifies the most accurate early biomarkers of nerve damage to better understand pathophysiology and diagnose diabetic neuropathy in the clinical care of patients, and in particular, permit an accurate evaluation of future therapies in clinical trials. This succinct reference focuses on the current data and research on diabetic neuropathy and is essential reading for researchers in endocrinology, neurology and pharmacology, along with clinicians that need to better understand the novel pathogenetic pathways leading to diabetic neuropathy and the treatments. Serves as a starting point for researchers and medical professionals on risk factors, prevention and newly discovered mechanisms involved in the pathogenesis and eventually treatments of diabetic neuropathy Discusses a broad range of issues relating to diabetic neuropathy, from epidemiology, to pathophysiology, genetics, advances in diagnostic techniques, and the latest clinical trials and clinical management

The diagnosis of diabetic neuropathy is based on the diagnosis of diabetes, typical symptoms and clinical findings, as well as exclusion of other causes leading to neuropathy. Neuropathy that affects the large fibres can be verified objectively by ENMG and small fibre neuropathy is revealed by quantitative sensory threshold testing. The loss of small nerve fibres may also be demonstrated by skin biopsy. Neuropathy may be the first sign of type 2 diabetes.The loss of protective sensation as a consequence of peripheral neuropathy is the most important risk factor of diabetic foot ulcer. Small fibre neuropathy may already emerge during the phase of impaired glucose tolerance. 11–25% of the patients may have peripheral neuropathy in the pre-diabetic phase already.

Diabetic neuropathy is very common, affecting up to 50 % of all diabetic patients. It can result in disabling neuropathic pain, lower extremity amputations and troublesome autonomic neuropathies. With the rising incidence of diabetes the prevalence of neuropathy is also likely to increase. This pocketbook discusses the condition in depth.

Comprised of contributions from a wealth of experts worldwide, this volume summarizes the latest research findings and new developments in diagnosis and treatment of diabetic neuropathy. While the actual cause of diabetic neuropathy, a common complication of diabetes mellitus, is not known, it is likely that no single mechanism predominates--rather that various mechanisms interact and culminate in the expression of neuropathy. The progressive nature of diabetic neuropathy and the high morbidity associated with it emphasize the need for early identification of patients at risk, particularly since the disease, if diagnosed early, can be corrected or controlled by intensified insulin treatment and strict metabolic control.

Wiesman provides hope, help, and comfort to patients, families, and caregivers.

Edited by internationally recognized pain experts, this book offers 73 clinically relevant cases, accompanied by discussion in a question-and-answer format.

Diabetic Neuropathy and Clinical Practice aims to improve the pathophysiological understanding of the entire spectrum from sensory motor to autonomic diabetic neuropathy, its correlation with the symptoms, improving thereby the communication with the patient including prognostication and other tools that one should utilize to better management. It also emphasizes the need to regain the grip on the basic sciences of clinical medicine to deal with it better - Anatomy, Physiology, Biochemistry and Pathology and gives the necessary details. The volume aims at explaining what the clinicians need most to help patients and may not possess.

Peripheral Neuropathies compiles lectures presented at the Symposium on Peripheral Neuropathies held in Milan, Italy on June 26-28, 1978. This book covers the basic problems in peripheral nerve pathology; axonal transport; neuropathies in chronic renal failure; peripheral neuropathies in diabetes; compression neuropathies; and metabolic, genetic, and inflammatory neuropathies. This text also discusses topics such as filamentous inclusions in Schwann cell nuclei; autonomie dysfunction and myokymia in gold neuropathy; study of the effect of gangliosides on experimental carbon disulfide neuropathy; and peripheral nerve changes in Refsum's disease before and after treatment. This compilation is a useful source of information for students and researchers conducting investigative work on peripheral neuropathy.

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson’s disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system. Offers a unique emphasis on the neurological manifestations of diabetes Provides thorough coverage of the clinical, experimental, mechanistic, therapeutic, peripheral, and central aspects of diabetic neuropathy Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Painful Diabetic Neuropathy in Clinical Practice provides a concise, didactic and essential resource for clinicians in the management of neuropathic pain in diabetic patients. This volume opens with overviews of epidemiology, classification and clinical features, including a discussion of the negative effect of painful neuropathic symptoms on quality of life. These are followed by a chapter on diagnosis and staging, which includes approaches to history taking, clinical examination, pain assessment scales, testing and staging. The book concludes with a chapter on the various approaches in the management of neuropathic pain, including the most up-to-date guidelines on the pharmacological treatment of this condition. This concise handbook is an invaluable reference for primary care practitioners and diabetologists who wish to keep up to date with the diagnosis and management of neuropathic pain.

Provides practical advice to help successfully manage diabetes and reduce the risk of serious complications, discussing monitoring blood sugar, developing an eating plan, achieving a healthy weight, and diabetes in children.

In this updated edition, leading medical specialists critically review for the general practitioner the latest techniques for the clinical management of diabetic neuropathy. The contributors focus on the practical aspects of diabetic neuropathy and describe in detail the treatments that are currently available or expected to become available in the near future. They also include concise discussions of the pathogenesis of diabetic neuropathy.

Diabetic neuropathy is amongst the most common of the late complications of diabetes, affecting up to 50% of older patients with Type 2 diabetes. It can result in disabling neuropathic pain, lower extremity amputations and troublesome autonomic neuropathies (gastroparesis, erectile dysfunction, sudden cardiac death and so forth). With the rising incidence of diabetes the prevalence of neuropathy is also likely to increase. Over recent years, there have been new advances in our understanding and treatment of diabetic neuropathies and the problems associated with the disease.

Leading medical specialists critically review for the general practitioner the latest techniques for the clinical management of diabetic neuropathy. These authoritative contributors focus on the practical aspects of diabetic neuropathy and describe in detail the treatments that are currently available or expected to become available in the near future. They also include concise discussions of the causes of diabetic neuropathy and highlight the relatively unknown features of neuropathy that can significantly impact a patient's life. Comprehensive, up-to-date bibliographies at the end of each chapter provide an opportunity for the interested physician to gain a more detailed picture of a particular topic. This book offers family physicians, internists, endocrinologists, podiatrists, cardiologists, neurologists, and gastroenterologists an authoritative practical guide and a vital day-to-day reference source for the management of their neuropathic diabetic patients.

This latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field. Offers a comprehensive overview of state-of-the-art research on diabetic neuropathy Provides personal critiques from experts in each field Provides a running commentary by editors throughout the book Explores a range of topics including mechanisms of nerve damage, neuropathic pain, new therapies, clinical trials, and animal models of diabetic neuropathy

Textbook of Peripheral Neuropathy is a practical but complete reference for neurologists in general practice who are evaluating patients with peripheral neuropathy. The book covers a broad range of neuropathies including mononeuropathy, mononeuritis multiplex, and polyneuropathy (which accounts for the greatest number of cases) and provides an evidence-based approach to testing, diagnosis, and treatment. The chapters are written by internationally renowned expert contributors with deep clinical experience and contain numerous tables, figures, and algorithms for quick access to key information. The book covers both inherited and acquired diseases, including neuropathies arising from physical injury, diabetes, alcoholism, toxins, autoimmune responses, nutritional deficiencies, vascular and metabolic disorders, medication-induced neuropathies, and idiopathic conditions.

Peripheral nerve analysis is a challenging task for pathologists, given the advent of new diagnoses and techniques of analysis and the impact of molecular genetics. This book presents a simple, logical method for constructing a differential diagnosis based on pathology and clinical presentation. It also provides advice on the selection of ancillary molecular, immunohistochemical and genetic techniques to establish a definitive diagnosis. Clear, authoritative guidance is offered on diagnosis of the full range of neuropathies with the aid of a wealth of high-quality color photomicrographs and electron micrographs. The pathologist will benefit greatly from the identification of a variety of artifacts and normal structures occasionally encountered in nerve biopsies that need to be distinguished from specific pathologic alterations. This user-friendly, practical text will be an invaluable aid in achieving the most specific diagnosis possible.