Cytogenomics

Cytogenomics
Author: Thomas Liehr
Publsiher: Academic Press
Total Pages: 428
Release: 2021-05-25
ISBN 10: 0128235802
ISBN 13: 9780128235805
Language: EN, FR, DE, ES & NL

Cytogenomics Book Review:

Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book’s second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease Features chapter contributions from international leaders in the field

Cytogenomics Structural Organization and Evolution of Genomes

Cytogenomics  Structural Organization and Evolution of Genomes
Author: Ricardo Utsunomia,Francisco J. Ruiz-Ruano,Magdalena Vaio
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-07-04
ISBN 10: 2889764915
ISBN 13: 9782889764914
Language: EN, FR, DE, ES & NL

Cytogenomics Structural Organization and Evolution of Genomes Book Review:

The AGT Cytogenetics Laboratory Manual

The AGT Cytogenetics Laboratory Manual
Author: Marilyn S. Arsham,Margaret J. Barch,Helen J. Lawce
Publsiher: John Wiley & Sons
Total Pages: 1218
Release: 2017-04-24
ISBN 10: 1119061229
ISBN 13: 9781119061229
Language: EN, FR, DE, ES & NL

The AGT Cytogenetics Laboratory Manual Book Review:

Cytogenetics is the study of chromosome morphology, structure, pathology, function, and behavior. The field has evolved to embrace molecular cytogenetic changes, now termed cytogenomics. Cytogeneticists utilize an assortment of procedures to investigate the full complement of chromosomes and/or a targeted region within a specific chromosome in metaphase or interphase. Tools include routine analysis of G-banded chromosomes, specialized stains that address specific chromosomal structures, and molecular probes, such as fluorescence in situ hybridization (FISH) and chromosome microarray analysis, which employ a variety of methods to highlight a region as small as a single, specific genetic sequence under investigation. The AGT Cytogenetics Laboratory Manual, Fourth Edition offers a comprehensive description of the diagnostic tests offered by the clinical laboratory and explains the science behind them. One of the most valuable assets is its rich compilation of laboratory-tested protocols currently being used in leading laboratories, along with practical advice for nearly every area of interest to cytogeneticists. In addition to covering essential topics that have been the backbone of cytogenetics for over 60 years, such as the basic components of a cell, use of a microscope, human tissue processing for cytogenetic analysis (prenatal, constitutional, and neoplastic), laboratory safety, and the mechanisms behind chromosome rearrangement and aneuploidy, this edition introduces new and expanded chapters by experts in the field. Some of these new topics include a unique collection of chromosome heteromorphisms; clinical examples of genomic imprinting; an example-driven overview of chromosomal microarray; mathematics specifically geared for the cytogeneticist; usage of ISCN’s cytogenetic language to describe chromosome changes; tips for laboratory management; examples of laboratory information systems; a collection of internet and library resources; and a special chapter on animal chromosomes for the research and zoo cytogeneticist. The range of topics is thus broad yet comprehensive, offering the student a resource that teaches the procedures performed in the cytogenetics laboratory environment, and the laboratory professional with a peer-reviewed reference that explores the basis of each of these procedures. This makes it a useful resource for researchers, clinicians, and lab professionals, as well as students in a university or medical school setting.

Human Interphase Chromosomes

Human Interphase Chromosomes
Author: Ivan Iourov,Svetlana Vorsanova,Yuri Yurov
Publsiher: Springer Nature
Total Pages: 178
Release: 2021-01-29
ISBN 10: 303062532X
ISBN 13: 9783030625320
Language: EN, FR, DE, ES & NL

Human Interphase Chromosomes Book Review:

This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the processing and inheritance of genetic information within and between species. Accordingly, post-genomic bioscience appeals to basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation opens new horizons for basic and applied bioscience Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in diagnostic and research practices to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This second edition serves as a source of updated valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology.

Iscn 2020

Iscn 2020
Author: Jean McGowan-Jordan,Ros J. Hastings,Sarah Moore
Publsiher: Unknown
Total Pages: 164
Release: 2020-12-31
ISBN 10: 9783318067064
ISBN 13: 3318067067
Language: EN, FR, DE, ES & NL

Iscn 2020 Book Review:

This reprint of 'Cytogenetic and Genome Research' contains contributions discussing the subject in-depth. 'Cytogenetic and Genome Research' is a well-respected, international peer-reviewed journal in genetics.

Genome and Genomics

Genome and Genomics
Author: K. V. Chaitanya
Publsiher: Springer Nature
Total Pages: 307
Release: 2019-11-17
ISBN 10: 9811507023
ISBN 13: 9789811507021
Language: EN, FR, DE, ES & NL

Genome and Genomics Book Review:

This book provides a detailed and up-to-dated information on the genomes belonging to three major life forms on Earth – archaea, prokaryotes and eukaryotes. Each section describes about the genome of a specific group of organisms, such as viruses, archaea, bacteria, eukaryotes and organellar genomes. Individual chapters provide details of their organization, structure, evolution, sequencing strategies and functions. Further, this book discusses the technologies that are applied for genome sequencing; assembly, annotation and gene prediction. Other topics include the genomes of important model organisms, mitochondria genome of Neanderthal fossil, etc. This book also examines the evolution of chloroplast and mitochondria genomes by comparing with bacteria, addresses the diseases that occur in humans due to the mutations in mitochondrial genome, gene therapy and engineering of chloroplast and mitochondrial genomes. Lastly, it features an overview of the role of proteomics, exposomics, connectomics, metabolomics, and microbiomics. This book is a fascinating read for students, lecturers and researchers in the field of genetics, genomics, microbiology and life sciences.

Cytogenetics in Plant Breeding

Cytogenetics in Plant Breeding
Author: J. Sybenga
Publsiher: Springer Science & Business Media
Total Pages: 469
Release: 2012-12-06
ISBN 10: 3642840833
ISBN 13: 9783642840838
Language: EN, FR, DE, ES & NL

Cytogenetics in Plant Breeding Book Review:

An introductory discussion of basic chromosome structure and function preceeds the main text on the application of cytogenetic approaches to the analysis of the manipulation of both the genetic make-up and the genetic transmission system of plant breeding material. Analysis using light and electron microscopy, segregations and molecular techniques, yields information for assessing the material before and after manipulation. Much attention is given to quantitative methods. Manipulation not only involves the construction of specific genotypes, but also chromosomal transmission systems. Although analysis and manipulation in the somatic cycle are considered, the focus is on the generative cycle, with emphasis on analysis and subsequent segregation of specifically constructed material. The book is intended for plant breeders and other scientists interested in the analysis and manipulation of breeding material at the chromosomal level. Comparisons with molecular and cell biological approaches are made, and the potential of the various methods is evaluated.

PlantOmics The Omics of Plant Science

PlantOmics  The Omics of Plant Science
Author: Debmalya Barh,Muhammad Sarwar Khan,Eric Davies
Publsiher: Springer
Total Pages: 825
Release: 2015-03-18
ISBN 10: 8132221729
ISBN 13: 9788132221722
Language: EN, FR, DE, ES & NL

PlantOmics The Omics of Plant Science Book Review:

PlantOmics: The Omics of Plant Science provides a comprehensive account of the latest trends and developments of omics technologies or approaches and their applications in plant science. Thirty chapters written by 90 experts from 15 countries are included in this state-of-the-art book. Each chapter describes one topic/omics such as: omics in model plants, spectroscopy for plants, next generation sequencing, functional genomics, cyto-metagenomics, epigenomics, miRNAomics, proteomics, metabolomics, glycomics, lipidomics, secretomics, phenomics, cytomics, physiomics, signalomics, thiolomics, organelle omics, micro morphomics, microbiomics, cryobionomics, nanotechnology, pharmacogenomics, and computational systems biology for plants. It provides up to date information, technologies, and their applications that can be adopted and applied easily for deeper understanding plant biology and therefore will be helpful in developing the strategy for generating cost-effective superior plants for various purposes. In the last chapter, the editors have proposed several new areas in plant omics that may be explored in order to develop an integrated meta-omics strategy to ensure the world and earth’s health and related issues. This book will be a valuable resource to students and researchers in the field of cutting-edge plant omics.

Cytogenetics

Cytogenetics
Author: Marcelo L. Larramendy,Sonia Soloneski
Publsiher: BoD – Books on Demand
Total Pages: 172
Release: 2019-05-10
ISBN 10: 1838804056
ISBN 13: 9781838804053
Language: EN, FR, DE, ES & NL

Cytogenetics Book Review:

Cytogenetics - Past, Present, and Further Perspectives discusses events that influenced the development of cytogenetics as a specialty within biology, with special attention paid to methodological achievements developed worldwide that have driven the field forward. Improvements to the resolution of chromosome analysis followed closely the introduction of innovative analytical technologies. In that sense, this book reviews and provides a brief account of the structure of chromosomes and stresses the high structural conservation in different species with an emphasis on aspects that require further research. However, it should be kept in mind that the future of cytogenetics will likely depend on improved knowledge of chromosome structure and function.

ISCN 2013

ISCN 2013
Author: International Standing Committee on Human Cytogenetic Nomenclature
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 140
Release: 2013
ISBN 10: 3318022535
ISBN 13: 9783318022537
Language: EN, FR, DE, ES & NL

ISCN 2013 Book Review:

This publication extends the now classic system of human cytogenetic nomenclature prepared by an expert committee and published in collaboration with Cytogenetic and Genome Research' since 1963. Revised and finalized by the ISCN Committee and its advisors at a meeting in Seattle, Wash., in April 2012, the ISCN 2013 updates, revises and incorporates all previous human cytogenetic nomenclature recommendations into one systematically organized publication that supersedes all previous ISCN recommendations. There are several new features in ISCN 2013: an update of the microarray nomenclature, many more illustrative examples of uses of nomenclature in all sections some definitions including chromothripsis and duplication a new chapter for nomenclature that can be used for any region-specific assay. The ISCN 2013 is an indispensable reference volume for human cytogeneticists, technicians and students for the interpretation and communication of human cytogenetic nomenclature.

Plant Cytogenetics

Plant Cytogenetics
Author: Hank Bass,James A. Birchler
Publsiher: Springer Science & Business Media
Total Pages: 350
Release: 2011-12-02
ISBN 10: 9780387708690
ISBN 13: 0387708693
Language: EN, FR, DE, ES & NL

Plant Cytogenetics Book Review:

This reference book provides information on plant cytogenetics for students, instructors, and researchers. Topics covered by international experts include classical cytogenetics of plant genomes; plant chromosome structure; functional, molecular cytology; and genome dynamics. In addition, chapters are included on several methods in plant cytogenetics, informatics, and even laboratory exercises for aspiring or practiced instructors. The book provides a unique combination of historical and modern subject matter, revealing the central role of plant cytogenetics in plant genetics and genomics as currently practiced. This breadth of coverage, together with the inclusion of methods and instruction, is intended to convey a deep and useful appreciation for plant cytogenetics. We hope it will inform and inspire students, researchers, and teachers to continue to employ plant cytogenetics to address fundamental questions about the cytology of plant chromosomes and genomes for years to come. Hank W. Bass is a Professor in the Department of Biological Science at Florida State University. James A. Birchler is a Professor in the Division of Biological Sciences at the University of Missouri.

Repetitive DNA

Repetitive DNA
Author: Manuel A. Garrido-Ramos
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 230
Release: 2012
ISBN 10: 3318021490
ISBN 13: 9783318021493
Language: EN, FR, DE, ES & NL

Repetitive DNA Book Review:

The experimental data that have been generated using new molecular techniques associated with the completion of genome projects have changed our perception of the structural features, functional implications and evolutionary dynamics of repetitive DNA sequences. This volume of Genome Dynamics provides a valuable update on recent developments in research into multigene families, centromeres, telomeres, microsatellite DNA, satellite DNA, and transposable elements. Each chapter presents a review by distinguished experts and analyzes repetitive DNA diversity and abundance, as well as the impact on genome structure, function and evolution. This publication is targeted at scientists and scholars at every level, from students to faculty members, and, indeed, anyone involved or interested in genetics, molecular evolution, molecular biology as well as genomics will find it a valuable source of up-to-date information.

The Principles of Clinical Cytogenetics

The Principles of Clinical Cytogenetics
Author: Steven L. Gersen,Martha B. Keagle
Publsiher: Springer Science & Business Media
Total Pages: 569
Release: 2013-03-26
ISBN 10: 1441916881
ISBN 13: 9781441916884
Language: EN, FR, DE, ES & NL

The Principles of Clinical Cytogenetics Book Review:

In this thoroughly revised and expanded third edition of the highly praised classic, The Principles of Clinical Cytogenetics, a panel of hands-on experts update their descriptions of the basic concepts and interpretations involved in chromosome analysis to include the many advances that have occurred in the field. Among the highlights are a full chapter devoted to advances in chromosome microarray, soon to become a standard of care in this field, as well as an update on chromosome nomenclature as reflected in ISCN 2009. Other features include an update on automation to reflect the current state of the art, an update on hematopoietic neoplasms to reflect the new WHO guidelines, and updates on all regulatory changes that have been implemented. Cutting edge and readily accessible, The Principles of Clinical Cytogenetics, Third Edition offers physicians who depend on the cytogenetics laboratory for the diagnosis of their patients, students in cytogenetics programs, graduate and medical students studying for board examinations, cytogenetics technologists, and cytogeneticists a clear understanding of what happens in the cytogenetics laboratory to facilitate accurate and timely diagnoses.

Cytogenetics

Cytogenetics
Author: P. K. Gupta
Publsiher: Rastogi Publications
Total Pages: 432
Release: 2007
ISBN 10: 9788171337378
ISBN 13: 8171337376
Language: EN, FR, DE, ES & NL

Cytogenetics Book Review:

Cancer Cytogenetics

Cancer Cytogenetics
Author: Sverre Heim,Felix Mitelman
Publsiher: John Wiley & Sons
Total Pages: 648
Release: 2015-06-29
ISBN 10: 1118795512
ISBN 13: 9781118795514
Language: EN, FR, DE, ES & NL

Cancer Cytogenetics Book Review:

The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date Now produced in full color for enhanced clarity Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible

Molecular Diagnostics

Molecular Diagnostics
Author: George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson
Publsiher: Academic Press
Total Pages: 520
Release: 2016-10-27
ISBN 10: 0128029889
ISBN 13: 9780128029886
Language: EN, FR, DE, ES & NL

Molecular Diagnostics Book Review:

Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field

Principles of Molecular Diagnostics and Personalized Cancer Medicine

Principles of Molecular Diagnostics and Personalized Cancer Medicine
Author: Dongfeng Tan,Henry T. Lynch
Publsiher: Lippincott Williams & Wilkins
Total Pages: 992
Release: 2012-12-07
ISBN 10: 1469820641
ISBN 13: 9781469820644
Language: EN, FR, DE, ES & NL

Principles of Molecular Diagnostics and Personalized Cancer Medicine Book Review:

The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Iscn 2016

Iscn 2016
Author: J. McGowan-Jordan,M. Schmid,A. Simons
Publsiher: Unknown
Total Pages: 140
Release: 2016-05-11
ISBN 10: 9783318058574
ISBN 13: 3318058572
Language: EN, FR, DE, ES & NL

Iscn 2016 Book Review:

The 2016 edition of the International System for Human Cytogenomic Nomenclature (ISCN 2016) offers standard nomenclature that is used to describe any genomic rearrangement identified by techniques ranging from karyotyping to FISH, microarray, various region specific assays, and DNA sequencing. Suggestions from the international cytogenetics community have been reviewed by the Standing Committee, an international group of experts, nominated by their peers. This updated edition offers: * many new examples, particularly for microarray and region specific assays * trackable changes in the main text compared to the previous edition for easier identification * a nomenclature standard to facilitate the description of chromosome rearrangements characterized by DNA sequencing developed through collaboration between the Human Genome Variation Society (HGVS) and ISCN to accommodate the increased use of sequencing technologies in the characterization of chromosomal abnormalities The ISCN 2016 is an indispensable reference volume for human cytogeneticists, molecular geneticists, technicians, and students for the interpretation and communication of human cytogenetic and molecular cytogenomic nomenclature. After a long collaboration with Cytogenetic and Genome Research, ISCN is now again a part of this leading journal on chromosome and genome research, combining the day-to-day business with the latest findings.

Gardner and Sutherland s Chromosome Abnormalities and Genetic Counseling

Gardner and Sutherland s Chromosome Abnormalities and Genetic Counseling
Author: R.J. McKinlay Gardner,David Amor
Publsiher: Oxford University Press
Total Pages: 634
Release: 2018-02-06
ISBN 10: 0199329028
ISBN 13: 9780199329021
Language: EN, FR, DE, ES & NL

Gardner and Sutherland s Chromosome Abnormalities and Genetic Counseling Book Review:

Even as classic cytogenetics has given way to molecular karyotyping, and as new deletion and duplication syndromes are identified almost every day, the fundamental role of the genetics clinic remains mostly unchanged. Genetic counselors and medical geneticists explain the "unexplainable," helping families understand why abnormalities occur and whether they're likely to occur again. Chromosome Abnormalities and Genetic Counseling is the genetics professional's definitive guide to navigating both chromosome disorders and the clinical questions of the families they impact. Combining a primer on these disorders with the most current approach to their best clinical approaches, this classic text is more than just a reference; it is a guide to how to think about these disorders, even as our technical understanding of them continues to evolve. Completely updated and still infused with the warmth and voice that have made it essential reading for professionals across medical genetics, this edition of Chromosome Abnormalities and Genetic Counseling represents a leap forward in clinical understanding and communication. It is, as ever, essential reading for the field.

Clinical Genomics

Clinical Genomics
Author: Shashikant Kulkarni,John Pfeifer
Publsiher: Academic Press
Total Pages: 488
Release: 2014-11-10
ISBN 10: 0124051731
ISBN 13: 9780124051737
Language: EN, FR, DE, ES & NL

Clinical Genomics Book Review:

Clinical Genomics provides an overview of the various next-generation sequencing (NGS) technologies that are currently used in clinical diagnostic laboratories. It presents key bioinformatic challenges and the solutions that must be addressed by clinical genomicists and genomic pathologists, such as specific pipelines for identification of the full range of variants that are clinically important. This book is also focused on the challenges of diagnostic interpretation of NGS results in a clinical setting. Its final sections are devoted to the emerging regulatory issues that will govern clinical use of NGS, and reimbursement paradigms that will affect the way in which laboratory professionals get paid for the testing. Simplifies complexities of NGS technologies for rapid education of clinical genomicists and genomic pathologists towards genomic medicine paradigm Tried and tested practice-based analysis for precision diagnosis and treatment plans Specific pipelines and meta-analysis for full range of clinically important variants