Conceptual Breakthroughs in the Evolutionary Biology of Aging

Conceptual Breakthroughs in the Evolutionary Biology of Aging
Author: Kenneth R. Arnold,Michael R. Rose
Publsiher: Academic Press
Total Pages: 296
Release: 2021-06-01
ISBN 10: 0128215461
ISBN 13: 9780128215463
Language: EN, FR, DE, ES & NL

Conceptual Breakthroughs in the Evolutionary Biology of Aging Book Review:

Conceptual Breakthroughs in the Evolutionary Biology of Aging continues the innovative Conceptual Breakthroughs series by providing a comprehensive outline of the major breakthroughs that built the evolutionary biology of aging as a leading scientific field. Following the evolutionary study of aging from its humble origins to the present, the book's chapters treat the field’s breakthroughs one at a time. Users will find a concise and accessible analysis of the science of aging viewed through an evolutionary lens. Building upon widely-cited studies conducted by author Michael Rose, this book covers 30 subsequent years of growth and development within the field. The book highlights key publications for those who are not experts in the field, providing an important resource for researchers. Given the prevailing interest in changing the aging process dramatically, it is a powerful tool for readers who have a vested interest in understanding its causes and future control measures. Reviews cell-molecular theories of aging in the light of evolutionary biology Offers an evolutionary analysis of prospects for mitigating aging not commonly discussed within private and public sectors Provides readers with a radically different perspective on contemporary biological gerontology, specifically through the lens of evolutionary biology

Conceptual Breakthroughs in Evolutionary Ecology

Conceptual Breakthroughs in Evolutionary Ecology
Author: Laurence Mueller
Publsiher: Academic Press
Total Pages: 204
Release: 2019-11-25
ISBN 10: 0128160144
ISBN 13: 9780128160145
Language: EN, FR, DE, ES & NL

Conceptual Breakthroughs in Evolutionary Ecology Book Review:

Although biologists recognize evolutionary ecology by name, many only have a limited understanding of its conceptual roots and historical development. Conceptual Breakthroughs in Evolutionary Ecology fills that knowledge gap in a thought-provoking and readable format. Written by a world-renowned evolutionary ecologist, this book embodies a unique blend of expertise in combining theory and experiment, population genetics and ecology. Following an easily-accessible structure, this book encapsulates and chronologizes the history behind evolutionary ecology. It also focuses on the integration of age-structure and density-dependent selection into an understanding of life-history evolution. Covers over 60 seminal breakthroughs and paradigm shifts in the field of evolutionary biology and ecology Modular format permits ready access to each described subject Historical overview of a field whose concepts are central to all of biology and relevant to a broad audience of biologists, science historians, and philosophers of science

Conceptual Breakthroughs in Evolutionary Genetics

Conceptual Breakthroughs in Evolutionary Genetics
Author: John C. Avise
Publsiher: Academic Press
Total Pages: 184
Release: 2014-01-18
ISBN 10: 0124202373
ISBN 13: 9780124202375
Language: EN, FR, DE, ES & NL

Conceptual Breakthroughs in Evolutionary Genetics Book Review:

Conceptual Breakthroughs in Evolutionary Genetics is a pithy, lively book occupying a special niche—the conceptual history of evolutionary genetics— not inhabited by any other available treatment. Written by a world-leading authority in evolutionary genetics, this work encapsulates and ranks 70 of the most significant paradigm shifts in evolutionary biology and genetics during the century-and-a-half since Darwin and Mendel. The science of evolutionary genetics is central to all of biology, but many students and other practitioners have little knowledge of its historical roots and conceptual developments. This book fills that knowledge gap in a thought-provoking and readable format. This fascinating chronological journey along the many conceptual pathways to our modern understanding of evolutionary and genetic principles is a wonderful springboard for discussions in undergraduate or graduate seminars in evolutionary biology and genetics. But more than that, anyone interested in the history and philosophy of science will find much of value between its covers. Provides a relative ranking of 70 seminal breakthroughs and paradigm shifts in the field of evolutionary biology and genetics Modular format permits ready access to each described subject Historical overview of a field whose concepts are central to all of biology and relevant to a broad audience of biologists, science historians, and philosophers of science Extensively cross-referenced with a guide to landmark papers and books for each topic

Chasing Methuselah

Chasing Methuselah
Author: Todd T. W. Daly
Publsiher: Wipf and Stock Publishers
Total Pages: 324
Release: 2021-02-04
ISBN 10: 153269802X
ISBN 13: 9781532698026
Language: EN, FR, DE, ES & NL

Chasing Methuselah Book Review:

The quest to live much longer has moved from legend to the laboratory. Recent breakthroughs in genetics and pharmacology have put humanity on the precipice of slowing down human aging to extend the healthy life span. The promise of longer, healthier life is enormously attractive, and poses several challenging questions for Christians. Who wouldn't want to live 120 years or more before dying quickly? How do we make sense of human aging in light of Jesus' invitation to daily take up our crosses with the promise of the resurrection to come? Is there anything wrong with manipulating our bodies technologically to live longer? If so, how long is too long? Should aging itself be treated as a disease? In Chasing Methuselah, Todd Daly examines the modern biomedical anti-aging project from a Christian perspective, drawing on the ancient wisdom of the Desert Fathers, who believed that the incarnation opened a way for human life to regain the longevity of Adam and the biblical patriarchs through prayer and fasting. Daly balances these insights with the christological anthropology of Karl Barth, discussing the implications for human finitude, fear of death, and the use of anti-aging technology, weaving a path between outright condemnation and uncritical enthusiasm.

Human Evolutionary Genetics

Human Evolutionary Genetics
Author: Mark Jobling,Matthew Hurles,Chris Tyler-Smith
Publsiher: Garland Science
Total Pages: 650
Release: 2013-06-25
ISBN 10: 1136844147
ISBN 13: 9781136844140
Language: EN, FR, DE, ES & NL

Human Evolutionary Genetics Book Review:

Human Evolutionary Genetics is a groundbreaking text which for the first time brings together molecular genetics and genomics to the study of the origins and movements of human populations. Starting with an overview of molecular genomics for the non-specialist (which can be a useful review for those with a more genetic background), the book shows how data from the post-genomic era can be used to examine human origins and the human colonization of the planet, richly illustrated with genetic trees and global maps. For the first time in a textbook, the authors outline how genetic data and the understanding of our origins which emerges, can be applied to contemporary population analyses, including genealogies, forensics and medicine.

Globalization Biosecurity and the Future of the Life Sciences

Globalization  Biosecurity  and the Future of the Life Sciences
Author: National Research Council,Institute of Medicine,Board on Global Health,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Advances in Technology and the Prevention of Their Application to Next Generation Biowarfare Threats
Publsiher: National Academies Press
Total Pages: 316
Release: 2006-06-07
ISBN 10: 9780309164757
ISBN 13: 0309164753
Language: EN, FR, DE, ES & NL

Globalization Biosecurity and the Future of the Life Sciences Book Review:

Biomedical advances have made it possible to identify and manipulate features of living organisms in useful ways--leading to improvements in public health, agriculture, and other areas. The globalization of scientific and technical expertise also means that many scientists and other individuals around the world are generating breakthroughs in the life sciences and related technologies. The risks posed by bioterrorism and the proliferation of biological weapons capabilities have increased concern about how the rapid advances in genetic engineering and biotechnology could enable the production of biological weapons with unique and unpredictable characteristics. Globalization, Biosecurity, and the Future of Life Sciences examines current trends and future objectives of research in public health, life sciences, and biomedical science that contain applications relevant to developments in biological weapons 5 to 10 years into the future and ways to anticipate, identify, and mitigate these dangers.

Evolutionary Biology of Aging

Evolutionary Biology of Aging
Author: Michael R. Rose
Publsiher: Oxford University Press on Demand
Total Pages: 221
Release: 1991
ISBN 10: 0195095308
ISBN 13: 9780195095302
Language: EN, FR, DE, ES & NL

Evolutionary Biology of Aging Book Review:

In this provocative book on the process of growing old, Michael Rose goes right to the heart of the fundamental "unsolved problem" of biology. Why do we grow old? The proposed theory is that to understand aging we must understand its evolution; only then do its taxonomic distribution and its genetic and physiological mechanisms become intelligible. Evidence is produced from the fields of cell biology, physiology, and gerontology.

Cancer Evolution

Cancer Evolution
Author: Charles Swanton
Publsiher: Perspectives Cshl
Total Pages: 350
Release: 2017
ISBN 10: 9781621821434
ISBN 13: 1621821439
Language: EN, FR, DE, ES & NL

Cancer Evolution Book Review:

Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

Mitochondrial Free Radical Theory of Aging

Mitochondrial Free Radical Theory of Aging
Author: Aubrey D. N. De Grey
Publsiher: Unknown
Total Pages: 215
Release: 1999
ISBN 10: 9781597342612
ISBN 13: 1597342610
Language: EN, FR, DE, ES & NL

Mitochondrial Free Radical Theory of Aging Book Review:

The vast complexity of organismal degeneration with age has too often intimidated gerontologists into over-cautious interpretation of their results. Therefore, theories of mammalian aging have been too open and preliminary to underpin the design of medical interventions. This book breaks new ground in the effort to overcome that inertia, by providing a highly detailed and experimentally well-founded model of mammalian aging, together with analysis of the ways in which that model may be exploited to influence the rate of aging. It will benefit biologists, clinicians and the scientifically-minde.

The Life Sciences

The Life Sciences
Author: Anonim
Publsiher: National Academies
Total Pages: 526
Release: 1970-01-01
ISBN 10: 1928374650XXX
ISBN 13: NAP:13064
Language: EN, FR, DE, ES & NL

The Life Sciences Book Review:

Strengthening Forensic Science in the United States

Strengthening Forensic Science in the United States
Author: National Research Council,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Policy and Global Affairs,Committee on Science, Technology, and Law,Committee on Identifying the Needs of the Forensic Sciences Community
Publsiher: National Academies Press
Total Pages: 348
Release: 2009-07-29
ISBN 10: 0309142393
ISBN 13: 9780309142397
Language: EN, FR, DE, ES & NL

Strengthening Forensic Science in the United States Book Review:

Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.

Progress in Cell Growth Process Research

Progress in Cell Growth Process Research
Author: Takumi Hayashi
Publsiher: Nova Publishers
Total Pages: 244
Release: 2007
ISBN 10: 9781604563252
ISBN 13: 1604563257
Language: EN, FR, DE, ES & NL

Progress in Cell Growth Process Research Book Review:

When used in the context of reproduction of living cells the phrase "cell growth" is shorthand for the idea of "growth in cell populations by means of cell reproduction." During cell reproduction one cell (the "mother" cell) divides to produce two daughter cells. Cell proliferation, which depends on the intimately linked processes of growth and division, is a fundamental systems-level attribute of all life forms. The precise regulation of proliferation in response to internal and external cues is critical for development, tissue renewal and evolutionary fitness, while the disregulation of cell proliferation underlies a variety of human diseases, most notably cancer and ageing. Historically, breakthroughs in our understanding of cell growth and division have derived from cross-fertilisation of results and ideas from researchers studying a wide range of model organisms, from yeast to humans. The basis for cell proliferation entails the control of key signalling and cell cycle regulators through transcriptional, translational, post-translational, genetic and epigenetic mechanisms. Indeed, many conceptual breakthroughs in cell regulation have derived from analyses of basic cell cycle mechanisms. This book is dedicated to new research from around the globe in this field.

Cell Growth Processes

Cell Growth Processes
Author: Daiki Kimura
Publsiher: Nova Publishers
Total Pages: 237
Release: 2008
ISBN 10: 9781604561326
ISBN 13: 1604561327
Language: EN, FR, DE, ES & NL

Cell Growth Processes Book Review:

The basis for cell proliferation entails the control of key signalling and cell cycle regulators through transcriptional, translational, post-translational, genetic and epigenetic mechanisms. Many conceptual breakthroughs in cell regulation have derived from analyses of basic cell cycle mechanisms. This book presents research in the field.

The Future of Aging

The Future of Aging
Author: Anonim
Publsiher: Springer Science & Business Media
Total Pages: 866
Release: 2010-07-28
ISBN 10: 9048139996
ISBN 13: 9789048139996
Language: EN, FR, DE, ES & NL

The Future of Aging Book Review:

Just as the health costs of aging threaten to bankrupt developed countries, this book makes the scientific case that a biological "bailout" could be on the way, and that human aging can be different in the future than it is today. Here 40 authors argue how our improving understanding of the biology of aging and selected technologies should enable the successful use of many different and complementary methods for ameliorating aging, and why such interventions are appropriate based on our current historical, anthropological, philosophical, ethical, evolutionary, and biological context. Challenging concepts are presented together with in-depth reviews and paradigm-breaking proposals that collectively illustrate the potential for changing aging as never before. The proposals extend from today to a future many decades from now in which the control of aging may become effectively complete. Examples include sirtuin-modulating pills, new concepts for attacking cardiovascular disease and cancer, mitochondrial rejuvenation, stem cell therapies and regeneration, tissue reconstruction, telomere maintenance, prevention of immunosenescence, extracellular rejuvenation, artificial DNA repair, and full deployment of nanotechnology. The Future of Aging will make you think about aging differently and is a challenge to all of us to open our eyes to the future therapeutic potential of biogerontology.

Ageing and Technology

Ageing and Technology
Author: Emma Domínguez-Rué,Linda Nierling
Publsiher: transcript Verlag
Total Pages: 342
Release: 2016-01-31
ISBN 10: 3839429579
ISBN 13: 9783839429570
Language: EN, FR, DE, ES & NL

Ageing and Technology Book Review:

The booming increase of the senior population has become a social phenomenon and a challenge to our societies, and technological advances have undoubtedly contributed to improve the lives of elderly citizens in numerous aspects. In current debates on technology, however, the »human factor« is often largely ignored. The ageing individual is rather seen as a malfunctioning machine whose deficiencies must be diagnosed or as a set of limitations to be overcome by means of technological devices. This volume aims at focusing on the perspective of human beings deriving from the development and use of technology: this change of perspective - taking the human being and not technology first - may help us to become more sensitive to the ambivalences involved in the interaction between humans and technology, as well as to adapt technologies to the people that created the need for its existence, thus contributing to improve the quality of life of senior citizens.

The Demography and Epidemiology of Human Health and Aging

The Demography and Epidemiology of Human Health and Aging
Author: Jacob S. Siegel
Publsiher: Springer Science & Business Media
Total Pages: 985
Release: 2011-09-30
ISBN 10: 9789400713154
ISBN 13: 9400713150
Language: EN, FR, DE, ES & NL

The Demography and Epidemiology of Human Health and Aging Book Review:

With this book, Siegel, an internationally known demographer and gerontologist, has made a unique contribution to the fledgling fields of health demography, and the demography and epidemiology of aging. The book represents a felicitous union of epidemiology, gerontology, and demography, and appears to be the first and only comprehensive text on this subject now available. Drawing on a wide range of sciences in addition to demography, gerontology, and epidemiology, including medical sociology, biostatistics, public policy, bioethics, and molecular biology, the author treats theoretical and applied issues, links methods and findings, covers the material internationally, nationally, and locally, and while focusing on the elderly, treats the entire life course. The methods, materials, and pespectives of demography and epidemiology are brought to bear on such topics as the prospects for future increases in human longevity, the relative contribution of life style, environment, genetics, and chance in human longevity, the measurement of the share of healthy years in total life expectancy, the role of population growth in the rising costs of health care, and the applications of health demography in serving the health needs of local communities. The separate chapters systematically develop the topics of the sources and quality of health data; mortality, life tables, and the measurement of health status; the interrelationships of health, on the one hand, and mortality, fertility, migration, and age structure, on the other; health conditions in the less developed countries; the concepts and theories of aging and projections of the aged population; and local health applications, public health policy, and bioethical issues in health demography. Given its comprehensiveness, clarity, interdisciplinary scope, and authencity, this book appeals to a wide range of users, from students and teachers of medical sociology, the demography of aging, and public health studies to practitioners in these areas, both as a text in health demography and the demography/epidemiology of aging, and as a reference work in these fields.

Emergent Theories of Aging

Emergent Theories of Aging
Author: James E. Birren,Vern L. Bengtson
Publsiher: Unknown
Total Pages: 530
Release: 1988
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015012588920
Language: EN, FR, DE, ES & NL

Emergent Theories of Aging Book Review:

The Logic of Chance

The Logic of Chance
Author: Eugene V. Koonin
Publsiher: FT Press
Total Pages: 528
Release: 2011-06-23
ISBN 10: 9780132623179
ISBN 13: 013262317X
Language: EN, FR, DE, ES & NL

The Logic of Chance Book Review:

The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and hypotheses on the key aspects of the evolution of life on earth in light of comparative genomics and systems biology. The author presents many specific examples from systems and comparative genomic analysis to begin to build a new, much more detailed, complex, and realistic picture of evolution. The book examines a broad range of topics in evolutionary biology including the inadequacy of natural selection and adaptation as the only or even the main mode of evolution; the key role of horizontal gene transfer in evolution and the consequent overhaul of the Tree of Life concept; the central, underappreciated evolutionary importance of viruses; the origin of eukaryotes as a result of endosymbiosis; the concomitant origin of cells and viruses on the primordial earth; universal dependences between genomic and molecular-phenomic variables; and the evolving landscape of constraints that shape the evolution of genomes and molecular phenomes. "Koonin's account of viral and pre-eukaryotic evolution is undoubtedly up-to-date. His "mega views" of evolution (given what was said above) and his cosmological musings, on the other hand, are interesting reading." Summing Up: Recommended Reprinted with permission from CHOICE, copyright by the American Library Association.

The Philosophy of Biology

The Philosophy of Biology
Author: Kostas Kampourakis
Publsiher: Springer Science & Business Media
Total Pages: 762
Release: 2013-06-18
ISBN 10: 9400765371
ISBN 13: 9789400765375
Language: EN, FR, DE, ES & NL

The Philosophy of Biology Book Review:

This book brings together for the first time philosophers of biology to write about some of the most central concepts and issues in their field from the perspective of biology education. The chapters of the book cover a variety of topics ranging from traditional ones, such as biological explanation, biology and religion or biology and ethics, to contemporary ones, such as genomics, systems biology or evolutionary developmental biology. Each of the 30 chapters covers the respective philosophical literature in detail and makes specific suggestions for biology education. The aim of this book is to inform biology educators, undergraduate and graduate students in biology and related fields, students in teacher training programs, and curriculum developers about the current state of discussion on the major topics in the philosophy of biology and its implications for teaching biology. In addition, the book can be valuable to philosophers of biology as an introductory text in undergraduate and graduate courses.

Handbook of Life Course Health Development

Handbook of Life Course Health Development
Author: Neal Halfon,Christopher B. Forrest,Richard M. Lerner,Elaine M. Faustman
Publsiher: Springer
Total Pages: 664
Release: 2017-11-20
ISBN 10: 3319471430
ISBN 13: 9783319471433
Language: EN, FR, DE, ES & NL

Handbook of Life Course Health Development Book Review:

This book is open access under a CC BY 4.0 license. ​This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.