Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance
Author: Mohmmad Younus Wani,Aijaz Ahmad
Publsiher: Academic Press
Total Pages: 268
Release: 2020-04-30
ISBN 10: 0128205784
ISBN 13: 9780128205785
Language: EN, FR, DE, ES & NL

Combination Therapy Against Multidrug Resistance Book Review:

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

Antibiotic Combination Therapy Against Multidrug resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine

Antibiotic Combination Therapy Against Multidrug resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine
Author: Anh Kim Lam
Publsiher: Unknown
Total Pages: 145
Release: 2020
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1176470166
Language: EN, FR, DE, ES & NL

Antibiotic Combination Therapy Against Multidrug resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine Book Review:

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components
Author: Mahendra Rai,Kateryna Kon
Publsiher: Academic Press
Total Pages: 296
Release: 2013-05-24
ISBN 10: 0124017088
ISBN 13: 9780124017085
Language: EN, FR, DE, ES & NL

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components Book Review:

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery Addresses the need to develop safe and effective approaches to coping with resistance to all classes of antimicrobial drugs Provides readers with current evidence-based content aimed at using herbal extracts and essential oils in antimicrobial drug development Includes chapters devoted to the activity of herbal products against herpes, AIDS, tuberculosis, drug-resistant cancer cells and more

Drug Discovery Targeting Drug Resistant Bacteria

Drug Discovery Targeting Drug Resistant Bacteria
Author: Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta
Publsiher: Academic Press
Total Pages: 432
Release: 2020-05-15
ISBN 10: 0128184817
ISBN 13: 9780128184813
Language: EN, FR, DE, ES & NL

Drug Discovery Targeting Drug Resistant Bacteria Book Review:

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Antibiotics and Bacterial Resistance

Antibiotics and Bacterial Resistance
Author: Wiley
Publsiher: John Wiley & Sons
Total Pages: 146
Release: 2013-01-14
ISBN 10: 1118580915
ISBN 13: 9781118580912
Language: EN, FR, DE, ES & NL

Antibiotics and Bacterial Resistance Book Review:

The need for novel antibiotics is greater now than perhaps anytime since the pre-antibiotic era. Indeed, the recent collapse ofmany pharmaceutical antibacterial groups, combined with theemergence of hypervirulent and pan-antibiotic-resistant bacteriahas severely compromised infection treatment options and led todramatic increases in the incidence and severity of bacterialinfections. This collection of reviews and laboratory protocols gives thereader an introduction to the causes of antibiotic resistance, thebacterial strains that pose the largest danger to humans (i.e.,streptococci, pneumococci and enterococci) and the antimicrobialagents used to combat infections with these organisms. Some newavenues that are being investigated for antibiotic development arealso discussed. Such developments include the discovery of agentsthat inhibit bacterial RNA degradation, the bacterial ribosome, andstructure-based approaches to antibiotic drug discovery. Two laboratory protocols are provided to illustrate differentstrategies for discovering new antibiotics. One is a bacterialgrowth inhibition assay to identify inhibitors of bacterial growththat specifically target conditionally essential enzymes in thepathway of interest. The other protocol is used to identifyinhibitors of bacterial cell-to-cell signaling. This e-book — a curated collection from eLS, WIREs, andCurrent Protocols — offers a fantastic introduction to thefield of antibiotics and antibiotic resistance for students orinterdisciplinary collaborators. Table of Contents: Introduction Antibiotics and the Evolution of Antibiotic Resistance eLS Jose L Martinez, Fernando Baquero Antimicrobials Against Streptococci, Pneumococci andEnterococci eLS Susan Donabedian, Adenike Shoyinka Techniques & Applications RNA decay: a novel therapeutic target in bacteria WIREs RNA Tess M. Eidem, Christelle M. Roux, Paul M. Dunman Antibiotics that target protein synthesis WIREs RNA Lisa S. McCoy, Yun Xie, Yitzhak Tor Methods High-Throughput Assessment of Bacterial Growth Inhibition byOptical Density Measurements Current Protocols Chemical Biology Jennifer Campbell Structure-Based Approaches to Antibiotic Drug Discovery Current Protocols Microbiology George Nicola, Ruben Abagyan Novel Approaches to Bacterial Infection Therapy by Interferingwith Cell-to-Cell Signaling Current Protocols Microbiology David A. Rasko, Vanessa Sperandio

Antimicrobial Pharmacodynamics in Theory and Clinical Practice

Antimicrobial Pharmacodynamics in Theory and Clinical Practice
Author: Nightingale,Mur
Publsiher: CRC Press
Total Pages: 427
Release: 2001-09-25
ISBN 10: 082474182X
ISBN 13: 9780824741822
Language: EN, FR, DE, ES & NL

Antimicrobial Pharmacodynamics in Theory and Clinical Practice Book Review:

This up-to-the-minute reference explores the pharmacodynamics of antimicrobials as well as the absorption, distribution, metabolism, and elimination of the major classes of antimicrobials-covering new agents such as ketolide antibiotics and highlighting the pharmacodynamic relationship between drug concentration and antimicrobial activity, as well as the relationship of pharmacodynamics to bacterial resistance. Contains specific examples and practical applications for the design of effective dosing regimens! Written by recognized experts in the field, Antimicrobial Pharmacodynamics in Theory and Clinical Practice describes the pharmacodynamic properties of all major classes of antibiotics parameters for microbiological activity of antimicrobial agents such as minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) serum/tissue protein binding and penetration rates differences between in vivo and in vitro postantibiotic effects (PAE) and more! With nearly 1000 references, tables, drawings, and illustrations, Antimicrobial Pharmacodynamics in Theory and Clinical Practice is a state-of-the-art reference for infectious disease specialists, pulmonologists, pharmacists, pharmacologists, microbiologists, biological chemists, epidemiologists, internists, and students in these disciplines.

Antibiofilm Agents

Antibiofilm Agents
Author: Kendra P. Rumbaugh,Iqbal Ahmad
Publsiher: Springer Science & Business Media
Total Pages: 497
Release: 2014-05-08
ISBN 10: 3642538339
ISBN 13: 9783642538339
Language: EN, FR, DE, ES & NL

Antibiofilm Agents Book Review:

This book provides a survey of recent advances in the development of antibiofilm agents for clinical and environmental applications. The fact that microbes exist in structured communities called biofilms has slowly become accepted within the medical community. We now know that over 80% of all infectious diseases are biofilm-related; however, significant challenges still lie in our ability to diagnose and treat these extremely recalcitrant infections. Written by experts from around the globe, this book offers a valuable resource for medical professionals seeking to treat biofilm-related disease, academic and industry researchers interested in drug discovery and instructors who teach courses on microbial pathogenesis and medical microbiology.

Combating Antimicrobial Resistance A One Health Approach

Combating Antimicrobial Resistance   A One Health Approach
Author: Ghassan M. Matar,Antoine Andremont
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-02-14
ISBN 10: 2889635155
ISBN 13: 9782889635153
Language: EN, FR, DE, ES & NL

Combating Antimicrobial Resistance A One Health Approach Book Review:

Drug Resistance in Bacteria Fungi Malaria and Cancer

Drug Resistance in Bacteria  Fungi  Malaria  and Cancer
Author: Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia
Publsiher: Springer
Total Pages: 630
Release: 2017-03-21
ISBN 10: 3319486837
ISBN 13: 9783319486833
Language: EN, FR, DE, ES & NL

Drug Resistance in Bacteria Fungi Malaria and Cancer Book Review:

This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Multifunctional Nanomaterials Role and Perspectives in Combination Therapies Against Cancer

Multifunctional Nanomaterials  Role and Perspectives in Combination Therapies Against Cancer
Author: Wang Zheng,Junjie Li,Jinbing Xie
Publsiher: Frontiers Media SA
Total Pages: 182
Release: 2022-06-30
ISBN 10: 2889764621
ISBN 13: 9782889764624
Language: EN, FR, DE, ES & NL

Multifunctional Nanomaterials Role and Perspectives in Combination Therapies Against Cancer Book Review:

Infection Control

Infection Control
Author: Silpi Basak
Publsiher: BoD – Books on Demand
Total Pages: 102
Release: 2013-05-29
ISBN 10: 9535111450
ISBN 13: 9789535111450
Language: EN, FR, DE, ES & NL

Infection Control Book Review:

Health Care associated infection (HAI) is an emerging problem worldwide. HAI causes increased morbidity, mortality and average length of stay of the patient in the hospital. HAI also imposes economic burden on the patient, health care set up and also State and National Health care system. It has been estimated that 5 10 % of all hospital admission suffers from HAI even in developed countries. But 30% of HAI are preventable, if we follow the infection control practices properly especially hand hygiene while giving patient care. Hence, in this book importance has been given to Infection Control practices along with emerging trends of HAI due to Pseudomonas aeruginosa, Acinetobacter species etc.

Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models

Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models
Author: Neang S. Ly
Publsiher: Unknown
Total Pages: 443
Release: 2014
ISBN 10: 1928374650XXX
ISBN 13: OCLC:961274163
Language: EN, FR, DE, ES & NL

Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models Book Review:

The emergence of multidrug-resistant (MDR) Gram-negative 'superbugs' coupled with a rapid decline in the development of new antibiotics has led to a serious, global health crisis. Polymyxin antibiotics, which include polymyxin E (colistin) and polymyxin B, were introduced over 50 years ago and were seldom used due to nephrotoxicity. However, recently, the polymyxins have re-emerged in the clinic as an antibiotic of last-resort. There are increasing reports of polymyxin resistance and failure during polymyxin monotherapy. While polymyxin based combination therapies are a promising alternative, there are significant gaps regarding the optimal use of such combinations. The primary goal of this dissertation is to rationally optimize polymyxin combination therapy based on pharmacokinetic/pharmacodynamic (PK/PD) principles. Menchanism-based (PK/PD) models (MBMs) were employed to evaluate mechanisms of antibiotic synergy. A secondary goal is to define the mechanisms of polymyxin tolerance and resistance utilizing genetically modified knockout strains and to develop MBMs that quantify the impact of bacterial regulatory systems including quorum sensing mechanisms on antibiotic PD.

Combination Therapy of Aids

Combination Therapy of Aids
Author: Erik De Clercq,Anne-Mieke Vandamme
Publsiher: Springer Science & Business Media
Total Pages: 260
Release: 2004
ISBN 10: 9783764366001
ISBN 13: 3764366001
Language: EN, FR, DE, ES & NL

Combination Therapy of Aids Book Review:

This book is the first to tackle, in a single treatise, a subject that has recently become a discipline in its own right, that of the combination antiretroviral therapy of AIDS. It is aimed at an audience of clinicians, researchers, public health workers, specialists or non-specialists in AIDS and particularly those who want to know how to optimally approach the treatment of AIDS. Combination drug treatment of AIDS is focussed from different angles and perspectives, historical, basic, economic, theoretical, virological, immunological, clinical and practical reasons for therapy failures are examined and strategies to prevent or overcome failing therapies are formulated. This book fills a gap in the current literature on clinical therapeutics. It should be particularly informative to those who want and need to know more about the current treatment of AIDS, with its successes and failures, but also with lessons and guidelines to affront these failures.

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components
Author: Kalpna D. Rakholiya,Mital J. Kaneria,Sumitra V. Chanda
Publsiher: Elsevier Inc. Chapters
Total Pages: 296
Release: 2013-05-24
ISBN 10: 0128066822
ISBN 13: 9780128066829
Language: EN, FR, DE, ES & NL

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components Book Review:

Antibiotics are antimicrobial agents that are used to treat infectious diseases. The outbreak of pathogenic antibiotic-resistant strains illustrates our urgent need to search for new alternative sources of treatment. Hence, an attempt has been made in this review to list some plant extracts, essential/volatile oils, and their antimicrobial activity against different microorganisms using different methods, as well as synergistic effects (plant extract-plant extract, plant extract-essential oils, plant extract-conventional antibiotics, phytochemical-antibiotics, and essential oil-essential oil). Plant products and their active constituents are useful in the treatment of infectious diseases caused by multidrug-resistant microbes, food borne diseases caused by food spoiling microbes, and oral pathogens. Products derived from plants have the potential to control microbial growth in diverse situations, and specifically in the treatment of disease. The various aspects of this review may be helpful for the food, cosmetic, and pharmaceutical industries.

Contemporary Topics of Pneumonia

Contemporary Topics of Pneumonia
Author: Zissis Chroneos
Publsiher: BoD – Books on Demand
Total Pages: 222
Release: 2017-12-20
ISBN 10: 9535137077
ISBN 13: 9789535137078
Language: EN, FR, DE, ES & NL

Contemporary Topics of Pneumonia Book Review:

Pneumonia is an inflammatory disease of the air sacs and surrounding interstitium caused by infectious agents or by endogenous inflammatory tissue disorder termed interstitial pneumonia. The present book covers contemporary topics of community, hospital, and health care-related bacterial and viral pneumonia in the setting of drug resistance, environmental exposures, climate change, hormonal influences, and gender. The topic of interstitial pneumonia is brought under the lens of an immune-related connective tissue disease.

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components
Author: Román Yesid Ramírez Rueda
Publsiher: Elsevier Inc. Chapters
Total Pages: 296
Release: 2013-05-24
ISBN 10: 0128066733
ISBN 13: 9780128066737
Language: EN, FR, DE, ES & NL

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components Book Review:

Methicillin-resistant Staphylococcus aureus (MRSA) is currently one of the most common causes of serious infections, in both hospital and community environments. This type of resistance was discovered in the 1960s, and now (50 years later) it has not been possible to develop an effective therapy to fight against it. This chapter compiles the results of several studies demonstrating the activity (mainly in vitro) of various extracts, essential oils, and plant-derived molecules that can act alone or in combination against MRSA. In addition, natural alternatives (other than from plants) being studied for the same purpose are described. Finally, the important role of phytotherapy in the development of new therapies against multidrug-resistant bacteria such as MRSA is emphasized.

Severe Community Acquired Pneumonia

Severe Community Acquired Pneumonia
Author: Jordi Rello,Kenneth V. Leeper
Publsiher: Springer Science & Business Media
Total Pages: 194
Release: 2013-11-11
ISBN 10: 1461516315
ISBN 13: 9781461516316
Language: EN, FR, DE, ES & NL

Severe Community Acquired Pneumonia Book Review:

Severe Community Acquired Pneumonia is a book in which chapters are authored and the same topics discussed by North American and European experts. This approach provides a unique opportunity to view the different perspectives and points of view on this subject. Severe CAP is a common clinical problem encountered in the ICU setting. This book reviews topics concerning the pathogenesis, diagnosis and management of SCAP. The discussions on the role of alcohol in severe CAP and adjunctive therapies are important topics that further our understanding of this severe respiratory infection.

Management of MDR TB

Management of MDR TB
Author: World Health Organization
Publsiher: World Health Organization
Total Pages: 50
Release: 2009
ISBN 10: 9241547766
ISBN 13: 9789241547765
Language: EN, FR, DE, ES & NL

Management of MDR TB Book Review:

Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) are increasingly encountered in resource-limited settings. In the context of a national response to MDR- and XDR-TB, health workers in TB clinics (in district hospitals and some accredited health centers) will need to diagnose MDR-TB, initiate second-line anti-TB drugs, and monitor MDR-TB treatment. This Field Guide was created to help health workers carry out these tasks. It is a job aid that medical officers and TB nurses are meant to use frequently during the day for quick reference. It is based on the Emergency Update 2008 of Guidelines for Programmatic Management of Drug-resistant Tuberculosis, and may be considered a companion document to these guidelines. It also draws on the experience of the international health NGO Partners In Health (PIH) in many countries. This module should be introduced to health workers in the context of a training course with a strong emphasis on TB-HIV co-management.

Antibiotics in Laboratory Medicine

Antibiotics in Laboratory Medicine
Author: Daniel Amsterdam
Publsiher: Lippincott Williams & Wilkins
Total Pages: 832
Release: 2014-08-08
ISBN 10: 1469883635
ISBN 13: 9781469883632
Language: EN, FR, DE, ES & NL

Antibiotics in Laboratory Medicine Book Review:

Antibiotics in Laboratory Medicine has been a mainstay resource for practitioners/providers, investigators, and pharmaceutical researchers of new anti-infective compounds for the past 30 years. This edition includes new chapters on the predictive value of in vitro laboratory testing and the improvement of patient care in the hospital environment through antimicrobial stewardship.

Introduction to Basics of Pharmacology and Toxicology

Introduction to Basics of Pharmacology and Toxicology
Author: Abialbon Paul,Nishanthi Anandabaskar,Jayanthi Mathaiyan,Gerard Marshall Raj
Publsiher: Springer Nature
Total Pages: 1156
Release: 2021-03-13
ISBN 10: 9813360097
ISBN 13: 9789813360099
Language: EN, FR, DE, ES & NL

Introduction to Basics of Pharmacology and Toxicology Book Review:

This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.