Colorectal Neoplasia and the Colorectal Microbiome

Colorectal Neoplasia and the Colorectal Microbiome
Author: Martin H. Floch
Publsiher: Academic Press
Total Pages: 270
Release: 2020-08-15
ISBN 10: 0128225610
ISBN 13: 9780128225615
Language: EN, FR, DE, ES & NL

Colorectal Neoplasia and the Colorectal Microbiome Book Review:

Colorectal Neoplasia and the Microbiome: Dysplasia, Probiotics, and Fusobacteria provides foundational knowledge on the gut microbiome and evidence for an association with colorectal neoplasia. It covers the role of microbiota in causing adenomatous polyps and colorectal cancer as well as the modulatory effect of diet and probiotics. Chapters explain a foundational history of microbiology in the colon, the epidemiology of colon polyps and cancer, dysbiosis, the role of immunology and bacteria, and the diet. The book combines medical and scientific aspects to show mechanistic aspects between microbiota and hosts, clearly presenting the association between microbiota, colonic lesions and possible causal links. The book is essential reading for everyone working with human microbiota including basic scientists, physiologists of the intestine, experts in intestinal microbiota, gastroenterologists, oncologists and surgeon. Provides foundational background on the complete history of microbiology in the colon Offers thorough coverage of the connection between fusobacterium nucleatum, diet and bacteria on colon health Presents the connection between immunology and bacteria in the colon

Inflammation Infection and Microbiome in Cancers

Inflammation  Infection  and Microbiome in Cancers
Author: Jun Sun
Publsiher: Springer Nature
Total Pages: 509
Release: 2021-04-20
ISBN 10: 3030679519
ISBN 13: 9783030679514
Language: EN, FR, DE, ES & NL

Inflammation Infection and Microbiome in Cancers Book Review:

This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.

Microbiome and Cancer

Microbiome and Cancer
Author: Erle S. Robertson
Publsiher: Springer
Total Pages: 401
Release: 2019-02-20
ISBN 10: 3030041557
ISBN 13: 9783030041557
Language: EN, FR, DE, ES & NL

Microbiome and Cancer Book Review:

This book ventures into a new and exciting area of discovery that directly ties our current knowledge of cancer to the discovery of microorganisms associated with different types of cancers. Recent studies demonstrate that microorganisms are directly linked to the establishment of cancers and that they can also contribute to the initiation, as well as persistence of, the cancers. Microbiome and Cancer covers the current knowledge of microbiome and its association with human cancers. It provides important reading for novices, senior undergraduates in cancer and microbiology, graduate students, junior investigators, residents, fellows and established investigators in the fields of cancer and microbiology. We cover areas related to known, broad concepts in microbiology and how they can relate to the ongoing discoveries of the micro-environment and the changes in the metabolic and physiologic states in that micro-environment, which are important for the ongoing nurturing and survival of the poly-microbial content that dictates activities in that micro-environment. We cover the interactions of microorganisms associated with gastric carcinomas, which are important for driving this particular cancer. Additional areas include oral cancers, skin cancers, ovarian cancers, breast cancers, nasopharyngeal cancers, lung cancers, mesotheliomas, Hodgkin’s and non-Hodgkin’s lymphomas, glioblastoma multiforme, hepatocellular carcinomas, as well as the inflammatory response related to the infectious agents in cancers. This book covers the metabolic changes that occur because of infection and their support for development of cancers, chronic infection and development of therapeutic strategies for detection and control of the infection. The field of microbiome research has exploded over the last five years, and we are now understanding more and more about the context in which microorganisms can contribute to the onset of cancers in humans. The field of microbiome research has demonstrated that the human body has specific biomes for tissues and that changes in these biomes at the specific organ sites can result in disease. These changes can result in dramatic differences in metabolic shifts that, together with genetic mutations, will produce the perfect niche for establishment of the particular infection programmes in that organ site. We are just beginning to understand what those changes are and how they influence the disease state. Overall, we hope to bring together the varying degrees of fluctuations in the microbiome at the major organ sites and how these changes affect the normal cellular processes because of dysregulation, leading to proliferation of the associated tissues.

The Gut Microbiome in Health and Disease

The Gut Microbiome in Health and Disease
Author: Dirk Haller
Publsiher: Springer
Total Pages: 356
Release: 2018-07-27
ISBN 10: 3319905457
ISBN 13: 9783319905457
Language: EN, FR, DE, ES & NL

The Gut Microbiome in Health and Disease Book Review:

The book provides an overview on how the gut microbiome contributes to human health. The readers will get profound knowledge on the connection between intestinal microbiota and immune defense systems. The tools of choice to study the ecology of these highly-specialized microorganism communities such as high-throughput sequencing and metagenomic mining will be presented. In addition the most common diseases associated to the composition of the gut flora are discussed in detail. The book will address researchers, clinicians and advanced students working in biomedicine, microbiology and immunology.

Mechanisms Underlying Host Microbiome Interactions in Pathophysiology of Human Diseases

Mechanisms Underlying Host Microbiome Interactions in Pathophysiology of Human Diseases
Author: Jun Sun,Pradeep K. Dudeja
Publsiher: Springer
Total Pages: 381
Release: 2018-01-26
ISBN 10: 149397534X
ISBN 13: 9781493975341
Language: EN, FR, DE, ES & NL

Mechanisms Underlying Host Microbiome Interactions in Pathophysiology of Human Diseases Book Review:

Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes.

Colonic Microbiota Nutrition and Health

Colonic Microbiota  Nutrition and Health
Author: G.R. Gibson,M.B. Roberfroid
Publsiher: Springer Science & Business Media
Total Pages: 304
Release: 2013-03-14
ISBN 10: 9401710791
ISBN 13: 9789401710794
Language: EN, FR, DE, ES & NL

Colonic Microbiota Nutrition and Health Book Review:

1 2 MARCEL B. ROBERFROID AND GLENN R. GIBSON 1 Universite Catholique de Louvain, Department of Pharmaceutical Sciences, Avenue Mounier 73, B-1200 Brussels, BELGIUM 2 Food Microbial Sciences Unit, Department of Food Science and Technology, The University of Reading, Reading, UK It is clear that diet fulfils a number of important human requirements. These include the provision of sufficient nutrients to meet the requirements of essential metabolic pathways, as well as the sensory (and social) values associated with eating. It is also evident that diet may control and modulate various body functions in a manner that can reduce the risk of certain diseases. This very broad view of nutrition has led to the development of foodstuffs with added "functionality". Many different definitions of functional foods have arisen. Most of these complicate the simple issue that a functional food is merely a dietary ingredient(s) that can have positive properties above its normal nutritional value. Other terms used to describe such foods include vitafoods, nutraceuticals, pharmafoods, foods for specified health use, health foods, designer foods, etc. Despite some trepidation, the concept has recently attracted much interest through a vast number of articles in both the popular and scientific media.

Inflammation and Cancer

Inflammation and Cancer
Author: Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publsiher: Springer
Total Pages: 490
Release: 2014-05-12
ISBN 10: 3034808372
ISBN 13: 9783034808378
Language: EN, FR, DE, ES & NL

Inflammation and Cancer Book Review:

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Gut Microbiome Related Diseases and Therapies

Gut Microbiome Related Diseases and Therapies
Author: Maria Gazouli,George Theodoropoulos
Publsiher: Springer Nature
Total Pages: 326
Release: 2021-04-24
ISBN 10: 3030596427
ISBN 13: 9783030596422
Language: EN, FR, DE, ES & NL

Gut Microbiome Related Diseases and Therapies Book Review:

This book reviews recent knowledge of the role of gut microbiome in health and disease. It covers extensive topics for several diseases, including metabolic-related diseases, allergies, gastrointestinal diseases, psychiatric diseases, and cancer, while also discussing therapeutic approaches by microbiota modification. Comprehensive and cutting-edge, Gut Microbiome-Related Diseases and Therapies deepens a reader’s theoretical expertise in gut microbiome. Graduate and postdoctoral students, medical doctors, and biomedical researchers will benefit from this book.

Novel Approaches to Colorectal Cancer

Novel Approaches to Colorectal Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 484
Release: 2021-06-18
ISBN 10: 0128240792
ISBN 13: 9780128240793
Language: EN, FR, DE, ES & NL

Novel Approaches to Colorectal Cancer Book Review:

Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, is composed of 11 reviews covering state-of-the-art research relating to the etiology, diagnosis, prevention and treatment of colorectal cancer. The book's chapters were written by recognized experts in the field, and include sections on molecular biomarkers in diagnosis and therapy, the interplay of diet, lifestyle, and the microbiome, early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process. Each of these topics provides novel insights and concepts on various aspects of the nature of colorectal cancer, offering new opportunities for the management of a major source of cancer incidence and mortality. Provides information on the timely nature of the included topics, which represent the most current concepts and approaches in cancer research Offers outstanding and original reviews on colorectal cancer research Provides the authority and expertise of the authors, all of whom are highly recognized and conducting state-of-the-art investigations in cancer, with this release focusing on colorectal cancer

Probiotics and Bioactive Carbohydrates in Colon Cancer Management

Probiotics and Bioactive Carbohydrates in Colon Cancer Management
Author: Maya Raman,Padma Ambalam,Mukesh Doble
Publsiher: Springer
Total Pages: 124
Release: 2015-10-27
ISBN 10: 8132225864
ISBN 13: 9788132225867
Language: EN, FR, DE, ES & NL

Probiotics and Bioactive Carbohydrates in Colon Cancer Management Book Review:

This book describes the dietary habits (such as use of probiotics, synbiotics, prebiotics and dietary fiber) that could modify and reduce the risk of developing colorectal cancer (CRC). The book will be of practical and scientific use to academicians, research scholars, students, health professionals, nutritionists, etc. and could support the cause of preventing CRC by adopting smarter food habits. CRC is the third leading cause of death, in terms of both incidence and mortality, among men and women. Excess consumption of red and processed meat, roasted coffee, etc. have shown an increase in CRC, indicating that compounds formed in food containing free amino acids and sugars interact at elevated temperatures to form mutagens or carcinogens. Standard treatment options for CRC include invasive surgery and chemotherapy or radiation. Several lifestyle and dietary factors could prevent this ailment. Probiotics, prebiotics and synbiotics that are found in functional foods, health supplements and nutraceuticals and short chain fatty acids that are formed in the colon as a result of microbial fermentation of undigested bioactive carbohydrates by Bifidobacterium and Lactobacillus inhibit colonic epithelial cells and minimize inflammation, thereby exhibiting immunomodulatory effects. This book tries to address the novel unexplored benefits and mechanism of action of these functional foods.

Study of Gut Microbiome and Metabolomics Profiling in Colorectal Cancer Patients

Study of Gut Microbiome and Metabolomics Profiling in Colorectal Cancer Patients
Author: Lucky Poh Wah Goh
Publsiher: Unknown
Total Pages: 135
Release: 2019
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1256756373
Language: EN, FR, DE, ES & NL

Study of Gut Microbiome and Metabolomics Profiling in Colorectal Cancer Patients Book Review:

Netter s Gastroenterology

Netter s Gastroenterology
Author: Martin H. Floch
Publsiher: ICON
Total Pages: 900
Release: 2005
ISBN 10: 9781929007134
ISBN 13: 1929007132
Language: EN, FR, DE, ES & NL

Netter s Gastroenterology Book Review:

This comprehensive volume covers major gastrointestinal diseases and conditions, presenting key information on etiology, clinical presentation, differential diagnosis, management and therapy using a consistent, quick-reference format and 300 classic Netter illustrations. Other top medical illustrators have contributed new illustrations--working in the Netter style--and have updated others where appropriate.

The Human Microbiota and Chronic Disease

The Human Microbiota and Chronic Disease
Author: Luigi Nibali,Brian Henderson
Publsiher: John Wiley & Sons
Total Pages: 544
Release: 2016-09-26
ISBN 10: 1118982878
ISBN 13: 9781118982877
Language: EN, FR, DE, ES & NL

The Human Microbiota and Chronic Disease Book Review:

Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

Foundations of Colorectal Cancer

Foundations of Colorectal Cancer
Author: Alejandro Pazos Sierra
Publsiher: Academic Press
Total Pages: 670
Release: 2021-10-28
ISBN 10: 0323885713
ISBN 13: 9780323885713
Language: EN, FR, DE, ES & NL

Foundations of Colorectal Cancer Book Review:

Foundations of Colorectal Cancer provides a holistic and comprehensive dive into colorectal cancer, discussing the contributions of each discipline that studies it, allowing its understanding from the most demographic and ethical facts, to the treatment process, its varieties and genetic background. Written by experts in diverse areas such as cancer research, oncology, genetics, biochemistry, psychology, social sciences, bioinformatics and palliative care, the book brings real-world experiences to help readers with any challenge they may face when dealing with patients or during their research workflow. The content is split into nine sections: Clinical manifestations and disease detection, covering primary and secondary prevention, and the role of primary care; Diagnosis and staging, discussing endoscopy, colonoscopy, molecular pathology, and anatomopathological diagnosis; Treatment, including endoscopic, surgical, radiological, and postoperative approaches; Molecular and biological mechanisms, with the role of intestinal microbiota, stem cells and signaling pathways; New diagnostic methods, encompassing biomarkers and bioinformatics tools for research; Biobanks, with an overview of their regulations and importance in the research; Epidemiological studies, focusing on incidence and mortality globally and by regions; Hereditary colorectal cancer, differentiating nonpolyposis and polyposis types; and Addressing the consequences of colorectal cancer, covering psychological effects, nutrition and ethical issues. Provides a multidisciplinary approach with a holistic view of colorectal cancer, ranging from basic science to population studies, with its social and environmental influences and impacts, interpreting the disease as a medical, chemical, physical, microbial, psychological, and social condition Written by a diverse group of specialists with complementary expertise, including oncologists, radiologists, biochemists, surgeons, psychologists, social workers and clinicians, all members of the Galician Research Network of Colorectal Cancer (REGICC) with vast collaboration experience to bring comprehensive knowledge on the subject Encompasses reliable information suitable for different workers within the healthcare sector and research community dedicated to colorectal cancer, from clinicians and healthcare providers, researchers on several aspects of cancer, to bioinformaticians who deal with health data Includes many case studies throughout the chapters discussed by specialists with high scientific accuracy and didactic value, in order to clearly and precisely share their professional experience on the subject with readers

Advancing the Science of Cancer in Latinos

Advancing the Science of Cancer in Latinos
Author: Amelie G. Ramirez,Edward J. Trapido
Publsiher: Springer Nature
Total Pages: 329
Release: 2019-11-21
ISBN 10: 303029286X
ISBN 13: 9783030292867
Language: EN, FR, DE, ES & NL

Advancing the Science of Cancer in Latinos Book Review:

This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Latinos – the largest, youngest, and fastest-growing minority group in the United States – are expected to face a 142% rise in cancer cases in coming years. Although there has been substantial advancement in cancer prevention, screening, diagnosis, and treatment over the past few decades, addressing Latino cancer health disparities has not nearly kept pace with progress. The diverse and dynamic group of speakers and panelists brought together at the Advancing the Science of Cancer in Latinos conference provided in-depth insights as well as progress and actionable goals for Latino-focused basic science research, clinical best practices, community interventions, and what can be done by way of prevention, screening, diagnosis, and treatment of cancer in Latinos. These insights have been translated into the chapters included in this compendium; the chapters summarize the presentations and include current knowledge in the specific topic areas, identified gaps, and top priority areas for future cancer research in Latinos. Topics included among the chapters: Colorectal cancer disparities in Latinos: Genes vs. EnvironmentBreast cancer risk and mortality in women of Latin American originDifferential cancer risk in Latinos: The role of dietOvercoming barriers for Latinos on cancer clinical trialsEs tiempo: Engaging Latinas in cervical cancer researchEmerging policies in U.S. health care Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities. It will find an engaged audience among researchers, academics, physicians and other healthcare professionals, patient advocates, students, and others with an interest in the broad field of Latino cancer.

The Human Microbiome An Issue of Clinics in Laboratory Medicine

The Human Microbiome  An Issue of Clinics in Laboratory Medicine
Author: Matthew R. Pincus
Publsiher: Elsevier Health Sciences
Total Pages: 129
Release: 2014-11-12
ISBN 10: 0323326579
ISBN 13: 9780323326575
Language: EN, FR, DE, ES & NL

The Human Microbiome An Issue of Clinics in Laboratory Medicine Book Review:

The Human Biome is a complex and essential biological system within the human body. The adult human harbors some 100 trillion bacteria in his gut alone. Balance of this system is essential to good health. This issue of Clinics in Laboratory Medicine focuses on treatments to realign this balance as well as advances in understanding the system in general. Topics include: Changes in microbiome in GERD; The relationship of microbiome, inflammation, and colon cancer; Gut microbiome and host genetics in Crohn's disease; Association of oral microbiome with head and neck cancer; The vaginal microbiome-disease, genetics and the environment;, The human virome in children and its relationship to febrile illness; Gut microbiome in irritable bowel syndrome; The neonatal microbiome and necrotizing enterocolitis; Fecal microbiota transplantation for clostridium difficile Infection.

The Gut Microbiome and Its Relationship to Colorectal Cancer

The Gut Microbiome and Its Relationship to Colorectal Cancer
Author: Elizabeth Shultes
Publsiher: Unknown
Total Pages: 34
Release: 2018
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1126284592
Language: EN, FR, DE, ES & NL

The Gut Microbiome and Its Relationship to Colorectal Cancer Book Review:

Humans are "supraorganisms" composed of human and microbial components. The microbial community, living in and on humans, along with their genome, is called the microbiome. The microbiome is essential to human health because it can play a role in the development of many diseases, including cancer. The gut microbiome contains the highest density of bacteria in the body. Changes in the composition of the gut microbiome are related to colorectal cancer, specifically through the production of metabolites that affect transcription of cancer suppressor genes. `Manipulation of the microbiome through diet and probiotics may lead to new cancer therapies.

Microbiome Immunity Digestive Health and Nutrition

Microbiome  Immunity  Digestive Health and Nutrition
Author: Debasis Bagchi,Bernard W. Downs
Publsiher: Academic Press
Total Pages: 537
Release: 2022-07-29
ISBN 10: 0128222395
ISBN 13: 9780128222393
Language: EN, FR, DE, ES & NL

Microbiome Immunity Digestive Health and Nutrition Book Review:

Microbiome, Immunity, Digestive Health and Nutrition: Epidemiology, Pathophysiology, Prevention and Treatment addresses a wide range of topics related to the role of nutrition in achieving and maintaining a healthy gut microbiome. Written by leading experts in the field, the book outlines the various foods, minerals, vitamins, dietary fibers, prebiotics, probiotics, nutritional supplements, phytochemicals and drugs that improve gut health. It specifically addresses molecular and cellular mechanisms and pathways by which these nutritional components contribute to the physiology and functionality of a healthy gut microbiome and gut health. Intended for nutrition researchers and practitioners, food experts, gastroenterologists, nurses, general practitioners, public health officials and health professionals, this book is sure to be a welcomed resource. Outlines the nutritional guidelines and healthy lifestyle that is important to boost gut health Demonstrates the effects of diverse environmental stressors in the disruption of the gastrointestinal ecology Discusses the molecular and immunological mechanisms associated with healthy gut microbiome functions Addresses how to boost healthy gut microflora and microbiome Suggests areas for future research of microbiome-based nutrition and therapies

Tertiary Lymphoid Structures

Tertiary Lymphoid Structures
Author: Marie-Caroline Dieu-Nosjean
Publsiher: Humana
Total Pages: 289
Release: 2019-09-07
ISBN 10: 9781493993727
ISBN 13: 1493993720
Language: EN, FR, DE, ES & NL

Tertiary Lymphoid Structures Book Review:

This volume explores the various methods used to study tertiary lymphoid structures (TLS) in pathological situations. Pre-clinical models are also discussed in detail to show how TLS structure, development, and maintenance can be targeted and studied in vivo. The chapters in this book cover topics such as humans and mice; strategies to quantify TLS in order to use it in stained tissue sections; classifying a gene signature form fixed and paraffin-embedded tissues; and development of murine inflammatory models to help look at TLS in the context of infection or malignancy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Tertiary Lymphoid Structures: Methods and Protocols is a valuable resource that increases the reader’s knowledge on immune functions and how they will pave the way to future therapeutic applications.

Colon Cancer Prevention

Colon Cancer Prevention
Author: American Institute for Cancer Research
Publsiher: Springer Science & Business Media
Total Pages: 184
Release: 2000-02-29
ISBN 10: 9780306462078
ISBN 13: 0306462079
Language: EN, FR, DE, ES & NL

Colon Cancer Prevention Book Review:

The Eighth Annual Research Conference of the American Institute for Cancer Research, held in Washington, D.C., September 3-4, 1998, was on the subject "Colon Cancer Prevention: Dietary Modulation of Cellular and Molecular Mechanisms," with participants representing various disciplines interested in this area. One of the speak ers provided an appropriate quote from 17th century physician Thomas Adams: "Pre vention is better than healing because it saves the labor of being sick," which aptly describes the need for the prevention of cancer. An overview of normal and abnormal colonic development emphasized that although the typical human colon undergoes 1013 cell divisions by age 60, with the asso ciated possibilities for error, relatively few colon tumors develop. Since dietary modu lation leads to extremely small changes in colonic cells over a long period, animal models are useful to time, observe, and delineate the events associated with colon cancer. In the development colon cancer, the inactivation of the adenomatous polyposis coli (Apc) gene is one of the earliest known events. Normally Apc downregulates the cellular protein beta-catenin, but this is lost during cancer development. Beta-catenin may itself be an oncogene; it has a short half-life, but it is stabilized by binding to is more prevalent in the cell nucleus, the gene shuttles caherin. Although the Apc between the nucleus and the cytoplasm.