Closed Loop Neuroscience

Closed Loop Neuroscience
Author: Ahmed El Hady
Publsiher: Academic Press
Total Pages: 304
Release: 2016-09-08
ISBN 10: 0128026413
ISBN 13: 9780128026410
Language: EN, FR, DE, ES & NL

Closed Loop Neuroscience Book Review:

Closed Loop Neuroscience addresses the technical aspects of closed loop neurophysiology, presenting the implementation of these approaches spanning several domains of neuroscience, from cellular and network neurophysiology, through sensory and motor systems, and then clinical therapeutic devices. Although closed-loop approaches have long been a part of the neuroscientific toolbox, these techniques are only now gaining popularity in research and clinical applications. As there is not yet a comprehensive methods book addressing the topic as a whole, this volume fills that gap, presenting state-of-the-art approaches and the technical advancements that enable their application to different scientific problems in neuroscience. Presents the first volume to offer researchers a comprehensive overview of the technical realities of employing closed loop techniques in their work Offers application to in-vitro, in-vivo, and hybrid systems Contains an emphasis on the actual techniques used rather than on specific results obtained Includes exhaustive protocols and descriptions of software and hardware, making it easy for readers to implement the proposed methodologies Encompasses the clinical/neuroprosthetic aspect and how these systems can also be used to contribute to our understanding of basic neurophysiology Edited work with chapters authored by leaders in the field from around the globe – the broadest, most expert coverage available

Closed Loop Systems for Next Generation Neuroprostheses

Closed Loop Systems for Next Generation Neuroprostheses
Author: Timothée Levi,Paolo Bonifazi, Paolo Massobrio,Michela Chiappalone
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2018-04-26
ISBN 10: 2889454665
ISBN 13: 9782889454662
Language: EN, FR, DE, ES & NL

Closed Loop Systems for Next Generation Neuroprostheses Book Review:

Millions of people worldwide are affected by neurological disorders which disrupt the connections within the brain and between brain and body causing impairments of primary functions and paralysis. Such a number is likely to increase in the next years and current assistive technology is yet limited. A possible response to such disabilities, offered by the neuroscience community, is given by Brain-Machine Interfaces (BMIs) and neuroprostheses. The latter field of research is highly multidisciplinary, since it involves very different and disperse scientific communities, making it fundamental to create connections and to join research efforts. Indeed, the design and development of neuroprosthetic devices span/involve different research topics such as: interfacing of neural systems at different levels of architectural complexity (from in vitro neuronal ensembles to human brain), bio-artificial interfaces for stimulation (e.g. micro-stimulation, DBS: Deep Brain Stimulation) and recording (e.g. EMG: Electromyography, EEG: Electroencephalography, LFP: Local Field Potential), innovative signal processing tools for coding and decoding of neural activity, biomimetic artificial Spiking Neural Networks (SNN) and neural network modeling. In order to develop functional communication with the nervous system and to create a new generation of neuroprostheses, the study of closed-loop systems is mandatory. It has been widely recognized that closed-loop neuroprosthetic systems achieve more favorable outcomes for users then equivalent open-loop devices. Improvements in task performance, usability, and embodiment have all been reported in systems utilizing some form of feedback. The bi-directional communication between living neurons and artificial devices is the main final goal of those studies. However, closed-loop systems are still uncommon in the literature, mostly due to requirement of multidisciplinary effort. Therefore, through eBook on closed-loop systems for next-generation neuroprostheses, we encourage an active discussion among neurobiologists, electrophysiologists, bioengineers, computational neuroscientists and neuromorphic engineers. This eBook aims to facilitate this process by ordering the 25 contributions of this research in which we highlighted in three different parts: (A) Optimization of different blocks composing the closed-loop system, (B) Systems for neuromodulation based on DBS, EMG and SNN and (C) Closed-loop BMIs for rehabilitation.

Closing the Loop Around Neural Systems

Closing the Loop Around Neural Systems
Author: Steve M Potter,Eberhard E Fetz,Ahmed El Hady
Publsiher: Frontiers Media SA
Total Pages: 423
Release: 2014-12-03
ISBN 10: 288919356X
ISBN 13: 9782889193561
Language: EN, FR, DE, ES & NL

Closing the Loop Around Neural Systems Book Review:

Closed-loop neurophysiology has been accelerated by recent software and hardware developments and by the emergence of novel tools to control neuronal activity with spatial and temporal precision, in which stimuli are delivered in real time based on recordings or behavior. Real-time stimulation feedback enables a wide range of innovative studies of information processing and plasticity in neuronal networks. This Research Topic e-Book comprises 16 Original Research Articles, seven Methods Articles, and seven Reviews, Mini- Reviews, and Perspectives, all peer-reviewed and published in Frontiers in Neural Circuits. The contributions deal with closed loop neurophysiology experiments at a variety of levels of neural circuit complexity. Some include modeling and theoretical analyses. New enabling technologies and techniques are described. Novel work is presented from experiments in vitro, in vivo, and in humans, along with their clinical and technological implications for improving the human condition.

Closed loop Neuroscience A Vision

Closed loop Neuroscience   A Vision
Author: Florian Walter,Alois Knoll
Publsiher: Unknown
Total Pages: 135
Release: 2020
ISBN 10: 1928374650XXX
ISBN 13: OCLC:1303394788
Language: EN, FR, DE, ES & NL

Closed loop Neuroscience A Vision Book Review:

Closed Loop Neurophysiology Clinical Research

Closed Loop Neurophysiology  Clinical Research
Author: George Morris
Publsiher: States Academic Press
Total Pages: 247
Release: 2021-11-16
ISBN 10: 9781639891146
ISBN 13: 1639891145
Language: EN, FR, DE, ES & NL

Closed Loop Neurophysiology Clinical Research Book Review:

Neurophysiology is the branch of physiology and neuroscience which is concerned with the study of nerve cells as they transmit and receive information. It focuses on the study of the brain and spinal cord, and their connection to the mental health. Some of the methods used for research in the field of neurophysiology are electrophysiological recordings such as voltage clamp, patch clamp, extracellular single-unit recording and recording of local field potentials. Closed-loop neuroscience is referred to as a field of study that considers the brain as a loop that interacts with itself, among themselves and with the environment in a relative manner. Closed loop neurophysiology is an upcoming field of science that has undergone rapid development over the past few decades. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in this field. It is appropriate for students seeking detailed information in this area as well as for experts.

Deep Brain Stimulation

Deep Brain Stimulation
Author: William S. Anderson,The Society for Innovative Neuroscience in Neurosurgery
Publsiher: Thieme
Total Pages: 190
Release: 2019-05-10
ISBN 10: 1626237980
ISBN 13: 9781626237988
Language: EN, FR, DE, ES & NL

Deep Brain Stimulation Book Review:

The one-stop resource on deep brain stimulation for functional neurosurgeons! Deep brain stimulation (DBS) is used to modulate dysfunctional circuits in the brain with stimulation pulses applied to specific target areas of the brain. Globally, DBS procedures have been most commonly performed for Parkinson's disease and essential tremor, but there are now new and growing research efforts studying DBS for psychiatric disorders and epilepsy. Deep Brain Stimulation: Techniques and Practices written by the Society for Innovative Neuroscience in Neurosurgery along with Dr. William S. Anderson and distinguished experts presents the latest DBS approaches. The book begins with a history of DBS, general frame-based techniques, patient selection primarily for movement disorders, multidisciplinary collaboration, and ethical considerations. Subsequent chapters detail diverse technologies and disease-specific treatment for Parkinson's disease, essential tremor, dystonia, OCD, epilepsy, major depression, Tourette syndrome, emerging psychiatric indications, and pediatric applications. Key highlights Lead placement techniques utilizing currently available customized platforms and robotics Microelectrode recording and image-based direct targeting with MRI and CT to enhance lead placement Lesioning methods including radiofrequency, and MR-guided focused ultrasound Discussion of recent innovations in tractography to delineate white matter tracts in the brain and closed loop stimulation DBS has helped thousands of patients with intractable conditions, allowing for a programmable therapy with durable treatment effect. This remarkable guide provides the essentials for functional neurosurgeons to pursue intraoperative research opportunities in this growing subspecialty and incorporate DBS into clinical practice.

New Techniques in Systems Neuroscience

New Techniques in Systems Neuroscience
Author: Adam D. Douglass
Publsiher: Springer
Total Pages: 301
Release: 2015-04-13
ISBN 10: 3319129139
ISBN 13: 9783319129136
Language: EN, FR, DE, ES & NL

New Techniques in Systems Neuroscience Book Review:

This volume is essential reading for anyone wishing to understand the recent explosion of experimental tools in neuroscience that now make it possible to manipulate, record, and understand neuronal activity within the intact brain, and which are helping us learn how the many neurons that comprise a network act together to control behavior. Leaders in the field discuss the latest developments in optogenetics, functional imaging, circuit mapping, and the application of these tools to complex biological problems.

Clinical Systems Neuroscience

Clinical Systems Neuroscience
Author: Kenji Kansaku,Leonardo G. Cohen,Niels Birbaumer
Publsiher: Springer
Total Pages: 387
Release: 2015-01-28
ISBN 10: 4431550372
ISBN 13: 9784431550372
Language: EN, FR, DE, ES & NL

Clinical Systems Neuroscience Book Review:

The impaired brain has often been difficult to rehabilitate owing to limited knowledge of the brain system. Recently, advanced imaging techniques such as fMRI and MEG have allowed researchers to investigate spatiotemporal dynamics in the living human brain. Consequently, knowledge in systems neuroscience is now rapidly growing. Advanced techniques have found practical application by providing new prosthetics, such as brain–machine interfaces, expanding the range of activities of persons with disabilities, or the elderly. The book’s chapters are authored by researchers from various research fields such as systems neuroscience, rehabilitation, neurology, psychology and engineering. The book explores the latest advancements in neurorehabilitation, plasticity and brain–machine interfaces among others and constitutes a solid foundation for researchers who aim to contribute to the science of brain function disabilities and ultimately to the well-being of patients and the elderly worldwide.

Psychiatric Neuroethics

Psychiatric Neuroethics
Author: Walter Glannon
Publsiher: Oxford University Press, USA
Total Pages: 408
Release: 2019-01-10
ISBN 10: 0198758855
ISBN 13: 9780198758853
Language: EN, FR, DE, ES & NL

Psychiatric Neuroethics Book Review:

Advances in psychiatric research and clinical psychiatry in the last 30 years have given rise to a host of new questions that lie at the intersection of psychiatry, neuroscience, philosophy and law. Such questions include: -Are psychiatric disorders diseases of the brain, caused by dysfunctional neural circuits and neurotransmitters? -What role do genes, neuro-endocrine, neuro-immune interactions and the environment play in the development of these disorders? -How do different explanations of the etiology and pathophysiology of mental illness influence diagnosis, prognosis and decisions about treatment? -Would it be rational for a person with a chronic treatment-resistant disorder to request euthanasia or assisted suicide to end their suffering? -Could psychiatric disorders be predicted and prevented? Psychiatric Neuroethics explores these questions in a comprehensive and systematic way, discussing the medical and philosophical implications of neuroscience and the Research Domain Criteria (RDoc) in the fields of psychiatry and mental health. It examines the extent to which circuit-based criteria can offer a satisfactory explanation of psychiatric disorders and how they compare with the symptom-based criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSMV). This book will be of interest to a multidisciplinary audience, including psychiatrists, neurologists, neurosurgeons, philosophers, psychologists and legal theorists.

The Neurology of Eye Movements Text and CD ROM

The Neurology of Eye Movements   Text and CD ROM
Author: Departments of Neurology R. John Leigh Professor, Neuroscience Otolaryngology and Biomedical Engineering Case Western Reserve University University Hospitals and Veterans Affairs Medical Center Cleveland Ohio,Departments of Neurology David S. Zee Professor, Ophthalmology Otolaryngology Head and Neck Surgery and Neuroscience
Publsiher: Oxford University Press, USA
Total Pages: 656
Release: 1999-08-26
ISBN 10: 0198029705
ISBN 13: 9780198029700
Language: EN, FR, DE, ES & NL

The Neurology of Eye Movements Text and CD ROM Book Review:

The Neurology of Eye Movements provides clinicians with a synthesis of current scientific information that can be applied to the diagnosis and treatment of disorders of ocular motility. Basic scientists will also benefit from descriptions of how data from anatomical, electrophysiological, pharmacological, and imaging studies can be directly applied to the study of disease. By critically reviewing such basic studies, the authors build a conceptual framework that can be applied to the interpretation of abnormal ocular motor behavior at the bedside. These syntheses are summarized in displays, new figures, schematics and tables. Early chapters discuss the visual need and neural basis for each functional class of eye movements. Two large chapters deal with the evaluation of double vision and systematically evaluate how many disorders of the central nervous system affect eye movements. This edition has been extensively rewritten, and contains many new figures and an up-to-date section on the treatment of abnormal eye movements such as nystagmus. A major innovation has been the development of an option to read the book from a compact disc, make use of hypertext links (which bridge basic science to clinical issues), and view the major disorders of eye movements in over 60 video clips. This volume will provide pertinent, up-to-date information to neurologists, neuroscientists, ophthalmologists, visual scientists, otalaryngologists, optometrists, biomedical engineers, and psychologists.

Advances in Network Electrophysiology

Advances in Network Electrophysiology
Author: Makoto Taketani,Michel Baudry
Publsiher: Springer Science & Business Media
Total Pages: 478
Release: 2006-11-22
ISBN 10: 0387258582
ISBN 13: 9780387258584
Language: EN, FR, DE, ES & NL

Advances in Network Electrophysiology Book Review:

Advances in Network Electrophysiology: Using Multi Electrode Arrays explores methods for using electrophysiological techniques for monitoring the concurrent activity of ensembles of single neurons. It reviews the recent progress in both electronics and computational tools developed to analyze the functional operations of large ensembles of neurons using multi-electrode arrays and in vitro preparations. In addition, it gives readers a sense of the applications made possible by these technological tools. This volume is the reference for researchers, industry, graduate students, and postdoctoral fellows in all areas of neuroscience, cognitive neuroscience, pharmaceutical science, and bioengineering.

Non Invasive Brain Stimulation

Non Invasive Brain Stimulation
Author: Carlo Miniussi,Giuseppe Vallar
Publsiher: Psychology Press
Total Pages: 224
Release: 2011-12
ISBN 10: 1848727569
ISBN 13: 9781848727564
Language: EN, FR, DE, ES & NL

Non Invasive Brain Stimulation Book Review:

Cognitive deficits are a common consequence of neurological disease, and there is evidence that specific cognitive training may be effective in rehabilitation. Behavioural dysfunction following neurological disease constitutes one of the major causes of disability worldwide, exerts a major impact on the daily life of affected individuals, and their families, also with a financial burden both for patients, and the society in general. Therefore, the adequate treatment of cognitive dysfunction is a much relevant issue, with social and economical implications, over and above the neuropsychological problem per se. Several investigations emphasise the fact that interacting with neural activity, by means of cortical stimulation, can affect cognitive performance. A number of studies have reported enhanced performance in specific cognitive tasks in patients with several types of neurological disease, after receiving Non Invasive Brain Stimulation (NIBS) to specific cortical areas, namely: Transcranial Magnetic Stimulation, and transcranial Electrical Stimulation. In general, the evidence highlights the possibility of inducing changes in cortical excitability, which, in turn, may lead to a plastic reorganization of dysfunctional networks, responsible for the impaired cognitive functions. Despite these advances, a number of important questions remain open, regarding the use of stimulation techniques in cognitive rehabilitation. This special issue puts together international leading experts in the field, to review and discuss recent advances as to whether NIBS techniques alone, or combined with behavioural cognitive rehabilitation, can lead to performance enhancements, and why. The issue is timely and promises to have a huge impact across many domains of clinical and basic neuroscience.

In Vitro Neuronal Networks

In Vitro Neuronal Networks
Author: Michela Chiappalone,Valentina Pasquale,Monica Frega
Publsiher: Springer
Total Pages: 387
Release: 2019-05-09
ISBN 10: 3030111350
ISBN 13: 9783030111359
Language: EN, FR, DE, ES & NL

In Vitro Neuronal Networks Book Review:

This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.

Methods of Behavior Analysis in Neuroscience

Methods of Behavior Analysis in Neuroscience
Author: Jerry J. Buccafusco
Publsiher: CRC Press
Total Pages: 352
Release: 2000-08-29
ISBN 10: 1420041819
ISBN 13: 9781420041811
Language: EN, FR, DE, ES & NL

Methods of Behavior Analysis in Neuroscience Book Review:

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Neuronal Dynamics

Neuronal Dynamics
Author: Wulfram Gerstner,Werner M. Kistler,Richard Naud,Liam Paninski
Publsiher: Cambridge University Press
Total Pages: 590
Release: 2014-07-24
ISBN 10: 1107060834
ISBN 13: 9781107060838
Language: EN, FR, DE, ES & NL

Neuronal Dynamics Book Review:

This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.

Neural Control Engineering

Neural Control Engineering
Author: Steven J. Schiff
Publsiher: MIT Press
Total Pages: 384
Release: 2011-11-10
ISBN 10: 0262015374
ISBN 13: 9780262015370
Language: EN, FR, DE, ES & NL

Neural Control Engineering Book Review:

How powerful new methods in nonlinear control engineering can be applied to neuroscience, from fundamental model formulation to advanced medical applications. Over the past sixty years, powerful methods of model-based control engineering have been responsible for such dramatic advances in engineering systems as autolanding aircraft, autonomous vehicles, and even weather forecasting. Over those same decades, our models of the nervous system have evolved from single-cell membranes to neuronal networks to large-scale models of the human brain. Yet until recently control theory was completely inapplicable to the types of nonlinear models being developed in neuroscience. The revolution in nonlinear control engineering in the late 1990s has made the intersection of control theory and neuroscience possible. In Neural Control Engineering, Steven Schiff seeks to bridge the two fields, examining the application of new methods in nonlinear control engineering to neuroscience. After presenting extensive material on formulating computational neuroscience models in a control environment—including some fundamentals of the algorithms helpful in crossing the divide from intuition to effective application—Schiff examines a range of applications, including brain-machine interfaces and neural stimulation. He reports on research that he and his colleagues have undertaken showing that nonlinear control theory methods can be applied to models of single cells, small neuronal networks, and large-scale networks in disease states of Parkinson's disease and epilepsy. With Neural Control Engineering the reader acquires a working knowledge of the fundamentals of control theory and computational neuroscience sufficient not only to understand the literature in this trandisciplinary area but also to begin working to advance the field. The book will serve as an essential guide for scientists in either biology or engineering and for physicians who wish to gain expertise in these areas.

Computational Models of Brain and Behavior

Computational Models of Brain and Behavior
Author: Ahmed A. Moustafa
Publsiher: John Wiley & Sons
Total Pages: 584
Release: 2017-11-13
ISBN 10: 1119159067
ISBN 13: 9781119159063
Language: EN, FR, DE, ES & NL

Computational Models of Brain and Behavior Book Review:

A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.

Neuroprosthetics

Neuroprosthetics
Author: Justin C. Sanchez
Publsiher: CRC Press
Total Pages: 236
Release: 2018-09-03
ISBN 10: 1466553243
ISBN 13: 9781466553248
Language: EN, FR, DE, ES & NL

Neuroprosthetics Book Review:

Master the tools of design thinking using Neuroprosthetics: Principles and Applications. Developed from successfully tested material used in an undergraduate and graduate level course taught to biomedical engineering and neuroscience students, this book focuses on the use of direct neural sensing and stimulation as a therapeutic intervention for complex disorders of the brain. It covers the theory and applications behind neuroprosthetics and explores how neuroprosthetic design thinking can enhance value for users of a direct neural interface. The book explains the fundamentals of design thinking, introduces essential concepts from neuroscience and engineering illustrating the major components of neuroprosthetics, and presents practical applications. In addition to describing the approach of design thinking (based on facts about the user’s needs, desires, habits, attitudes, and experiences with neuroprosthetics), it also examines how effectively "human centered" neuroprosthetics can address people’s needs and interactions in their daily lives. Identifying concepts and features of devices that work well with users of a direct neural interface, this book: Outlines the signal sensing capabilities and trade-offs for common electrode designs, and determines the most appropriate electrode for any neuroprosthetic application Specifies neurosurgical techniques and how electronics should be tailored to capture neural signals Provides an understanding of the mechanisms of neural–electrode performance and information contained in neural signals Provides understanding of neural decoding in neuroprosthetic applications Describes the strategies that can be used to promote long-term therapeutic interventions for humans through the use of neuroprosthetics The first true primary text for undergraduate and graduate students in departments of neuroscience and bioengineering that covers the theory and applications behind this science, Neuroprosthetics: Principles and Applications provides the fundamental knowledge needed to understand how electrodes translate neural activity into signals that are useable by machines and enables readers to master the tools of design thinking and apply them to any neuroprosthetic application.

Challenges of Interdisciplinary Research in the Field of Critical Sex Gender Neuroscience

Challenges of Interdisciplinary Research in the Field of Critical  Sex  Gender  Neuroscience
Author: Hannah Fitsch,Flora Lysen,Suparna Choudhury
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-02-17
ISBN 10: 2889742865
ISBN 13: 9782889742868
Language: EN, FR, DE, ES & NL

Challenges of Interdisciplinary Research in the Field of Critical Sex Gender Neuroscience Book Review:

The Zebrafish in Biomedical Research

The Zebrafish in Biomedical Research
Author: Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders
Publsiher: Academic Press
Total Pages: 718
Release: 2019-11-22
ISBN 10: 0128124326
ISBN 13: 9780128124321
Language: EN, FR, DE, ES & NL

The Zebrafish in Biomedical Research Book Review:

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series