Chelation Therapy in the Treatment of Metal Intoxication

Chelation Therapy in the Treatment of Metal Intoxication
Author: Jan Aaseth,Guido Crisponi,Ole Anderson
Publsiher: Academic Press
Total Pages: 388
Release: 2016-04-18
ISBN 10: 0128030739
ISBN 13: 9780128030738
Language: EN, FR, DE, ES & NL

Chelation Therapy in the Treatment of Metal Intoxication Book Review:

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Evidence Based Clinical Chelation

Evidence Based Clinical Chelation
Author: Dr. Eleonore Blaurock-Busch, PhD,Dr. Swaran J.S. Flora, PhD,Dr. Ebrahim Sulaiman, MD
Publsiher: BoD – Books on Demand
Total Pages: 120
Release: 2020-06-02
ISBN 10: 3750428670
ISBN 13: 9783750428676
Language: EN, FR, DE, ES & NL

Evidence Based Clinical Chelation Book Review:

This is an easy-to-read manual about chelation therapy. It contains specific protocols for the treatment of chronic metal overexposure, all of which are evidence-based, aiding the inexperienced and the experienced therapist in selecting the optimal chelating agent for the metal(s) in question. Expert chemists and chelation therapists have contributed invaluable knowledge and experience to this book. Most importantly, this is not a book promoting personal views or preferences. In fact, the information presents and explains different approaches, and allows the reader to draw his own conclusion. All the protocols listed have been modified for the treatment of chronic metal intoxication, included are oral and intravenous treatment plans. The authors explain in simple terms how a chelating agent ́s bioavailability affects metal binding and how various protocols such as the Cutler Protocol affect the detoxification process, why DMPS binds mercury and which chelators are useful for the detoxification of certain organ system. Also discussed is the importance and effect of treatment pauses. Diagnostic tests are discussed, and which are useful under certain conditions. Shown are tables comparing the average metal binding ability of the various EDTAs, DMPS, DMSA and other chelating agents. Detailed information explains which chelator binds which metal and why, all of which aids the therapist in finding optimal treatment schedules. Novel chelating agents are presented such as MIADMSA, a new oral chelator specifically designed for arsenic intoxication, or how natural Pectin may be used an alternative for gadolinium intoxication, which metals are bound by lipoic acid and why a slightly alkaline environment supports metal binding, even preventing the often-feared metal redistribution. All in all, this evidence-based chelation "cookbook" should be in medical libraries and on the bookshelf of every physician treating environmental disease.

Iron Chelation Therapy

Iron Chelation Therapy
Author: Chaim Hershko
Publsiher: Springer Science & Business Media
Total Pages: 277
Release: 2012-12-06
ISBN 10: 1461505933
ISBN 13: 9781461505938
Language: EN, FR, DE, ES & NL

Iron Chelation Therapy Book Review:

Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Handbook of Arsenic Toxicology

Handbook of Arsenic Toxicology
Author: Swaran Jeet Singh Flora
Publsiher: Academic Press
Total Pages: 752
Release: 2014-12-26
ISBN 10: 0124199550
ISBN 13: 9780124199552
Language: EN, FR, DE, ES & NL

Handbook of Arsenic Toxicology Book Review:

Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. Brings together current findings on the effects of arsenic on the environment and human health Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms Provides all the information needed for effective risk assessment, prevention and countermeasure

Introduction to Basics of Pharmacology and Toxicology

Introduction to Basics of Pharmacology and Toxicology
Author: Gerard Marshall Raj,Ramasamy Raveendran
Publsiher: Springer Nature
Total Pages: 417
Release: 2019-11-16
ISBN 10: 9813297794
ISBN 13: 9789813297791
Language: EN, FR, DE, ES & NL

Introduction to Basics of Pharmacology and Toxicology Book Review:

This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.

Hepatotoxicity

Hepatotoxicity
Author: Hyman J. Zimmerman
Publsiher: Unknown
Total Pages: 597
Release: 1978
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015046945336
Language: EN, FR, DE, ES & NL

Hepatotoxicity Book Review:

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Toxicological Profile for Arsenic Update

Toxicological Profile for Arsenic  Update
Author: Selene Chou
Publsiher: DIANE Publishing
Total Pages: 447
Release: 2010-08
ISBN 10: 1437930689
ISBN 13: 9781437930689
Language: EN, FR, DE, ES & NL

Toxicological Profile for Arsenic Update Book Review:

Characterizes the toxicologic and adverse health effects for arsenic, which has been found in many sites targeted for long-term fed. cleanup activities. Contents: (1) The examination, summary, and interpretation of available toxicologic info. and epidemiologic evaluations on arsenic to ascertain the levels of significant human exposure for the substance and the associated chronic health effects; (2) A determination of whether adequate info. on the health effects of arsenic is available to determine levels of exposure that present a significant risk to human health of chronic health effects; and (3) Identification of toxicologic testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans. Illus.

Cancer Causing Substances

Cancer Causing Substances
Author: Faik Atroshi
Publsiher: BoD – Books on Demand
Total Pages: 80
Release: 2018-05-16
ISBN 10: 178923140X
ISBN 13: 9781789231403
Language: EN, FR, DE, ES & NL

Cancer Causing Substances Book Review:

Cancer risk factors include exposure to certain substances, which may contribute to the development of cancer. However, substances can have different levels of cancer-causing potential, and the risk of developing cancer is dependent on several factors, including individual genetic background and the amount and duration of the exposure. This book focuses on various cancer risk factors, covering numerous known, probable, and possible carcinogens; their role in carcinogenesis; mechanisms of carcinogenicity; and methods for detecting carcinogens. And due to the growing concerns over the effects that substances and environmental exposures can have on human health, the chapters also emphasize on the vital need for further topic-related research as well as development and implementation of beneficial approaches.

Lead Toxicity

Lead Toxicity
Author: Sarah E. Royce
Publsiher: Unknown
Total Pages: 55
Release: 2000
ISBN 10: 1928374650XXX
ISBN 13: UOM:39015051606617
Language: EN, FR, DE, ES & NL

Lead Toxicity Book Review:

The Therapeutic Use of N Acetylcysteine NAC in Medicine

The Therapeutic Use of N Acetylcysteine  NAC  in Medicine
Author: Richard Eugene Frye,Michael Berk
Publsiher: Springer
Total Pages: 394
Release: 2018-09-20
ISBN 10: 9811053111
ISBN 13: 9789811053115
Language: EN, FR, DE, ES & NL

The Therapeutic Use of N Acetylcysteine NAC in Medicine Book Review:

Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.

Metallothionein IV

Metallothionein IV
Author: C. Klaasen
Publsiher: Birkhäuser
Total Pages: 650
Release: 2012-11-05
ISBN 10: 9783034897990
ISBN 13: 3034897995
Language: EN, FR, DE, ES & NL

Metallothionein IV Book Review:

The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.

Biomedical Applications of Metals

Biomedical Applications of Metals
Author: Mahendra Rai,Avinash P. Ingle,Serenella Medici
Publsiher: Springer
Total Pages: 325
Release: 2018-02-24
ISBN 10: 3319748149
ISBN 13: 9783319748146
Language: EN, FR, DE, ES & NL

Biomedical Applications of Metals Book Review:

Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., “Ayurveda”. In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma’s and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers.

Heavy Metals and Health

Heavy Metals and Health
Author: Lance Castillo
Publsiher: Unknown
Total Pages: 202
Release: 2016-11-13
ISBN 10: 9781634856102
ISBN 13: 1634856104
Language: EN, FR, DE, ES & NL

Heavy Metals and Health Book Review:

Heavy metals are persistent in the environment and their elevated emission during longer periods of time can cause contamination of the environment. They are emitted in all environmental media, but can also be easily transported between them due to the atmospheric deposition, water runoff, etc., and thus accumulate in the environment or penetrate the food chains. The main routes of human exposure to heavy metals are through ingestion, inhalation or via dermal contact. Hence, there is a need for better understanding of absorption, distribution and deposition of heavy metals in the human body. This information is of a crucial importance for the evaluation of heavy metal potential health implications. In this book, Chapter One provides an overview of the heavy metal health hazards, presented as a consequence of heavy metal pollution, their availability and cycling between different media in the environment. Chapter Two comprehensively discusses the roles and harmful effects of heavy metals on human health, as well as the sources and techniques of removing heavy metals from the environment. Chapter Three explores the mechanisms of mercury cardiovascular toxicity, with a particular emphasis on its effects toward endothelial cells. Chapter Four focuses on the effects of exposure to soil contaminated by metals. Chapter Five examines antimicrobial functionalized textiles. Chapter Six discusses thallium poisoning. Chapter Seven provides a review of heavy metal pollution, human exposure and public health implications in Nigeria.

Applications of Biodegradable and Bio Based Polymers for Human Health and a Cleaner Environment

Applications of Biodegradable and Bio Based Polymers for Human Health and a Cleaner Environment
Author: Iuliana Stoica,Omari Mukbaniani,Neha Kanwar Rawat,A. K. Haghi
Publsiher: CRC Press
Total Pages: 576
Release: 2021-12-23
ISBN 10: 1000345637
ISBN 13: 9781000345636
Language: EN, FR, DE, ES & NL

Applications of Biodegradable and Bio Based Polymers for Human Health and a Cleaner Environment Book Review:

The world faces significant challenges as the population and consumption continue to grow while nonrenewable fossil fuels and other raw materials are depleted at ever-increasing rates. This informative volume provides a technical approach to address these issues using green design and analysis. It takes an interdisciplinary look at concepts that can be applied across engineering disciplines in the development of products, processes, and systems to minimize environmental impacts across all life cycle phases. Topics include polymers for pollutant removal, wood-based biopolymers, bio-based polymers for drug formulations, biomaterial-based medical implants, biodegradabilty of biopolymer materials, bio-based polymers for food packaging applications, biodegradable polymers for tissue engineering applications, and more.

Integrative Medicine E Book

Integrative Medicine   E Book
Author: David Rakel
Publsiher: Elsevier Health Sciences
Total Pages: 1072
Release: 2017-03-21
ISBN 10: 0323496172
ISBN 13: 9780323496179
Language: EN, FR, DE, ES & NL

Integrative Medicine E Book Book Review:

Stay on the cutting edge of today’s most promising trends in complementary and alternative medical treatments with Dr. David Rakel’s Integrative Medicine, 4th Edition. Written by physicians who are experts in both traditional and integrative medicine, this highly regarded, evidence-based reference covers therapies such as botanicals, supplements, mind-body, lifestyle choices, nutrition, exercise, spirituality, and more. Integrative Medicine, 4th Edition uses a clinical, disease-oriented approach, offering practical guidance for reducing costs and improving patient care. Helps you safely and effectively incorporate complementary and alternative therapies into your everyday practice, while focusing on prevention and wellness for a better quality of life. Uses the reliable SORT method (Strength of Recommendation Taxonomy) to provide evidence-based ratings, grading both the evidence and the relative potential harm. Explains how to make the best use of integrative medicine and the mechanisms by which these therapeutic modalities work, keeping you at the forefront of the trend toward integrative health care. Includes 13 brand-new chapters, covering hot topics such as personalized medicine, MTHFR mutation, food allergy and intolerance, the gut-immune influence on systemic inflammation and disease, chelation therapy, testosterone deficiency, adrenal fatigue, and much more. Features more than 100 significantly revised chapters and hundreds of new figures and tables throughout.

Personalized and Precision Integrative Cardiovascular Medicine

Personalized and Precision Integrative Cardiovascular Medicine
Author: Mark Houston
Publsiher: Lippincott Williams & Wilkins
Total Pages: 500
Release: 2019-10-08
ISBN 10: 1975115295
ISBN 13: 9781975115296
Language: EN, FR, DE, ES & NL

Personalized and Precision Integrative Cardiovascular Medicine Book Review:

Encompassing functional cardiology, integrative medicine, and metabolic medicine/cardiology, this unique reference offers an up-to-date, expert approach to heart health wellness and treating the diseased heart and blood vessels. It provides today’s practitioners with insight into various treatment options and alternatives to pharmaceutical care and surgery, incorporating new scientific information on metabolic and integrative cardiovascular medicine from peer-reviewed articles, evidence-based medicine, and human clinical research as a foundation for practical clinical information.

Abiotic and Biotic Stress in Plants

Abiotic and Biotic Stress in Plants
Author: Arun Shanker,Chitra Shanker
Publsiher: BoD – Books on Demand
Total Pages: 768
Release: 2016-02-17
ISBN 10: 9535122509
ISBN 13: 9789535122500
Language: EN, FR, DE, ES & NL

Abiotic and Biotic Stress in Plants Book Review:

The impact of global climate change on crop production has emerged as a major research priority during the past decade. Understanding abiotic stress factors such as temperature and drought tolerance and biotic stress tolerance traits such as insect pest and pathogen resistance in combination with high yield in plants is of paramount importance to counter climate change related adverse effects on the productivity of crops. In this multi-authored book, we present synthesis of information for developing strategies to combat plant stress. Our effort here is to present a judicious mixture of basic as well as applied research outlooks so as to interest workers in all areas of plant science. We trust that the information covered in this book would bridge the much-researched area of stress in plants with the much-needed information for evolving climate-ready crop cultivars to ensure food security in the future.

Medicinal Applications of Coordination Chemistry

Medicinal Applications of Coordination Chemistry
Author: Chris J Jones,John R Thornback
Publsiher: Royal Society of Chemistry
Total Pages: 366
Release: 2007-10-31
ISBN 10: 1847557759
ISBN 13: 9781847557759
Language: EN, FR, DE, ES & NL

Medicinal Applications of Coordination Chemistry Book Review:

Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for a number of different applications, the design of new drugs and the relationship between structure and function. Key sections include diagnostic applications of metal compounds in anatomical and functional imaging, and therapeutic applications of metals compounds. This book is ideal for researchers in academia and industry and comes complete with examples of real life applications.

Metal Chelation in Medicine

Metal Chelation in Medicine
Author: Robert R Crichton,Roberta J Ward,Robert C Hider
Publsiher: Royal Society of Chemistry
Total Pages: 322
Release: 2016-10-18
ISBN 10: 1782623892
ISBN 13: 9781782623892
Language: EN, FR, DE, ES & NL

Metal Chelation in Medicine Book Review:

Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

Reproductive and Developmental Toxicology

Reproductive and Developmental Toxicology
Author: Ramesh C. Gupta
Publsiher: Academic Press
Total Pages: 1460
Release: 2017-03-24
ISBN 10: 0128042400
ISBN 13: 9780128042403
Language: EN, FR, DE, ES & NL

Reproductive and Developmental Toxicology Book Review:

Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis